Medicine and Health Sciences Commons^™

Inputs Drive Cell Phenotype Variability., James Park, Anthony Brureau, Kate Kernan, Alexandria Starks, Sonali Gulati, Babatunde Ogunnaike, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

What is the significance of the extensive variability observed in individual members of a single-cell phenotype? This question is particularly relevant to the highly differentiated organization of the brain. In this study, for the first time, we analyze the in vivo variability within a neuronal phenotype in terms of input type. We developed a large-scale gene-expression data set from several hundred single brainstem neurons selected on the basis of their specific synaptic input types. The results show a surprising organizational structure in which neuronal variability aligned with input type along a continuum of sub-phenotypes and corresponding gene regulatory modules. Correlations …

Using Auditory Feedback To Improve The Performance Of Judokas During Uchi Komi, Taylor Easton Ferguson

USF Tampa Graduate Theses and Dissertations

Auditory feedback has been shown to be highly effective at teaching new skills to athletes in a variety of sports. This method consists of targeting a routine, breaking down the specific skills required to complete the routine, and training an individual on those skills using an auditory device to provide feedback on correct responses. This study evaluated the effectiveness of auditory feedback for improving a judo technique. One set of techniques taught in judo are standing throws, which require a partner to receive the technique (uke.) These throws require specific skills to successfully implement the technique. Auditory feedback was evaluated …

Trends And Costs Of Industry-Related Injuries In The United States [1998 - 2009], Delphine Fontcha

USF Tampa Graduate Theses and Dissertations

In order to describe the trend, characteristics, and cost of occupational injuries that occurred in industrial settings across the United States between 1998 and 2009, a cross sectional analysis based on hospital discharge data was conducted. The National Inpatient Sample (NIS) data from the Healthcare and Cost Utilization Project (HCUP)(1) was used. Identification of relevant injuries from the sample was performed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9 CM) code E849.3 (industrial place and premises)(8).

A total of 307,586 (weighted) patients with industrial related injuries were discharged from hospitals in the United States during the period …

Behavioral Assessment And Hplc/Ms/Ms Identification Of The Synthetic Cannabinoid, Cp47,497, In Mice, Kimberly L. Samano

Theses and Dissertations

CP47,497 and other synthetic cannabinoid compounds were incipiently synthesized as research tools to investigate the mechanisms by which marijuana affects the brain and to aid in the development of therapeutic agents. Recently, these cannabinoid compounds have resurfaced in the designer drug market, marketed as “herbal incense products” (HIPs). Their popular use has resulted in an alarming rate of reported adverse effects and toxicities. Current legislation classified CP47,497 and several other synthetic cannabinoids compounds as Schedule I agents, but abuse of these compounds persists with serious consequences to public health and safety. In vivo studies examining the behavioral consequences of abused …

Elective Early Term Delivery And Adverse Infant Outcomes In A Population-Based Multiethnic Cohort, Jason Lee Salemi

USF Tampa Graduate Theses and Dissertations

The length of human pregnancy, arguably the most natural of physiological processes, is undergoing subtle but consequential modification in order to adapt to modern societal demands. The gestational age distribution of births in the United States has been shifting to lower gestational ages over the past two decades, parallel to a concomitant rise in obstetrical intervention in pregnancy. The result has been an increase in elective deliveries at 37-38 weeks (early term).

A population-based retrospective cohort study of over 616,000 live-born full-term singleton infants was conducted to investigate the association between elective early term delivery and subsequent infant morbidity, mortality, …

Altered Expression Of Transmembrane Mucins, Muc1 And Muc4, In Bladder Cancer: Pathological Implications In Diagnosis., Sukhwinder Kaur, Navneet Momi, Subhankar Chakraborty, David G. Wagner, Adam J. Horn, Subodh M. Lele, Dan Theodorescu, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

PURPOSE: Radical changes in both expression and glycosylation pattern of transmembrane mucins have been observed in various malignancies. We and others have shown that MUC1 and MUC4, two transmembrane mucins, play a sentinel role in cell signaling events that drive several epithelial malignancies. In the present study, we investigated the expression profile of MUC1 and MUC4 in the non-neoplastic bladder urothelium, in various malignant neoplasms of bladder and in bladder carcinoma cell lines.

MATERIAL AND METHODS: Immunohistochemistry was performed on tissue sections from the urinary bladder biopsies, resection samples and tissue microarrays (TMAs) with monoclonal antibodies specific for MUC1 and …

What’S In A Name? How Huntington’S Disease Gene Carriers Are Seen By Themselves And Others, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Statistical And Prognostic Modeling Of Clinical Outcomes With Complex Physiologic Data, Monica A. Puertas

USF Tampa Graduate Theses and Dissertations

Laboratory tests are a primary resource for diagnosing patient diseases. However, physicians often make decisions based on a single laboratory result and have a limited perspective of the role of commonly-measured parameters in enhancing the diagnostic process. By providing a dynamic patient profile, the diagnosis could be more accurate and timely, allowing physicians to anticipate changes in the recovery trajectory and intervene more effectively.

The assessment and monitoring of the circulatory system is essential for patients in intensive care units (ICU). One component of this system is the platelet count, which is used in assessing blood clotting. However, platelet counts …

The Pediatric Milestones Project: Part Ii, Kris Rooney Md, Diana Drogalis-Kim Do

Department of Pediatrics

No abstract provided.

Alcohol Screening And Brief Intervention As Standard Practice In Indian Country, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Bonnie Duran, Catherine N. Dulmus Phd, Amy R. Manning

Brown School Faculty Publications

Alcohol use and the resulting problems associated with high-risk drinking in the American Indian/Native Alaskan (AI/NA) population are well-documented, as alcohol misuse has taken an incredible toll on many AI/NA communities. Presently, both overall health issues and alcohol use occur disproportionately within this population. This article provides an updated overview of the impact of alcohol use in the United States and within AI/NA communities specifically. It also provides recommendations for an alcohol-related screening and brief intervention instrument that social workers can begin using in their practice and can be utilized within the AI/NA community.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Diabetes and Colorectal Cancer Screening

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Diabetes and Colorectal Cancer Screening

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Diabetes and Colorectal Cancer Screening

Characterization Of Iron Response In Gynecological Cell Lines, Kyle A. Bauckman

USF Tampa Graduate Theses and Dissertations

Ovarian carcinoma afflicts over 22,000 women each year with a 5 year survival rate of only 18% for stage IV patients [23]. Current treatment options are limited due to high rates of drug resistance and recurrence. Further, the identity of "precursor lesions" which give rise to various subclasses of epithelial ovarian cancer has been evasive. This is due to discovery of the cancer at already an advanced stage. Interestingly, endometriosis a benign but invasive gynecological disease has been described as a "precursor lesion" in the development of specific subtypes of ovarian cancer. Endometriotic cyst development involves the accumulation of "old …

Resources Matter: The Role Of Social Capital And Collective Efficacy In Mediating Gun Violence, Jennifer Lynne Dean

USF Tampa Graduate Theses and Dissertations

Abstract

This study explains how community activists make use of available social capital and collective efficacy while attempting to mediate gun violence. It specifically focuses on twelve in-depth interviews of activists' perspectives, processes and rationales to alleviate community gun violence, based on informal social control models. Findings suggest activists must establish trust and respect with youth they work with before mediation begins, which is established through similar life experiences or backgrounds. Once a strong bond is established with youth, activists identified five core processes to reduce violence: 1) improve the mindset, 2) provide life skills, 3) assist youth as their …

Perceptions Of Mentoring From Fourth Year Medical Students, Stephen Charles

USF Tampa Graduate Theses and Dissertations

This mixed-methods research study investigated medical students' perspectives of professional mentoring through a web-based survey/needs assessment. The participants are fourth year medical students from three large urban research institutions and two regional branch campuses. The web-based survey/needs assessment was created, peer reviewed, and validated. A strategic sampling of focus groups was conducted to gather additional information regarding the results from the web-based survey. The information and data obtained from the survey and focus groups was used to provide recommendations for administrators and faculty about the mentoring program for each campus. A new proposed model of mentoring was developed upon analysis …

A Unification Of Mediation And Interaction: A Four-Way Decomposition, Tyler J. Vanderweele

Harvard University Biostatistics Working Paper Series

It is shown that the overall effect of an exposure on an outcome, in the presence of a mediator with which the exposure may interact, can be decomposed into four components: (i) the effect of the exposure in the absence of the mediator, (ii) the interactive effect when the mediator is left to what it would be in the absence of exposure, (iii) a mediated interaction, and (iv) a pure mediated effect. These four components, respectively, correspond to the portion of the effect that is due to neither mediation nor interaction, to just interaction (but not mediation), to both mediation …

What's Happening: March 24, 2014, Maine Medical Center

What's Happening

No abstract provided.

International Telemedicine Consultations For Neurodevelopmental Disabilities, Phillip L. Pearl, Craig A. Sable, Sarah Helen Evans, Joseph Knight, Parker Cunningham, Gaetano R. Lotrecchiano, Andrea L. Gropman, Sheela Stuart, Penny J. Glass, Anne Conway, Issam Ramadan, Tania Paiva, Mark L. Batshaw, Roger J. Packer

Neurology Faculty Publications

Background: A telemedicine program was developed between the Children's National Medical Center (CNMC) in Washington, DC, and the Sheikh Khalifa Bin Zayed Foundation in the United Arab Emirates (UAE). A needs assessment and a curriculum of on-site training conferences were devised preparatory to an ongoing telemedicine consultation program for children with neurodevelopmental disabilities in the underserved eastern region of the UAE.

Materials and Methods: Weekly telemedicine consultations are provided by a multidisciplinary faculty. Patients are presented in the UAE with their therapists and families. Real-time (video over Internet protocol; average connection, 768 kilobits/s) telemedicine conferences are held weekly following previews …

Current Pathophysiological Concepts In Cerebral Small Vessel Disease., Fred Rincon, Clinton B Wright

Department of Neurology Faculty Papers

The association between cerebral small vessel disease (SVD) - in the form of white matter lesions, infarctions, and hemorrhages - with vascular cognitive impairment (VCI), has mostly been deduced from observational studies. Pathological conditions affecting the small vessels of the brain and leading to SVD have suggested plausible molecular mechanisms involved in vascular damage and their impact on brain function. However, much still needs to be clarified in understanding the pathophysiology of VCI, the role of neurodegenerative processes such as Alzheimer's disease, and the impact of aging itself. In addition, both genetic predispositions and environmental exposures may potentiate the development …

The Effects Of Laryngeal Desiccation And Nebulized Isotonic Saline In Trained Male Singers, Robert B. Fujiki

Theses and Dissertations

Vocal fold hydration is important for healthy function of the vocal mechanism. Vocal fold surface fluid protects the mucosa and facilitates efficient vocal fold oscillation. Dry air exposure, mouth breathing, insufficient intake of liquids, and behavioral factors may contribute to laryngeal dehydration. Singers are believed to be particularly at risk for voice problems related to dehydration due to environmental and voice use factors. Laryngeal desiccation and nebulized hydration treatments have been shown to influence phonation threshold pressure (PTP) and self-perceived phonatory effort (PPE) in females. However, little research exists exploring the effects of hydration in males. Additionally, few studies have …

Promoting Generalization Of Skills Acquired Through Behavioral Skills Training With Embedded Visual Prompts, Andrea N. Perdomo

USF Tampa Graduate Theses and Dissertations

Studies on the "Tools" for Positive Behavior Change were originally conducted with people involved in the foster care system. Few studies have conducted the trainings in classroom environments to increase the positive interactions between teachers and their students. Numerous studies have demonstrated the usefulness of behavioral skills training in teaching a wide variety of behavioral skills; however, relatively few of them have shown generalization to their natural environment and maintenance of appropriate responding following the training. Methods of prompting following the initial trainings that have been utilized are often quite intrusive especially when it interrupts the flow of the participants' …

Medical School Watercooler Newsletter - March 23, 2014, Lindsey Lyle

Watercooler Newsletter

This is the March 23, 2014 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• IMPACT Magazine - Mailing this Week
• USA Health System Offers Free Skin Cancer Screenings
• Neurology Spring Symposium a Success
• Med School Café - Expert Advice for the Community
• March is National Colorectal Cancer Awareness Month

Aging Aggravates Nitrate-Mediated Ros/Rns Changes., Qian Fan, Lifen Chen, Shujuan Cheng, Fang Li, Wayne Bond Lau, Le Feng Wang, Jing Hua Liu

Department of Emergency Medicine Faculty Papers

Nitrates are the most frequently prescribed and utilized drugs worldwide. The elderly are a major population receiving nitrate therapy. Both nitrates and aging can increase in vivo reactive oxygen species (ROS) and reactive nitrogen species (RNS). To date, the effects of aging upon nitrate-induced ROS/RNS alteration are unknown. The present study tested the effects of aging upon nitrate-induced ROS/RNS alteration in vivo. 32 adults and 43 elderly unstable angina (UA) patients were subjected to 48 hours of isosorbide dinitrate intravenous injection (50  μg/minutes) in this clinical study. Blood samples were obtained at baseline and conclusion. Outcome measures of oxidative stress …

Indirect Cyclopexy For Treatment Of A Chronic Traumatic Cyclodialysis Cleft With Hypotony, Nisha Chadha, Tania Lamba, David A. Belyea, Kunal Y. Merchant

Ophthalmology Faculty Publications

Cyclodialysis cleft is a rare clinical finding and therefore, reports on surgical repair techniques in the literature are limited. Additionally, hypotony can make repair technically challenging. We share a novel, simple surgical approach to management of a case of chronic traumatic cyclodialysis cleft with a successful outcome.

The Burden Of Influenza-Like Illness In The Us Workforce, Y. Tsai, F. Zhou, I. K. Kim

United States Public Health Resources

Background -- The disease burden of influenza-like illnesses (ILIs) on the working population has been documented in the literature, but statistical evidence of ILI-related work absenteeism in the USA is limited due to data availability.

Aims -- To assess work absenteeism due to ILIs among privately insured employees in the USA in 2007–8 and 2008–9.

Methods -- We used the 2007–9 MarketScan® research databases. Full-time employees aged 18–64 years, with the ability to incur work absence and continuously enroled in the same insurance plan during each season were included. We identified ILI episodes using ICD-9 codes for influenza and …

Swing Dancing Along The Spectrum: A Proposed Unique Adjunctive Treatment Approach For Individuals With Autism Spectrum Disorder, Alia Mulder-Rosi

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Autism Spectrum Disorder (ASD) is a class of developmental disorders typically diagnosed during childhood. ASD is characterized by social deficits and repetitive behavioral patterns, which cause clinically significant impairment and are not better explained by intellectual disability (American Psychiatric Association, 2013). This doctoral paper proposes swing dancing as an adjunctive treatment option for high functioning adults with ASD. Swing dance is a category of social, partner dance initially set to swing style jazz music. This category most notably includes Lindy Hop, Charleston, Jitterbug and Balboa. Swing dance is an activity which grants social structure, is typically surrounded by an accepting …

What Does Performance Theory Have To Teach Us About The Treatment Of Severe And Persistent Mental Illness (Spmi) In Prison?, Kaley Joanne Raskin

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Deinstitutionalization of psychiatric hospitals, which occurred in the 1970's, led to an overwhelming number of mentally ill individuals within jails and prisons. In fact, correctional facilities have become the mainline providers of mentally ill inmates; however, these facilities' primary form of intervention is psychotropic medication. Although beneficial in some instances, when viewed through the lens of Goffman's theories of performance and stigma, simply providing medication promotes the role of mental patient. Arguably, within correctional facilities, medication management assists in maintaining security in the institution (i.e., external change); however, this prohibits the inmate from internal change, which might otherwise be facilitated …

Cardiovascular Health Among Us And Argentine University Students: A Comparative Study Of Behaviors And Risk Factors, Gina Fitzgerald, Gabriella Smith

Seaver College Research And Scholarly Achievement Symposium

Cardiovascular disease for some time has been the leading cause of death in the Western world. Primary prevention is the only way to halt the onset of cardiovascular disease, yet there is little information on the prevalence of risk factors for cardiovascular disease in young adults. This study seeks to evaluate students from the Catholic University of Argentina and Pepperdine University of America for the prevalence of CVD risk factors, as well as knowledge of CVD and daily habits that contribute to heart health. Thus we compared two cultures with very different lifestyles and prevalence of risk factors. We hypothesized …

The Effect Of Shear Stress, Potassium, And Adenosine On Α-1 Adrenergic Vasoconstriction Of Rat Soleus Feed Arteries, Tanner J. Heckle

Seaver College Research And Scholarly Achievement Symposium

During exercise, sympathetic nerve activity increases, augmenting the release of the neurotransmitter norepinephrine (NE) at the arterial wall and into the blood. NE binds to arterial adrenergic receptors to cause vasoconstriction, yet arteries in contracting skeletal muscle dilate during exercise. Previous evidence from Ives et al. suggests that heat and acidosis may partially inhibit constriction resulting from α-1 adrenergic receptors (termed sympatholysis). Our lab has previously demonstrated that rat soleus feed arteries respond to sympathetic signaling solely by α-1 adrenoceptors. We hypothesized that increased levels of arterial wall shear stress, potassium, or adenosine also contribute to sympatholysis, thereby reducing sympathetic …