Medicine and Health Sciences Commons^™

Endovascular Treatment Of Intracranial Aneurysms Using Balloon Remodeling Technique, Wasey Jilani, Tanveer Ul Haq

Pakistan Journal of Neurological Sciences (PJNS)

Endovascular treatment with coils is widely used in the management of intracranial aneurysms. However, this type of treatment can be technically challenging for anatomic reasons, particularly when the neck of the aneurysm is wide or when the dome-to-neck ratio is not favorable. Previous studies described the remodeling technique for extending the indications and feasibility of the endovascular treatment to wide-neck intracranial aneurysms. In remodeling technique, a non-detachable balloon is temporarily inflated in front of the neck of the aneurysm during each coil placement. At the end of the procedure, the remodeling balloon is removed and no device is left in …

Autism- Towards Comprehensive Assessment And Management, Ayesha Mian

Pakistan Journal of Neurological Sciences (PJNS)

Autism is a pervasive, neurodevelopmental disorder characterized by stereotyped movements and impairment in social skills and communication patterns. Prevalence patterns show an increasing burden of about 1 in 150 children affected by the disorder. Most affected individuals have symptoms that interfere greatly with quality of life. Although a burgeoning concern, research on the prevalence, etiological factors and presentation patterns is limited in LAMI countries, leading to a minimal understanding of the disorder at individual, professional and societal level. There is an urgent need to enhance awareness and education to decrease stigma that maybe associated with autism.

Psychiatric Disorders In Neurology, Rizwan Taj, Mamoona Manzoor

Pakistan Journal of Neurological Sciences (PJNS)

Psychiatric disorders (PDs) are very frequent in neurological illnesses. Depression, anxiety and cognitive impairment are frequently seen in many neurological disorders such as stroke, Parkinson disease (PD), epilepsy and multiple sclerosis (MS). In addition, hallucinations, delusions, obsessive-compulsive disorder, sleep disorders, Impulse control disorders (ICDs), somatization, bipolar disorder, behavior problems and psychological problem are also seen. Depression in stroke and epilepsy has bidirectional relationship. Lesion location affects both frequency and severity of depression in stroke patients.

การปรับตัวในมหาวิทยาลัยของนิสิตชั้นปีที่ 1คณะแพทยศาสตร์จุฬาลงกรณ์มหาวิทยาลัย, ณัฐวุฒิ ศรีวัฒนาวานิช, ณัทธร พิทยรัตน์เสถียร

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : การปรับตัวในมหาวิทยาลัยเป็นการปรับตัวช่วงหนึ่งที่มีความสำคัญของวัยรุ่น แต่การศึกษาการปรับตัวในมหาวิทยาลัยในประเทศไทยยังมีค่อนข้างน้อย และการศึกษาในอดีตจะเป็นการศึกษากับนิสิตทุกคณะ การศึกษาครั้งนี้อาจจะเป็นข้อมูลที่ใช้เป็นแนวทางในการช่วยเหลือพัฒนาการปรับตัวในมหาวิทยาลัยของนิสิตชั้นปีที่ 1คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยวัตถุประสงค์ : เพื่อศึกษาการปรับตัวในมหาวิทยาลัย และปัจจัยที่มีความสัมพันธ์กับการปรับตัวในมหาวิทยาลัยของนิสิตชั้นปีที่ 1 คณะแพทยศาสตร์จุฬาลงกรณ์มหาวิทยาลัยรูปแบบการวิจัย : การศึกษาวิจัย ณ จุดเวลาใดเวลาหนึ่งสถานที่ทำการศึกษา : คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยตัวอย่างและวิธีการศึกษา : ประชากรตัวอย่าง คือ นิสิตชั้นปีที่ 1 ระดับปริญญาตรี คณะแพทยศาสตร์จุฬาลงกรณ์มหาวิทยาลัย ที่ศึกษาในภาคการศึกษาต้น ปีการศึกษา2556 จำนวน 247 คน เครื่องมือของการเก็บรวบรวมข้อมูล คือแบบสอบถามข้อมูลส่วนบุคคล และแบบประเมินการปรับตัวในมหาวิทยาลัย สถิติที่ใช้ในการวิเคราะห์ คือ ค่าเฉลี่ย, ร้อยละ, Pearsoncorrelation, Spearman’s rhocorrelation, independent samplest - test, one way ANOVA, และ regression analysis.ผลการศึกษา : ผลการศึกษาพบว่านิสิตชั้นปีที่ 1 คณะแพทยศาสตร์ส่วนใหญ่มีการปรับตัวโดยรวม การปรับตัวด้านการเรียน การปรับตัวด้านส่วนตัวและอารมณ์ และการปรับตัวด้านสังคม ระดับปานกลางค่อนข้างดี และการปรับตัวด้านความผูกพันกับสถานศึกษาและความมุ่งมั่นในเป้าหมายระดับดี ปัจจัยส่วนบุคคลที่ทำนายการปรับตัวในมหาวิทยาลัยคือ อายุ ผลการเรียนเฉลี่ยในระดับชั้นมัธยมศึกษาตอนปลาย และการทำกิจกรรมนอกหลักสูตรขณะเรียนมหาวิทยาลัย โดยพบว่าการปรับตัวโดยรวมมีปัจจัยในการทำนาย คือ การทำกิจกรรมในระดับมาก(p = 0.001) การทำกิจกรรมในระดับปานกลาง (p = 0.018) อายุ(p = 0.040) และผลการเรียนเฉลี่ยในระดับชั้นมัธยมศึกษาตอนปลาย(p = 0.048) การปรับตัวด้านการเรียนมีปัจจัยทำนาย คือ ผลการเรียนเฉลี่ยในระดับชั้นมัธยมศึกษาตอนปลาย (p = 0.026) การปรับตัวด้านส่วนตัวและอารมณ์มีปัจจัยทำนาย คือ อายุ (p = 0.010) การปรับตัวด้านสังคมมีปัจจัยในการทำนาย คือ การทำกิจกรรมในระดับมาก(p <0.001) การทำกิจกรรมในระดับปานกลาง (p = 0.004) และอายุ(p = 0.029) และการปรับตัวด้านความผูกพันกับสถานศึกษา และความมุ่งมั่นในเป้าหมายมีปัจจัยในการทำนาย คือ การทำกิจกรรมในระดับมาก (p = 0.003) และการทำกิจกรรมในระดับปานกลาง(p = 0.032)สรุป : นิสิตส่วนใหญ่มีการปรับตัวในมหาวิทยาลัยโดยรวม การปรับตัวด้านการเรียน ด้านส่วนตัวและอารมณ์ และด้านสังคม ระดับปานกลางค่อนข้างดี และการปรับตัวด้านความผูกพันกับสถานศึกษาและความมุ่งมั่นในเป้าหมายระดับดี ปัจจัยส่วนบุคคลที่มีความสัมพันธ์กับการปรับตัวในมหาวิทยาลัย คือ อายุ ผลการเรียนเฉลี่ยในระดับชั้นมัธยมศึกษาตอนปลาย และการทำกิจกรรมนอกหลักสูตรขณะเรียนมหาวิทยาลัย ผลการศึกษานี้อาจจะนำไปใช้ในการวางแผนจัดกิจกรรมในการพัฒนาการปรับตัวในมหาวิทยาลัยของนิสิตชั้นปีที่ 1คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย ต่อไป.

Mechanisms Responsible For Decreased Rat Pulmonary Arterial H2o2 Levels In A Model Of Chronic Hypoxia-Induced Pulmonary Hypertension, Danielle Rachel Plomaritas

Biomedical Sciences ETDs

Our laboratory has demonstrated an important role for acid-sensing ion channel 1 (ASIC1) in pulmonary hypertension through augmented Ca2+ influx in pulmonary arterial smooth muscle cells (PASMC) following chronic hypoxia (CH). However, this enhanced calcium (Ca2+) influx is not dependent on an increase in ASIC1 protein expression. This suggests other regulatory mechanisms influencing ASIC1 activity are altered following CH. ASIC1 is a redox sensitive ion channel and recent studies from our laboratory have shown that the oxidant hydrogen peroxide (H2O2) inhibits ASIC1-dependent Ca2+ influx in PASMC. Reactive oxygen species are known to be altered in pulmonary hypertension, however the direction …

A Qualitative Evaluation Of Blood Pressure Screening Procedures In The Illinois Wisewomen Program, James Broadbear, Barbara Broadbear, Adrian Lyde, Sharon Mills

Internet Journal of Allied Health Sciences and Practice

Hypertension is a major modifiable risk factor for cardiovascular disease and various other conditions. Approximately 70 million Americans are hypertensive. Among women age 18 and over, 31.7% have high blood pressure (BP) and only about 60% of those women have it under control. The purpose of this evaluation was to understand blood pressure screening procedures among Illinois WISEWOMAN Program (IWP) providers. Procedures at primary care providers (PCP) compared to obstetrician/gynecologists (OB/GYN) were of interest. A qualitative approach was used featuring interviews with allied health staff members who conduct blood pressure screenings. The focus of the interviews included the use and …

Profiling Thiol Metabolites And Quantification Of Cellular Glutathione Using Ft-Icr-Ms Spectrometry, Sadakatali S. Gori, Pawel Lorkiewicz, Daniel S. Ehringer, Alex C. Belshoff, Richard M. Higashi, Teresa W-M Fan, Michael H. Nantz

Toxicology and Cancer Biology Faculty Publications

We describe preparation and use of the quaternary ammonium-based α-iodoacetamide QDE and its isotopologue *QDE as reagents for chemoselective derivatization of cellular thiols. Direct addition of the reagents to live cells followed by adduct extraction into n-butanol and analysis by FT-ICR-MS provided a registry of matched isotope peaks from which molecular formulae of thiol metabolites were derived. Acidification to pH 4 during cell lysis and adduct formation further improves the chemoselectivity for thiol derivatization. Examination of A549 human lung adenocarcinoma cells using this approach revealed cysteine, cysteinylglycine, glutathione, and homocysteine as principal thiol metabolites as well as the sulfinic acid …

Pharmacy Law Brief: The Federal False Claims Act, Joseph L. Fink Iii

Pharmacy Practice and Science Faculty Publications

No abstract provided.

Utilizing The Technology Acceptance Model To Predict System Use Of An Interactive Behavior Change Technology To Deliver Virtual Diabetes Health Education, Koren Sher'keyer Goodman

Health Services Research Dissertations

Diabetes is expected to affect more than 21% of the U.S. adult population by the year 2050 (Boyle, Thompson, Gregg, Barker, & Williamson, 2010). What is important to understand about diabetes is that there are safe, effective non-pharmaceutical lifestyle modifications and pharmaceutical treatment options that can prevent and delay the onset of complications. Telehealth efforts are practical solutions increasingly used in the health services delivery model to improve self-care management practices among patients with multiple chronic conditions (Davis, Hitch, Salaam, Herman, Zimmer-Galler, & Mayer-Davis, 2010; Eng, Gustafson, Henderson, Jimison, & Patrick, 1999; Fitzner & Moss, 2013; Gruman, 2011; Lin, 1999; …

Radiographic Evaluation Of Accuracy Of Surgical Stent For Implant Placement In Knife Edge Posterior Mandibular Ridge In Cases Of Ridge Splitting, Fardos N. Rizk, Engy Abdelhamed

Dentistry

Aim: This study was conducted to evaluate the efficacy of using conventional surgical stents guided by cone beam computed tomography in determining the position and buccolingual inclination of implants placed in posterior mandibular knife edge ridge in cases of ridge splitting with and without bone grafting material. Materials and Methods: The study was conducted on sixteen implants placed bilaterally in posterior knife edge mandibular ridge of four patients, where each patient received four implants in the form of two in each side. Implants on the right side of the ridge were placed following ridge splitting and bone grafting (group A). …

Prevalence Of Pelvic Insufficiency Fracture In Patients Investigated By Ct Or Mri For Pelvis Or Bone Scan After Pelvic Irradiation At King Chulalongkorn Memorial Hospital (Kcmh), Sawarin Eowchye, Pataramon Vasavid, Numphung Numkarunarunrote, Tassapong Raiyawa

Chulalongkorn Medical Journal

Background : Pelvic insufficiency fracture (PIF) is one of the common complications in patients who have received pelvic irradiation. If clinicians and/or radiologists misunderstand the pathophysiology and associated radiographic findings, the diagnosis of this condition is delayed or misdiagnosed as pathologic fractures from metastasis. Objective : To evaluate prevalence and distribution of pelvic insufficiency fracture in patients who have been investigated by CT or MRI for pelvis or bone scan after pelvic irradiation. Design : Retrospective study. Setting : Department of Radiology, Faculty of Medicine, Chulalongkorn University. Materials and Methods : We retrospectively reviewed 260 patients with known history of …

Causative Bacterial Pathogens Of Septic Patients At Emergency Department Of King Chulalongkorn Memorial Hospital, Hassamanee Malaikanok, Atthasit Komindr, Somratai Vadcharavivad

Chulalongkorn Medical Journal

Background : Sepsis is a clinical syndrome associated with a high mortality rate. Antimicrobial therapy is one of the milestones in the treatment of sepsis. Knowing the distribution of pathogens and local susceptibility of antimicrobials would be beneficial for empirical antimicrobial usage. Objective : To determine the prevalence and characteristics of causative bacterial pathogens in culture-positive septic patients admitted to the Emergency Department (ED) of King Chulalongkorn Memorial Hospital (KCMH). Study design : Retrospective descriptive study. Setting : The Emergency Department, KCMH, Bangkok, Thailand. Method : We reviewed medical records and computer databases of adult patients admitted to the ED …

ภาวะแทรกซ้อนจากการผ่าตัด Medial Patellofemoral Ligament Reconstruction ในผู้ป่วยกระดูกสะบ้าเคลื่อนหลุดซ้ำ, ไตร พรหมแสง, พงศ์ศักดิ์ ยุกตะนันทน์

Chulalongkorn Medical Journal

ปัจจุบันการผ่าตัด medial patellofemoral ligament reconstruction (MPFL reconstruction)เป็นหัตถการที่ได้รับการยอมรับเป็นมาตรฐาน (standard treatment) ในการรักษาผู้ป่วยกระดูกสะบ้าเคลื่อนหลุดซ้ำ ถึงแม้ว่าการผ่าตัด MPFL reconstruction จะเริ่มนำมาใช้มากกว่า 10 ปีแล้วก็ตามแต่แพทย์ออร์โธปิดิกส์ก็ยังไม่มีข้อสรุปที่เป็นมาตรฐานเดียวกันในเรื่องของเทคนิคการผ่าตัด จะพบว่าในปัจจุบันมีเทคนิคการผ่าตัดที่หลากหลายมาก อย่างไรก็ตามสิ่งที่ต้องคำนึงถึงเป็นอันดับแรกเมื่อมีการพัฒนาการผ่าตัดชนิดใหม่ขึ้นมาก็คือ ภาวะแทรกซ้อนจากการผ่าตัดที่เฉพาะเจาะจงกับการเทคนิคผ่าตัดนั้น ๆบทฟื้นฟูวิชาการนี้ จะทำการทบทวนภาวะแทรกซ้อนที่เกิดจากการผ่าตัด MPFL reconstructionโดยจะกล่าวถึง patellar fracture, recurrent patellar instability และ loss of knee motionอย่างละเอียด เนื่องจากเป็นภาวะแทรกซ้อนที่รุนแรงและต้องการการผ่าตัดแก้ไข ซึ่งภาวะเหล่านี้สามารถป้องกันได้ โดยการพัฒนาเทคนิคการผ่าตัดของแพทย์ออร์โธปิดิกส์ผู้ทำการผ่าตัดเอง.

Leg Dynamic Strength Predictors Of A Pre-Planned Change Of Direction Task In Ncaa Division 1 Soccer Players, Chieh-Ying Chiang, Christopher A. Bailey, Christohper J. Sole, Timothy J. Suchomel, Kimitake Sato, Michael H. Stone

ETSU Faculty Works

The purpose of this investigation was to evaluate the relationships between two types of vertical jumps and change of direction (COD) test in collegiate soccer players (n=24). 5-5 COD test was utilized to measure soccer athletes’ COD ability. 3m acceleration (3mAcc), Total time (TT) and Partial time (PT) were measured by two sets of timing gates. Countermovement jump (CMJ) and static jump (SJ) with 2 different loading conditionings (0kg and 20kg) were employed to evaluate athletes’ leg dynamic strength. Strong statistically significant relationships were found between COD test variables (r =0.71 to 0.90), and between vertical jump variables with PT …

Modeling Solutions For Prevention Of Medicare Insolvency For The Baby Boomer Generation (Born 1946 - 1964), Gregory Thomas Scott

Health Services Research Dissertations

Medicare, a United States social insurance program operated by the United States federal government, began operating in a deficit in the year 2010. More funding was expended than revenue received for medical care, creating significant shortfalls for the Medicare Trust Fund. This study examined possible initiatives to describe Medicare funding related to issues as financial shortfalls utilizing mathematical modeling and simulation. The Park Conceptual Model is a framework created to identify internal and external changes that influence bankruptcies related to municipalities, and this Model served as the theoretical basis for this study.

The following study addressed insolvency as negative cash …

Microstructure And Mechanical Properties Of Nickel-Free And Nickel-Containing Stainless Steel Orthodontic Wires, Amanda Olejniczak

Master's Theses (2009 -)

Introduction: In orthodontics, contact dermatitis caused by nickel allergy should be of concern with the number of nickel-containing appliances and wires used. Stainless steel archwires are commonly used throughout orthodontic treatment. With the release of nickel from these wires, some manufacturers have turned to nickel-free stainless steel alternatives. The goal of this research was to compare nickel-free stainless steel with traditional stainless steel archwires with regard to mechanical properties and microstructure. Materials and Methods: Nickel-free stainless steel and regular stainless steel archwires from four companies were included. Five random samples of each wire, vertically mounted in fast-set acrylic, were indented …

Dimensional Changes Of Facial Soft Tissue Associated With Rapid Palatal Expansion, Peter Charles Longo

Master's Theses (2009 -)

Introduction: Orthodontic treatment demands excellent outcomes in both function and esthetics. Despite the popularity of rapid palatal expansion in orthodontic treatment, few studies have examined its consequences on facial soft tissue using direct anthropometric measurements. The primary goal of this study was to determine facial soft tissue changes immediately following rapid palatal expansion. Materials and Methods: Twenty-eight patients (age range, 8-17 years) attending Marquette Dental School Orthodontic Post-Graduate Clinic were enrolled in the study. Facial soft tissue measurements were taken with digital calipers at two separate time points (T0: initial exam and T1: thirty days following expansion); measurements were recorded …

Composition, Phase Structure, And Corrosion Of Nickel-Free And Nickel-Containing Stainless Steel Orthodontic Wires, Amrita Rakalla

Master's Theses (2009 -)

Stainless steel wires have long been used in orthodontics. The austenitic stainless steel used in orthodontics contains approximately 18 wt% chromium and 8 wt% nickel. Nickel improves the corrosion resistance and helps maintain the austenite structure of stainless steel. Nickel is the most allergenic metal and is the most common metal associated with contact dermatitis in orthodontics. Nickel-free wires have been developed, and it was the goal of this study to compare nickel-free and nickel-containing stainless steel orthodontic wires to determine and compare their composition, phase structure, and corrosion properties. For each test, nickel-free and conventional stainless steel wires were …

Comparing The Vertical Misfit Of Casts Produced By Two Verification Jigs, Abdulaziz Saeed Alqahtani

Master's Theses (2009 -)

Purpose: To compare the dimensional accuracy between master casts fabricated with verification jigs made of acrylic resin and light cure Triad. Materials and Methods: 10 GC Pattern resin Pattern verifications jigs and 10 Triad gel verification jigs fabricated of a master cast of a mandibular model of 4 internal hex implants. A stone base was fabricated for each verification jig. One screw test was used to evaluate the vertical gap at the terminal abutment using a digital micrometer with an accuracy of 1μm to record the vertical gap for each sample. Results: Triad Gel group has the lowest average distortion …

An Investigation Into The Bonding Properties Of New Generation Ceramic Brackets As Compared To A Stainless Steel Bracket, Ami Inoue

Master's Theses (2009 -)

Introduction: More patients are seeking esthetic alternatives for their orthodontic treatment options, which has led to increased use of ceramic brackets in recent years. These brackets were marketed before independent scientific research was completed. Many of the early ceramic brackets used a silane coupling agent to allow for a chemical bond between the bracket and the adhesive resin. Early reports from clinicians of increased bond strengths and iatrogenic tooth damage after bracket removal were common. Manufacturers have made changes to their base designs, relying more on mechanical retention for bond strength. The goal of this study was to test the …

Effect Of Mechanical Vibration On Resistance To Sliding In The Fixed Orthodontic Appliance, David Robert Kennedy

Master's Theses (2009 -)

Objective: To determine the effects of mechanical vibrations produced from electric tooth brushes and a commercially available device called AcceleDent, on the resistance to sliding at the bracket-arch wire interface. Materials and Methods: All as-received wires and brackets were cleaned with 95% ethanol prior to testing. An individual metal bracket was mounted on a custom metal fixture. The custom metal fixture had a polyurethane material that resembled the mechanical feature of the human periodontal ligament. The test metal bracket was aligned and bonded passively with 4 other non-movable brackets using a straight piece of .0215" X .025" SS wire. Another …

A Model Of Children's Acquisition Of Grammatical Word Categories Using An Adaptation And Selection Algorithm, Teresa Young

Theses and Dissertations

Most children who follow a typical developmental timeline learn the grammatical categories of words in their native language by the time they enter school. Researchers have worked to provide a number of explicit, testable models or algorithms in an attempt to model this language development. These models or algorithms have met with some varying success in terms of determining grammatical word categories from the transcripts of adult input to children. A new model of grammatical category acquisition involving an application of evolutionary computing algorithms may provide further understanding in this area. This model implements aspects of evolutionary biology, such as …

A Glimmer Of Hope? Assessing Hope As A Moderator Of The Relationship Between Parenting And Adolescent Depressive Symptoms, Lisa D. Bishop

Theses and Dissertations

Prior research has established that a portion of depressive symptoms in adolescents is predicted by parenting behaviors. The purpose of this study was to identify the moderating role of hope on the relationship between two parenting variables (warmth and psychological control) and adolescent depressive symptoms. Participants included 459 adolescents ages 13 to 14 years and their families from waves 3 and 4 of the Flourishing Families Project. Path analysis was utilized to answer the proposed hypotheses and research questions. Multiple group analysis was utilized to determine if results were different for boys and girls. Significant results indicated that in low-hope …

Partner Attachment And The Parental Alliance, Ashley B. Bell

Theses and Dissertations

Previous research has demonstrated that cooperation and support between parents, called the parental alliance, is an important predictor of parent and child well-being. Consequently, it is important to understand what factors promote the formation of a strong parental alliance. Because of research on the impact of attachment security on individuals' abilities to depend and rely on others and to appropriately manage conflict, partner attachment is a potential predictor of the parental alliance, with insecure attachment negatively weakening the parental alliance. This study analyzed data from 321 couples to examine the relationship between partner attachment and the parental alliance. Using the …

Death Of A Child In The Emergency Department., Patricia O'Malley, Isabel Barata, Sally Snow, American Academy Of Pediatrics Committee On Pediatric Emergency Medicine, American College Of Emergency Physicians Pediatric Emergency Medicine Committee, Gregory P. Conners

Manuscripts, Articles, Book Chapters and Other Papers

The death of a child in the emergency department (ED) is one of the most challenging problems facing ED clinicians. This revised technical report and accompanying policy statement reaffirm principles of patient- and family-centered care. Recent literature is examined regarding family presence, termination of resuscitation, bereavement responsibilities of ED clinicians, support of child fatality review efforts, and other issues inherent in caring for the patient, family, and staff when a child dies in the ED. Appendices are provided that offer an approach to bereavement activities in the ED, carrying out forensic responsibilities while providing compassionate care, communicating the news of …

Factors Associated With Quality Of Life Among Mothers Of Children With Autism Spectrum Disorder, Marian Marconyak

Health Services Research Dissertations

The increasing prevalence of Autism Spectrum Disorder (ASD) has levied associated effects upon the quality of life (QOL) of mothers of children with ASD. These mothers are subjected to various influences upon their lives as a result of their role as caregivers to children with ASD. The purpose of this study was to assess the International Classification of Functioning, Disability and Health (ICF) Body Functions and Structures, Activities, Participation, Environmental, and Personal Factors associated with QOL among mothers of children with ASD.

English literate, inhabitants of the United States, mothers over the age of 18, of children with ASD were …

Evaluation Of An Educational Breastfeeding Program For A Non-Profit Agency In South Texas, Marcela Urbina Zavala

Theses and Dissertations - UTB/UTPA

Breastfeeding has been recognized as the most cost effective practice to promote healthier babies among populations (Dennis, 2002). The purpose of the study was to evaluate the effect of an educational breastfeeding and a prenatal + breastfeeding program for individuals attending group classes and to compare the differences between Spanish only and English only versions of the curriculum. Two research questions were stated to know if there were significant differences between pre and post-tests scores and if there were any significant differences in the impact of the intervention between English only and Spanish only versions of the classes. The present …

Decreases In Self-Reported Alcohol Consumption Following Hiv Counseling And Testing At Mulago Hospital, Kampala, Uganda, Judith A. Hahn, Robin Fatch, Rhoda K. Wanyenze, Steven Baveewo, Moses R. Kamya, David Bangsberg, Thomas J. Coates

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Alcohol use has a detrimental impact on the HIV epidemic, especially in sub-Saharan Africa. HIV counseling and testing (HCT) may provide a contact opportunity to intervene with hazardous alcohol use; however, little is known about how alcohol consumption changes following HCT.

Methods: We utilized data from 2056 participants of a randomized controlled trial comparing two methods of HCT and subsequent linkage to HIV care conducted at Mulago Hospital in Kampala, Uganda. Those who had not previously tested positive for HIV and whose last HIV test was at least one year in the past were eligible. Participants were asked at …

Small-Molecule Probes Targeting The Viral Ppxy-Host Nedd4 Interface Block Egress Of A Broad Range Of Rna Viruses., Ziying Han, Jianhong Lu, Yuliang Liu, Benjamin Davis, Michael S Lee, Mark A Olson, Gordon Ruthel, Bruce D Freedman, Matthias J. Schnell, Jay E Wrobel, Allen B Reitz, Ronald N Harty

Department of Microbiology and Immunology Faculty Papers

Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses. As L domains are important for budding and are highly conserved in a wide array of RNA viruses, they represent potential broad-spectrum targets for the development of antiviral drugs. To identify potential competitive blockers, we used the known Nedd4 WW domain-PPxY interaction interface as the basis of an in silico screen. Using PPxY-dependent budding of Marburg (MARV) VP40 virus-like particles (VLPs) as our model system, …

Systemic Hematogenous Maintenance Of Memory Inflation By Mcmv Infection., Corinne J Smith, Holly Turula, Christopher M. Snyder

Department of Microbiology and Immunology Faculty Papers

Several low-grade persistent viral infections induce and sustain very large numbers of virus-specific effector T cells. This was first described as a response to cytomegalovirus (CMV), a herpesvirus that establishes a life-long persistent/latent infection, and sustains the largest known effector T cell populations in healthy people. These T cells remain functional and traffic systemically, which has led to the recent exploration of CMV as a persistent vaccine vector. However, the maintenance of this remarkable response is not understood. Current models propose that reservoirs of viral antigen and/or latently infected cells in lymph nodes stimulate T cell proliferation and effector differentiation, …