Medicine and Health Sciences Commons^™

Depletion Of Pre-Mrna Splicing Factor Cdc5l Inhibits Mitotic Progression And Triggers Mitotic Catastrophe., R Mu, Y-B Wang, M Wu, Y Yang, W Song, T Li, W-N Zhang, B Tan, A-L Li, N Wang, Q Xia, W-L Gong, Chenguang Wang, T Zhou, N Guo, Z-H Sang, H-Y Li

Department of Cancer Biology Faculty Papers

Disturbing mitotic progression via targeted anti-mitotic therapy is an attractive strategy for cancer treatment. Therefore, the exploration and elucidation of molecular targets and pathways in mitosis are critical for the development of anti-mitotic drugs. Here, we show that cell division cycle 5-like (Cdc5L), a pre-mRNA splicing factor, is a regulator of mitotic progression. Depletion of Cdc5L causes dramatic mitotic arrest, chromosome misalignments and sustained activation of spindle assembly checkpoint, eventually leading to mitotic catastrophe. Moreover, these defects result from severe impairment of kinetochore-microtubule attachment and serious DNA damage. Genome-wide gene expression analysis reveals that Cdc5L modulates the expression of a …

Single Nucleotide Polymorphism Of Srebf-1 Gene Associated With An Increased Risk Of Endometrial Cancer In Chinese Women., Chun-Ping Qiu, Qing-Tao Lv, Samina Dongol, Chenguang Wang, Jie Jiang

Department of Cancer Biology Faculty Papers

AIM: Elevated levels of sterol regulatory element-binding protein-1 (SREBP-1) have been found in endometrial cancer (EC), suggesting that it is essential to the development of EC. Obesity and diabetes have been established as known risk factors of EC, while SREBF-1 gene polymorphisms have also been found to be associated with obesity and type II diabetes. Therefore, we hypothesize that single nucleotide polymorphism (SNP) in SREBF-1 gene may be associated with increased risk of EC.

METHOD: We analyzed the sequence of SREBF-1 in tissue samples from 30 EC cases and 6 benign controls using high throughput method. Based on the primary …

Graduate Students’ Perceptions Of Written Feedback At A Private University In Pakistan, Lubna Ghazal, Raisa B. Gul, Mehnaz Hanzala, Tansy Jessop, Ambreen Tharani

School of Nursing & Midwifery

Excellence in academic performance at the graduate level requires good command of writing skills. Teachers’ written feedback can help students to develop their writing skills. However, several personal and contextual factors may influence feedback processes and its utilization by students. Therefore, understanding these factors is essential to improve the practice of written feedback. This study aimed to appraise the quality of written feedback in the graduate programmes and to ascertain students’ perceptions about it at a private university in Pakistan. A purposive sample of 15 participants comprised the study. The data were collected through in-depth students’ interviews and the teachers’ …

Low Doses Of Colony-Stimulating Factors Lead To Resolution Of Neutropenia In Cancer Patients Through Increased Levels Of Dihydrofolate Reductase, Mohammad Perwaiz Iqbal, Ikram Ali Burney

Department of Biological & Biomedical Sciences

Low doses of granulocyte- colony stimulating factor (G-CSF) and granulocyte macrophage- colony stimulating factor (GM-CSF) have been shown to be beneficial in reducing duration of systemic antibiotic therapy and in-patient hospitalization by decreasing the period of neutropenia in cancer patients undergoing chemotherapy. Since the underlying mechanism is unclear, the aim of this study was to investigate whether the administration of G-CSF and GM-CSF in two different doses (low dose and standard dose) would result into resolution of neutropenia with concomitant increase in multiple forms of dihydrofolate reductase (DHFR, a pivotal enzyme in the pathway of de novo DNA synthesis). Thirty …

Security Of Graph Data: Hashing Schemes And Definitions, Muhammad U. Arshad, Ashish Kundu, Elisa Bertino, Krishna Madhavan, Arif Ghafoor

Cyber Center Publications

Use of graph-structured data models is on the rise - in graph databases, in representing biological and healthcare data as well as geographical data. In order to secure graph-structured data, and develop cryptographically secure schemes for graph databases, it is essential to formally define and develop suitable collision resistant one-way hashing schemes and show them they are efficient. The widely used Merkle hash technique is not suitable as it is, because graphs may be directed acyclic ones or cyclic ones. In this paper, we are addressing this problem. Our contributions are: (1) define the practical and formal security model of …

Evidence-Based Smoking Cessation Treatment For Disparate Populations, Chizimuzo T.C. Okoli

Nursing Presentations

Overview of this presentation:

• Describe Research Group and Program of Research among disparate Populations
• Discuss smoking among persons with substance use and mental illness
• Present smoking cessation outcomes from evidence-based programs for persons with substance use disorders and mental Illness
• Conclusion with current and future Projects

Community Health Workers: Implementing A System In Kentucky, S. Makwana, Frances J. Feltner, J. Chamness, C. White, S. Mayfield Gibson

Center of Excellence in Rural Health Presentations

A Community Health Worker (CHW) is a frontline public health worker who is a trusted member of and/or has an unusually close understanding of the community served. This trusting relationship enables the CHW to serve as a liaison/link/intermediary between health/social services and the community to facilitate access to services and improve the quality and cultural competence of service delivery. A CHW also builds individual and community capacity by increasing health knowledge and self-sufficiency through a range of activities such as outreach, community education, informal counseling, social support and advocacy. (American Public Health Association)

Recognized as professional members of the health …

New Dentist News (March 2014), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Deep Rna Sequencing Reveals Hidden Features And Dynamics Of Early Gene Transcription In Paramecium Bursaria Chlorella Virus 1, Guillaume Blanc, Michael Mozar, Irina V. Agarkova, James R. Gurnon, Giane Yanai-Balser, Janet M. Rowe, Yuannan Xia, Jean-Jack Riethoven, David D. Dunigan, James L. Van Etten

Nebraska Center for Virology: Faculty Publications

Paramecium bursaria chlorella virus 1 (PBCV-1) is the prototype of the genus Chlorovirus (family Phycodnaviridae) that infects the unicellular, eukaryotic green alga Chlorella variabilis NC64A. The 331-kb PBCV-1 genome contains 416 major open reading frames. A mRNA-seq approach was used to analyze PBCV-1 transcriptomes at 6 progressive times during the first hour of infection. The alignment of 17 million reads to the PBCV-1 genome allowed the construction of single-base transcriptome maps. Significant transcription was detected for a subset of 50 viral genes as soon as 7 min after infection. By 20 min post infection (p.i.), transcripts were detected for …

Quality Assurance And Its Application In Medical Education., M. Tariq, Syed Ahsan Ali

Department of Medicine

No abstract provided.

Distribution, Severity And Radiologic Features Of Intracranial Stenosis In Asymptomatic Pakistanis., Ayeesha Kamran Kamal, Farzin Majeed, Muhammad S. Ilyas, Munawar Hussain, Kamran Masood, Bilal Ahmed, Hasan Rehman,, Zafar Sajjad, Scott E. Kasner8

Department of Medicine

Background: Intracranial atherosclerotic disease (ICAD) is the most common ischemic stroke subtype globally. It accounts for 30–50% of all ischemic strokes in Asians. Aims—The aim of the study is to report the frequency of asymptomatic ICAD and its associated Magnetic Resonance Imaging (MRI) findings.

Methods: 200 adult participants were recruited from the Radiology Departments of two major diagnostic centers in Karachi. Eligible participants were confirmed for the absence of stroke symptoms via the Questionnaire for Verifying Stroke Free Status (QVSFS). QVSFS negative subjects underwent MRI on a 1.5 Tesla scanner. Images were centrally reviewed on Di com Viewer 3.0 with …

Accuracy Of Esophageal Scintigraphy For Evaluation Of Esophageal Motility Disorders, Vana Sangsasri, Sasitorn Sirisalipoch, Sutep Gonlachanvit, Tawatchai Chaiwatanarat

Chulalongkorn Medical Journal

Background : Esophageal scintigraphy is a non-invasive tool for detection of esophageal functional abnormality. But the lack of standardized procedure results in a wide range of reported sensitivity and specificity. Concerning the method of data acquisition, some studies found from their data that several swallowing provide a better result than single swallowing technique. Objective : To compare the accuracy of single swallowing and multiple swallowing methods in detection of esophageal functional abnormality using manometry as gold standard. Methods : and Materials Thirty-six patients who were clinically suspected of esophageal motility abnormality were examined using six consecutive swallows of the radiolabeled …

Traumatic Brain Injury: The Efficacy Of A Half-Day Training For School Psychologists, Susan C. Davies, Ashlyn M. Ray

Counselor Education and Human Services Faculty Publications

The incidence rates of traumatic brain injuries (TBI) are increasing, yet educators continue to be inadequately trained in assessing and serving students with TBIs. This study examined the efficacy of a half-day TBI training program for school psychologists designed to improve their knowledge and skills. Results of quantitative and qualitative survey analysis indicated there was little increase in knowledge and skills from pre-training to one-year follow-up, although participants did increase in confidence related to their decision-making abilities in working with students with TBI. The data indicate a need for future study of more effective training models.

Uchunguzi (Journal Watch/Montre De Journal) March 2014, Benjamin Wachira

Family Medicine, East Africa

Uchunguzi means investigation in Swahili and provides a summary of some of the most recent international literature as presented in other leading journals, but with an emphasis on what is relevant to our continent.

5-Fu Induced Acute Toxic Leukoencephalopathy: Early Recognition And Reversibility On Dwi-Mri, Shayan Sirat Maheen Anwar,, Fatima Mubarak, Zafar Sajjad, Muhammad Azeemuddin

Department of Radiology

Acute toxic leukoencephalopathy (ATL) is a rare adverse effect of 5-Fluorouracil (5-FU) chemotherapeutic agent. It is imperative for the radiologist to confidently identify the white matter changes caused by this agent in case of toxicity. This will help in early detection and appropriate management of patient, as the condition is reversible both clinically and on imaging. We report a case of a 29 years old gentleman, known case of carcinoma of esophagus who suffered from acute toxic leukoencephalopathy secondary to leukotoxic therapeutic agent 5-FU, and illustrate the reversible imaging findings of this condition on withdrawal of the inciting agent.

Lymphatic Filariasis:Homoeopathic Approach, Rajat Chattopadhyay

Indian Journal of Research in Homoeopathy

No abstract provided.

Research Highlights, Ritika Narula, Subhranil Saha, Munmun Koley

Indian Journal of Research in Homoeopathy

No abstract provided.

A Case Of Haemorrhoids In A 12-Year-Old Boy, Padmalaya Rath, Harleen Kaur

Indian Journal of Research in Homoeopathy

Haemorrhoids is a very common condition that a physician would encounter in day to day practice. However, haemorrhoids in children is not as common. The only known treatment for the condition in conventional medicine is surgical excision, which is generally not favoured at this age. The case reported here is that of an internal haemorrhoids in a 12-year-old child, who was treated successfully with homoeopathic medicine. The patient has been observed for more than 2 years without recurrence. Photographs were taken before and after treatment to record changes in the condition. Non-recurrence of complaint in the past two and half …

The Problem Is My Partner: Treating Couples When One Partner Wants The Other To Change, Kieran T. Sullivan, Joanne Davila

Psychology

Partners commonly present to couple therapy expecting that the relationship will only improve if their partner changes. In other words, the partner is the problem. In this paper we review research on people's capacity for change, the process of behavior change, and personality change, especially the role of attachment theory. We then review techniques for working with couples based on empirically validated approaches to couple therapy and general change principles in therapy. Finally, we present a case study and recommendations for working with change-demanding couples, emphasizing the importance of focusing on emotional acceptance.

บทบาทของรังสีรักษาในผู้ป่วยเด็ก Hodgkin Lymphoma, ทัศน์พงศ์ รายยวา

Chulalongkorn Medical Journal

ผู้ป่วยเด็ก Hodgkin lymphoma มีอัตราการรอดชีวิตที่ 10 ปี สูงกว่า 90% ส่งผลให้พบผลข้างเคียงระยะยาวจากการรักษาเพิ่มมากขึ้น ดังนั้นการรักษาในปัจจุบันจึงมุ่งเน้นที่ลดความเข้มข้นของการรักษาเพื่อลดผลข้างเคียงระยะยาวจากการรักษา เช่น การลดขอบเขตการฉายรังสี ปรับลดการรักษาตามกลุ่มความเสี่ยง การงดฉายรังสีในผู้ป่วยที่ตอบสนองดีต่อเคมีบำบัด และเทคนิคการฉายรังสีอันทันสมัย เป็นต้น.

ผลของการใช้กระต่ายช่วยบำบัดต่อความรู้สึกเห็นคุณค่าในตนเอง ภาวะซึมเศร้าและความสุขของเด็กที่ถูกกระทำทารุณกรรม, แก้วกุล ตันติพิสิฐกุล, ณัทธร พิทยรัตน์เสถียร

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : การนำกระต่ายช่วยในการบำบัดเป็นหนึ่งในการนำสัตว์ช่วยการบำบัดที่เป็นศาสตร์แพทย์ทางเลือกของวงการแพทย์ไทย เนื่องจากสัตว์เป็นสิ่งมีชีวิตที่ใกล้ชิดกับมนุษย์และเป็นสิ่งมีชีวิตที่สามารถมอบความรักให้ได้โดยไม่มีเงื่อนไข จึงสอดคล้องกับความต้องการของเด็กที่ถูกกระทำทารุณกรรม จึงอาจจะเป็นอีกทางเลือกหนึ่งที่น่าสนใจที่จะเป็นส่วนช่วยเหลือหรือพัฒนาจิตใจของที่ถูกกระทำทารุณกรรมให้ เห็นคุณค่าในตนเอง ลดภาวะซึมเศร้า และมีความสุขในการใช้ชีวิตมากขึ้นวัตถุประสงค์ : เพื่อศึกษาผลของการนำกระต่ายมาช่วยในการบำบัดต่อความรู้สึกเห็นคุณค่าในตนเอง ภาวะซึมเศร้า และความสุขของเด็กที่ถูกกระทำทารุณกรรมรูปแบบการวิจัย : การวิจัยเชิงทดลองสถานที่ทำการศึกษา : สถานพัฒนาและฟื้นฟูเด็ก จังหวัดลำปางตัวอย่างและวิธีการศึกษา : กลุ่มตัวอย่าง คือ เด็กที่ถูกกระทำทารุณกรรมทางเพศ ร่างกายและจิตใจ อายุ 13 - 18 ปี จำนวน 22 คน แบ่งเป็นกลุ่มทดลองและกลุ่มควบคุมอย่างละ 11 คน โดยให้กลุ่มทดลองเข้าร่วมโปรแกรมกระต่ายช่วยบำบัดเป็นระยะเวลา 5 วัน ทั้งหมด 10 กิจกรรม และกลุ่มควบคุมดำเนินชีวิตประจำวันปกติ เครื่องมือที่ใช้เป็นแบบประเมินการเห็นคุณค่าในตนเอง แบบประเมินภาวะซึมเศร้า และประเมินความสุขผลการศึกษา : เด็กที่ถูกกระทำทารุณกรรมในกลุ่มทดลองมีคะแนนเห็นคุณค่าในตนเองเพิ่มขึ้น ภาวะซึมเศร้าลดลง และความสุขเพิ่มขึ้นหลังจากการเข้าร่วมโปรแกรมกระต่ายบำบัด อย่างไม่มีนัยสำคัญทางสถิติสรุป : ผลการวิจัยพบว่าผลของการใช้กระต่ายบำบัด ทำให้ค่าเฉลี่ยของระดับคะแนนความรู้สึกเห็นคุณค่าในตนเอง ภาวะซึมเศร้าและความสุข ระหว่างกลุ่มทดลองและ กลุ่มควบคุมแตกต่างอย่างไม่มีนัยสำคัญ.

Comparing The Characteristics Of Homeless Adults In Poland And The United States, Paul A. Toro, Karen Hobden, Kathleen Wyszacki Durham, Marta Oko-Riebau, Anna Bokszczanin

Psychology Faculty Research Publications

This study compared the characteristics of probability samples of homeless adults in Poland (N = 200 from two cities) and the United States (N = 219 from one city), using measures with established reliability and validity in homeless populations. The same measures were used across nations and a systemic translation procedure assured comparability of measurement. The two samples were similar on some measures: In both nations, most homeless adults were male, many reported having dependent children and experiencing out-of-home placements when they themselves were children, and high levels of physical health problems were observed. Significant national differences were …

Pharmacy Law Brief: Medications And Lawful Executions, Joseph L. Fink Iii

Pharmacy Practice and Science Faculty Publications

No abstract provided.

Acceptability Of Condoms, Circumcision And Prep Among Young Black Men Who Have Sex With Men: A Descriptive Study Based On Effectiveness And Cost, Richard A. Crosby, Angelica Geter, Ralph J. Diclemente, Laura F. Salazar

Health, Behavior & Society Faculty Publications

The current study examined and compared the willingness of young Black men who have sex with men (YBMSM) to accept pre-exposure prophylaxis (PrEP), adult male circumcision, and condoms for reducing their risk of HIV acquisition. The majority (67%) reported unprotected receptive anal sex in the last six months. About three-quarters (71%) would accept using PrEP if it was 100% effective. Cost influenced PrEP acceptance with 19% indicating acceptance at $100 per month co-pay. Of those not circumcised, 50% indicated willingness if circumcision was 100% effective. Acceptance of circumcision decreased markedly to 17% with co-pays of $100. About 73% of men …

Tobacco Use Among Adults Initiating Treatment For Hiv Infection In Rural Uganda, Gina R. Kruse, David Bangsberg, Judith A. Hahn, Jessica E. Haberer, Peter Hunt, Conrad Muzoora, John P. Bennett, Jeffrey N. Martin, Nancy A, Rigotti

OHSU-PSU School of Public Health Faculty Publications and Presentations

We conducted a longitudinal study of tobacco use among adults initiating antiretroviral therapy (ART) in Mbarara, Uganda where 11% of men and 3% of women use tobacco according to the 2011 Demographic and Health Survey. In a prospective cohort, self-reported tobacco use was assessed before starting ART and reassessed every 3–4 months. Plasma cotinine, a nicotine metabolite, was measured in a subset of adults pre-ART to verify self-report. Among 496 subjects, 50 (10%) reported current tobacco use (20% of men, 6% of women). Most (53%) adults with elevated cotinine levels (>15 ng/mL) reported no tobacco use. By 6 months …

Postoperative Urinary Retention (Pour): What Are The Risk Factors?, Eric H. Tischler, Ba, Camilo Restrepo, Md, Jennifer Oh, Ba, Mitchell Maltenfort, Phd, Javad Parvizi, Md, Frcs

Rothman Institute Conference Posters

Introduction

Total hip arthroplasty (THA) is a successful procedure alleviating pain in patients with debilitating arthritis. Postoperative urinary retention (POUR) is a common complication following surgery and is managed with intermittent or continued urinary catheterization. POUR has been estimated in retrospective literature to be on the order of 5% – 70% of surgical cases with early catheter removal or without a catheter. At our institution, and based on a Level 1 study here, urinary catheter is not used routinely in patients undergoing THA under regional anesthesia. The purpose of this study was to evaluate the incidence of POUR and risk …

Myd88-Dependent Immunity To A Natural Model Of Vaccinia Virus Infection Does Not Involve Toll-Like Receptor 2., Michael L Davies, Janet J Sei, Nicholas A Siciliano, Ren-Huan Xu, Felicia Roscoe, Luis J Sigal, Laurence C. Eisenlohr, Christopher C Norbury

Department of Microbiology and Immunology Faculty Papers

UNLABELLED: Although the pattern recognition receptor Toll-like receptor 2 (TLR2) is typically thought to recognize bacterial components, it has been described to alter the induction of both innate and adaptive immunity to a number of viruses, including vaccinia virus (VACV). However, many pathogens that reportedly encode TLR2 agonists may actually be artifactually contaminated during preparation, possibly with cellular debris or merely with molecules that sensitize cells to be activated by authentic TLR2 agonists. In both humans and mice, the most relevant natural route of infection with VACV is through intradermal infection of the skin. Therefore, we examined the requirement for …

Training The Resident In Percutaneous Nephrolithotomy, Muhammad Hammad Ather, Chi-Fai Ng, Gholamraza Pourmand, Palle J. Osther

Section of Urology

Objective: From the trainers' perspective percutaneous nephrolithotomy (PCNL) is one of the most challenging endourological procedures. In this review we examine the problems arising when training residents in PCNL, and how to facilitate this process.
Methods: The recommendations are derived from discussions and consensus during the First European Urolithiasis Society (EULIS) meeting held in London in September 2011. In addition, we searched Medline for articles identified using the keywords 'training', 'percutaneous surgery', 'renal calculi', 'PCNL', 'virtual reality' and 'simulators'. We also assessed the effect of modern technology, including the availability of virtual reality models vs. operating room training, and how …

Urology Training In The Developing World: The Trainers' Perspective, M Hammad Ather, Tahmeena Siddiqui

Section of Urology

Context: Despite producing some of the leading urologists in the world, urological training in the developing world is marred by inconsistency, and a lack of structure and focus on evidence-based practice. In this review we address these issues from the trainers' perspective.
Introduction: Teaching the art and science of urological practice is a demanding task. It not only involves helping the resident to develop the depth of cognitive knowledge, but also to have an appropriate surgical judgement, and an ability to act quickly but thoughtfully and, when necessary, decisively.
Discussion: The surgeon must have compassion, communication skills, be perceptive and …

Oncolog, Volume 59, Number 03, March 2014, Bryan Tutt, Joe Munch, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Expanding the Use of Laparoscopic Liver Resection: Minimally invasive surgical resection of liver tumors once was used only in select patients with easily accessible lesions located in the anterior of the liver. However, recent improvements in surgical techniques and the use of preoperative imaging have made laparoscopic approaches possible for even compels liver resection
• Physicians Refining Lung Cancer Screening Program: Lung cancer screening with low-dose computed tomography (CT) has been shown to reduce the rate of lung cancer-specific mortality in people at high risk for the disease
• Should the Primary Tumor Be Treated in Patients With Metastatic Prostate Cancer?: Researchers …