Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2014

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 7951 - 7980 of 9579

Full-Text Articles in Medicine and Health Sciences

Molecular Discrimination Of Echinococcus Granulosus And Echinococcus Multilocularis By Sequencing And A New Pcr-Rflp Method With The Potential Use For Other Echinococcus Species, Çağri Şakalar, Sali̇h Kuk, Ahmet Erensoy, Adi̇le Ferda Dağli, İbrahi̇m Hani̇fi̇ Özercan, Ülfet Çeti̇nkaya, Süleyman Yazar Jan 2014

Molecular Discrimination Of Echinococcus Granulosus And Echinococcus Multilocularis By Sequencing And A New Pcr-Rflp Method With The Potential Use For Other Echinococcus Species, Çağri Şakalar, Sali̇h Kuk, Ahmet Erensoy, Adi̇le Ferda Dağli, İbrahi̇m Hani̇fi̇ Özercan, Ülfet Çeti̇nkaya, Süleyman Yazar

Turkish Journal of Medical Sciences

To develop a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol using a new genomic marker sequence and a novel set of restriction enzymes in order to detect and discriminate 2 Echinococcus species, E. granulosus and E. multilocularis, found in formalin-fixed paraffin-embedded (FFPE) human tissues. Materials and methods: DNA was isolated from 11 FFPE human tissue samples positive for cystic echinococcosis or alveolar echinococcosis. A mitochondrial genomic marker region was amplified and sequenced using a novel primer pair and a new PCR-RFLP protocol was developed for the detection and discrimination of E. granulosus and E. multilocularis using a set …

Go to article

Effects Of Ozone Therapy And Taurine On Ischemia/Reperfusion-Induced Testicular Injury In A Rat Testicular Torsion Model, Tolga Reşat Aydos, Mehmet Murad Başar, Oğuz Kul, Hasan Tarik Atmaca, Tuba Uzunali̇oğlu, Üçler Kisa, Oğuzhan Eki̇n Efe Jan 2014

Effects Of Ozone Therapy And Taurine On Ischemia/Reperfusion-Induced Testicular Injury In A Rat Testicular Torsion Model, Tolga Reşat Aydos, Mehmet Murad Başar, Oğuz Kul, Hasan Tarik Atmaca, Tuba Uzunali̇oğlu, Üçler Kisa, Oğuzhan Eki̇n Efe

Turkish Journal of Medical Sciences

To investigate the effect of ozone and/or taurine treatment comparatively on testicular damage due to ischemia/reperfusion (I/R) injury in an experimental torsion model in rats. Materials and methods: Adult Wistar rats with and without torsion/detorsion were used. In order to monitor the effect of ozone and/or taurine treatment on testicular damage due to I/R injury, following histopathological investigation apoptotic indexes were scored by TUNEL method. Moreover, tumor necrosis factor receptor 1 (TNFR1), caspase 3, caspase 8, endothelial nitric oxide synthase (eNOS), tumor necrosis factor alpha (TNF\alpha), and cytochrome C immunostainings were performed and the levels of malondialdehyde, glutathione peroxidase, superoxide …

Go to article

Early Extracorporeal Life Support Experiences In 2 Tertiary Pediatric Intensive Care Units In Turkey, Makbule Ni̇lüfer Öztürk, Koray Ak, Ni̇lgün Erkek, Edanur Yeşi̇l, Muhterem Duyu, Pinar Yazici, Ayşen Yaprak Engi̇n, Bülent Karapinar Jan 2014

Early Extracorporeal Life Support Experiences In 2 Tertiary Pediatric Intensive Care Units In Turkey, Makbule Ni̇lüfer Öztürk, Koray Ak, Ni̇lgün Erkek, Edanur Yeşi̇l, Muhterem Duyu, Pinar Yazici, Ayşen Yaprak Engi̇n, Bülent Karapinar

Turkish Journal of Medical Sciences

Extracorporeal membrane oxygenation (ECMO) is a unique life-support modality offered to patients unresponsive to optimal medical therapy. The aim of this study was to evaluate early experiences with ECMO support in 2 tertiary Turkish pediatric intensive care units (PICUs). Materials and methods: We retrospectively evaluated a total of 10 ECMO-supported patients between March 2012 and March 2013 in Marmara and Ege University Hospital PICUs. We reported data regarding demographics, laboratory and diagnostic information, and the clinical course of the patients. Results: The study consisted of 6 males and 4 females from 5 months to 14 years of age (mean age: …

Go to article

Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi Jan 2014

Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi

Turkish Journal of Medical Sciences

Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH). Materials and methods: This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects. Results: Mean IGF-I levels and median ALT levels were higher in patients with IH and …

Go to article

Investigating The Effects Of Negative-Calorie Diet Compared With Low-Calorie Diet Under Exercise Conditions On Weight Loss And Lipid Profile In Overweight/Obese Middle-Aged And Older Men, Mohammadreza Rezaeipour, Gennady Leonidovich Apanasenko, Vladimir Ivanovich Nychyporuk Jan 2014

Investigating The Effects Of Negative-Calorie Diet Compared With Low-Calorie Diet Under Exercise Conditions On Weight Loss And Lipid Profile In Overweight/Obese Middle-Aged And Older Men, Mohammadreza Rezaeipour, Gennady Leonidovich Apanasenko, Vladimir Ivanovich Nychyporuk

Turkish Journal of Medical Sciences

Negative-calorie diets (NCDs) are among the popular dieting guides for weight loss; however, there is still little knowledge about this method. The present study aimed to determine the effects of a NCD supplemented with exercise on weight loss and lipid profile, and to compare its efficiency with low-calorie diets (LCDs) with exercise among elderly adult men with abnormal weight gain. Materials and methods: Participants included sedentary men (aged 45-75 years) who were overweight or obese (n = 37). They were randomly divided into 2 groups: a group with a NCD and exercise, and a group with a LCD with exercise. …

Go to article

Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim Jan 2014

Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim

Turkish Journal of Medical Sciences

Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung associated with progressive airflow limitation. The aim of this study is to assess the influence of tiotropium treatment on airway inflammation and symptoms in stable COPD patients. Materials and methods: Inflammatory markers were measured in the expired breath condensate fluid (EBC) before starting tiotropium treatment and at the end of the first month. Results: Twenty-two patients (81% men) with a mean age of 65.4 ± 10.1 years completed the study. The mean nitrotyrosine and 8-isoprostane levels for oxidative stress markers in EBC before and after treatment were 4.5 …

Go to article

Leptin And Leptin Receptor Polymorphisms Are Related To Body Mass Index In A Turkish Population, Uzay Görmüş, Özlem Ti̇mi̇rci̇ Kahraman, Bahar Toptaş, Turgay İsbi̇r, Çavlan Çi̇ftçi̇, Hasan Hakan Berkkan, Altay Burak Dalan, Muti̇a Canan Karatay Jan 2014

Leptin And Leptin Receptor Polymorphisms Are Related To Body Mass Index In A Turkish Population, Uzay Görmüş, Özlem Ti̇mi̇rci̇ Kahraman, Bahar Toptaş, Turgay İsbi̇r, Çavlan Çi̇ftçi̇, Hasan Hakan Berkkan, Altay Burak Dalan, Muti̇a Canan Karatay

Turkish Journal of Medical Sciences

Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal was to investigate the association between leptin levels and leptin receptor polymorphisms in a Turkish population. Materials and methods: The sample pool of this study consisted of 202 subjects. G2548A variant in the promoter region of the leptin gene and Q223R polymorphism of the leptin receptor gene were evaluated by using PCR-RFLP. Leptin levels were determined by ELISA. Results: Leptin levels were significantly higher …

Go to article

The Relation Between Helicobacter Pylori And Ulcerative Colitis, Sedat Caner, Aki̇f Altinbaş, Yusuf Yeşi̇l, Yavuz Beyazit, Bariş Yilmaz, Osman Yüksel Jan 2014

The Relation Between Helicobacter Pylori And Ulcerative Colitis, Sedat Caner, Aki̇f Altinbaş, Yusuf Yeşi̇l, Yavuz Beyazit, Bariş Yilmaz, Osman Yüksel

Turkish Journal of Medical Sciences

Besides some genetic explanations of the native course of ulcerative colitis (UC), the most attributable factors are pathogenic bacterial agents. There are some conflicting data about the relationship between Helicobacter pylori and the rate of UC in the literature. Therefore, we aimed to investigate the rate of H. pylori in UC patients. Materials and methods: Forty-nine individuals diagnosed with UC who had undergone upper gastrointestinal tract endoscopy for different reasons were included in the study. The presence of H. pylori in the stomach was checked by histopathological examination. Results: H. pylori positivity was present in 57.1% of patients with UC. …

Go to article

The Correlation Of Echo Findings Of Right Cardiac Pathologies With Bnp, Uric Acid, And Crp In Osas, Ömer Araz, Eli̇f Yilmazel Uçar, Hüsnü Deği̇rmenci̇, Di̇dem Pulur, Hami̇t Acemoğlu, Ednan Bayram, Fuat Gündoğdu, Meti̇n Akgün Jan 2014

The Correlation Of Echo Findings Of Right Cardiac Pathologies With Bnp, Uric Acid, And Crp In Osas, Ömer Araz, Eli̇f Yilmazel Uçar, Hüsnü Deği̇rmenci̇, Di̇dem Pulur, Hami̇t Acemoğlu, Ednan Bayram, Fuat Gündoğdu, Meti̇n Akgün

Turkish Journal of Medical Sciences

Right cardiac pathologies develop in patients with obstructive sleep apnea syndrome (OSAS) and in most patients there are no symptoms in the early stages of right cardiac disorders. We aimed to evaluate a possible relationship between B-type natriuretic peptide (BNP), blood uric acid, C-reactive protein (CRP), and the right cardiac pathologies in patients with OSAS, and the role of these parameters in the management of patients with OSAS. Materials and methods: A total of 98 subjects, 31 (31.6%) controls and 67 (68.4%) with OSAS, were included in the study. All the subjects underwent polysomnography, and standard and tissue Doppler echocardiography …

Go to article

Polymorphisms In Mmp-2 And Timp-2 In Turkish Patients With Prostate Cancer, Kürşat Oğuz Yaykaşli, Muhammet Ali̇ Kayikçi, Nesi̇be Yamak, Hati̇ce Soğuktaş, Selma Düzenli̇, Ali̇ Osman Arslan, Ahmet Meti̇n, Ertuğrul Kaya, Ömer Faruk Hati̇poğlu Jan 2014

Polymorphisms In Mmp-2 And Timp-2 In Turkish Patients With Prostate Cancer, Kürşat Oğuz Yaykaşli, Muhammet Ali̇ Kayikçi, Nesi̇be Yamak, Hati̇ce Soğuktaş, Selma Düzenli̇, Ali̇ Osman Arslan, Ahmet Meti̇n, Ertuğrul Kaya, Ömer Faruk Hati̇poğlu

Turkish Journal of Medical Sciences

Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the remodeling of the extracellular matrix (ECM). The imbalance between MMPs and TIMPs may lead to an emergence of pathological processes such as cancer. In this study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) polymorphisms and prostate cancer in the Turkish population was investigated. Materials and methods: Sixty-one prostate cancer patients and 46 healthy subjects were included in the study. DNA was isolated from 2 …

Go to article

Does Lymph Node Involvement Affect The Patterns Of Recurrence In Stage Ib Cervical Cancer?, Işin Üreyen, Ülkü Aksoy, Betül Dündar, Ömer Lütfi̇ Tapisiz, Mustafa Alper Karalök, Ahmet Taner Turan, Nuretti̇n Boran, Hakki Gökhan Tulunay Jan 2014

Does Lymph Node Involvement Affect The Patterns Of Recurrence In Stage Ib Cervical Cancer?, Işin Üreyen, Ülkü Aksoy, Betül Dündar, Ömer Lütfi̇ Tapisiz, Mustafa Alper Karalök, Ahmet Taner Turan, Nuretti̇n Boran, Hakki Gökhan Tulunay

Turkish Journal of Medical Sciences

To investigate the variations in the recurrence patterns of stage IB cervical cancer according to lymph node involvement. Materials and methods: We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007. Results: Among the patients in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 patients developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence …

Go to article

A Case--Ontrol Study Of The Factors Affecting Male Infertility, Mohammad Mahboubi, Fezollah Foroughi, Fariba Ghahramani, Hanieh Shahandeh, Sahar Moradi, Tooraj Shirzadian Jan 2014

A Case--Ontrol Study Of The Factors Affecting Male Infertility, Mohammad Mahboubi, Fezollah Foroughi, Fariba Ghahramani, Hanieh Shahandeh, Sahar Moradi, Tooraj Shirzadian

Turkish Journal of Medical Sciences

Infertility is defined as the inability to conceive after at least 1 year of unprotected intercourse. In about one third of infertile couples, a male factor is the primary problem. Thus, the present study aimed to determine the most common risk factors for male infertility in Iranian men. Materials and methods: This case-control study included 268 men attending an infertility clinic in Shiraz, Iran. In this study, 161 fertile men were compared with 108 infertile ones regarding risk factors such as smoking habits, drug consumption, hernia, varicocele, job, and BMI. The data were analyzed using logistic regression analysis and t-test. …

Go to article

Surgery For Intractable Temporal Lobe Epilepsy: Experience Of A Single Institution, Gökhan Kurt, Mehmet Tönge, Emrah Çelti̇kçi̇, İrem Çapraz, Ayşe Serdaroğlu, Erhan Bi̇li̇r Jan 2014

Surgery For Intractable Temporal Lobe Epilepsy: Experience Of A Single Institution, Gökhan Kurt, Mehmet Tönge, Emrah Çelti̇kçi̇, İrem Çapraz, Ayşe Serdaroğlu, Erhan Bi̇li̇r

Turkish Journal of Medical Sciences

In the treatment of epilepsy, encouraging results have been achieved with surgical treatment, especially for temporal lobe epilepsy (TLE). Drug resistance must be diagnosed as early as possible, because the ensuing seizures can be eliminated surgically via temporal lobe surgery in a high percentage (70%-90%) of patients. In this study we share our experience, in a single institution, of surgical treatment of intractable TLE. Materials and methods: Between March 2006 and November 2010 we performed 127 corticoamygdalohippocampectomy (CAH) procedures. All CAH surgical procedures were done as described by Niemeyer's technique. Resection lengths were 4-4.5 cm from the temporal pole. Results: …

Go to article

Expression And Clinical Implications Of P53, P63, And P73 Protein In Malignant Tumor Of The Parotid Gland, Mei Yong, Ling Yang, Qimuge Suyila, Wenyan Han, Hongwei Yuan, Cheng Zhao, Xiulan Su Jan 2014

Expression And Clinical Implications Of P53, P63, And P73 Protein In Malignant Tumor Of The Parotid Gland, Mei Yong, Ling Yang, Qimuge Suyila, Wenyan Han, Hongwei Yuan, Cheng Zhao, Xiulan Su

Turkish Journal of Medical Sciences

To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics. Materials and methods: A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P73 protein expression by immunohistochemistry. Statistical analysis was performed by using the chi-square test. Results: P53, P63, and P73 protein expression in malignant parotid gland tumors was higher than their expression in adjacent nonneoplastic tissue (P = 0.030, 0.001, and 0.001, respectively). Expression of P53, …

Go to article

Comparative Study Of Photodynamic Therapy Monotherapy Versus Triple Management In Age-Related Macular Degeneration, Ahmet Seli̇m, Ni̇lüfer Koçak, Hüseyi̇n Aslankara, Süleyman Kaynak Jan 2014

Comparative Study Of Photodynamic Therapy Monotherapy Versus Triple Management In Age-Related Macular Degeneration, Ahmet Seli̇m, Ni̇lüfer Koçak, Hüseyi̇n Aslankara, Süleyman Kaynak

Turkish Journal of Medical Sciences

To compare the effectiveness of photodynamic therapy (PDT) and PDT combined with intravitreal triamcinolone (IVTA) and vascular endothelial growth factor inhibition (anti-VEGF) in age-related macular degeneration (AMD). Materials and methods: Eighty eyes of 80 patients diagnosed with choroidal neovascularization (CNV) caused by AMD were included in the study. PDT was carried out on 40 eyes in group I, and PDT combined with 4 mg IVTA and anti-VEGF (1.25 mg bevacizumab in 20 eyes, 0.3 mg pegaptanib sodium in 20 eyes) was carried out in group II. The primary efficacy endpoint was the mean change from baseline visual acuity at month …

Go to article

Early Surgical Results Of A 23-Gauge Trocar Combined With A One-Directional Valve System In Primary And Secondary Pars Plana Vitrectomy, Ayşe Gül Altintaş, Hasan Basri̇ Ari̇foğlu, Şükrü Gülteki̇n Köklü, Kenan Sönmez Jan 2014

Early Surgical Results Of A 23-Gauge Trocar Combined With A One-Directional Valve System In Primary And Secondary Pars Plana Vitrectomy, Ayşe Gül Altintaş, Hasan Basri̇ Ari̇foğlu, Şükrü Gülteki̇n Köklü, Kenan Sönmez

Turkish Journal of Medical Sciences

To elucidate the early surgical advantages of a 23-gauge trocar combined with a one-directional valve system in transconjunctival pars plana vitrectomies. Materials and methods: Early surgical results of 432 eyes of 432 patients (190 female and 242 male) who underwent 23-gauge (23G) transconjunctival sutureless vitrectomies (TSV) were evaluated. Sixty-three patients out of 432 underwent a second operation, 29 of them underwent silicone oil extraction, and 34 had phacoemulsification surgery with the help of vitreous infusion. If any sign of leakage was observed after the withdrawal of the cannulae, a suture was applied at the conjunctiva-scleral opening site. Results: A total …

Go to article

Calcifying Fibrous Pseudotumor Of Lungs, Serdar Özkan, Funda Demi̇rağ, Erdal Yekeler, Nuretti̇n Karaoğlanoğlu Jan 2014

Calcifying Fibrous Pseudotumor Of Lungs, Serdar Özkan, Funda Demi̇rağ, Erdal Yekeler, Nuretti̇n Karaoğlanoğlu

Turkish Journal of Medical Sciences

Calcified fibrous pseudotumors can generally be detected as solitary masses in various regions of the body, and were first described in 1988. In this case report, we discuss an adult patient whose tumor was localized in the lung, which has not been reported in the literature before.

Go to article

Computational Modeling Of Allosteric Regulation In The Hsp90 Chaperones: A Statistical Ensemble Analysis Of Protein Structure Networks And Allosteric Communications, Kristin Blacklock, Gennady M. Verkhivker Jan 2014

Computational Modeling Of Allosteric Regulation In The Hsp90 Chaperones: A Statistical Ensemble Analysis Of Protein Structure Networks And Allosteric Communications, Kristin Blacklock, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

A fundamental role of the Hsp90 chaperone in regulating functional activity of diverse protein clients is essential for the integrity of signaling networks. In this work we have combined biophysical simulations of the Hsp90 crystal structures with the protein structure network analysis to characterize the statistical ensemble of allosteric interaction networks and communication pathways in the Hsp90 chaperones. We have found that principal structurally stable communities could be preserved during dynamic changes in the conformational ensemble. The dominant contribution of the inter-domain rigidity to the interaction networks has emerged as a common factor responsible for the thermodynamic stability of the …

Go to article

Allosteric Regulation Of The Hsp90 Dynamics And Stability By Client Recruiter Cochaperones: Protein Structure Network Modeling, Kristin Blacklock, Gennady M. Verkhivker Jan 2014

Allosteric Regulation Of The Hsp90 Dynamics And Stability By Client Recruiter Cochaperones: Protein Structure Network Modeling, Kristin Blacklock, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The fundamental role of the Hsp90 chaperone in supporting functional activity of diverse protein clients is anchored by specific cochaperones. A family of immune sensing client proteins is delivered to the Hsp90 system with the aid of cochaperones Sgt1 and Rar1 that act cooperatively with Hsp90 to form allosterically regulated dynamic complexes. In this work, functional dynamics and protein structure network modeling are combined to dissect molecular mechanisms of Hsp90 regulation by the client recruiter cochaperones. Dynamic signatures of the Hsp90-cochaperone complexes are manifested in differential modulation of the conformational mobility in the Hsp90 lid motif. Consistent with the experiments, …

Go to article

Assessment Of Left Ventricular Function By Strain–Strain Rate Echocardiography In Patients With Celiac Disease, Cenk Sari, Ayli̇n Demi̇rezer Bolat, Fatma Ebru Akin, Ni̇hal Akar Bayram, Sevi̇l Özer Sari, Serdal Baştuğ, Emi̇ne Bi̇len, Hüseyi̇n Ayhan, Telat Keleş, Tahi̇r Durmaz, Osman Ersoy, Engi̇n Bozkurt Jan 2014

Assessment Of Left Ventricular Function By Strain–Strain Rate Echocardiography In Patients With Celiac Disease, Cenk Sari, Ayli̇n Demi̇rezer Bolat, Fatma Ebru Akin, Ni̇hal Akar Bayram, Sevi̇l Özer Sari, Serdal Baştuğ, Emi̇ne Bi̇len, Hüseyi̇n Ayhan, Telat Keleş, Tahi̇r Durmaz, Osman Ersoy, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Celiac is predominantly a disease of the small intestine characterized by chronic malabsorption in genetically susceptible individuals who ingest grains containing gluten, such as wheat, barley, and rye. In the present study, we evaluate left ventricular function in patients with celiac disease by using strain and strain rate echocardiography imaging. Materials and methods: Twenty celiac patients and 20 healthy controls were included in this study. Left ventricle systolic and diastolic functions were evaluated with standard 2-dimension, M-mode, conventional Doppler echocardiography. Strain and strain rate parameters were obtained for 8 segments of the left ventricle. Results: There were no significant differences …

Go to article

Relationship Of Admission Neutrophil-To-Lymphocyte Ratio With In-Hospital Mortality In Patients With Acute Type-I Aortic Dissection, Gökhan Lafçi, Ömer Faruk Çi̇çek, Haci Alper Uzun, Adnan Yalçinkaya, Adem İlkay Di̇ken, Osman Turak, Kumral Çağli, İrfan Taşoğlu, Hi̇kmet Selçuk Gedi̇k, Kemal Korkmaz, Orhan Eren Günertem, Keri̇m Çağli Jan 2014

Relationship Of Admission Neutrophil-To-Lymphocyte Ratio With In-Hospital Mortality In Patients With Acute Type-I Aortic Dissection, Gökhan Lafçi, Ömer Faruk Çi̇çek, Haci Alper Uzun, Adnan Yalçinkaya, Adem İlkay Di̇ken, Osman Turak, Kumral Çağli, İrfan Taşoğlu, Hi̇kmet Selçuk Gedi̇k, Kemal Korkmaz, Orhan Eren Günertem, Keri̇m Çağli

Turkish Journal of Medical Sciences

Acute aortic dissection is a life-threatening cardiovascular emergency. Neutrophil-to-lymphocyte ratio is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. The aim of the present study was to evaluate the relationship between admission neutrophil-to-lymphocyte ratio and in-hospital mortality in acute type I aortic dissection. Materials and methods: We retrospectively evaluated 123 consecutive patients who had undergone emergent surgery for acute type I aortic dissection. Patients were divided into 2 groups as patients dying in the hospital (Group 1) and those discharged alive (Group 2). All parameters, including neutrophil-to-lymphocyte ratio, were compared …

Go to article

Evaluation Of Hepatocellular Carcinoma With Computed Tomography Perfusion Imaging, Ümmügülsüm Bayraktutan, Abdulmeci̇t Kantarci, Hayri̇ Oğul, Yeşi̇m Kizrak, Ömer Özyi̇ği̇t, Zeyneb Yüceler, Berhan Genç, Bünyami̇ Özoğul Jan 2014

Evaluation Of Hepatocellular Carcinoma With Computed Tomography Perfusion Imaging, Ümmügülsüm Bayraktutan, Abdulmeci̇t Kantarci, Hayri̇ Oğul, Yeşi̇m Kizrak, Ömer Özyi̇ği̇t, Zeyneb Yüceler, Berhan Genç, Bünyami̇ Özoğul

Turkish Journal of Medical Sciences

To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC). Materials and methods: Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples. Results: A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma. Conclusion: CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.

Go to article

A Comparison Of The Generation Of Free Radicals In Saliva Of Active And Passive Smokers, Murat Demi̇rtaş, Ünal Şenel, Sevda Yüksel, Mustafa Yüksel Jan 2014

A Comparison Of The Generation Of Free Radicals In Saliva Of Active And Passive Smokers, Murat Demi̇rtaş, Ünal Şenel, Sevda Yüksel, Mustafa Yüksel

Turkish Journal of Medical Sciences

To reveal any correlation between cigarette smoke and malondialdehyde (MDA) values in the saliva fluid of subjects who are active smokers or nonsmoking subjects who are exposed to cigarette smoke in their environments. Materials and methods: Saliva samples were taken from 3 groups: a control group (group 1), a group inhaling smoke passively (group 2), and a test group (group 3) smoking 20 cigarettes per day; each group consisted of 20 members, giving a total sample of 60 people, aged 20 to 45 years. MDA, which is an indicator of lipid peroxidation, was measured via the colorimetric method. Results: Salivary …

Go to article

A Comparison Of The Effects Of Hyperbaric And Isobaric Bupivacaine Spinal Anesthesia On Hemodynamics And Heart Rate Variability, Mehmet Toptaş, Si̇nan Uzman, İlke İşi̇temi̇z, Tümay Uludağ Yanaral, İbrahi̇m Akkoç, Gülşen Bi̇can Jan 2014

A Comparison Of The Effects Of Hyperbaric And Isobaric Bupivacaine Spinal Anesthesia On Hemodynamics And Heart Rate Variability, Mehmet Toptaş, Si̇nan Uzman, İlke İşi̇temi̇z, Tümay Uludağ Yanaral, İbrahi̇m Akkoç, Gülşen Bi̇can

Turkish Journal of Medical Sciences

To compare the effects of hyperbaric and isobaric bupivacaine spinal anesthesia on hemodynamics and heart rate variability (HRV) in nonobstetric surgery. Materials and methods: Sixty patients were randomly allocated to 2 groups. Group I (n = 30) received 15 mg (3 mL) of hyperbaric bupivacaine and Group II (n = 30) received 15 mg (3 mL) of isobaric bupivacaine for spinal anesthesia. Hemodynamic parameters were recorded before and after spinal anesthesia over 30 min. Analyses of HRV were performed on the day of surgery, after volume loading, and 20 min after spinal injection. Low frequency (LF) values, high frequency (HF) …

Go to article

Prevalence Study Of Genital Tract Infections In Pregnant Women Referred To Health Centers In Iran, Mahmood Mobasheri, Narges Saedi Varnamkhast, Ali Karimi, Shayesteh Banaeiyan Jan 2014

Prevalence Study Of Genital Tract Infections In Pregnant Women Referred To Health Centers In Iran, Mahmood Mobasheri, Narges Saedi Varnamkhast, Ali Karimi, Shayesteh Banaeiyan

Turkish Journal of Medical Sciences

Pregnancy has its own complications such as premature rupture of membranes, preterm delivery, premature birth, low-birth-weight children, and infection. This study aimed to determine the prevalence rate of reproductive tract infections among pregnant women. Materials and methods: In this cross-sectional study, 85 randomly selected pregnant women referred to the ambulatory care facilities of Ardal County, Iran, were recruited via a systematic classified random sampling. Questionnaires, clinical examination by midwives, and laboratory assessments were used to gather the required data. Results: According to the laboratory tests, 71.76% of samples were infectious. Candida albicans (35.76%), Escherichia coli (17.97%), and Streptococcus (13.06%) were …

Go to article

Expression Of Nadph-D In The Vagal Nuclei Of The Chronic Esophagitis Model In Rats, Ümi̇t Süleyman Şehi̇rli̇, Hali̇l Tuğtepe, Ural Veri̇mli̇, Özlem Ki̇razli, Mazhar Özkan, Emrullah Tolga Dağli Jan 2014

Expression Of Nadph-D In The Vagal Nuclei Of The Chronic Esophagitis Model In Rats, Ümi̇t Süleyman Şehi̇rli̇, Hali̇l Tuğtepe, Ural Veri̇mli̇, Özlem Ki̇razli, Mazhar Özkan, Emrullah Tolga Dağli

Turkish Journal of Medical Sciences

To evaluate the changes in the number of NADPH diaphorase (NADPH-d) stained neurons in the vagal nuclei in a chronic esophagitis model. Materials and methods: There were 3 groups of rats examined: 1) a chronic gastroesophageal reflux rat group, which was created by a partial gastric outlet obstruction; 2) a sham group; and 3) a ranitidine treated group. Serial sections of brainstems of all groups were cut and NADPH-d staining, which selectively stains the nitric acid synthase-containing neurons, was done. Results: Histopathological changes due to chronic reflux esophagitis was observed in the reflux group. The ranitidine treatment and sham control …

Go to article

A Comparison Of Total Thyroidectomies Carried Out Through Ligasure And Harmonic Scalpel: A Retrospective Study, Kemal Peker, Ayça Tuba Dumanli Özcan, Murat Şahi̇n, Abdullah İnal, Kemal Kiliç, Fati̇h Özçi̇çek Jan 2014

A Comparison Of Total Thyroidectomies Carried Out Through Ligasure And Harmonic Scalpel: A Retrospective Study, Kemal Peker, Ayça Tuba Dumanli Özcan, Murat Şahi̇n, Abdullah İnal, Kemal Kiliç, Fati̇h Özçi̇çek

Turkish Journal of Medical Sciences

Both LigaSure (LS) and Harmonic Scalpel (HS) are new surgical technologies that have been used to secure hemostasis in various fields of surgery. There is little information in the literature about the use of LS and HS in thyroid surgery. The aim of this study was to report our experience with LS and HS in thyroid surgery. Materials and methods: In this nonrandomized retrospective study 326 consecutive patients who underwent primary thyroid surgery were reviewed. HS was used in 136 patients and LS was used in 126 patients. A conventional technique was used in 64 patients. The were 42 male …

Go to article

The Place Of Androgen Receptor Gene Mutation Analysis In The Molecular Diagnosis Of Prostate Cancer And Genotype–Phenotype Relationship, Fuat Kizilay, Mustafa Serdar Kalemci̇, Adnan Şi̇mşi̇r, Burak Turna, Oktay Nazli, Afi̇g Berdeli̇ Jan 2014

The Place Of Androgen Receptor Gene Mutation Analysis In The Molecular Diagnosis Of Prostate Cancer And Genotype–Phenotype Relationship, Fuat Kizilay, Mustafa Serdar Kalemci̇, Adnan Şi̇mşi̇r, Burak Turna, Oktay Nazli, Afi̇g Berdeli̇

Turkish Journal of Medical Sciences

To determine the relationship between androgen receptor (AR) gene polymorphism and prostate cancer in our society. Materials and methods: Thirty-nine patients diagnosed with prostate cancer and 34 benign prostatic hyperplasia (BPH) patients who were diagnosed in 2010 met the study criteria. The inclusion criteria included patients whose diagnosis was confirmed with a biopsy, with the presence of adequate pathologic material for review, between the ages of 40 and 80, and who were healthy men without a family history of prostate cancer. The exclusion criteria excluded men diagnosed with another cancer and those who had kin with a history of prostate …

Go to article

Comparison Of Different Ligation Techniques In Laparoscopic Varicocelectomy, Yi̇ği̇t Akin, Mutlu Ateş, Selçuk Yücel, Işil Başara, Orçun Çeli̇k, Ali̇seydi̇ Bozkurt, Bariş Nuhoğlu Jan 2014

Comparison Of Different Ligation Techniques In Laparoscopic Varicocelectomy, Yi̇ği̇t Akin, Mutlu Ateş, Selçuk Yücel, Işil Başara, Orçun Çeli̇k, Ali̇seydi̇ Bozkurt, Bariş Nuhoğlu

Turkish Journal of Medical Sciences

To evaluate the effects of different intracorporeal ligation techniques with titanium clips, Plasma Trisector (Gyrus, USA) (PTG), and surgical silk on bilateral laparoscopic varicocelectomy (LPVx). Materials and methods: Between May 2009 and August 2012, 100 patients who underwent bilateral LPVx were evaluated. The demographic parameters of patients, preoperative radiological findings, semen analysis, operative data, and follow-up were recorded. All of the patients were divided into 3 groups, randomized prospectively. The patients whose veins were ligated by 5-mm titanium clips were included in group I, those whose veins were ligated by PTG were included in group II, and those whose veins …

Go to article

Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer Jan 2014

Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer

Turkish Journal of Medical Sciences

The hepatitis B virus (HBV) is an important healthcare problem. Chronic hepatitis B infection may present with a wide range of manifestations from inactive carrier state to cirrhosis and hepatocellular cancer. Therefore, treatment is very important in chronic hepatitis B. In this study, the treatment results of 199 chronic hepatitis B patients taking entecavir 0.5 mg/day for 48 weeks were evaluated. Materials and methods: This study retrospectively evaluated data of 199 treatment-naive chronic hepatitis B patients who were treated with entecavir. Results: Of the 199 treatment-naive chronic hepatitis B patients, 141 (70.9%) were males and 58 (29.1%) were females, and …

Go to article

First Prev Next Last