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2014

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Articles 7921 - 7950 of 9579

Full-Text Articles in Medicine and Health Sciences

The Use Of Physical Restraints Among Nursing Home Residents: Do Disparities Exist?, Shekinah Fashaw Jan 2014

The Use Of Physical Restraints Among Nursing Home Residents: Do Disparities Exist?, Shekinah Fashaw

HIM 1990-2015

Introduction: The purpose of this study is to examine how nursing home (NH) characteristics, specifically racial composition of nursing homes residents, influences the use of physical restraints. As the population ages and becomes more diverse, it is essential to mitigate/eliminate racial/ethnic disparities in quality care. Methods: This is cross-sectional study using a 2010 national data set from Brown University Center for Gerontology and Healthcare Research. This study employs Donabedian's Structure-Process-Outcome (SPO) conceptual framework. Statistical analysis includes univariate, bivariate, and a logistic regression model. It is hypothesized that nursing homes with higher proportions of black residents, more Medicaid residents, and for-profit …

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Mycobacterium Tuberculosis Regulation Of Efflux Pump Tap By Transcriptional Activator Whib7, Aaron Pollock Jan 2014

Mycobacterium Tuberculosis Regulation Of Efflux Pump Tap By Transcriptional Activator Whib7, Aaron Pollock

HIM 1990-2015

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a debilitating disease that affects the health of millions annually. Understanding its ability to persist within host and resist eradication by antibiotics is of utmost importance in the effort to develop new interventions. This study will focus on the transcriptional activator WhiB7 and its regulation of the multidrug Tap efflux pump encoded by Rv1258c. WhiB7 is thought to respond to redox stress induced by antibiotics and a variety of in vivo stresses by activating multiple genes including Rv1258c. Much remains to be determined regarding the role of WhiB7 and downstream genes in Mtb …

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3-Amino-2-Piperidinequinoline A Novel Natural Product-Inspiried Synthetic Compound With Antimalarial Activity, Cristhian Valor Jan 2014

3-Amino-2-Piperidinequinoline A Novel Natural Product-Inspiried Synthetic Compound With Antimalarial Activity, Cristhian Valor

HIM 1990-2015

Malaria afflicts about 500 million people worldwide thus causing significant global economic toll. The drugs available to treat the disease are rapidly losing their efficacy because of widespread prevalence of drug resistant parasites. Thus there is an urgent need to discover novel malaria therapeutics. This research is focused on to study the properties of a novel naturallike synthetic scaffold and analyze its selectivity, and cellular mechanism of action in Plasmodium falciparum. We have identified a novel compound, 3-amino-2-piperidinequinoline (APQ), which we termed UCF401. APQ demonstrated IC[sub50] at submicromolar concentrations against Plasmodium falciparum using the SYBR Green-I fluorescence assay measuring cellular …

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Host And Bacterial Determinants Of Staphylococcus Aureus Nasal Colonization In Humans, Gowrishankar Muthukrishnan Jan 2014

Host And Bacterial Determinants Of Staphylococcus Aureus Nasal Colonization In Humans, Gowrishankar Muthukrishnan

Electronic Theses and Dissertations

Staphylococcus aureus (SA), an opportunistic pathogen colonizing the anterior nares in approximately 30% of the human population, causes severe hospital-associated and community-acquired infections. SA nasal carriage plays a critical role in the pathogenesis of staphylococcal infections and SA eradication from the nares has proven to be effective in reducing endogenous infections. To understand SA nasal colonization and its relation with consequent disease, assessment of nasal carriage dynamics among a diverse population and determining factors responsible for SA nasal carriage have become major imperatives. Here, we report on an extensive longitudinal monitoring of SA nasal carriage in 109 healthy individuals over …

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Endocrine And Contralateral Muscle Responses To Short-Term Unilateral Resistance Training, Carleigh Boone Jan 2014

Endocrine And Contralateral Muscle Responses To Short-Term Unilateral Resistance Training, Carleigh Boone

Electronic Theses and Dissertations

PURPOSE: The purpose of this study was to examine the effects of short-term lower body unilateral resistance training on hormonal, muscle morphological, and performance measures in young men. METHODS: Seventeen healthy, untrained young men (Age: 22.8 ± 3.7 y; BMI: 26.5 ± 4.9 kg/m2) were randomly assigned to one of two groups (UT: 22.9 ± 4.6 y, 25.3 ± 4.2 kg/m2; CON: 24.0 ± 4.6 y, 27.7 ± 5.1 kg/m2). Resistance training consisted of 4 weeks of unilateral lower body and bilateral upper body exercises on 3 days per week. Each training session entailed unilateral countermovement jumps (3 × 8), …

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Development Of The Taiwanese Mandarin Main Concept Analysis And Linguistic Communication Measure: Normative And Preliminary Aphasic Data, Chun-Chih Yeh Jan 2014

Development Of The Taiwanese Mandarin Main Concept Analysis And Linguistic Communication Measure: Normative And Preliminary Aphasic Data, Chun-Chih Yeh

Electronic Theses and Dissertations

Aphasia is a language disorder resulting from damage to brain areas that control language expression and reception. Clinically, the narrative production of Persons with Aphasia (PWA) provides valuable information for diagnosis of aphasia. There are several types of assessment procedures for analysis of aphasic's narrative production. One of them is to use quantification systems, such as the Cantonese Linguistic Communication Measure (CLCM; Kong & Law, 2004) or the Main Concept Analysis (MCA; Kong, 2009), for objective quantification of aphasic's discourse. The purposes of this study are (1) to translate the MCA and CLCM to a Taiwanese Mandarin Main Concept Analysis …

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Acoustic Analysis Of Prolonged Vowels In Adolescents And Young Adults With Friedreich's Ataxia, Kaylea Hardin Jan 2014

Acoustic Analysis Of Prolonged Vowels In Adolescents And Young Adults With Friedreich's Ataxia, Kaylea Hardin

Electronic Theses and Dissertations

This study employed spectral analyses for acoustic measures of sustained vowel productions from a group of 20 adolescents and young adults with Friedreich's Ataxia (FA) and compared findings with a group of 20 age-equivalent and gender-matched normal control participants. State-of-the art spectral analyses from the Analysis of Dysphonia in Speech and Voice (ADSV) program, developed for various voice disorders from Kay Elemetrics, were applied to initial 2 second sustained vowel segments of the vowels /a/, /i/, and /o/. Spectral analyses included averages and standard deviations of Cepstral Peak Prominence (CPP), Cepstral Peak Prominence Standard Deviation (CPP SD), Low/High Spectral Ratio …

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The Effect Of Moderate Altitude On High Intensity Running Performance During A Game With Collegiate Female Soccer Players, Jonathan Bohner Jan 2014

The Effect Of Moderate Altitude On High Intensity Running Performance During A Game With Collegiate Female Soccer Players, Jonathan Bohner

Electronic Theses and Dissertations

Competition often requires teams that reside at sea level to compete against opponents whose residence is at a moderate altitude. This may pose a potential competitive disadvantage considering that moderate altitude may cause decrements in VO2max, distance covered, and time to exhaustion in endurance athletes. The purpose of this study was to examine the effect of altitude on game performance measures. Six NCAA Division I female soccer players (20.33 ± 1.21 y; 168 ± 6.45 cm; 62.5 ± 6.03 kg) were retrospectively examined. Comparisons were made between two competitions that were played at sea level (SL) within two weeks of …

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Art Or Science?, Allison Marsh Jan 2014

Art Or Science?, Allison Marsh

Section 3: Imaging the Fast Moving

No abstract provided.

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Antipsychotic Prescriptions For Children Aged 5 Or Younger: Do We Need Policy Oversight Standards?, Ana Lopez-De Fede, Medha Vyavaharkar, Jessica D. Bellinger Jan 2014

Antipsychotic Prescriptions For Children Aged 5 Or Younger: Do We Need Policy Oversight Standards?, Ana Lopez-De Fede, Medha Vyavaharkar, Jessica D. Bellinger

Publications

The use of antipsychotics in very young children is of concern given the lack of empirical evidence in their efficacy and long-term impact on children’s health. This study examined the prescription of antipsychotics among children aged ≤5 years enrolled in a state Medicaid program. Secondary data analysis was conducted using the Medicaid administrative data of a southeastern state. Using SAS 9.3, descriptive statistics were performed to examine socio-demographic characteristics, psychiatric diagnoses, off-label use, receipt of medications from multiple psychotropic drug classes, and receipt of non-pharmacologic psychiatric services among children aged ≤5 years who received antipsychotic prescriptions in calendar year (CY) …

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Evaluation Of Histopathologic And Histomorphometric Changes Of Testicular Tissue And Gonadotropin Levels Following Consumption Of Methylphenidate In Male Mice, Simin Fazelipour, Zahra Tootian, Zahra Ghahri Saremi, Minoo Shafii, Mohammad Taghi Sheibani, Seyed Babak Kiaei, Mehrnoush Kiumarsi, Fardin Assadi Jan 2014

Evaluation Of Histopathologic And Histomorphometric Changes Of Testicular Tissue And Gonadotropin Levels Following Consumption Of Methylphenidate In Male Mice, Simin Fazelipour, Zahra Tootian, Zahra Ghahri Saremi, Minoo Shafii, Mohammad Taghi Sheibani, Seyed Babak Kiaei, Mehrnoush Kiumarsi, Fardin Assadi

Turkish Journal of Medical Sciences

One of the most common psychiatric disorders in children is attention-deficit/hyperactivity disorder, which is treated extensively by methylphenidate. This study investigates the assessment of the effects of methylphenidate on histopathologic and histomorphometric changes of the testes and serum levels of gonadotropin in mice. Materials and methods: In this study, 36 adult male mice were used. After determining their body weights, the animals were divided randomly into 2 experimental groups and 1 control group. The experimental groups received methylphenidate (2 and 10 mg kg^{-1} day^{-1}) via gavage for a period of 40 days. After evaluation of body weight, general anesthesia was …

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The Effect Of Lycopene On The Ototoxicity Induced By Cisplatin, Mehmet Turan Çi̇çek, Mahmut Tayyar Kalci̇oğlu, Tuba Bayindir, Yüksel Toplu, Mustafa Iraz Jan 2014

The Effect Of Lycopene On The Ototoxicity Induced By Cisplatin, Mehmet Turan Çi̇çek, Mahmut Tayyar Kalci̇oğlu, Tuba Bayindir, Yüksel Toplu, Mustafa Iraz

Turkish Journal of Medical Sciences

To determine the efficacy of lycopene, which is considered an antioxidant agent, in decreasing the cochlear damage induced by cisplatin. Materials and methods: A total of 38 rats were randomized into 4 groups: control, cisplatin, cisplatin + lycopene, and lycopene-treated groups. In all groups, the distortion-product otoacoustic emission measurements were performed on days 0, 1, 2, and 5. Results: There were no significant differences between the control and lycopene groups at any frequencies. In the cisplatin group, the statistically significant differences were found in the measurements taken between day 0 and day 5 at all frequencies and between days 1 …

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Is There A Genetic Predisposition For Turkish Patients With Sarcoidosis In The 329-Bp Region Containing The Btnl2 Rs2076530 Polymorphism?, Muhsi̇n Özdemi̇r, Faruk Saydam, Emel Kurt, İrfan Deği̇rmenci̇, Tunç Tuncel, Oğuz Çi̇li̇ngi̇r, Hasan Veysi̇ Güneş, Sevi̇lhan Artan Jan 2014

Is There A Genetic Predisposition For Turkish Patients With Sarcoidosis In The 329-Bp Region Containing The Btnl2 Rs2076530 Polymorphism?, Muhsi̇n Özdemi̇r, Faruk Saydam, Emel Kurt, İrfan Deği̇rmenci̇, Tunç Tuncel, Oğuz Çi̇li̇ngi̇r, Hasan Veysi̇ Güneş, Sevi̇lhan Artan

Turkish Journal of Medical Sciences

Sarcoidosis is a complex, multifactorial immune disorder with unknown etiology. A single nucleotide polymorphism ( G->A, rs2076530) in the butyrophilin-like 2 (BTNL2) gene results in a truncating protein formation. It has been previously reported that this variation may be a risk factor for sarcoidosis in certain ethnic groups. This study was conducted to determine whether there is any genetic predisposition for the BTNL2 rs2076530 polymorphism in the 329-bp region in Turkish patients with sarcoidosis. Materials and methods: DNA samples were obtained from volunteers including 53 Turkish patients with sarcoidosis and 52 healthy controls. Analysis of the 329-bp region was …

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Clinical And Demographic Findings Of Patients With Rheumatoid Arthritis And Ankylosing Spondylitis Treated In A Tertiary Care Center In Turkey, Özlem Cemeroğlu, Zeynep Sila Yaşar, Mustafa Sağlam, Haşi̇m Çakirbay Jan 2014

Clinical And Demographic Findings Of Patients With Rheumatoid Arthritis And Ankylosing Spondylitis Treated In A Tertiary Care Center In Turkey, Özlem Cemeroğlu, Zeynep Sila Yaşar, Mustafa Sağlam, Haşi̇m Çakirbay

Turkish Journal of Medical Sciences

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are 2 common rheumatic diseases that are frequent causes of disability. In this descriptive study, demographic, clinical, and laboratory findings of patients with RA and AS being followed in a tertiary care center in Turkey were reported. Materials and methods: The patient data of 45 RA and 45 AS cases were collected retrospectively from electronic medical records. Demographic findings, clinical and laboratory assessments of disease activity, drugs used for the treatment, and effect on quality of life of patients with RA and AS were analyzed. Results: In RA patients, 27% had mild, 44% …

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Comparison In Clinical Features And Life Impact Between Juvenile-Onset And Adult-Onset Ankylosing Spondylitis, Mingqiang Guan, Jian Wang, Zhigang Zhu, Jun Xiao, Liang Zhao, Zhihan Li, Zhanjun Shi Jan 2014

Comparison In Clinical Features And Life Impact Between Juvenile-Onset And Adult-Onset Ankylosing Spondylitis, Mingqiang Guan, Jian Wang, Zhigang Zhu, Jun Xiao, Liang Zhao, Zhihan Li, Zhanjun Shi

Turkish Journal of Medical Sciences

To compare the differences in clinical characteristics and disease impact on life between patients with juvenile-onset ankylosing spondylitis (JoAS) and patients with adult-onset AS (AoAS). Materials and methods: Demographic and clinical data were collected from 139 AS patients. Disease activity was defined with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Functional status was assessed with the Bath Ankylosing Spondylitis Functional Index (BASFI). Status of quality of life was evaluated with the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: There were 50 patients with JoAS (36.0%) and 89 with AoAS (64.0%). The JoAS group showed more onset with peripheral …

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Oxaliplatin And Ototoxicity: Is It Really Safe For Hearing?, Sali̇m Yüce, Mehmet Meti̇n Şeker, Sema Koç, İsmai̇l Önder Uysal, Turgut Kaçan, Mehtap Doğan, Mansur Doğan, Nalan Akgül Babacan, Saadetti̇n Kiliçkap Jan 2014

Oxaliplatin And Ototoxicity: Is It Really Safe For Hearing?, Sali̇m Yüce, Mehmet Meti̇n Şeker, Sema Koç, İsmai̇l Önder Uysal, Turgut Kaçan, Mehtap Doğan, Mansur Doğan, Nalan Akgül Babacan, Saadetti̇n Kiliçkap

Turkish Journal of Medical Sciences

Oxaliplatin is an effective and widely used chemotherapeutic agent in the treatment of many solid tumors. The most common side effects are peripheral neuropathy, gastrointestinal toxicity, and neutropenia. There have been some case reports about ototoxicity with oxaliplatin, but no clinical trials. In this trial, we explored whether or not oxaliplatin has ototoxic effects. Materials and methods: A total of 18 patients, 14 with colorectal cancer and 4 with pancreatic cancer, were included in this study. Four patients (22%) were treated with a capecitabine and oxaliplatin (CapeOx) regimen, and 14 patients (78%) were treated with fluorouracil, leucovorin, and oxaliplatin (FOLFOX-6). …

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Pharmacological Profile Of A Nitric Oxide Donor Spermine Nonoate In The Mouse Corpus Cavernosum, Fatma Peyman Ertuğ, Erği̇n Şi̇ngi̇ri̇k, Hacer Si̇nem Büyüknacar, Cemi̇l Göçmen, Mehmet Ata Seçi̇lmi̇ş Jan 2014

Pharmacological Profile Of A Nitric Oxide Donor Spermine Nonoate In The Mouse Corpus Cavernosum, Fatma Peyman Ertuğ, Erği̇n Şi̇ngi̇ri̇k, Hacer Si̇nem Büyüknacar, Cemi̇l Göçmen, Mehmet Ata Seçi̇lmi̇ş

Turkish Journal of Medical Sciences

To investigate the effects of spermine NONOate in the cavernous tissue obtained from mice treated or untreated with sildenafil. Materials and methods: We studied the effects of spermine NONOate on the tone and nitrergic relaxation responses of isolated mouse corpus cavernosum and compared them with sodium nitroprusside in the absence or presence of L-nitroarginine, hydroxocobalamin, pyrogallol, diethyldithiocarbamate (DETCA), or 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ). The neurogenic contractions and relaxations of the tissues were induced by electrical field stimulation. Some mice received a single oral dose of sildenafil and after 1 h the effects of spermine NONOate were evaluated by in vitro studies. Results: …

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The Comparison Of Folate And Vitamin B12 Levels Between Depressive And Nondepressive Postmenopausal Women, Özlem Şengül, Di̇lek Uygur, Mustafa Güleç, Berna Di̇lbaz, Esma Meltem Şi̇mşek, Ümi̇t Göktolga Jan 2014

The Comparison Of Folate And Vitamin B12 Levels Between Depressive And Nondepressive Postmenopausal Women, Özlem Şengül, Di̇lek Uygur, Mustafa Güleç, Berna Di̇lbaz, Esma Meltem Şi̇mşek, Ümi̇t Göktolga

Turkish Journal of Medical Sciences

To investigate if there is any association between the serum folate and vitamin B12 status and the depressive symptoms in postmenopausal women. Materials and methods: The study included 95 postmenopausal women. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess their depressive symptoms. The investigated women were classified into 2 groups based on the existence of depressive symptoms. These 2 groups were compared in terms of folic acid and vitamin B12 levels. Results: Among 95 cases, 27 postmenopausal women scored 16 or more on the CES-D scale and were classified as the depressive group (Group 1), and …

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Incidence Of Maternal Vitamin D Deficiency In A Region Of Ankara, Turkey: A Preliminary Study, Gökçe Gür, Ayhan Abaci, Adem Yasi̇n Köksoy, Ahmet Anik, Gönül Çatli, Fati̇h Mehmet Kişlal, Kadi̇r Okhan Akin, Nesi̇be Andiran Jan 2014

Incidence Of Maternal Vitamin D Deficiency In A Region Of Ankara, Turkey: A Preliminary Study, Gökçe Gür, Ayhan Abaci, Adem Yasi̇n Köksoy, Ahmet Anik, Gönül Çatli, Fati̇h Mehmet Kişlal, Kadi̇r Okhan Akin, Nesi̇be Andiran

Turkish Journal of Medical Sciences

To evaluate vitamin D levels and risk factors for vitamin D deficiency in healthy newborns and their mothers. Materials and methods: Ninety-nine healthy pregnant women (≥37 weeks of gestation) were enrolled in the study. Previous history of pregnancies and births, nutritional status, multivitamin supplementation, educational status, type of clothing, and the economic level of the family were recorded. Blood samples were drawn from the mothers and the umbilical cord of the newborns to measure serum 25(OH)D3, calcium, phosphorus, and parathormone levels. Results: While vitamin D insufficiency was identified as 62.6% in mothers, it was 58.6% in newborns; on the other …

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Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir Jan 2014

Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir

Turkish Journal of Medical Sciences

To assess whether osteocytes have an effect on reflex myoelectrical activity during whole-body vibration (WBV) in postmenopausal women. Materials and methods: Participants were classified into 2 groups: the low bone mineral density (BMD) group (n = 37) and normal BMD group (n = 43). Hip BMD was measured using dual-energy X-ray absorptiometry. Surface electromyography data recorded from the adductor longus muscle were processed to obtain vibration-induced reflex myoelectrical activity. Changes in plasma sclerostin (SOST) levels with WBV were expressed as a standardized vibration-induced SOST index. Results: The standardized vibration-induced SOST index was 1.03 ± 0.24 in the low BMD group …

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Determining Torsion Angle Of Humerus Head Using Mri Method, Ayfer Meti̇n Telli̇oğlu, Saci̇de Karakaş, Füsun Taşkin Jan 2014

Determining Torsion Angle Of Humerus Head Using Mri Method, Ayfer Meti̇n Telli̇oğlu, Saci̇de Karakaş, Füsun Taşkin

Turkish Journal of Medical Sciences

To measure the torsion angle of the humerus using images obtained via magnetic resonance imaging (MRI) in healthy volunteers and to evaluate outcomes with respect to sex and age groups. Materials and methods: The study consisted of 36 healthy adults (18 males and 18 females aged between 20 and 68 years). The humeral torsion angle (HTA) was calculated using axial MRI images. Differences between results in terms of sex and age groups were evaluated with the Mann-Whitney U test. Results: The median HTA was 21.5° (25th to 75th percentile: 7.8°-28°; range: -4° to 36°) in females, while it was 18.5° …

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Clonal Comparison Of Acinetobacter Strains Isolated From Intensive Care Patients And The Intensive Care Unit Environment, Esra Kirkgöz, Yasemi̇n Zer Jan 2014

Clonal Comparison Of Acinetobacter Strains Isolated From Intensive Care Patients And The Intensive Care Unit Environment, Esra Kirkgöz, Yasemi̇n Zer

Turkish Journal of Medical Sciences

Acinetobacter baumannii is one of the most commonly encountered microorganisms in nosocomial infections. It is thought that strains found in the environment can be a source for contamination of patients by Acinetobacter strains that are resistant to environmental conditions. This study was carried out to compare Acinetobacter strains isolated from a variety of nonviable environments and from patients in intensive care units (ICUs), and to explore whether environmental areas may be a source for bacterial contamination. Materials and methods: We studied A. baumannii strains isolated from ICU patients. When A. baumannii was isolated from the clinical sample of a patient, …

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Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya Jan 2014

Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya

Turkish Journal of Medical Sciences

To better understand the knowledge, attitudes, and demographic factors that influence the rate of influenza vaccination among high socioeconomic status parents. Materials and methods: questionnaire exploring the attitudes of parents to the influenza vaccine, and their knowledge about influenza and its vaccination, was given to parents of children from 1 through 16 years of age attending the Turgut Özal University Hospital after the 2011/12 influenza season. Results: In the present study, 285 mothers and their children participated and 8.8% (n = 25) of children had the influenza vaccination. Between the vaccinated and nonvaccinated groups, there were statistically significantly differences for …

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Hepatitis C Virus Genotypes In Adana And Antakya Regions Of Turkey, Agah Bahadir Öztürk, Ümi̇t Bi̇lge Doğan, Nevi̇n Akçaer Öztürk, Gonca Özyazici, Mehmet Demi̇r, Mustafa Sali̇h Akin, Ali̇ Suha Bi̇ngöl Jan 2014

Hepatitis C Virus Genotypes In Adana And Antakya Regions Of Turkey, Agah Bahadir Öztürk, Ümi̇t Bi̇lge Doğan, Nevi̇n Akçaer Öztürk, Gonca Özyazici, Mehmet Demi̇r, Mustafa Sali̇h Akin, Ali̇ Suha Bi̇ngöl

Turkish Journal of Medical Sciences

Hepatitis C virus (HCV) genotype 1 was found to be dominant in Turkey. In this study, HCV genotypes were examined in the Adana and Antakya regions of Turkey. Materials and methods: The study consisted of 639 HCV-RNA–positive patients with chronic HCV infection in Adana (214 males and 101 females) and Antakya (139 males and 185 females) in Turkey. Real time-polymerase chain reaction was used for genotype determination. Results: In Antakya, it was determined that the percentages of genotypes of type 1a (0.31%), 1b (86.73%), 2 (9.26%), 3 (0.93%), and 4 (2.78%) were compatible with the nationwide results seen in Turkey. …

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The Relationship Between Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia And Erectile Dysfunction: The Role Of Autonomic Hyperactivity, Mehmet Umul, Ahmet Bariş Altay, Fi̇kret Bademkiran, Burak Turna, Mehmet Bülent Semerci̇, Erdal Apaydin, Necmetti̇n Çikili Jan 2014

The Relationship Between Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia And Erectile Dysfunction: The Role Of Autonomic Hyperactivity, Mehmet Umul, Ahmet Bariş Altay, Fi̇kret Bademkiran, Burak Turna, Mehmet Bülent Semerci̇, Erdal Apaydin, Necmetti̇n Çikili

Turkish Journal of Medical Sciences

To investigate whether autonomic nervous system (ANS) hyperactivity may be a potential cause for the relationship between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Materials and methods: Twenty-four patients were recruited for this study. Complete physical examinations, urine analysis, uroflowmetry, and postvoid residual urine volume (PVRU) analysis were performed. The potential impact of some factors such as hyperglycemia, obesity, and hyperlipidemia were analyzed. These values were correlated with the various symptom scores. We performed an electromyographic and an electrocardiographic evaluation. The alterations after treatment with 2 different alpha-blockers were also analyzed. Results: The electromyographic and electrocardiographic assessments revealed …

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The Effect Of Lateral Internal Sphincterotomy On Resting Anal Sphincter Pressures, Kemal Peker, İsmayi̇l Yilmaz, İsmai̇l Demi̇ryilmaz, Abdullah İnal, Arda Işik Jan 2014

The Effect Of Lateral Internal Sphincterotomy On Resting Anal Sphincter Pressures, Kemal Peker, İsmayi̇l Yilmaz, İsmai̇l Demi̇ryilmaz, Abdullah İnal, Arda Işik

Turkish Journal of Medical Sciences

Anal fissures are one of the most common proctologic disorders. This study aimed to investigate alterations in anal sphincteric resting pressures after lateral internal sphincterotomy, which was performed for chronic anal fissure treatment. Materials and methods: Fifty-six (68.3%) male and 26 (31.7%) female patients were included in this study. Patients complicated with fistula-in-ano, abscess, cancer, inflammatory bowel disease, dermatitis, poor general condition, allergy to any of the standard medications, previous history of anal trauma, previous anal surgery, or diagnosis of a neurological disease and patients who did not give consent to the trial were excluded from the study. Two groups …

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Early Graft Dysfunction And Mortality Rate In Marginal Donor Liver Transplantation, Pinar Sarkut, Bariş Gülcü, Remzi̇ İşçi̇men, Murat Kiyici, Gürkan Türker, Nai̇le Bolca Topal, Yilmaz Özen, Ekrem Kaya Jan 2014

Early Graft Dysfunction And Mortality Rate In Marginal Donor Liver Transplantation, Pinar Sarkut, Bariş Gülcü, Remzi̇ İşçi̇men, Murat Kiyici, Gürkan Türker, Nai̇le Bolca Topal, Yilmaz Özen, Ekrem Kaya

Turkish Journal of Medical Sciences

To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients. Materials and methods: Donors with any 1 of following were considered marginal donors: age =>65 years, sodium level =>165 mmol/L and cold ischemia time =>12 h. Donors were classified according to the donor risk index (DRI) 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if 20. Early graft dysfunction (EGD) and mortality rate were evaluated. Results: During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients …

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Comparison Of High-Resolution Melting Analysis To Denaturing High Performance Liquid Chromatography In The Detection Of Point Mutations In Mefv, F5, And F2 Genes, Hülya Sümer Çelebi̇, Hi̇lal Özdağ Jan 2014

Comparison Of High-Resolution Melting Analysis To Denaturing High Performance Liquid Chromatography In The Detection Of Point Mutations In Mefv, F5, And F2 Genes, Hülya Sümer Çelebi̇, Hi̇lal Özdağ

Turkish Journal of Medical Sciences

Sensitive and cost-effective detection of point mutations is important in genetics research. Denaturing high-performance liquid chromatography (DHPLC) is known to be one of the most sensitive techniques for point mutation detection. A more recent technique, high-resolution melting (HRM), is based on the melting behavior of PCR products. In this study, the efficiency and sensitivity of HRM and DHPLC for the detection of MEFV, F5, and F2 gene point mutations were evaluated. Materials and methods: We studied 15 patients with MEFV mutations (E148Q, M680I, M694V, or V726A), 7 patients with the F51691G>A mutation, and 12 patients with the F220210G>A …

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Evaluation And Comparison Of Alpha- And Beta-Amanitin Toxicity On Mcf-7 Cell Line, Ertuğrul Kaya, Recep Bayram, Kürşat Oğuz Yaykaşli, İsmai̇l Yilmaz, Sai̇t Bayram, Emi̇ne Yaykaşli, Muhsi̇ne Zeynep Yavuz, Ali̇ Akçahan Gepdi̇remen Jan 2014

Evaluation And Comparison Of Alpha- And Beta-Amanitin Toxicity On Mcf-7 Cell Line, Ertuğrul Kaya, Recep Bayram, Kürşat Oğuz Yaykaşli, İsmai̇l Yilmaz, Sai̇t Bayram, Emi̇ne Yaykaşli, Muhsi̇ne Zeynep Yavuz, Ali̇ Akçahan Gepdi̇remen

Turkish Journal of Medical Sciences

Alpha- and beta-amanitins are the main toxins of the poisonous Amanita phalloides mushroom. Although there are many studies available concerning alpha-amanitin, there are limited data about beta-amanitin in the literature. Therefore, this study is aimed at comparing the toxic effects of alpha- and beta-amanitin on the MCF-7 cell line. Materials and methods: The alpha- and beta-amanitins used for this research were purified from Amanita phalloides by preparative high-performance liquid chromatography. The MCF-7 breast cancer cell line was used, and specific concentrations of the toxins (100, 10, 1, 0.1, and 0.01 µg/mL) were applied to the cells. The MTT test was …

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The Effect Of Malaysian Honey And Its Major Components On The Proliferation Of Cultured Fibroblasts, Al-Mahdi Al-Jadi, Francis Kanyang Enchang, Kamaruddi̇n Mohd Yusoff Jan 2014

The Effect Of Malaysian Honey And Its Major Components On The Proliferation Of Cultured Fibroblasts, Al-Mahdi Al-Jadi, Francis Kanyang Enchang, Kamaruddi̇n Mohd Yusoff

Turkish Journal of Medical Sciences

To examine, for the first time, the effect of a selected Malaysian honey and its major components on the proliferation of cultured fibroblasts. Materials and methods: Honey and some of its components, which include the sugars, the proteins, the hydrogen peroxide produced, and the phenolics, were exposed to cultured fibroblasts. The MTT colorimetric assay was used to assess cell viability and proliferation. Results: The stimulatory effect of honey on fibroblast proliferation was observed to be time- and dose-dependent. The continuous production of hydrogen peroxide by the honey-glucose oxidase system also acts to stimulate cell proliferation in a time- and dose-dependent …

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