Medicine and Health Sciences Commons^™

Minutes Of 04/04/2014 Hsc Board Of Directors Mtg, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Notice Of 04/04/2014 Hsc Board Of Directors Mtg, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

The Effect Of Early Head Start On Child Welfare System Involvement: A First Look At Longitudinal Child Maltreatment Outcomes, Beth L. Green, Catherine Ayoub, Jessica Dym Bartlett, Adam Von Ende, Carrie Jeanne Furrer, Rachel Chazen-Cohen, Claire Vallotton, Joanne Klevens

Center for Improvement of Child and Family Services Publications

The high societal and personal costs of child maltreatment make identification of effective early prevention programs a high research priority. Early Head Start (EHS), a dual generational program serving low-income families with children prenatally through age three years, is one of the largest federally funded programs for infants and toddlers in the United States. A national randomized trial found EHS to be effective in improving parent and child outcomes, but its effectiveness in reducing child maltreatment was not assessed. The current study used administrative data from state child welfare agencies to examine the impact of EHS on documented abuse and …

Outcomes Of Recurrent Rectal Cancer After Transanal Excision, Sachin Vaid, Christopher Buzas, John S. Park Md, Robert J. Sinnott Md

Department of Surgery

No abstract provided.

Diagnosis Of Pancreatic Neoplasms Using A Novel Method Of Dna Methylation Analysis Of Mucin Expression In Pancreatic Juice., Seiya Yokoyama, Sho Kitamoto, Michiyo Higashi, Yuko Goto, Taro Hara, Dai Ikebe, Taketo Yamaguchi, Yoshifumi Arisaka, Toru Niihara, Hiroto Nishimata, Sadao Tanaka, Kyoichi Takaori, Surinder K. Batra, Suguru Yonezawa

Journal Articles: Biochemistry & Molecular Biology

Mucins (MUC) play crucial roles in carcinogenesis and tumor invasion in pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasms (IPMNs). Our immunohistochemistry (IHC) studies have shown a consensus position on mucin expression profiles in pancreatic neoplasms as follows: MUC1-positive but MUC2-negative expression in PDACs; MUC1-negative but MUC2-positive expression in intestinal-type IPMNs (dangerous type); MUC1-negative and MUC2-negative expression in gastric-type IPMNs (safe type); High MUC4 expression in PDAC patients with a poor outcome; and MUC4-positive expression in intestinal-type IPMNs. We also showed that three mucin genes (MUC1, MUC2 and MUC4) expression in cancer cell line was regulated by DNA methylation. …

Core Aspects Of Curriculum Development: A Literature Review And Development Of Program Handbook For Health Informatics And Information Management, Nicole Yon

Honors Theses

TIle purpose of this review was to determine the basic principles of curriculum design and to understand how they are used to develop a competent curriculum handbook. The findings were used to develop a handbook for the Health Informatics and Information Management major at Western Michigan University. This literature review focuses on a variety of web pages, articles and books that analyzed the topics of curriculum design and curriculum handbook development. A review of the Bronson School of Nursing Handbook and the Temple University - Health Information Management Department B.S. in Health Information Management (HiM) Student Handbook was also conducted. …

Modeling The Natural History And Detection Of Lung Cancer Based On Smoking Behavior, Xing Chen, Millennia Foy, Marek Kimmel, Olga Y. Gorlova

Dartmouth Scholarship

In this study, we developed a method for modeling the progression and detection of lung cancer based on the smoking behavior at an individual level. The model allows obtaining the characteristics of lung cancer in a population at the time of diagnosis. Lung cancer data from Surveillance, Epidemiology and End Results (SEER) database collected between 2004 and 2008 were used to fit the lung cancer progression and detection model. The fitted model combined with a smoking based carcinogenesis model was used to predict the distribution of age, gender, tumor size, disease stage and smoking status at diagnosis and the results …

Benefits Of Exercise Intervention In Reducing Neuropathic Pain, John L. Dobson, James L. Mcmillan, Li Li

Health Sciences & Kinesiology: Faculty Publications

Peripheral neuropathy is a widespread and potentially incapacitating pathological condition that encompasses more than 100 different forms and manifestations of nerve damage. The diverse pathogenesis of peripheral neuropathy affects autonomic, motor and/or sensory neurons, and the symptoms that typify the condition are abnormal cutaneous sensation, muscle dysfunction and, most notably, chronic pain. Chronic neuropathic pain is difficult to treat and is often characterized by either exaggerated responses to painful stimuli (hyperalgesia) or pain resulting from stimuli that would not normally provoke pain (allodynia). The objective of this review is to provide an overview of some pathways associated with the development …

Generic Competition And Price Regulation In The European Union Pharmaceutical Market: The Case Of Cardiovascular Medicines, Berna Colak

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation is to examine the extent of competition between generic products and therapeutic substitutes under different regulatory regimes in the European Union

(EU) pharmaceutical industry. In particular, this study investigates generic competition among the five largest European pharmaceutical markets; the United Kingdom, Germany, France, Italy

and Spain, with comprehensive IMS data for 10 years (1994-2003), in order to estimate the effect of generic entry on drug prices at the product level. This analysis finds that generic entry

has a negative effect on prices in countries with free pricing originator market, whereas in EU countries with strict …

Les Facteurs Influençant Le Retour Au Travail Après Une Dépression : Le Point De Vue Et Le Rôle Des Acteurs Syndicaux, Marc Corbière, Louise St-Arnaud, Marie-José Durand, Marie-France Coutu, Tania Lecomte, Alessia Negrini, Marianne Renard

Rapports de recherche scientifique

En 2005, l’Organisation mondiale de la Santé (OMS) stipulait que dans moins d’une décennie, la dépression constituerait une des premières causes d’incapacité avec les maladies cardiovasculaires (World Health Organization, 2005). En effet, on constate une augmentation des prestations d’invalidité attribuables aux troubles mentaux, notamment la dépression. Celles-ci sont à l’origine de plus de 40% de toutes les réclamations d’assurance-salaire (MSSS, 2005). Le retour au travail des employés qui ont dû s’absenter en raison d’une dépression est parfois complexe car il implique plusieurs acteurs. À notre connaissance, peu d’études se sont intéressées au point de vue des acteurs syndicaux quant aux …

The Santa Clara, 2014-04-03, Santa Clara University

The Santa Clara

No abstract provided.

The Targeted Open Online Course (Tooc) Model, Credence Baker, James Gentry

Administrative Issues Journal

In an era of increasingly hyped Massive Open Online Courses (MOOCs) that seem to evoke feelings of both promise and peril for higher education, many institutions are struggling to find their niche among top-tier Ivy League schools offering courses to thousands of participants for free. While the effectiveness of MOOCs in terms of learning outcomes and student persistence is still unclear (see Daniel, 2012; Kirschner, 2012; and Jordan, 2013), one benefit of the trend are the innovative adaptations that smaller-sized, regional institutions have begun testing as alternative in-roads into the MOOC era. The Targeted Open Online Course (TOOC) model allowed …

Inactivation Of Genes For Antigenic Variation In The Relapsing Fever Spirochete Borrelia Hermsii Reduces Infectivity In Mice And Transmission By Ticks, Sandra J. Raffel, James M. Battisti, Robert J. Fischer, Tom G. Schwan

Biological Sciences Faculty Publications

Borrelia hermsii, a causative agent of relapsing fever of humans in western North America, is maintained in enzootic cycles that include small mammals and the tick vector Ornithodoros hermsi. In mammals, the spirochetes repeatedly evade the host’s acquired immune response by undergoing antigenic variation of the variable major proteins (Vmps) produced on their outer surface. This mechanism prolongs spirochete circulation in blood, which increases the potential for acquisition by fast-feeding ticks and therefore perpetuation of the spirochete in nature. Antigenic variation also underlies the relapsing disease observed when humans are infected. However, most spirochetes switch off the bloodstream …

Development Of The Classroom Sensory Environment Assessment (C-Sea), Heather Miller-Kuhaneck, Jacqueline P. Kelleher

Occupational Therapy Faculty Publications

The Classroom Sensory Environment Assessment (C-SEA) allows teachers to examine the sensory aspects of classroom tasks and environments. The purpose is to assist in determining ways to modify tasks and environments to improve engagement and reduce problem behaviors in elementary school students with Autism Spectrum Disorder.

A Random Sequential Mechanism Of Aminoglycoside Acetylation By Mycobacterium Tuberculosis Eis Protein, Oleg V. Tsodikov, Keith D. Green, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

An important cause of bacterial resistance to aminoglycoside antibiotics is the enzymatic acetylation of their amino groups by acetyltransferases, which abolishes their binding to and inhibition of the bacterial ribosome. Enhanced intracellular survival (Eis) protein from Mycobacterium tuberculosis (Mt) is one of such acetyltransferases, whose upregulation was recently established as a cause of resistance to aminoglycosides in clinical cases of drug-resistant tuberculosis. The mechanism of aminoglycoside acetylation by MtEis is not completely understood. A systematic analysis of steady-state kinetics of acetylation of kanamycin A and neomycin B by Eis as a function of concentrations of these aminoglycosides …

Effects Of Hazardous And Harmful Alcohol Use On Hiv Incidence And Sexual Behaviour: A Cohort Study Of Kenyan Female Sex Workers, Matthew F. Chersich, Wilkister Bosire, Nzioki King’Ola, Marleen Temmerman, Stanley Luchters

Obstetrics and Gynaecology, East Africa

Aims: To investigate putative links between alcohol use, and unsafe sex and incident HIV infection in sub-Saharan Africa.

Methods: A cohort of 400 HIV-negative female sex workers was established in Mombasa, Kenya. Associations between categories of the Alcohol Use Disorders Identification Test (AUDIT) and the incidence at one year of unsafe sex, HIV and pregnancy were assessed using Cox proportional hazards models. Violence or STIs other than HIV measured at one year was compared across AUDIT categories using multivariate logistic regression.

Results: Participants had high levels of hazardous (17.3%, 69/399) and harmful drinking (9.5%, 38/399), while 36.1% abstained from alcohol. …

The Role Of P2x Receptors In Hiv And Opiate-Related Neurotoxicity, Mary Sorrell

Theses and Dissertations

Emerging evidence suggests that opioid drugs can exacerbate neuroAIDS. Microglia are the principal neuroimmune effectors thought to be responsible for neuron damage in HIV-infected individuals, and evidence suggests that drugs acting via opioid receptors in microglia aggravate the neuropathophysiological effects of HIV. The P2X family of ATP activated ligand-gated ion channels regulates key aspects of microglial function. In addition, opioid-dependent microglial activation has been reported to be mediated through P2X4 signaling, prompting us to investigate P2X receptors contribution to the neurotoxic effects of HIV and morphine. In vitro experiments showed treatment with TNP-ATP prevented the neurotoxic effects of morphine and/or …

Neuroplasticity And Mindfulness Meditation, Richard Widdett

Honors Theses

My thesis topic of choice was how mindfulness meditation is linked to neuroplasticity in the brain. The brain is an incredibly complex and powerful organ. Each area of the brain serves a specific purpose and is interconnected. Neuroplasticity is the term used to describe the molding and shaping of the brain based on our experiences from the moment we are born. Mindfulness is defined as the “ability to pay total attention to the present moment with a nonjudgmental awareness of the inner and/or outer experiences.” Many studies have been conducted researching the brain and meditation. The findings from these studies …

Leveraging User Data To Drive A Website Redesign, Michael Blake

GW Research Days 2014

Background: One of the most challenging aspects of redesigning an organization's website is balancing the needs of existing users while optimizing the experience for future users. This balance is especially crucial in academia where new users arrive every semester and may remain for anywhere from a year to a decade or more. When faced with the task of redesigning its website, GW's Himmelfarb Health Sciences Library conducted extensive user research in an attempt to design a site that preserved the positive aspects of the experience of existing users while improving their experience and reducing the learning curve for new users. …

Assessing The Impact Of Family Status, Family Cohesion, And Acculturation On Youth Violence Among Immigrant Latinos, Susan Lin, Sean D. Cleary, Mark Edberg

GW Research Days 2014

Background/Objectives: Latino youth violence is an emerging public health concern. The objective is to assess the impact of family status, family cohesion, and acculturation on youth violence among Latino immigrants in Langley Park, MD compared with a control community in Culmore, VA.

Methods: Constructs were generated from survey questions to represent family support and cohesion, acculturation, and youth violence. Bivariate and multivariate regression analyses were modeled to evaluate the relationships between family support and cohesion, acculturation, and violence, after adjusting for confounders.

Results: After controlling for covariates, family support consistently reduced victimization (PE = ‐0.02, SE = 0.01, t = …

Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, Samantha Ahle, Jill Krapf, Kirsten Marie Brown, Juliet Lee, Gisela Butera, Ellen Goldman, Myriam Ferzli, Rosalyn A. Jurjus

GW Research Days 2014

Background: It is well documented in the medical education literature that students retain minimal anatomy knowledge when transitioning from pre-clinical didactics to clinical application on the wards. In a previous study at our own institution we were able to quantify this knowledge deficit in students on surgical clerkships, specifically surgery and obstetrics and gynecology (OB/GYN). Using our previous data, we designed an integrated, nested clinical teaching model utilizing e-modules to review clinically relevant surgical anatomy during their clinical rotations.

Objective: The goal of this study is to evaluate the impact of a newly designed method of teaching clinically relevant anatomy …

Intermediate-Term Results Of Extracorporeal Membrane Oxygenation Support Following Congenital Heart Surgery, Syed Murfad Peer, Dominic A. Emerson, John P. Costello, Michael K. Shu, David Zurakowski, Richard A. Jonas, John T. Berger, Dilip S. Nath

GW Research Days 2014

Background: Although there are considerable data regarding in-hospital results of congenital heart surgery patients requiring post-operative extracorporeal membrane oxygenation support, there is limited information on intermediate-term outcomes.

Methods: A single institution retrospective review of 25 consecutive post-operative congenital heart surgery patients who required extracorporeal membrane oxygenation and survived to hospital discharge between January 2003 and June 2008. Survival was estimated by the Kaplan-Meier method.

Results: At a median follow-up of 3.3 years (interquartile range: 1.2-5.9 years), there was 1 death which occurred at 6 months post-surgery. Kaplan-Meier estimated survival at 3 years was 95% (95% confidence interval: 90-100%). Indications for …

Utility Of Pelvic Examination In Lower Abdominal Pain Without Vaginal Complaints, L. Sharan, J. Chien, T. Maiers, Wb Lau

Sigma Xi Student Research Day

Abstract

Abdominal pain is the most common presenting ED complaint. ED texts advocate speculum bimanual pelvic exam to differentiate pathology of abdominal versus pelvic etiology in women of childbearing age. However, the exam is invasive and requires significant ED resources. We hypothesize that routine pelvic exams of females complaining of abdominal pain without vaginal complaints in the ED does not alter clinical management. We performed a retrospective observational study of ED patients in an urban Level 1 trauma center for all non-pregnant women seen from January 2013 to July 2013, aged 18-50, with a chief complaint of isolated lower abdominal …

Neuroimaging Of Unusual Glioblastoma Using Diffusion Tensor Imaging, Akshita Mehta, Lucien M. Levy, M. Isabel Almira-Suarez, Raymond Tu

GW Research Days 2014

Background: Gliosarcoma refers to an uncommon astrocytic tumor of the central nervous system. These tumors include both glial and mesenchymal components by definition, and are extremely malignant. Gliosarcomas are particular to tumors with distinct gliomatous and sarcomatous constituents, and are distinguished from gliobastomas which have undergone mesenchymal metaplasia. Gliosarcomas encompass 2-8% of all glioblastoma cases and tend to occupy the supratentorial regions of the brain, especially the temporal lobe. Rare infratentorial lesions including the cerebellar hemisphere, intraventricular, and multi-focal tumors have also been reported. Accurate neuroimaging diagnosis is critical and diffusion tensor imaging (DTI) and spectroscopy can be useful to …

Effector-Independent Motor Sequence Representations Exist In Extrinsic And Intrinsic Reference Frames., Tobias Wiestler, Sheena Waters-Metenier, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

Many daily activities rely on the ability to produce meaningful sequences of movements. Motor sequences can be learned in an effector-specific fashion (such that benefits of training are restricted to the trained hand) or an effector-independent manner (meaning that learning also facilitates performance with the untrained hand). Effector-independent knowledge can be represented in extrinsic/world-centered or in intrinsic/body-centered coordinates. Here, we used functional magnetic resonance imaging (fMRI) and multivoxel pattern analysis to determine the distribution of intrinsic and extrinsic finger sequence representations across the human neocortex. Participants practiced four sequences with one hand for 4 d, and then performed these sequences …

Preoperative And Operative Factors Associated With Complications Following Radical Nephroureterectomy, A. Arnouk, C. Lallas, E. Trabulsi, J. Raman

Sigma Xi Student Research Day

Abstract

Radical nephroureterectomy (RNU) is the gold standard for managing upper-tract urothelial carcinoma. We review preoperative, operative, and pathologic characteristics of patients undergoing RNU to identify factors associated with perioperative complications. A retrospective review of institutional databases from 8 academic centers identified 732 patients who underwent RNU. Data on preoperative, operative, and pathologic indices were collected. Almost 40% of patients in our cohort experienced a complication within 30 days of RNU. Increasing age, higher Charlson score, and lower baseline renal function were independently associated with patients developing complications. Longer OR duration and intraoperative transfusion requirement were also associated with post-RNU …

Combat Paper Project, William Joiner Institute For The Study Of War And Social Consequences, University Of Massachusetts Boston

Office of Community Partnerships Posters

Coming home from war is enormously difficult. A new language is required to express the magnitude of war’s effects and consequences. Combat Paper transforms the uniforms of battle to paper and from this transformation comes art. Developed by veterans of Iraq and Afghanistan in San Francisco, the project has now traveled broadly across the United States and the world.

Survey Of The Perception Of Nurses In The Critical Care Setting Concerning End-Of-Life Care, Jeff Brown, Dr. Renea Beckstrand

Journal of Undergraduate Research

In an intensive care center, one sees many patients suffering and staff rushing about, caring for patients’ needs. The most important thing about working in the area of intensive care is efficiency. Dr. Renea Beckstrand of the Brigham Young University College of Nursing has been researching the best way to organize and run Intensive Care Units in the United States for several years. She has discovered many ways to improve patient care and resolve nurse burnout issues by asking nurses what they believe helps or impedes nursing care.

Skin Cancer Prevention Coverage In Popular Us Women’S Health And Fitness Magazines: An Analysis Of Advertisements And Articles, Corey Hannah Basch, Danna Ethan, Grace Clarke Hillyer, Alyssa Berdnik

Publications and Research

The desire to be tan is a phenomenon that public health researchers have investigated, as exposure to UV radiation increases the chances of developing skin cancer. Media messages in women’s magazines have been shown to contribute to this problem. Much less is known about the prevalence of skin cancer prevention messages in these magazines. This study's aim was to identify the number and type of articles and advertised products devoted to skin health (sun protection and skin cancer prevention in particular) within five popular U.S. greater than women’s health and fitness magazines. We analyzed articles and advertisements over seven months …

Implementing A Community-Based Intervention For African American Mothers And Daughters, Teri Aronowitz, Nandini Sengupta

Office of Community Partnerships Posters

Adolescents represent one of the fastest growing risk groups for HIV. Inner-city, minority youth are at highest risk because of concentration of HIV in inner-city areas, higher rates of STDs, and early sexual initiation. Mothers are the primary sex educator of daughters, and girls state their relationship with their mother was an important influence on their delaying sexual activity. With 70% of adolescent HIV seroconversions occurring among African American (AA) females, studies are urgently needed to enhance mother-daughter sexual communication. The purpose of this poster is to offer insights on the logistics of carrying out a manualized program.