Medicine and Health Sciences Commons^™

The Effects Of Size On Ag Nanosphere Toxicity In Macrophage Cell Models And Lung Epithelial Cell Lines Is Dependent On Particle Dissolution, Raymond F. Hamilton, Sarah Buckingham, Andrij Holian

Public and Community Health Sciences Faculty Publications

Silver (Ag) nanomaterials are increasingly used in a variety of commercial applications. This study examined the effect of size (20 and 110 nm) and surface stabilization (citrate and PVP coatings) on toxicity, particle uptake and NLRP3 inflammasome activation in a variety of macrophage and epithelial cell lines. The results indicated that smaller Ag (20 nm), regardless of coating, were more toxic in both cell types and most active in the THP-1 macrophages. TEM imaging demonstrated that 20 nm Ag nanospheres dissolved more rapidly than 110 nm Ag nanospheres in acidic phagolysosomes consistent with Ag ion mediated toxicity. In addition, there …

Historical Health Conditions In Major Us Cities: The Hue Data Set, Carlos Villareal, Brian Bettenhausen, Eric Hanss, Jonathan Hersh

Economics Faculty Articles and Research

The Historical Urban Ecological data set is a new resource detailing health and environmental conditions within seven major U.S. cities during the study period from 1830 to 1930. Researchers collected and digitized ward-level data from annual reports of municipal departments that detail the epidemiological, economic, and demographic conditions within each city. They then drafted new geographic information system data to link the tabular records to ward geographies. These data provide a new foundation to revisit questions surrounding the urban mortality transition and the growth of U.S. cities.

The Effect Of Size On Ag Nanosphere Toxicity In Macrophage Cell Models And Lung Epithelial Cell Lines Is Dependent On Particle Dissolution, Raymond F. Hamilton, Sarah Buckingham, Andrij Holian

Biomedical and Pharmaceutical Sciences Faculty Publications

Silver (Ag) nanomaterials are increasingly used in a variety of commercial applications. This study examined the effect of size (20 and 110 nm) and surface stabilization (citrate and PVP coatings) on toxicity, particle uptake and NLRP3 inflammasome activation in a variety of macrophage and epithelial cell lines. The results indicated that smaller Ag (20 nm), regardless of coating, were more toxic in both cell types and most active in the THP-1 macrophages. TEM imaging demonstrated that 20 nm Ag nanospheres dissolved more rapidly than 110 nm Ag nanospheres in acidic phagolysosomes consistent with Ag ion mediated toxicity. In addition, there …

2014 April 22 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

A Comparison Of Clustering And Missing Data Methods For Health Sciences, Ran Zhao, Deanna Needell, Christopher Johansen, Jerry L. Grenard

CMC Faculty Publications and Research

In this paper, we compare and analyze clustering methods with missing data in health behavior research. In particular, we propose and analyze the use of compressive sensing's matrix completion along with spectral clustering to cluster health related data. The empirical tests and real data results show that these methods can outperform standard methods like LPA and FIML, in terms of lower misclassification rates in clustering and better matrix completion performance in missing data problems. According to our examination, a possible explanation of these improvements is that spectral clustering takes advantage of high data dimension and compressive sensing methods utilize the …

The Role Of Vitamin D Deficiency In Early Childhood Caries, Tiffany Williams

Theses and Dissertations

Purpose: This is a pilot study to determine if there is a relationship between vitamin D deficiency and the development of early childhood caries (ECC). Methods: Serum 25(OH) vitamin D, parathyroid hormone and calcium were measured from children with ECC, who presented for dental rehabilitation under general anesthesia. Samples were obtained from caries free controls examined during a well-child medical check. Parents from both sample sizes filled out a questionnaire consisting of 22 questions regarding the child and parent’s medical and dental history as well as socioeconomic background. Results: ECC patients were found to have deficient serum levels of 25(OH) …

Development Of A Simplified Pediatric Obstructive Sleep Apnea (Osa) Screening Tool, Jo Cronly

Theses and Dissertations

Background: Obstructive sleep apnea has become recognized as one of the most common, under-diagnosed chronic diseases. Recently studies have shown increased numbers among the pediatric and adolescent population. OSA in children is associated with behavioral problems, poor school achievements, and in severe cases, pulmonary hypertension. OSA is often the Achilles heel of pediatric sedation and analgesic programs; during sedation, children with OSA have an increased vulnerability of their airway undergoing pharyngeal collapse and of having upper airway obstruction. Consequently, pediatric dentists who practice sedation dentistry should exercise extra precautions when treating patients with risk of sleep apnea. Currently there is …

Subsequent Primary Malignancies In Survivors Of Childhood Cancer, Emily Matson, Dr. Ray Merrill

Journal of Undergraduate Research

Although cancer is often considered a disease of old age, it kills more children ages 1 to 14 years in the United States than any other cause, except unintentional injuries [1]. Through advances in diagnosing and treating cancer, child survival of cancer has improved in recent years [1, 2]. However, more research is needed on the risk of subsequent cancer following an initial diagnosis of cancer, of the same or another anatomical site. Associations between childhood and secondary cancers have implications for patient follow-up, by providing health professionals with better information on which subsequent cancer sites are most likely to …

Today - April 22, 2014, Loma Linda University Health

TODAY

Inside this issue:

-- Loma Linda University Health 12th annual PossAbilities Triathlon promises fun for athletes and their families
-- Nursing research studies seek to improve patient experience
-- Living by prevention - personally and professionally
-- School of Dentistry introduces associate and assistant deans
-- Rosemary White-Traut to highlight nursing research conference at LLUH
-- Guild to present evening of fashion and music to benefit LLU Children's Hospital
-- Whole-person cancer care focuses on treating people, not diseases
-- Fourth annual Black History Vespers and Dinner focuses on the future
-- A trip to create fabulous meals: discover seasonal …

Eculizumab In The Successful Treatment Of Postpartum Hemolytic Uremic Syndrome - A Case Report, Craig A. Mackaness Do, Frederick S. Fleszler Md

Department of Medicine

No abstract provided.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Dr.Ledlow as the first Chair for HPM Department

Women’S Understanding Of The Effects Of Obesity On Pregnancy, Rachel A. Daniel

Senior Honors Theses

Obesity is a serious issue and is becoming a significant problem around the world. Obesity in general causes and complicates many health problems. As obesity increases in the population at large, the incidence of obesity in pregnancy continues to increase. Obesity during pregnancy has been linked in numerous studies to multiple complications, and the issues and risks have been clearly established. Also becoming pregnant or having multiple pregnancies increases the likelihood of developing obesity. Obese women of childbearing age many times do not even know these risks exist. There is a need to educate these women before they become pregnant, …

Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle

Senior Honors Theses

Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency. Mutated genes such as Fat Mass and Obesity Associated (FTO), Leptin (LEP), Leptin Receptor (LEPR), Melanocortin 4 Receptor (MC4R), Adiponectin C1Q and Collagen Domain Containing (ADIPOQ), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) all contribute to the development of childhood obesity. In the presence of high cholesterol caused by obesity, the genetic condition known as familial hypercholesterolemia is exacerbated. Familial hypercholesterolemia is caused by a …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Dr. Ledlow as the first Chair for HPM Department

Frailty And Depression: A Latent Trait Analysis, Matthew Lohman

Theses and Dissertations

Background: Frailty, a state indicating vulnerability to poor health outcomes, is a common condition in later life. However, research and intervention progress is hindered by the current lack of a consensus frailty definition and poor understanding of relationships between frailty and depression. Objectives: The goal of this research is to understand the interrelationships between frailty and depression among older adults. Specifically, this project aims 1) to examine the construct overlap between depression and three definitions of frailty (biological syndrome, medical burdens, and functional domains), 2) to determine the degree to which this overlap varies by age, gender, race/ethnicity and other …

The Relationships Between Sleep Disturbances, Depression, Inflammatory Markers, And Sexual Trauma In Female Veterans, Ellen Marcolongo

USF Tampa Graduate Theses and Dissertations

The purpose of this secondary data analysis was to assess for the relationships among sleep disturbances, depressive symptoms, inflammatory markers, and sexual trauma in female veterans. This may contribute to an understanding of the physical and mental health effects of sexual trauma in female veterans. Correlational analyses were conducted to evaluate the strength of these relationships. A reported history of sexual trauma was significantly correlated with longer sleep latencies, poorer sleep efficiency, shorter sleep durations, more daytime dysfunction, and poorer overall sleep quality in female veterans. A reported history of sexual trauma was also significantly correlated with depressive symptoms including …

New Payment Models: What’S Driving Them, And What Do They Mean For What It Takes To Be A Good Doctor?, Richard Baron, Md

Department of Medicine Presentations and Grand Rounds

Learning Objectives:

1. Describe details of new non-fee for service payment models, including Bundled Payment, Accountable Care Organizations and Advanced Primary Care
2. Explain administrative structures required to implement these kinds of models
3. Articulate the new values-congruent roles physicians will play under new payment models and the skills they will need to play them.

PowerPoint slides only.

The Facts And Fiction About The Use Of Sign Language With Young Children, Naomi Greenblat

Undergraduate Research Symposium

In this study we sought to determine how parents and caregivers perceived the use of sign language with young children. We asked participants Likert scale questions concerning their agreement with various statements about sign language. The participants were asked questions about using sign language for communication, expressing emotion, advancing intelligence, and promoting pro-social behavior. We also asked participants open ended questions about what they had previously heard about sign language use, their thoughts about using sign language, and if they had every purchased or used materials to teach a child sign language. The responses show that on average most participants …

History Of Women And Alternative Medicine, Megan Eineke

Undergraduate Research Symposium

Alternative medicine has been used all over the world for centuries. From meditation to hydrotherapy, both men and women practice these modalities. Alternative medicine is an important part of the history of medicine and women have played a crucial role in traditional medical and other healing-related careers. This research project examines health activism among feminists and how that has played a role in what alternative medicine has become today. Information gathered from journals, articles, books, and biographies will be used to create a timeline to share how and when specific events and women influenced the reemergence of alternative medicine and …

Localization And Expression Level Of Vascular Endothelial Growth Factor After Partial Hepatectomy Of Wky Rats, Adam Kronebusch, Tyler Koonst

Undergraduate Research Symposium

Inflammation and fibrosis are indicative of liver regeneration following injury and chronic liver diseases, such as cirrhosis and hepatocellular carcinoma. The formation of new vasculature via the process of angiogenesis is vital to the pathological progression of liver regeneration and these diseases. Thus, inhibiting the process of angiogenesis could have the potential to stop or slow the progression of chronic liver diseases. Vascular endothelial growth factor (VEGF) is the most potent and specific growth factor for initiating the process of angiogenesis, making it a prime target to inhibit angiogenesis. Bevacizumab is an antibody that binds to VEGF, inhibiting it from …

Comparing Perceptions Of Motivation To Change: Clinicians Versus Their Substance-Abuse Clients, Arthur Tabrizi

Graduate Research Symposium (2010 - 2017)

Although some clients enter treatment voluntarily to seek intervention for their substance abuse problems, most enter under coercive external pressures that may be perceived by clinicians as less influenced by addressing substance abuse than by appeasing mandates from the judicial system, family, or employers. Little research has examined and compared how clinicians assess clients’ extrinsic and intrinsic motivation to change as opposed to how the clients assess themselves. A congruency between the two parties’ assessments may inform the quality of the therapeutic relationship and facilitate an effective treatment plan. Using the Circumstance, Motivation, and Readiness Scales (CMR) and availability sampling …

Acceptability Of Sexting In Same-Sex Relationships, Carly Shadid, Katherine M. Hertlein, Sarah M. Steelman

Graduate Research Symposium (2010 - 2017)

For individuals who identify as part of the LGB community, the Internet can be seen as a tool to take control of their lives, may promote self-esteem, and foster a sense of belonging. The purpose of the study was to learn about sexting practices on college campuses. It builds on the existing body of knowledge by attending specifically to sexting rather than the previous literature about engagement in sexual behavior online (see, for example, Daneback, Cooper, & Månsson, 2005). Findings indicated that sexting is viewed as more acceptable in same sex relationships as compared to heterosexual relationships.

Family-Farm Therapy: An Urban Therapy Clinic To Address The Multifaceted Needs Of Multi-Stressed Families And Their Surrounding Communities, Felisa M. Huene

Graduate Research Symposium (2010 - 2017)

Family-Farm Therapy incorporates a therapeutic clinic within an urban farming community site, and focuses on multi-stressed family systems and the larger community system. The goal is for systemic change within the family and the community by creating positive relationships and personal acceptance. Farming has traditionally been a family endeavor which makes it a unique environment to be utilized as metaphors for family systems, their interactions, behaviors, and structure. Multi-stressed families have socioeconomic hurdles that complicate their ability to adjust to change and crisis in their family. Farming addresses such hurdles by offering economic sustenance, increased physical health, and community acceptance. …

A Critical Analysis Of Intellectual Disabilities And End-Of-Life Decision Making, Saritha Farris

Graduate Research Symposium (2010 - 2017)

Presently, research suggests the involvement of individuals with intellectual disabilities (IDs) in making end-of-life (EOL) decisions appears to be minimal (Ellison & Rosielle, 2008).

The reasons for the lack of involvement include but are not limited to communication challenges, lack of education on caring for individuals with IDs by the medical community, incorrect assumptions that the individual lacks cognitive capacity to consent, and fear of legal consequences if formal caregivers are accused of not providing enough care. (Wagemans et al., 2010).

These factors then often culminate in the individual with IDs having decisions made for them by someone else, whom …

Ada News - 04/21/2014, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Visual Influences On Self-Served Foods, Tami Cirerol

College of Health Sciences Presentations

Objective: With an increasing dinner plate and portion sizes, a better understanding of self-serving food behaviors is needed to help individuals develop and maintain healthy eating habits. The goal of this project is to educate students on the Delboeuf Illusion to increase self-efficacy and minimize over-serving food to oneself.

Method: This project examines four aspects of self-serving behaviors of college students by using pre- and post-test measurements. An understanding of the difference between a serving and a portion, and daily-recommended servings, is evaluated. Knowledge of food serving equivalencies to common, everyday objects is reviewed. The influence of the Delboeuf Illusion …

Measured Expiratory Resistance Of The Blue And Green Acapella Devices As Setting Is Increased From 1–5; Amplitude 20, 30, 40, Amanda Wroblewski, Scott Hawkins

College of Health Sciences Presentations

Background: After reviewing the literature on both high flow and low flow Acapella devices, it was determined that most researchers evaluated only three frequency dial settings. Due to this gap, we chose to determine the expiratory resistance at each frequency dial setting for both high flow and low flow Acapella devices, as patient effort (amplitude) is increased on an electronic lung simulator. Hypothesis: 1) As the frequency dial setting is increased on the Acapella, the expiratory resistance will increase, and 2) as the patient effort (amplitude) is increased, the expiratory resistance will increase.

Methods: Each Acapella device was attached, separately, …

Health Literacy Of Older Refugees And Its Impact On Health Communication With Health Care Providers, Mohamed Almehawes

College of Health Sciences Presentations

Senior refugees often face great challenges in the process of resettling in the United States. In addition to the struggle to gain Basic English language skills to pass the Citizenship Exam, they are most likely to suffer other health issues related to their age status. The purpose of this qualitative study is to look into barriers to health as they are related to health literacy in older refugee population enrolled in ELC program and its impact on their access to healthcare. Data gathering will be accomplished using three methods including: searching the materials presented in the (ELC)class for health literacy …

Peru Telemedicine Website Development Project, Jose Garcia, Tanveer Morshed, Sean Wakeley, Christopher Llyod

College of Business and Economics Presentations

Physicians working in rural communities of Peru find themselves removed from many of the resources commonly available to physicians in urban environments. The rural physicians are often limited in their ability to communicate with colleagues and other healthcare providers regarding professional matters. To improve patient care, a new user-friendly, Internet-based communication platform is needed to allow these doctors to better communicate with other rural physicians and with specialists located in urban medical centers. Our project focused on the design, development, testing of a website that will allow rural doctors in Peru to post diagnostic questions and related information on a …

Meeting The Healthcare Needs Of A Rural State, Brittney Ramert

College of Health Sciences Presentations

The question of how to provide timely and effective healthcare to residents of rural states is being discussed at both local and national levels. Idaho is included in these discussions because many of the state’s residents live in rural and frontier areas and have limited healthcare access. Telehealth, the use of technology to deliver healthcare remotely, has the potential to change the healthcare landscape throughout Idaho. Currently, the state is lacking a much-needed integrated telehealth system to deliver quality care in rural areas. This presentation will identify the many factors which create a need for telehealth services in Idaho. These …