Medicine and Health Sciences Commons^™

การพัฒนาแบบประเมินศักยภาพพยาบาลในการส่งเสริมคุณภาพชีวิตผู้ป่วยมะเร็งเต้านม, สุรีย์ ธรรมมิกบวร, ชลิยา วามะลุน, นงค์นุช จิตภิรมย์ศักดิ์, โสภิต ทับทิมหิน, ทิพาพร บุญมานะ, อาภาเพ็ญ ทำนุ

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อพัฒนาแบบประเมินศักยภาพพยาบาลในการส่งเสริมคุณภาพชีวิตของผู้ป่วยมะเร็งเต้านม\n \nรูปแบบการวิจัย: การพัฒนาเครื่องมือ\n \nวิธีดําเนินการวิจัย: กลุ่มตัวอย่าง คือ พยาบาลที่มีประสบการณ์การดูแลผู้ป่วยมะเร็งเต้านม โดยคัดเลือก จากพยาบาลวิชาชีพที่ดูแลผู้ป่วยมะเร็งเต้านม จํานวน 120 คน ดําเนินการสร้างแบบประเมินศักยภาพ พยาบาล ตามขั้นตอนดังนี้ 1) กําหนดคํานิยามเชิงปฏิบัติการ จากการศึกษาแนวคิดและทําการ สนทนากลุ่มกับพยาบาลที่ให้การดูแลผู้ป่วยมะเร็งเต้านม จํานวน 19 คน 2) สร้างข้อคําถามตามคํานิยาม ที่ได้ 6 มิติ จํานวนทั้งหมด 30 ข้อ ลักษณะคําตอบเป็นมาตรวัดประมาณค่า 5 ระดับ ตั้งแต่ ปฏิบัติประจํา (5 คะแนน) ถึง ไม่เคยปฏิบัติ (1 คะแนน) 3) ตรวจสอบความตรงเชิงเนื้อหาของแบบประเมินโดยผู้เชี่ยวชาญ 3 คน ได้ค่าดัชนีความตรงเท่ากับ .93 โดยไม่มีข้อใดถูกตัดออก 4) หาความเที่ยงโดยนําไปทดลองใช้กับ พยาบาลผู้ให้การดูแลผู้ป่วยมะเร็งเต้านม จํานวน 30 คน ได้สัมประสิทธิ์อัลฟ่าของครอนบาค เท่ากับ .80 และ 5) ตรวจสอบความตรงเชิงโครงสร้าง (Construct validity) โดยการวิเคราะห์ปัจจัย (Factor analysis) ของแบบประเมินที่นําไปใช้กับพยาบาลวิชาชีพที่ดูแลผู้ป่วยมะเร็งเต้านม จํานวน 120 คน\n\nผลการศึกษา: พบว่า แบบประเมินศักยภาพพยาบาลมีองค์ประกอบหลัก 3 องค์ประกอบ รวม 30 ข้อ คือ 1) ศักยภาพการดํารงตน ประกอบด้วยข้อคําถาม จํานวน 20 ข้อ สามารถอธิบายความแปรปรวนได้ ร้อยละ 67.14 2) ศักยภาพการดูแลวิถีสุขภาพของตนเอง ประกอบด้วยข้อคําถาม จํานวน 5 ข้อ สามารถ อธิบายความแปรปรวนได้ร้อยละ 4.53 และ 3) ศักยภาพการดูแลปัญหาเฉพาะโรค ประกอบด้วยข้อคําถาม …

ความสัมพันธ์ระหว่างอาการ การสนับสนุนทางสังคมและคุณภาพชีวิตของผู้ป่วยมะเร็งศีรษะ และคอเพศชายภาคใต้ขณะได้รับรังสีรักษา, สุชาดา ธราพร, สุรีพร ธนศิลป์

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาอาการ กลวิธีการจัดการกับอาการ และคุณภาพชีวิตของผู้ป่วยมะเร็งศีรษะและ คอเพศชายขณะได้รับรังสีรักษา และศึกษาความสัมพันธ์ระหว่างอาการ การสนับสนุนทางสังคม และคุณภาพชีวิตของผู้ป่วยมะเร็งศีรษะและคอเพศชายขณะได้รับรังสี\n \nรูปแบบการวิจัย: การวิจัยแบบบรรยายเชิงความสัมพันธ์\n \nวิธีดําเนินการวิจัย: กลุ่มตัวอย่าง คือ ผู้ป่วยมะเร็งศีรษะและคอเพศชายขณะได้รับรังสีรักษา ณ ศูนย์มะเร็ง สุราษฎร์ธานี คัดเลือกตามสะดวก จํานวน 130 คน เก็บรวบรวมข้อมูลโดยใช้ แบบสอบถามข้อมูลส่วน บุคคล แบบสอบถามอาการแบบสอบถามกลวิธีการจัดการกับอาการ แบบสอบถามการสนับสนุนทางสังคม และแบบสอบถามคุณภาพชีวิตของผู้ป่วยมะเร็งศีรษะและคอที่ได้รับรังสีรักษา มีค่าดัชนีความตรงเชิง เนื้อหาเท่ากับ .80, .87, .80, และ .81 ตามลําดับ มีค่าสัมประสิทธิ์อัลฟาของครอนบาคเท่ากับ .80, .75, .80, และ .71 ตามลําดับ วิเคราะห์ข้อมูลโดยการหาค่าความถี่ ร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และสถิติสัมประสิทธิ์สหสัมพันธ์ของเพียร์สัน\n \nผลการวิจัย: 1) อาการน้ำลายเหนียว/คอแห้ง มีความถี่และความรุนแรงของอาการมากที่สุด โดยจัดการ กับอาการด้วยการใช้น้ำยาบ้วนปาก การใช้ยาแก้ปวด และการใส่สายให้อาหาร มากที่สุด 2) คุณภาพ\nชีวิตของผู้ป่วยมะเร็งศีรษะและคอเพศชายภาคใต้ขณะได้รับรังสีรักษาอยู่ในระดับสูง (x̄ = 2.90, SD = 0.52) 3) ความถี่และความรุนแรงของอาการมีความสัมพันธ์ทางลบในระดับต่ำและระดับปานกลางกับคุณภาพ ชีวิตของผู้ป่วยมะเร็งศีรษะและคอเพศชายภาคใต้ขณะได้รับรังสีรักษา (r = -.28, = -.38, p<.05) และ 4) การสนับสนุนทางสังคมมีความสัมพันธ์ทางบวกในระดับต่ำกับคุณภาพชีวิตของผู้ป่วยมะเร็งศีรษะและ คอเพศชายภาคใต้ขณะได้รับรังสีรักษา (r=.13, p<.05)\n \nสรุป: อาการต่างๆ ที่เกิดขึ้นกับผู้ป่วยส่งผลต่อคุณภาพชีวิตของผู้ป่วยในด้านร่างกายมากที่สุด ดังนั้นพยาบาล จึงควรมีการพัฒนากลวิธีการจัดการกับอาการที่เกิดขึ้นอย่างเหมาะสม โดยส่วนใหญ่เกิดในช่องปากที่มีทั้ง ความรุนแรงและความถี่ โดยให้สมาชิกในครอบครัวเข้ามามีส่วนร่วม โดยเริ่มตั้งแต่ก่อน ขณะ และหลัง สิ้นสุดการรักษา เพื่อให้เป็นแนวทางในการดูแลผู้ป่วยอย่างต่อเนื่อง\n

Effect Of Water Immersion And Jet Perturbation On Balance In Older And Younger Adults, Matthew Baldwin

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Background: Although balance exercises are often performed in shallow pools, the efficacy of this practice is not well understood. Purpose: To quantify the effect of water depth and jet intensity on measures of balance in older and younger adults. Subjects: Sixteen older (age = 62.8 °” 9.56 yrs) and fifteen younger (age = 22.5 °” 1.85 yrs) adults. Methods: Posturography data were collected as participants stood quietly for 90 seconds on land and at various water depths and jet intensities. Results: Main effects < 0.001) and pairwise comparisons revealed that all measurements increased with increasing water depth and jet intensity,with older adults increasing statistically less than younger adults at higher jet intensities. Conclusions: Water immersion to the xiphoid process and water jet intensities at or above 40% seem to be environmental conditions that produce the greatest postural sway.

Assessment Of Morphosyntactic Development Of Preschool Children With Hearing Loss Using The Clinical Evaluation Of Language Fundamentals-Preschool Second Edition, Angela Anderson

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

It is recommended that children with HL are assessed using standardized assessments normed on hearing peers (Houston & Caraway, 2009; Joint Commission on Infant Hearing (JCIH), 2007). However, as these assessments are more commonly administered to children with HL there is reason to further investigate the sensitivity of these assessments particularly in their ability to identify weaknesses specific to HL. The CELF-Preschool 2 (Clinical Evaluation of Language Fundamentals – Preschool (Wiig, Secord & Semel, 2004)) has been found to be a valid tool for diagnosing language impairment in normal hearing children (Spaulding, Plante, & Farinella, 2006). However, this assessment has …

The Mental Health Disparity Among Nonheterosexuals: Risk, Resiliency, And New Perspectives To Consider In The Context Of Mormonism, Katherine Ann Crowell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nonheterosexuals disproportionately experience mental illness when compared with heterosexuals. Although it has been well established that the apparent mental health disparity among sexually diverse populations is almost exclusively derived from minority stress (i.e., the excess stress associated with culturally maintained sexual stigma), our understanding of how specific aspects of minority stress lead to specific psychological syndromes (e.g., depression) remains limited. On the other hand, in attempts to destigmatize individuals who do not identify as heterosexual, researchers have increasingly begun to shift the focus of their work towards understanding the specific characteristics or experiences that facilitate individuals’ capacity to adapt and …

Predictors Of Persistence And Resurgence: Evaluation Of A Behavioral Momentum-Based Approach, Mary M. Sweeney

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Mary M. Sweeney, graduate student in the Experimental and Applied Psychological Sciences program at Utah State University, will complete this dissertation as part of the requirements of the degree of Doctor of Philosophy in Psychology.

One approach to reducing a behavior with a history of reward is to remove the reward for the target behavior to be reduced and introduce reward for an alternative behavior. When alternative reward is removed, though, relapse termed resurgence can occur. The broad purpose of this dissertation is to examine the variables that contribute to the persistence and resurgence of a behavior. The results of …

The Impact Of Body Image On Women In Later Life: Effects On Quality Of Life And Body Perception, Rachel L. Avants

Graduate Theses and Dissertations

Physical, mental, and emotional changes can occur throughout the aging process, making it important to treat different age groups as separate populations when researching body image. Yet, very few instruments have been validated for middle-aged and older adults. An online survey was used to perform a validation of the Body Image Quality of Life Inventory (BIQLI) and examine demographic relationships, with a sample of 947 women, ages 40-79, from across the United States. A principal component analysis (PCA) and convergent validity supported the use of the BIQLI for women ages 40 to 79. A one-factor model was validated for comparing …

"The Claims Of Religion Upon Medical Men": Protestant Christianity And Medicine In Nineteenth-Century America, Ronald James Gordon

Graduate Theses and Dissertations

This is the first study to examine how pastors lost authority over bodily healing in the nineteenth century. I argue that clergymen adapted to the scientific and cultural developments of the post-Darwin era by encouraging a separation of bodily healing and spiritual healing that was unprecedented in Christianity. In 1840, ministers wielded much more authority than physicians, who still practiced a heroic medicine whose foundations predated Christ. Ministers insisted that doctors' value lay in their willingness to be proselytizing Christians. The doctor who wanted to reach the upper echelon of his profession had to save the souls of the wayward …

The Effect Of School And Neighborhood Environmental Factors On Childhood Obesity, Yiwei Qian

Graduate Theses and Dissertations

The dissertation consists of three chapters exploring the effect of school program and neighborhood environment on childhood obesity outcome using individual panel data set of Arkansas public schoolchildren.

The first chapter (Section 2) investigates how the Fresh Fruit and Vegetable Program (FFVP), a program that provides funding for the distribution of free fresh fruits and vegetables to students in participating schools, affects childhood obesity. We combine matching methodology and difference-in-differences analysis to estimate the effect of the FFVP on childhood BMI outcomes. Estimates of the FFVP effect are sensitive to different matching methods. Methods that provide a good balance between …

Chitosan Reduces Enteric Colonization Of Campylobacter In Young Chickens, But Not On Post-Harvest Chicken Skin Samples, Hanna Royce Arambel

Graduate Theses and Dissertations

Worldwide, Campylobacter is one of the leading causes of foodborne bacterial gastroenteritis causing an estimated 1.3 million infections in the United States alone. Consumption and/or cross-contamination of raw or undercooked poultry products have been linked as the most common source of Campylobacter infection, making the poultry industry a target for Campylobacter reduction strategies. Campylobacter is prevalent in most poultry flocks in the United States, with as many as 90% of flocks Campylobacter-positive at the time of slaughter. It is estimated that a reduction of Campylobacter in poultry would greatly reduce the risk of campylobacteriosis in humans. Unfortunately, there are …

Effects Of The Endocannabinoid Anandamide On Excitability And Calcium Signaling In Rat Ventricular Myocytes, Lina Tareq Al-Kury

Dissertations

Endogenous cannabinoids (endocannabinoids) exert a wide range of biological effects. In addition to having their well-known neurobehavioral effects, a role for the major endocannabinoid anandamide (N-arachidonoyl ethanolamide; AEA), in the cardiovascular system in various pathological conditions has been reported. The aim of this thesis is to explore the effects of AEA on contractility, Ca2+ signaling, and action potential (AP) characteristics in rat ventricular myocytes. A video edge detection system was used to measure myocyte shortening. Intracellular Ca2+ was measured in cells loaded with the fluorescent indicator fura-2 AM. AEA (1 μM) caused a significant decrease in the amplitude of electrically-evoked …

Cushing’S Storm Secondary To Ectopic Acth Secreting Metastatic Breast Cancer, Maura Bucciarelli Do, Ya-Yu Lee Md, Vasudev G. Magaji Md, Ms

Department of Medicine

No abstract provided.

Physio@Home: Design Explorations To Support Movement Guidance, Richard Tang, Hesam Alizadeh, Anthony Tang, Scott Bateman, Joaquim A.P. Jorge

Research Collection School Of Computing and Information Systems

Patients typically undergo physiotherapy with the help of a physiotherapist who teaches, guides, and corrects the patients as they perform exercises. It would be nice if people could repeat these exercises at home, potentially improving their recovery rate. However, without guidance and/or corrective feedback from a physiotherapist, the patient will not know whether they are doing their exercises correctly. To address this problem, we implemented a prototype that guides patients through pre-recorded exercise movements using visual guides overlaid atop a mirror-view of the patient on a wall-mounted display. We conducted informal evaluations and pilot studies to assess our prototype and …

Medical Imaging Specialists And 3d: A Domain Perspective On Mobile 3d Interactions, Teddy Seyed, Frank Maurer, Francisco Marinho Rodrigues, Anthony Tang

Research Collection School Of Computing and Information Systems

3D volumetric medical images, such as MRIs, are commonly explored and interacted with by medical imaging experts using systems that require keyboard and mouse-based techniques. These techniques have presented challenges for medical imaging specialists: 3D spatial navigation is difficult, in addition to the detailed selection and analysis of 3D medical images being difficult due to depth perception and occlusion issues. In this work, we explore a potential solution to these challenges by using tangible interaction techniques with a mobile device to simplify 3D interactions for medical imaging specialists. We discuss preliminary observations from our design sessions with medical imaging specialists …

Haptics In Remote Collaborative Exercise Systems For Seniors, Hesam Alizadeh, Richard Tang, Ehud Sharlin, Anthony Tang

Research Collection School Of Computing and Information Systems

Group exercise provides motivation to follow and maintain a healthy daily exercise schedule while enjoying beneficial encouragement and social support from friends and exercise partners. However, mobility and transportation issues frequently prevent seniors from engaging in group activities. To address this problem, we investigated the exercise needs of seniors and developed a prototype remote exercise system. Our system uses haptic feedback to simulate assistive pushing and pulling of limbs when exercising with a partner. We developed three distinct vibration metaphors -- constant push/pull, corrective feedback, and notification -- to convey engagement and connection between exercise partners. We conducted a preliminary …

Propagation Of Oligomeric Α-Synuclein And Amyloid-Β: Implications For Parkinson's And Alzheimer's Diseases, Matthew Stephen Planchard

Master's Theses

The aggregation of amyloidogenic proteins is a critical event in the pathology of a variety of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The proteins α-synuclein (αS) and amyloid-β (Aβ) are involved in the formation of amyloid lesions observed in PD and AD, respectively. Both PD and AD exhibit a significant amount of co-pathology in clinical settings, and the αS and Aβ proteins have been shown to interact in vitro. Recent experimental consensus has shown oligomeric species to be significant, if not primary, sources of toxicity in these diseases. …

Role Of Myd88 Protein In The Maintenance Of Immunological Self-Tolerance: Induction Of Autoimmunity By Salmonella Infection Consequent To Myd88 Deficiency., Jincy Merin Issac

Theses

Activation of the innate immune system is a prerequisite for the induction of adaptive immune responses to both infectious and non-infectious agents. Toll-like receptors (TLRs) are a family of proteins important for recognizing pathogen associated molecular patterns. MyD88 is an adaptor molecule whose function is critical in TLR signaling. MyD88-deficient (MyD88^-/-) mice exhibit heightened susceptibility to infections, even by attenuated strains of Salmonella enterica serovar Typhimurium. Paradoxically, despite their hypersusceptibility, infected MyD88^-/- mice produce elevated serum levels of anti-Salmonella antibodies regardless of the route of infection. This hypergammaglobulinemia was observed with both Th1-driven (IgG2c and IgG3) …

The Role Of Glutamate Signalling In Diabetic Neuropathy, Nadia Hussain

Dissertations

The majority of diabetics develop neuropathy, which can be debilitating, but the underlying pathophysiological mechanisms are poorly understood. Diabetic neuropathy progresses in a distal to proximal manner. Previous studies have shown that glutamate, the most common excitatory neurotransmitter, plays a role in the pathogenesis of neuropathy. The reason why the role of glutamate in nociception becomes a problem in diabetes and the mechanisms that are involved are unknown. Based on the preliminary data, the hypothesis was that glutamate pathways are likely to be involved in diabetic neuropathy particularly neuropathic pain. Pathways were investigated to look for changes that might reflect …

Hypoxic Signals In The Ischemic Myocardium: Role Of Galectin-1 And Galectin-3, Satwat Hashmi

Dissertations

Myocardial infarction is the most serious manifestation of coronary artery disease and the cause of significant levels of mortality and morbidity worldwide. Galectin-1 (GAL-1) and Galectin-3 (GAL-3) are beta galactoside binding lectins with diverse functions. Hypoxia inducible factor-1 alpha (HIF-1α) is a transcription factor mediating early and late responses to myocardial ischemia. We aim to study the direct effects of ischemia on GAL-1, GAL-3 and HIF-1α in the heart. Male C57B6/J and GAL-3 knockout mice were used for our two disease models. In the Myocardial infarction (MI) model, the left anterior descending artery of the heart is permanently ligated to …

Role Of Myd88 Protein In The Maintenance Of Immunological Self-Tolerance: Induction Of Autoimmunity By Salmonella Infection Consequent To Myd88 Deficiency, Jincy Merin Issac

Dissertations

Activation of the innate immune system is a prerequisite for the induction of adaptive immune responses to both infectious and non-infectious agents. Toll-like receptors (TLRs) are a family of proteins important for recognizing pathogen associated molecular patterns. MyD88 is an adaptor molecule whose function is critical in TLR signaling. MyD88-deficient (MyD88-/-) mice exhibit heightened susceptibility to infections, even by attenuated strains of Salmonella enterica serovar Typhimurium. Paradoxically, despite their hypersusceptibility, infected MyD88-/- mice produce elevated serum levels of anti-Salmonella antibodies regardless of the route of infection. This hypergammaglobulinemia was observed with both Th1-driven (IgG2c and IgG3) and Th2-driven (IgG1) antibody …

Epigenetic Remodeling In An Imr-32 Cell Line And Transgenic Mouse Model Of Alzheimer's Disease, Matthew S. Baker

Senior Honors Theses

The pathological features of Alzheimer’s disease (AD) have been researched and documented extensively, however the causes of these features are still unknown. The following studies sought to determine if epigenetic methylation alterations contribute to AD. Two studies were sequentially carried out, first using an IMR-32 model and then using a transgenic mouse model overexpressing beta-amyloid. A few assay and confirmation methods were carried out to determine the promoter regions in disease state models undergoing drastic change, and the genes linked to these promoter regions were analyzed to determine significant gene ontology being altered by this epigenetic modification. This data was …

Tethered Il-15 To Augment The Therapeutic Potential Of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, And Antitumor Activity, Lenka Hurton

Dissertations and Theses (Open Access)

Tethered IL-15 to augment the therapeutic potential of T cells expressing chimeric antigen receptor: Maintaining memory potential, persistence, and antitumor activity

Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by the expression of a chimeric antigen receptor (CAR). Infusion of CAR-modified T cells for the treatment B-cell malignancies has demonstrated promise in preclinical and clinical trials. These data highlight the ability of infused CD19-specific T cells to be synchronously activated by large burdens of CD19⁺ leukemia and lymphoma. This can lead to dramatic antitumor effects, but also exposes the recipient to …

Differential Regulation Of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex To Rc2 Modulates Aurora A Kinase Expression, Roy L. Voice Iii

Dissertations and Theses (Open Access)

Identifying the mechanisms that contribute to tumorigenesis is a major area of focus in our fight against cancer. Epithelial malignant tumors, such as breast, colon, ovarian and pancreatic cancers have been shown to overexpress proteins that control cell mitosis, growth, and proliferation. One of those proteins is the Aurora A kinase. Aurora A kinase is a member of a small family of kinases that contribute to mitotic events such as centrosome duplication, separation, and maturation. Aurora A overexpression leads to genomic instability, which can contribute to tumorigenesis, on the other hand, inhibiting Aurora A expression leads to apoptosis, making it …

Combination Therapy With Aerosol Il-2 And Nk Cells For The Treatment Of Osteosarcoma Lung Metastasis, Sergei R. Guma

Dissertations and Theses (Open Access)

The survival of patients with osteosarcoma lung metastases has not improved in the last 20 years. Novel alternative therapies are needed. The purpose of this investigation was to evaluate the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the treatment of osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors and 56 from lung metastases). We discovered that osteosarcoma expresses the ligands for the NKG2D. In vitro studies demonstrated that NK-mediated killing of osteosarcoma cells is dependent on the …

Competition Between Grb2 And Plcγ1 For Binding To Fgfr2 Regulates Phospholipase And Pten Activity, Leading To Cell Invasion And Proliferation, Zahra Timsah

Dissertations and Theses (Open Access)

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Fluctuations in the relative concentrations of proteins in non-stimulated cells can lead to aberrant signaling. In a novel interaction, the SH3 domain of Plcγ1 competes with the SH3 domain of Grb2 for binding to FGFR2 in a concentration-dependent manner. Consequently, reduction of cellular concentrations of Grb2 lead to receptor-dependent recruitment of unphosphorylated Plcγ1. Bringing of the phospholipase to the membrane in this way …

Mechanisms Underlying Distinct Egfr Versus Fgfr-3 And -1 Dependency In Human Bladder Cancer Cells, Tiewei Cheng

Dissertations and Theses (Open Access)

The epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) are activated by gene amplification, mutation and overexpression in bladder cancer, which drives tumor development and progression. Both EGFR and FGFR inhibitors are currently being tested in clinical trials. However, bladder cancer (BC) cells show remarkably heterogeneous sensitivities to both inhibitors, and the molecular determinants of this heterogeneity are presently unclear. Therefore, in this study, using selective EGFR and FGFR inhibitors in BC cells, we demonstrated that FGFR3 and FGFR1 play largely non-overlapping roles in mediating proliferation and invasion in the distinct “epithelial” and “mesenchymal” subsets of human …

The Association Between The Il-1 Pathway, Isaac C. Wun

Dissertations and Theses (Open Access)

Cutaneous malignant melanoma (CMM) is a potentially lethal malignancy that warrants attention and further research, as it is known to that there is an increasing rate of incidence in theUnited States, and it is also known that exposure to UV light is its most crucial risk factor, and family history of melanoma is also an important risk factor. Melanoma is an aggressive and lethal cancer in humans. There are an estimated new 132,000 melanoma cases annually worldwide, and the trend has doubled in the past 20 years. However, attempts to treat melanoma have encountered considerable resistance and remained ineffective. The …

Development Of A Multi-Purpose Automated Synthesis Module For Production Of Novel Pet Radiopharmaceuticals, I Hong Shih

Dissertations and Theses (Open Access)

Among radiopharmaceuticals of positron emission tomography (PET), ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG) made from commercialized automated synthesis module is the most frequently used in tumor diagnoses. But the false positive findings, such as infectious tissues and post-operative surgical conditions, show strong uptake of ¹⁸F-FDG in PET scans which requires extra clinical procedures to confirm the results. Moreover, the false negative findings, such as low glycolytic activity tumors, reduce the accuracy of PET scans. Therefore, there will be new PET radiopharmaceuticals to redeem the defects of ¹⁸FDG-PET applications.

Current commercialized automated synthesis modules are suitable for clinical use, but …

Systematic Methodology For The Identification Of A Novel Autosomal Dominant Retinitis Pigmentosa Disease-Causing Gene, Jennifer D. Churchill

Dissertations and Theses (Open Access)

Retinitis pigmentosa (RP) is an inherited retinal disease that leads to degeneration of the retina through loss of rod and cone photoreceptor cells and subsequent loss of vision. RP affects approximately 1.5 million people world-wide. Mutations causing autosomal dominant retinitis pigmentosa (adRP) have been identified in 23 different genes. However, these mutations only account for approximately 70% of known adRP cases in Caucasians of Western-European origin and for an even smaller percentage of cases in other ethnicities. My research aims to increase the number of known genes associated with adRP by using an array of advanced genetic techniques to search …

The Novel Upstream Regulator Of Fbxw7, Ji-Hyun Shin

Dissertations and Theses (Open Access)

SCF^FBXW7 is a tumor suppressor E3 ligase protein that targets numerous oncoproteins such as Cyclin E, c-Myc, c-Jun and MCL1. The deregulation of these proteins often leads to the proliferation of cancer cells. Thus, intracellular stability and functional activity of FBXW7 is critical for regulating cancer. However, there is a gap of knowledge about the intracellular signaling pathway or if there is another ubiquitin ligase that regulates FBXW7 stability. Here, I identify a novel mechanism of FBXW7 stability regulation which involves constitutive photomorphogenic 1 (COP1), AKT and CSN6 (i.e. the COP9 signalosome 6).

COP1 is an E3 ubiquitin ligase …