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2014

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Articles 4141 - 4170 of 9579

Full-Text Articles in Medicine and Health Sciences

Availability Of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis, Andrea M. Lewis May 2014

Availability Of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis, Andrea M. Lewis

Dissertations and Theses (Open Access)

Background: Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant colorectal cancer predisposition associated with the development of hundreds to thousands of adenomatous colorectal polyps beginning in childhood or adolescence. Both malignant and non-malignant extracolonic manifestations are associated with APC gene mutations, including approximately 17% of individuals with various dental anomalies. The availability of dental anomaly information in the medical record remains to be evaluated.

Methods: Medical records were reviewed for documentation of dental anomalies. Dental questionnaires were mailed to 271 individuals with FAP at The University of Texas M. D. Anderson Cancer Center (UTMDACC) to …


Fact Sheet #3: How Do Parents Rate Dental Services For Children In Mainecare?, Jean A. Talbot Phd, Mary Lindsey Smith Phd, Msw, Kimberley S. Fox Mpa May 2014

Fact Sheet #3: How Do Parents Rate Dental Services For Children In Mainecare?, Jean A. Talbot Phd, Mary Lindsey Smith Phd, Msw, Kimberley S. Fox Mpa

Population Health & Health Policy

The annual Survey of Children Served by MaineCare, which collects an abundance of data on the experiences of MaineCare families, provides important information on how parents evaluate the dental care that their children receive.


Use Of Antiepileptic Drugs And Lipid-Lowering Agents In The United States., Scott Mintzer, Vittorio Maio, Kathleen Foley May 2014

Use Of Antiepileptic Drugs And Lipid-Lowering Agents In The United States., Scott Mintzer, Vittorio Maio, Kathleen Foley

Department of Neurology Faculty Papers

INTRODUCTION: The extent to which enzyme-inducing antiepileptic drugs (EIAEDs) are used as first-line treatment in the United States remains unknown. Studies suggest that EIAEDs produce elevation of serum lipids, which could require additional treatment. We assessed the current use of EIAED in monotherapy for epilepsy in the U.S., as well as the correlation between the use of EIAEDs and subsequent new prescriptions for HMG-CoA reductase inhibitors ("statins") for hyperlipidemia.

METHODS: We queried the MarketScan® databases between July 2009 and January 2013, covering 66million patients with commercial or supplemental Medicare insurance. We identified individuals who had a diagnosis of seizures, continuous …


A Content And Visual Analysis Of Promotional Pieces Used To Promote The Arkansas Soybean Promotion Board, Amy Hughes May 2014

A Content And Visual Analysis Of Promotional Pieces Used To Promote The Arkansas Soybean Promotion Board, Amy Hughes

Graduate Theses and Dissertations

A communications campaign was developed for a commodity promotion board in the southern region of the United States with promotional pieces produced and disseminated by a third-party communications group to reach the general public, soybean producers, and animal agriculture producers target audiences through key themes and messages. A systematic, content-driven approach assessed the potential impact on perceptions of individuals. This study utilized a content and visual analysis based on semiotic theory to analyze creative pieces and focus groups to assess content quality and impact.

Many of the creative pieces displayed too many themes, and the themes did not accurately represent …


Self-Awareness, Coping Strategies And Related Factors Among Patients Attending Substance Treatment Program, P Kulkansawat, A. Sughondhabirom May 2014

Self-Awareness, Coping Strategies And Related Factors Among Patients Attending Substance Treatment Program, P Kulkansawat, A. Sughondhabirom

Chulalongkorn Medical Journal

Background : Treatment of drug dependence requires understanding of self-awareness and coping strategies for drug dependence which are key factors to facilitate drug dependent person to stop using drug. Objective : To study self-awareness and coping strategies as well as relevant factors among patients under drug dependence treatment at Thanyarak Institute. Design : A cross – sectional descriptive study. Setting : Thanyarak institute. Materials and Methods : Sample group consisted of 110 drug-dependent persons who were on treatment at Thanyarak Institute. Self responding questionnaire was used to collect data relating to: 1) Personal information: 2) Self-awareness: 3) Coping strategies. Statistics …


A Comparative Study Of Depression Between The Elderly Living In Their Own Home And Those In Nursing Home For The Aged, Mueang District, Chiang Mai, S Suwattanakoop, B. Kanchanatawan May 2014

A Comparative Study Of Depression Between The Elderly Living In Their Own Home And Those In Nursing Home For The Aged, Mueang District, Chiang Mai, S Suwattanakoop, B. Kanchanatawan

Chulalongkorn Medical Journal

Background : Depression is a common mental health problem in the elderly in the community and home for the aged. An international research found that older people who live in communities were more depressed than those living in nursing home for the aged. Therefore, researcher wanted to determine difference of depression between the elderly living in their own home and those living in nursing home for the aged in Thailand in a different context. Objective : To study and compare the prevalence of depression and factors associated with depression in the elderly living in their own home and those living …


บริการการดูแลระยะยาวสำหรับผู้สูงอายุที่มีภาวะพึ่งพิงและความต้องการของญาติผู้ดูแล สำหรับการดูแลผู้สูงอายุที่มีภาวะพึ่งพิงของจังหวัดภูเก็ต, ชญานิศ ลือวานิช, รัตนา ลือวานิช, จิตร โรมินทร์ May 2014

บริการการดูแลระยะยาวสำหรับผู้สูงอายุที่มีภาวะพึ่งพิงและความต้องการของญาติผู้ดูแล สำหรับการดูแลผู้สูงอายุที่มีภาวะพึ่งพิงของจังหวัดภูเก็ต, ชญานิศ ลือวานิช, รัตนา ลือวานิช, จิตร โรมินทร์

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาบริการการดูแลผู้สูงอายุที่มีภาวะพึ่งพิงระยะยาวและความต้องการของญาติผู้ดูแล สําหรับการดูแลผู้สูงอายุที่มีภาวะพึ่งพิงของจังหวัดภูเก็ต\n\n รูปแบบการวิจัย: การวิจัยเชิงคุณภาพ\n\n วิธีดําเนินการวิจัย: ผู้ให้ข้อมูล คือ ผู้สูงอายุที่มีภาวะพึ่งพิง ญาติผู้ดูแล บุคลากรสาธารณสุข อาสาสมัคร สาธารณสุข (อสม.) อาสาสมัครผู้ดูแลผู้สูงอายุ (อผส.) บุคลากรในสังกัดศูนย์พัฒนาการจัดสวัสดิการ สังคมผู้สูงอายุ จังหวัดภูเก็ต และบุคลากรสถานบริบาล รวมจํานวน 43 คน เก็บรวบรวมข้อมูลด้วยการ สัมภาษณ์เชิงลึก การสนทนากลุ่ม และการศึกษาเอกสาร วิเคราะห์ข้อมูลด้วยการเปรียบเทียบอย่างต่อเนื่อง\n \nผลการวิจัย: พบว่า จังหวัดภูเก็ตมีบริการการดูแลผู้สูงอายุที่มีภาวะพึ่งพิง 5 ลักษณะ คือ การดูแลโดย ศูนย์พัฒนาการจัดสวัสดิการสังคมผู้สูงอายุ โดยญาติผู้ดูแล โดยบุคลากรสาธารณสุขจากโรงพยาบาล ส่งเสริมสุขภาพ (รพ.สต.) โดย อสม. /อผส. และโดยสถานบริบาล สิ่งที่ญาติผู้ดูแลมีความต้องการใน การดูแลผู้สูงอายุที่มีภาวะพึ่งพิงระยะยาวประกอบด้วย รพ.สต. ควรมียาสํารอง ให้การสนับสนุนผ้าอ้อมผู้ใหญ่ และต้องการการช่วยเหลือด้านการเงิน ผู้ให้ข้อมูลหลักได้เสนอแนะบริการการดูแลผู้สูงอายุที่มี ภาวะพึ่งพิง ดังนี้ 1) ควรมีสถานที่ดูแลผู้สูงอายุในชุมชนหรือคนพิการในชุมชน โดยเฉพาะให้การดูแลผู้สูงอายุ ที่ไม่มีญาติ ญาติทํางานนอกบ้าน 2) ควรมีผู้มีจิตอาสา / บุคลากรสาธารณสุขไปดูแลผู้สูงอายุที่บ้าน 3) ควรมี Day care สําหรับดูแลผู้สูงอายุโดยบริหารจัดการในรูปจิตอาสา และ 4) ควรมีแหล่งให้คําปรึกษา ในการดูแลผู้สูงอายุแก่ญาติผู้ดูแล\n \nสรุป: ปัจจุบันการดูแลผู้สูงอายุระยะยาวนับเป็นสิ่งจําเป็น หน่วยบริการปฐมภูมิจะต้องได้รับการพัฒนา ศักยภาพในด้านการให้บริการ ผู้กําหนดนโยบายด้านสาธารณสุขของจังหวัดภูเก็ตจะต้องมีนโยบายที่ ชัดเจนในการดูแลผู้สูงอายุระยะยาวในชุมชน อีกทั้งควรจัดให้มีหน่วยงานให้คําแนะนํา ปรึกษาในการ ดูแลผู้สูงอายุแก่ญาติผู้ดูแล\n


การมีชีวิตอยู่กับภาวะสมองเสื่อมระยะเริ่มต้นของผู้สูงอายุ: การศึกษารายกรณีเชิงคุณภาพ, นิตติยา น้อยสีภูมิ, ศิริพันธุ์ สาสัตย์ May 2014

การมีชีวิตอยู่กับภาวะสมองเสื่อมระยะเริ่มต้นของผู้สูงอายุ: การศึกษารายกรณีเชิงคุณภาพ, นิตติยา น้อยสีภูมิ, ศิริพันธุ์ สาสัตย์

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาการมีชีวิตอยู่กับภาวะสมองเสื่อมระยะเริ่มต้นของผู้สูงอายุ\n \nรูปแบบการวิจัย: การวิจัยเชิงคุณภาพแบบกรณีศึกษาหลายกรณี (Multiple case studies)\n \nวิธีดําเนินการวิจัย: กรณีศึกษา คือ ผู้สูงอายุที่ได้รับการวินิจฉัยว่ามีภาวะสมองเสื่อมระยะเริ่มต้น มี ประสบการณ์ในการใช้ชีวิตหลังจากที่ทราบว่าตนเองได้รับการวินิจฉัยโรค จํานวนทั้งหมด 7 ราย ที่เข้า รับการรักษาที่แผนกผู้ป่วยนอกอายุรกรรมศัลยกรรม คลินิกผู้สูงอายุ และคลินิกความทรงจําของโรงพยาบาล 3 แห่ง โดยเลือกกรณีศึกษาแบบเฉพาะเจาะจง เก็บรวบรวมข้อมูลโดยการสัมภาษณ์แบบเชิงลึกรายกรณี ร่วมกับการสังเกตแบบมีส่วนร่วม วิเคราะห์ข้อมูลด้วยวิธีการวิเคราะห์เนื้อหาร่วมกับการวิเคราะห์แบบ ข้ามกรณี\n \nผลการวิจัย: ผู้สูงอายุที่มีภาวะสมองเสื่อมระยะเริ่มต้นบอกเล่าประสบการณ์ของตนเองที่มีชีวิตอยู่กับภาวะ สมองเสื่อมใน 5 ประเด็น คือ 1) การรับรู้ความผิดปกติที่เกิดขึ้นจากอาการที่เปลี่ยนแปลงไป 2) ผลกระทบ ที่ได้รับจากการมีภาวะสมองเสื่อมระยะเริ่มต้น 3) การทําใจยอมรับกับเหตุการณ์โดยใช้ศาสนา 4) การ จัดการกับอาการสมองเสื่อมระยะเริ่มต้น และ 5) ความคาดหวังการได้รับการดูแล\n \nสรุป: ผลการศึกษาครั้งนี้ บุคลากรทางสุขภาพสามารถนําความรู้ที่ได้ไปใช้เป็นแนวทางในการวางแผน ให้การพยาบาลผู้ป่วยสมองเสื่อมในระยะเริ่มต้นและผู้ดูแลผู้ป่วยสมองเสื่อมในการดูแลสุขภาพ เพื่อช่วย ให้สามารถเผชิญและจัดการกับอาการและผลกระทบที่เกิดขึ้นตอบสนองความต้องการและให้การดูแลผู้ป่วย สมองเสื่อมจนกระทั่งเสียชีวิต\n


Rural Residents More Likely To Be Enrolled In High-Deductible Health Plans, Jennifer D. Lenardson Mhs, Erika C. Ziller Phd, Andrew F. Coburn Phd May 2014

Rural Residents More Likely To Be Enrolled In High-Deductible Health Plans, Jennifer D. Lenardson Mhs, Erika C. Ziller Phd, Andrew F. Coburn Phd

Access / Insurance

Enrollment in high deductible health plans (HDHPs) has increased amid concerns about growing health care costs to patients, employers, and insurers. Prior research indicates that rural individuals are more likely than their urban counterparts to face high out-of-pocket health care costs relative to income, despite coverage through private health insurance, a difference related both to the lower income of rural residents generally and to the quality of the private plans through which they have coverage. Using the 2007-2010 National Health Interview Survey, this study examines rural residents’ enrollment in HDHPs and the implications for evolving Affordable Care Act Health Insurance …


Implications Of Rurality And Psychiatric Status For Diabetic Care Use Among Adults With Diabetes, Jean A. Talbot Phd, Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, David Hartley Phd May 2014

Implications Of Rurality And Psychiatric Status For Diabetic Care Use Among Adults With Diabetes, Jean A. Talbot Phd, Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, David Hartley Phd

Access / Insurance

This research examined patterns of diabetic preventive care use among adults with diabetes, to determine whether these patterns varied according to respondents’ rural/urban residence or psychiatric status (i.e., the presence/absence of a mental health diagnosis). Specifically, we considered whether rural people with diabetes are less likely than urban peers to use diabetic preventive services; whether having a mental health diagnosis affects preventive service use among diabetics; and, whether rural/ urban differences in service use vary depending on the presence or absence of a mental health diagnosis.


High Deductible Health Insurance Plans In Rural Areas, Jennifer D. Lenardson Mhs, Erika C. Ziller Phd, Andrew F. Coburn Phd May 2014

High Deductible Health Insurance Plans In Rural Areas, Jennifer D. Lenardson Mhs, Erika C. Ziller Phd, Andrew F. Coburn Phd

Access / Insurance

Enrollment in high deductible health plans (HDHPs) has increased amid concerns about growing health care costs to patients, employers, and insurers. Prior research indicates that rural individuals are more likely than their urban counterparts to face high out-of-pocket health care costs relative to income, despite coverage through private health insurance, a difference related both to the lower income of rural residents generally and to the quality of the private plans through which they have coverage. Using the 2007-2010 National Health Interview Survey, this study examines rural residents’ enrollment in HDHPs and the implications for evolving Affordable Care Act Health Insurance …


Integrated Care For Older Adults In Rural Communities, Eileen Griffin Jd, Andrew F. Coburn Phd May 2014

Integrated Care For Older Adults In Rural Communities, Eileen Griffin Jd, Andrew F. Coburn Phd

Mental Health / Substance Use Disorders

Recognizing that traditional models of health care delivery and payment often produce fragmented and costly care and poor outcomes for those with the highest needs, many reforms under the Affordable Care Act (ACA) focus on realigning payment incentives and integrating care. These reforms presuppose the existence of supporting infrastructure and capacity, including dedicated care management staffing and health information technology and exchange. With a focus on community-dwelling older adults in need of integrated physical, behavioral health services, and long term services and supports (LTSS), this brief reviews the opportunities and challenges these reform initiatives present for rural communities: How easily …


Integrated Care Management In Rural Communities, Eileen Griffin Jd, Andrew F. Coburn Phd May 2014

Integrated Care Management In Rural Communities, Eileen Griffin Jd, Andrew F. Coburn Phd

Mental Health / Substance Use Disorders

No abstract provided.


A School-Based Intervention’S Impact On Children’S Knowledge And Self-Efficacy Related To Physical Activity And Nutrition: A Pilot Study, Katherine Turley Jenkins May 2014

A School-Based Intervention’S Impact On Children’S Knowledge And Self-Efficacy Related To Physical Activity And Nutrition: A Pilot Study, Katherine Turley Jenkins

Theses and Dissertations

Childhood obesity has become epidemic in the United States. One of the best places to combat this problem is within the school system. The purpose of this study was to examine changes in exercise self-efficacy, science interest, and science knowledge of children who participated in a school-based anatomy and healthy lifestyle intervention called Anatomy Academy. In this pilot study, 212 study participants were recruited from 5th and 6th grade children enrolled in one of three charter schools who participated in our 7-week intervention, Anatomy Academy. Children completed four questionnaires pre and post intervention: (1) a science knowledge questionnaire, (2) a …


The Impact Of The Ohana Mana Challenge On Native Hawaiian And Pacific Islander Children, Kristin Kay Van Tassell May 2014

The Impact Of The Ohana Mana Challenge On Native Hawaiian And Pacific Islander Children, Kristin Kay Van Tassell

Theses and Dissertations

In this four-week, family-focused pilot intervention study, researchers studied the impact of culturally relevant nutrition and activity sessions on eleven children from eight Native Hawaiian and Pacific Islander (NHPI) families. Mixed methods were used in analysis. In their favorite meal drawings, children included more fruits and vegetables at week four than week one, which was consistent with their self-reported intake of healthy foods that were new to them. From week one to four, mean total scores increased on the nutrition and exercise knowledge exercise questionnaire and the physical activity self-efficacy tool; however, the mean total score decreased on healthy diet …


Lean Body Mass May Explain Apparent Racial Differences In Carotid Intima-Media Thickness In Obese Children., Shahryar M. Chowdhury, Melissa H. Henshaw, Brad Friedman, J Philip Saul, Girish S. Shirali, Janet Carter, Bryana M. Levitan, Tom Hulsey May 2014

Lean Body Mass May Explain Apparent Racial Differences In Carotid Intima-Media Thickness In Obese Children., Shahryar M. Chowdhury, Melissa H. Henshaw, Brad Friedman, J Philip Saul, Girish S. Shirali, Janet Carter, Bryana M. Levitan, Tom Hulsey

Manuscripts, Articles, Book Chapters and Other Papers

Background: Racial differences in carotid intima-media thickness (cIMT) have been suggested to be associated with the disproportionally high prevalence of cardiovascular disease in black adults. The objective of this study was to evaluate the effects of cardiovascular risk factors on the racial differences seen in cIMT in obese children.

Methods: Obese subjects aged 4 to 21 years were recruited prospectively. Height, weight, blood pressure, fasting insulin, glucose, lipid panel, high-sensitivity C-reactive protein, and body composition by dual-energy x-ray absorptiometry were obtained. B-mode carotid imaging was analyzed by a single blinded physician.

Results: A total of 120 subjects (46 white, 74 …


A Refresher On Tourette Syndrome., James R. Batterson, Shayla Sullivant, Jean-Baptist Lepichon, Christy Kleinsorge, Sandy Price, Stephanie Andrews May 2014

A Refresher On Tourette Syndrome., James R. Batterson, Shayla Sullivant, Jean-Baptist Lepichon, Christy Kleinsorge, Sandy Price, Stephanie Andrews

Manuscripts, Articles, Book Chapters and Other Papers

Tourette Syndrome (TS) is recognized as a more common neurodevelopmental disorder than once thought. In this article we present an update on TS including the DSM-5 revised criteria, new findings in the genetics of TS, treatment advances such as new medications for tics and the use of new tools including Cognitive Behavioral Intervention for Tics (CBIT). We also explore supportive services for the ongoing care of patients using nursing education and family therapy.


Biomechanical Analysis Of Gait Kinetics Resulting From Use Of A Vacuum Socket On A Transtibial Prosthesis, Maria De Lourdes Ramos Gonzalez May 2014

Biomechanical Analysis Of Gait Kinetics Resulting From Use Of A Vacuum Socket On A Transtibial Prosthesis, Maria De Lourdes Ramos Gonzalez

Honors College Theses

The technology and design of lower limb prosthetics have evolved greatly since their introduction. The current study proposed to compare the effects of a conventional pin socket attachment and a vacuum socket attachment for a transtibial amputee. Whereas traditional measurements of gait utilize force plates and camera systems, this study made use of a small tri-axial load cell located at the base of the socket to measure the forces and moments exerted during a regular gait cycle. The hypothesis tested stated that a vacuum pump socket attachment, when compared to a non-vacuum (pin) socket, will have a significant effect on …


Metal Stopping Reagents Facilitate Discontinuous Activity Assays Of The De Novo Purine Biosynthesis Enzyme Pure, Kelly L. Sullivan, Loredana C. Huma, Elwood Mullins, Michael E. Johnson, T. Joseph Kappock May 2014

Metal Stopping Reagents Facilitate Discontinuous Activity Assays Of The De Novo Purine Biosynthesis Enzyme Pure, Kelly L. Sullivan, Loredana C. Huma, Elwood Mullins, Michael E. Johnson, T. Joseph Kappock

Department of Biochemistry Faculty Publications

The conversion of 5-aminoimidazole ribonucleotide (AIR) to 4-carboxy-AIR (CAIR) represents an unusual divergence in purine biosynthesis: microbes and nonmetazoan eukaryotes use class I PurEs while animals use class II PurEs. Class I PurEs are therefore a potential antimicrobial target; however, no enzyme activity assay is suitable for high throughput screening (HTS). Here we report a simple chemical quench that fixes the PurE substrate/product ratio for 24 h, as assessed by the Bratton-Marshall assay (BMA) for diazotizable amines. The ZnSO4 stopping reagent is proposed to chelate CAIR, enabling delayed analysis of this acid-labile product by BMA or other HTS methods


The Effect Of Winter Versus Summer Running On Lower Extremity Musculoskeletal Injury Rate In Recreational Runners, Elizabeth Frieseke May 2014

The Effect Of Winter Versus Summer Running On Lower Extremity Musculoskeletal Injury Rate In Recreational Runners, Elizabeth Frieseke

All NMU Master's Theses

The effects of cryotherapy on body tissues suggest that cold exposure can decrease performance measures, including proprioception, strength, and agility. Since a decrease in proprioception and strength have been linked with an increase of injury rates, this suggests that exposure to cold conditions may increase injury rates. The main purpose of this study was to determine if there is a difference in musculoskeletal injury rates in the winter compared to the summer months in recreational runners. The participants were surveyed on their injury history for the past year. The results of this study showed that the injury rate for musculoskeletal …


Acute Effects Of Long Distance Running On C-Reactive Protein And Arterial Stiffness, Bridget E. Durocher May 2014

Acute Effects Of Long Distance Running On C-Reactive Protein And Arterial Stiffness, Bridget E. Durocher

All NMU Master's Theses

Abstract

Central arterial stiffness, indicated by pulse wave velocity (PWV), is increased during the hour post ultramarathon (ULT), but it's currently unknown if PWV remains elevated 24 hours after ULT or marathon (MAR). PURPOSE: To determine the effects of ULT and MAR on C-reactive protein (CRP), aortic blood pressure (BP), aortic augmentation index (AIx), PWV, and LF:HF ratio. We hypothesized that CRP, AIx, PWV and LF:HF ratio would be elevated 24 hours post-race. Our secondary hypothesis was that changes in PWV would be inversely correlated to the percentage of moderate activity (3-6 METs) during competition. METHODS: Applanation tonometry was used …


Genetic Architecture Of Limit Dextrinase Inhibitor (Ldi) Activity In Tibetan Wild Barley, Yuqing Huang, Shengguan Cai, Lingzhen Ye, Yong Han, Dezhi Wu, Fei Dai, Chengdao Li, Guoping Zhang May 2014

Genetic Architecture Of Limit Dextrinase Inhibitor (Ldi) Activity In Tibetan Wild Barley, Yuqing Huang, Shengguan Cai, Lingzhen Ye, Yong Han, Dezhi Wu, Fei Dai, Chengdao Li, Guoping Zhang

Publications

BACKGROUND: Limit dextrinase inhibitor (LDI) inhibits starch degradation in barley grains during malting because it binds with limit dextrinase (LD). There is a wide genetic variation in LDI synthesis and inactivation during barley grain development and germination. However, the genetic control of LDI activity remains little understood. RESULTS: In this study, association analysis was performed on 162 Tibetan wild accessions by using LDI activity, 835 Diversity Arrays Technology (DArT) markers and single nucleotide polymorphisms (SNPs) of the gene HvLDI encoding LDI. Two DArT markers, bpb-8347, bpb-0068, and 31 SNPs of HvLDI were significantly associated with LDI activity, explaining 10.0%, 6.6% …


The Effect Of Repeated Mild Traumatic Brain Injury On Ventricular Volume And Microglial Activation, Lillian Rose Talbot May 2014

The Effect Of Repeated Mild Traumatic Brain Injury On Ventricular Volume And Microglial Activation, Lillian Rose Talbot

Honors Scholar Theses

As the leading cause of death and disability in individuals under the age of 45-years-old, Traumatic Brain Injury (TBI) is a public health crisis that demands the attention of the scientific and medical community [28]. The majority of all TBIs that occur in the United States each year are a non-deadly yet detrimental form of closed brain injury known as mild TBI (mTBI) or concussion [6]. Athletes, young people and military personnel all face a high risk of acquiring mTBI as a result of their environments. In our study we have chosen to model repeated mTBI (rmTBI) in the mouse …


Factors Associated With Abnormal Weights In Infants In The First Year Of Life: Results From The 2010 National Ambulatory Medical Care Survey, Nikaela R. Larossa May 2014

Factors Associated With Abnormal Weights In Infants In The First Year Of Life: Results From The 2010 National Ambulatory Medical Care Survey, Nikaela R. Larossa

Honors Scholar Theses

Purpose: To examine the predictors associated with abnormal infant weights for lengths in the first year of life as seen in ambulatory care settings.

Data Sources: A secondary data analysis was conducted using the 2010 National Ambulatory Medical Care Survey (NAMCS), in which practitioners documented single patient visits. World Health Organization (WHO) growth charts and recommendations were used to evaluate infant weight for length. Of the total visits, 603 infants were less than one year old, and 595 infants were within the length range of the WHO growth charts. Of the 595 cases, 13.6% were underweight, 5.5% were overweight, 41.2% …


Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino May 2014

Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino

Honors Scholar Theses

The following series of studies investigates the elimination and uptake trends of halothane, acetone, and ethanol vapors in the airways of C57BL/6J mice. These vapors were chosen because they span a wide range of solubilities, as indicated by their blood-air partition coefficients, and are not associated with any significant airway metabolism or reactivity with tissue substrates in vivo. Mice were exposed to a homogeneous vapor mixture containing a 1:1:1 ratio of halothane, acetone, and ethanol at relative concentrations of approximately 10 ppm. Exposure studies were performed with mice in two states, conscious and deceased, in order to provide control …


Effects On Pinniped Immune Response Upon In Vitro Exposure To The Perfluorinated Compounds, Pfos And Pfoa, Elizabeth J. Meiman May 2014

Effects On Pinniped Immune Response Upon In Vitro Exposure To The Perfluorinated Compounds, Pfos And Pfoa, Elizabeth J. Meiman

Honors Scholar Theses

This study investigated the effects of environmental toxicants on the immune system of two pinniped species, grey seals (Halichoerus grypus) and hooded seals (Cystophora cristata). The toxicants included two perfluorinated compounds (PFC), perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), compounds commonly found in a wide variety of household consumer products, including Scotchguard and Teflon. Although corporations such as 3M curtailed the use of these chemicals in the past decade, concentrations of these chemicals are increasing in the arctic aquatic ecosystem and have been measured in the tissues and blood of arctic pinnipeds. However, the effects of …


An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins May 2014

An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins

Honors Scholar Theses

Patients with depression, schizophrenia, and other related disorders often show effort-related motivational symptoms such as anergia, psychomotor slowing, lassitude, and fatigue. Several studies have indicated that dopamine (DA) within the nucleus accumbens (NAc) is involved in the regulation of effort-related behavior. Interference with NAc DA alters response allocation in effort related choice procedures, biasing animals towards the alterative that can be obtained with minimal effort. Previous studies have shown that administration of the vesicular monoamine transporter-2 (VMAT-2) inhibitor tetrabenazine (TBZ) shifts behavior in rats responding on the FR5/chow choice procedure causing a decrease in lever pressing and a compensatory increase …


Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer May 2014

Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer

Honors Scholar Theses

Somatic mutations may drive tumorigenesis or lead to new, immunogenic epitopes (neoantigens). The immune system is thought to represses neoplastic growths through the recognition of neoantigens presented only by tumor cells. To study mutations as well as the immune response to mutation-generated antigens, we have created a conditional knockin mouse line with a gene encoding, 5’ to 3’, yellow fluorescent protein (YFP), ovalbumin (which is processed to the immunologically recognizable peptide, SIINFEKL), and cyan fluorescent protein (CFP), or, YFP-ovalbumin-CFP. A frame shift mutation has been created at the 5’ end of the ovalbumin gene, hence YFP should always be expressed, …


Prediction Modeling For Graduate Athletic Training Education Programs, Scott L. Bruce May 2014

Prediction Modeling For Graduate Athletic Training Education Programs, Scott L. Bruce

Masters Theses and Doctoral Dissertations

The purposes of this study were: • to develop a prediction model to identify factors associated with eligibility and first-attempt success on the Board of Certification (BOC) examination for students enrolled in a professional (entry-level) graduate athletic training program (GATP) • to identify applicant characteristics that are most likely to predict both academic success in the GATP and success on the BOC exam. A cohort of 119 students was used for both purposes. Multiple analyses yielded three-factor and two-factor models for prediction of passing the BOC exam. The three-factor model demonstrates that a student with ≥ 2 predictors had an …


Follicular Dendritic Cell Sarcoma: A Rare Entity With Variable Pathologic Features And Prognosis, Sharif A. Ali Md, Miriam L. Enriquez Md, Shereen M. Gheith Md May 2014

Follicular Dendritic Cell Sarcoma: A Rare Entity With Variable Pathologic Features And Prognosis, Sharif A. Ali Md, Miriam L. Enriquez Md, Shereen M. Gheith Md

Department of Pathology & Laboratory Medicine

No abstract provided.