Medicine and Health Sciences Commons^™

Differences In Definitions Of Ebph And Evidence: Implications For Communication With Practitioners., Robert E. Aronson, Kay Lovelace, Mark Smith, Gulzar H. Shah

Frontiers in Public Health Services and Systems Research

In this study, we interviewed twelve members of an expert panel to elicit their views on Evidence-based Public Health (EBPH), including how they define EBPH, what constitutes “evidence”, and what LHDs do that can be described as EBPH. Telephone interviews lasting 60 minutes were recorded and transcribed for basic content analysis. Experts differed in their definitions of EBPH and their views of what constitutes evidence. Definitions of EBPH ranged from the adoption and implementation of rigorously tested interventions to the application of evidence to decision making for population health improvement. Views on what constitutes evidence also varied, from strict “evidence …

What's Happening: April 28, 2014, Maine Medical Center

What's Happening

No abstract provided.

Predictors Of Success In Entry-Level Master's Degree Programs In Athletic Training, Mary E. Murray

Seton Hall University Dissertations and Theses (ETDs)

ABSTRACT

Athletic training educational program directors use a variety of admission criteria to select qualified applicants who they anticipate will succeed academically and professionally. No standard sets of admission criteria exist for identifying a student’s ability to succeed in an entry-level master’s degree athletic training program or on the Board of Certification (BOC) examination. The purpose of this retrospective study was to investigate the relationship between entry-level master’s degree athletic training student demographic and academic factors and first- attempt passing rate on the BOC examination. The research questions examined the relationship between age, gender, admission grade point average (GPA), final …

Prevalence And Distribution Of Periapical Lesions Submitted For Histopathologic Analysis By Endodontists, Gerhard Claire Siegel

Theses and Dissertations

The current understanding of the distribution and frequency of periapical pathoses include biopsies submitted by all specialists and general dentists. As a result, they do not accurately reflect the distribution seen by endodontists. This retrospective chart review aims to determine the prevalence of periapical pathoses and associated demographics from biopsies submitted by endodontists over 30 years. All biopsy reports submitted to the Virginia Commonwealth University Oral Pathology Diagnostic Service from January 1, 1983 to December 31, 2012 were reviewed. Only reports submitted by verified endodontists and those with a periapical location were included. The following data was recorded from each …

Clinical And Radiographic Evaluation Of Mta Pulpotomies: A Retrospective Study, Claudia Colorado

Theses and Dissertations

Vital pulp therapy is the group of procedures indicated to maintain pulp vitality allowing for continued root development and apical closure in the presence of pulp exposure due to caries or trauma. Complete maturation results in stronger tooth structure that is more able to withstand occlusal forces. Historically, calcium hydroxide (Ca(OH)2) was the material of choice for a vital pulpotomy. Recently mineral trioxide aggregate (MTA) has been used as a pulp sealing material because of its biocompatibility and its ability to induce hard tissue barrier formation. The purpose of this retrospective study was to evaluate the clinical and radiographic outcome …

The Roles Of Krüppel-Like Transcription Factors Klf1 And Klf2 In Mouse Embryonic And Human Fetal Erythropoiesis, Divya Vinjamur

Theses and Dissertations

Hemoglobinopathies are some of the most common monogenic disorders in the world, affecting millions of people and representing a growing burden on health systems worldwide. Although the pathophysiology of sickle cell anemia and beta-thalassemia, two of the most common hemoglobinopathies, have been the focus of much research over the last century, patients affected by these diseases still lack a widely applicable and easily available cure. Sickle cell anemia and beta-thalassemia are caused by defects in the structure and production of the beta-globin chains that, along with the alpha-globin chains make up the heterotetrameric hemoglobin molecule. Studies geared towards re-expression of …

The Dna Methylome And Transcriptome Of Different Brain Regions In Schizophrenia And Bipolar Disorder, Yun Xiao, Cynthia Camarillo, Yanyan Ping, Tania Bedard Arana, Hongying Zhao, Peter M. Thompson, Chaohan Xu, Brenda Su, Michael A. Escamilla, Chunxiang Mao, Chun Xu

Health & Biomedical Sciences Faculty Publications

Extensive changes in DNA methylation have been observed in schizophrenia (SC) and bipolar disorder (BP), and may contribute to the pathogenesis of these disorders. Here, we performed genome-scale DNA methylation profiling using methylated DNA immunoprecipitation followed by sequencing (MeDIP-seq) on two brain regions (including frontal cortex and anterior cingulate) in 5 SC, 7 BP and 6 normal subjects. Comparing with normal controls, we identified substantial differentially methylated regions (DMRs) in these two brain regions of SC and BP. To our surprise, different brain regions show completely distinct distributions of DMRs across the genomes. In frontal cortex of both SC and …

Methylation Of Leukocyte Dna And Ovarian Cancer: Relationships With Disease Status And Outcome, Brooke L. Fridley, Sebastian M. Armasu, Mine S. Cicek, Melissa C. Larson, Chen Wang, Stacey J. Winham, Kimberly R. Kalli, Devin C. Koestler

Dartmouth Scholarship

Genome-wide interrogation of DNA methylation (DNAm) in blood-derived leukocytes has become feasible with the advent of CpG genotyping arrays. In epithelial ovarian cancer (EOC), one report found substantial DNAm differences between cases and controls; however, many of these disease-associated CpGs were attributed to differences in white blood cell type distributions. We examined blood-based DNAm in 336 EOC cases and 398 controls; we included only high-quality CpG loci that did not show evidence of association with white blood cell type distributions to evaluate association with case status and overall survival.

The Microbiome In Pediatric Cystic Fibrosis Patients: The Role Of Shared Environment Suggests A Window Of Intervention, Thomas H. Hampton, Deanna M. Green, Garry R. Cutting, Hilary G. Morrison, Mitchell L. Sogin, Alex H. Gifford, Bruce A. Stanton, George A. O’Toole

Dartmouth Scholarship

Cystic fibrosis (CF) is caused by mutations in the CFTR gene that predispose the airway to infection. Chronic infection by pathogens such as Pseudomonas aeruginosa leads to inflammation that gradually degrades lung function, resulting in morbidity and early mortality. In a previous study of CF monozygotic twins, we demonstrate that genetic modifiers significantly affect the establishment of persistent P. aeruginosa colonization in CF. Recognizing that bacteria other than P. aeruginosa contribute to the CF microbiome and associated pathology, we used deep sequencing of sputum from pediatric monozygotic twins and nontwin siblings with CF to characterize pediatric bacterial communities and the …

The Effect Of Commercial Tests For Aneuploidy Screening Using Cell-Free Fetal Dna On Rates Of Invasive Testing In Clinical Practice, Adetola Louis-Jacques Md, Courtney R. Burans Ms, Cgc, Sarah Robinson, Elizabeth A. Schofield, Joanne Quiñones Md, Msce, John C. Smulian Md, Mph, Meredith Rochon Md

Department of Obstetrics & Gynecology

No abstract provided.

Use Of Commercial Tests For Aneuploidy Screening Using Cell-Free Fetal Dna In Clinical Practice (Poster), Adetola Louis-Jacques Md, Courtney R. Burans Ms, Cgc, Sarah Robinson, Elizabeth A. Schofield, Joanne Quiñones Md, Msce, John C. Smulian Md, Mph, Meredith Rochon Md

Department of Obstetrics & Gynecology

No abstract provided.

Drug Use And Social Support Outcomes In Probationers: A Longitudinal Social Network Analysis, Anne Rhodes

Theses and Dissertations

This study focuses on the social networks of probationers, who comprise the largest segment of the criminal justice population in the United States, but about whom there are few studies of network processes. It provides information on how elements of a probationer’s social network change over time and can affect drug use. This study employs longitudinal analysis of the social networks for 251 substance abusers on probation to examine how these networks are influenced by an intervention designed to increase pro-social behaviors and how network changes impact drug use. Baseline drug use of the probationers was examined according to the …

Cytoprotective Versus Non-Protective Autophagy Induced By Radiation In Head And Neck Cancer Cells, Duaa Bakhshwin

Theses and Dissertations

The primary treatment options for head and neck cancer are radiation therapy or surgery, or both combined; chemotherapy is often used as an additional, or adjuvant, treatment. Patients treated with radiotherapy are exposed to a high cumulative dose of radiation over a period of time and there is a 17-33% chance of recurrence. High cumulative doses of radiation, a long time course of treatment, side effects and the possibility of recurrence provide the rationale for developing approaches for radiation sensitization, which could be helpful to patients in decreasing the dose, duration of radiation, side effects, or the chance of recurrence. …

Studies On Rationally Designed, Allosteric, Coagulation Inhibitors, Rio Boothello

Theses and Dissertations

Heparin is a natural allosteric modulator, with numerous structural and conformational variations leading to many reports of bleeding complications and variations in anticoagulant effects. A flurry of research has been directed towards understanding this puzzle. This work entails the utilization of three unique strategies to further our understanding of this complex issue. Traditional synthetic, biosynthetic and biophysical approaches have failed to conquer the GAG-protein complexity. Computational analysis however could serve as a powerful approach to decipher this dilemma. A dual filter algorithm was incorporated to identify unique hexasaccharide sequences for HCII and AT. Our experimental studies exhibit a good correlation …

Medical School Watercooler Newsletter - April 27, 2014, Lindsey Lyle

Watercooler Newsletter

This is the April 27, 2014 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Dr. Donna Cioffi Awarded for Excellence in Respiratory Physiology, Medicine
• USA Medical Students Cook for Ronald McDonald Families
• USA Health System Welcomes Garry Adkins
• Medical Alumni Association Hosts Distinguished Alumnus Lecture
• Dr. Andrea Kahn Named Pathology Residency Program Director

The Effect Of Mutations In Prmt5 On Its Ability To Oligomerize, Rachel Scarl

Senior Honors Projects

Atherosclerosis is a cardiovascular disease caused by a chronic inflammatory response in the cells lining blood vessels, vascular endothelial cells. In these cells, a network of interacting proteins regulates inflammation. One of these proteins, PRMT5, regulates the inflammatory response by methylating other proteins involved in inflammation. For PRMT5 to carry out its function, it must first oligomerize with itself and various other proteins. In this study, I determined whether mutations to specific PRMT5 methylation sites affect its ability to oligomerize. By expressing PRMT5 in HEK293 cells and studying the effects of adding a chemical cross-linking agent, DMS, I was able …

The Relationship Of Body Mass Index On Primary Care Physician Practice Behaviors With Their Overweight And Obese Patients, Kevin A. Vrablik Md, Mph, Facoem, Judith Green-Mckenzie Md, Mph, Facoem, Steven W. Godin Phd, Mph, Phi Certificate

Department of Medicine

No abstract provided.

Engaging Staff To Change A Culture, Mary Kunkel, Erin Joyce Rn

Patient Care Services / Nursing

No abstract provided.

Why 'Down Under' Is A Cut Above: A Comparison Of Rates Of And Reasons For Caesarean Section In England And Australia, Samantha J. Prosser, Yvette D. Miller, Rachel Thompson, Maggie Redshaw

Dartmouth Scholarship

Background: Most studies examining determinants of rising rates of caesarean section have examined patterns in documented reasons for caesarean over time in a single location. Further insights could be gleaned from cross-cultural research that examines practice patterns in locations with disparate rates of caesarean section at a single time point.

Methods: We compared both rates of and main reason for pre-labour and intrapartum caesarean between England and Queensland, Australia, using data from retrospective cross-sectional surveys of women who had recently given birth in England (n = 5,250) and Queensland (n = 3,467).

A Cross-Cultural Study Exploring Structural Factors Of Men's Sheds, Kaitlyn Mcgrail

Honors Theses

The Men’s Shed program was developed in Australia in 2006 with the explicit goal of establishing a place for men to socially interact and to help maintain their health and well-being. The Men’s Shed program has grown tremendously and has continued their growth in many other countries. There is limited research conducted about the organizational and structural features of the Men’s Shed program. There has been no research to date conducted cross-culturally on the program. The aim of this study is to conduct a descriptive, cross-cultural study on Men’s Shed organizations and the characteristics of the Men’s Shed participants. By …

Amniotic Fluid Index Or Deepest Vertical Pocket?, Joanne Quiñones Md, Msce, R Melody Reynolds Md, Daniel G. Kiefer Md, Meredith Rochon Md, Katie Karabasz-Brown, John C. Smulian Md, Mph

Department of Obstetrics & Gynecology

No abstract provided.

Does Cervical Ripening Via Intracervical Balloon Placement Increase The Risk Of Chorioamnionitis In Patients With Premature Rupture Of Membranes At Term?, Irena B. Cabrera Md, Joanne Quiñones Md, Msce, Danielle E. Durie Md, Jacob Rust, John C. Smulian Md, Mph, William E. Scorza Md

Department of Obstetrics & Gynecology

No abstract provided.

Rct Evaluating Safety & Efficacy Of Sodium Hyaluronate/Carboxymethylcellulose At Cesarean Delivery, Daniel G. Kiefer Md, Jolene C. Muscat Md, Jarrett Santorelli Bs, Martin R. Chavez Md, Cande V. Ananth Phd, Mph, John C. Smulian Md, Mph, Anthony M. Vintzileos Md

Department of Obstetrics & Gynecology

No abstract provided.

A Device For Performing Automated Balloon Catheter Inflation Ischemia Studies, Silas Leavesley, Whitley Ledkins, Petra Rocic

NYMC Faculty Publications

Coronary collateral growth (arteriogenesis) is a physiological adaptive response to transient and repetitive occlusion of major coronary arteries in which small arterioles (native collaterals) with minimal to no blood flow remodel into larger conduit arteries capable of supplying adequate perfusion to tissue distal to the site of occlusion. The ability to reliably and reproducibly mimic transient, repetitive coronary artery occlusion (ischemia) in animal models is critical to the development of therapies to restore coronary collateral development in type II diabetes and the metabolic syndrome. Current animal models for repetitive coronary artery occlusion implement a pneumatic occluder (balloon) that is secured …

Honokiol Enhances Paclitaxel Efficacy In Multi-Drug Resistant Human Cancer Model Through The Induction Of Apoptosis, Xu Wang, Jonathan J. Beitler, Hong Wang, Michael J. Lee, Wen Huang, Lydia Koenig, Sreenivas Nannapaneni, Arm R. Amin, Michael Bonner, Hyung Ju C. Shin, Zhuo Georgia Chen, Jack L. Arbiser, Dong M. Shin

Pharmaceutical Science and Research

Resistance to chemotherapy remains a major obstacle in cancer therapy. This study aimed to evaluate the molecular mechanism and efficacy of honokiol in inducing apoptosis and enhancing paclitaxel chemotherapy in pre-clinical multi-drug resistant (MDR) cancer models, including lineage-derived human MDR (KB-8-5, KB-C1, KB-V1) and their parental drug sensitive KB-3-1 cancer cell lines. In vitro analyses demonstrated that honokiol effectively inhibited proliferation in KB-3-1 cells and the MDR derivatives (IC₅₀ ranging 3.35±0.13 µg/ml to 2.77±0.22 µg/ml), despite their significant differences in response to paclitaxel (IC₅₀ ranging 1.66±0.09 ng/ml to 6560.9±439.52 ng/ml). Honokiol induced mitochondria-dependent and death receptor-mediated apoptosis in …

Health Reform Implementation: Update And Implications For Kentucky, Glen P. Mays

Health Management and Policy Presentations

This talk reviews the progress of health reform implementation in Kentucky with a focus on opportunities for aligning systems for medical care, public health, and social support delivery to improve population health.

Hispanic Laborer Killed When Struck By Falling Plywood On A Commercial Construction Site, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Construction

On a clear windy Wednesday, around 11:50 a.m., a 24 year-old Hispanic laborer was helping his brother-in-law load trusses on the ground, when a gust of wind ripped an 8 foot by 4 foot sheet of plywood from another Hispanic laborer’s hands as he was handing the plywood to a co-worker 60 feet above on a commercial construction site roof. The co-worker on the roof tried to grab the sliding plywood by jumping onto it, but could not stop it. The co-worker’s life line prevented him from falling over the edge of the roof. As the plywood reached the edge …

Endodontic Radiolucency On A Mature Permanent Tooth In The Pediatric Population: Can The Tooth Be Vital?, Erika Lentini

Theses and Dissertations

The objective was to determine the prevalence of vital teeth requiring non-surgical root canal therapy (NSRCT) that present with radiolucencies in mature permanent teeth in a pediatric population. A retrospective electronic dental chart review of children treated with NSRCT at VCU’s School of Dentistry between November 30, 2009 and March 1, 2013 was conducted. The presence or absence of a periapical radiolucency was determined from digital radiographs by three calibrated dentists. Specific characteristics of each tooth were collected. Statistical analysis using logistic regression was completed on all teeth with radiolucencies and vital teeth with radiolucencies. NSRCT was completed on 551 …

Polyethylene Glycol Containing Rompolymers For The Modification Of Neuro-Protective Hemoglobin, Andrea L. Mccollum

Honors College Theses

Polyethylene glycol (PEG) has shown the ability to improve compatibility when used in combination with cell-free hemoglobin in the treatment of traumatic brain injuries. It has been demonstrated that the covalently bonded PEG increases the hydrodynamic radius of the hemoglobin and hence generates a physical barrier while slowing down the oxygen delivery of the strongly oxidative hemoglobin. In this context, I have been working on the development of synthetic pathways to incorporate PEG into monomers and polymers through both direct modification of (7-oxa)norbornene derivatives and post polymerization modification. Starting from the (7-oxa)norbornene anhydride derivatives, we have developed pathways to cationic …

A Dna Microarray-Based Assay To Detect Dual Infection With Two Dengue Virus Serotypes, Alvaro Diaz-Badillo, María De Lourdes Muñoz, Gerardo Pérez-Ramírez, Victor Altuzar, Juan Burgueño, Julio G. Mendoza-Alvarez, Jorge P. Martínez-Muñoz, Alejandro Cisneros, Joel Navarrete-Espinosa, Feliciano Sanchez-Sinencio

School of Medicine Publications

Here; we have described and tested a microarray based-method for the screening of dengue virus (DENV) serotypes. This DNA microarray assay is specific and sensitive and can detect dual infections with two dengue virus serotypes and single-serotype infections. Other methodologies may underestimate samples containing more than one serotype. This technology can be used to discriminate between the four DENV serotypes. Single-stranded DNA targets were covalently attached to glass slides and hybridised with specific labelled probes. DENV isolates and dengue samples were used to evaluate microarray performance. Our results demonstrate that the probes hybridized specifically to DENV serotypes; with no detection …