Medicine and Health Sciences Commons^™

Cryptorchidism And Infertility In Rats With Targeted Disruption Of The Adamts16 Locus, Shakila Abdul-Majeed, Blair Mell, Surya M. Nauli, Bina Joe

Pharmacy Faculty Articles and Research

A Disintegrin And Metalloproteinase with ThromboSpondin motifs16 (ADAMTS-16) is a member of a family of metalloproteinases. Using a novel zinc-finger nuclease based gene-edited rat model harboring a targeted mutation of the Adamts16 locus, we previously reported this gene to be linked to blood pressure regulation. Here we document our observation with this model that Adamts16 is essential for normal development of the testis. Absence of Adamts16 in the homozygous Adamts16(mutant) males resulted in cryptorchidism and male sterility. Heterozygous Adamts16(mutant) males were normal, indicating that this is a recessive trait. Testes of homozygous Adamts16(mutant) males were significantly smaller with significant histological …

Bacteria On Shared Mobile Phones Can Lead To Infections, Roberta Basol, Jean Beckel, Judy Gilsdorf-Gracie, Amy Hilleren-Listerud, Terri Mccaffrey, Sherri Reischl, Pamela Rickbeil, Mary Schimnich, Kirsten Skillings, Mary A. Struffert

Articles

It's now a common practice for hospital-owned mobile phones to be shared among healthcare employees from shift to shift. Despite the benefit of increased, timely communication between caregivers, sharing mobile devices can lead to the spread of healthcare-associated infections (HAIs) if they aren't properly disinfected. The Guidelines for Disinfection and Sterilization in Healthcare Facilities describe "non-critical environmental surfaces" as items that are frequently touched by the hand and may pose a risk of secondary infection transmission.

Effects Of Dfo-Induced Hypoxia On Key Signaling Mediators, Jennifer Candelora

Seton Hall University Dissertations and Theses (ETDs)

While diseases such as cancer and diabetes, or surgery and traumatic injury can cause hypoxia through a decrease in blood circulation to bodily regions or decrease cardiac output they can also associate with hypoxia-induced pain. Clinically, opioids, such as morphine, are used to modulate pain. The mu-opioid receptors (MORs) are one of three main types of opioid receptors and are key mediators in morphine-induced analgesia. Therefore, in this study, the effect of hypoxia on MOR gene expression was examined using human neuronal cells treated with DFO to create a hypoxic-mimic condition. We found that MOR expression was shown to decrease …

Associations Between Prenatal Exposure To Air Pollution, Small For Gestational Age, And Term Low Birthweight In A State-Wide Birth Cohort, Lisa C. Vinikoor-Imler, J. Allen Davis, Robert E. Meyer, Lynne C. Messer, Thomas J. Luben

Community Health Faculty Publications and Presentations

A range of health effects, including adverse pregnancy outcomes, have been associated with exposure to ambient concentrations of particulate matter (PM) and ozone (O₃). The objective of this study was to determine whether maternal exposure to fine particulate matter (PM_2.5) and O₃ during pregnancy is associated with the risk of term low birthweight and small for gestational age infants in both single and co-pollutant models. Term low birthweight and small for gestational age were determined using all birth certificates from North Carolina from 2003 to 2005. Ambient air concentrations of PM_2.5 and O_{3 …}

The “Fit But Fat” Paradigm Addressed Using Accelerometer-Determined Physical Activity Data, Paul D. Loprinzi, Ellen Smit, Hyo Lee, Carlos J. Crespo, Ross Andersen, Steven N. Blair

Community Health Faculty Publications and Presentations

Background: No studies have addressed the "fit but fat" paradigm using accelerometry data.

Aim: The study was to determine if 1) higher levels of accelerometer-determined physical activity are favorably associated with biomarkers in overweight or obese persons (objective 1); and 2) overweight or obese individuals who are sufficiently active have better or similar biomarker levels than normal weight persons who are not sufficiently active (objective 2).

Materials and Methods: Data from the 2003-2006 National Health and Nutrition Examination Survey were analyzed and included 5,146 participants aged 20-85 years.

Results: Regarding objective 1, obese active individuals had more favorable waist circumference, …

The Flame, 2013-2014, Mennonite College Of Nursing

The Flame (1985-present)

The Flame is a newsletter of Illinois State University's Mennonite College of Nursing

Determination Of Corrosion Inhibitor Lubricity Improver In Jet Fuel By Liquid Chromatography-Electrospray Ionization Mass Spectrometry, David W. Johnson, Milissa Flake, Ryan Adams

Chemistry Faculty Publications

Military jet fuel (JP-8) is very similar to commercial jet fuel (Jet A) except for the presence of three additives, fuel system icing inhibitor, corrosion inhibitor–lubricity improver (CI-LI), and antistatic additive, which are added to improve characteristics of JP-8. Of particular interest is the CI-LI additive; the most common active ingredient is a dimer of linoleic acid. This article focuses on quantification of the active ingredient in the CI-LI additive by liquid chromatography–mass spectrometry (LC–MS). This method will allow the determination of CI-LI content in military jet fuel samples.

Characterization Of Lipid-Anchored Inhibitor Rulers As A Measure Of Enzyme Topography In Coagulation Enzyme Factor Xa, Robin C. Conley

PCOM Biomedical Studies Student Scholarship

The blood coagulation cascade is activated under various circumstances such as an injury. This system involves a tightly regulated series of events. The enzymes involved assemble with their respective cofactors on lipid membranes to reach their full procoagulant complex potential. The coagulation cascade is divided into intrinsic and extrinsic portions, both of which converge into a common pathway with the activation of factor X (FX_a). FX_a is a very important part of the blood coagulation cascade because its activation is primarily responsible for thrombin generation. Activation of FX_a alone is, however, insufficient to produce a fully …

Considering Sport Participation As A Source For Physical Activity Among Adolescents, Jennifer Pharr, Nancy L. Lough

Environmental & Global Health Faculty Research

BACKGROUND:

Studies have shown participation in sport is lower among girls than boys, decreases as students matriculate through high school, is lowest among Black and Hispanic girls and has a positive relationship with SES. With sport recognized as a contributor to physical activity and health in adolescents, consideration of diminishing rates of participation appears warranted. The purpose of this study was to identify patterns related to differences in self-reported sport participation between genders, ethnic groups, grades and SES.

METHODS:

This study was a cross-sectional, secondary analysis of data collected for a sport interest survey. All students in grades 8-11 attending …

Vcam-1/Α4Β1 Integrin Interaction Is Crucial For Prompt Recruitment Of Immune T Cells Into The Brain During The Early Stage Of Reactivation Of Chronic Infection With Toxoplasma Gondii To Prevent Toxoplasmic Encephalitis, Qila Sa, Eri Ochiai, Tomoko Sengoku, Melinda E. Wilson, Morgan Brogli, Stephen Crutcher, Sara A. Michie, Baohui Xu, Laura Payne, Xisheng Wang, Yasuhiro Suzuki

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Reactivation of chronic infection with Toxoplasma gondii can cause life-threatening toxoplasmic encephalitis in immunocompromised individuals. We examined the role of VCAM-1/α4β1 integrin interaction in T cell recruitment to prevent reactivation of the infection in the brain. SCID mice were infected and treated with sulfadiazine to establish a chronic infection. VCAM-1 and ICAM-1 were the endothelial adhesion molecules detected on cerebral vessels of the infected SCID and wild-type animals. Immune T cells from infected wild-type mice were treated with anti-α4 integrin or control antibodies and transferred into infected SCID or nude mice, and the animals received the same antibody every other …

Growing South Dakota (Summer 2014), College Of Agriculture &. Biological Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 2 Extending Knowledge, Changing Lives: SDSU Extension Marks 100-Year Milestone
[Page] 5 Preparing for SDSU Extension’s Future
[Page] 5 SDSU College of Agriculture & Biological Sciences Administrative Team [Page] 6 Summer College News
[Page] 7 Profiles In Leadership: Joseph Cassady; Local Leadership Important For Ag’s Future
[Page] 8 Advancing Agriculture: SDSU Precision Ag Program Evolves, Expands [Page] 9 On The Front Line: ADRDL Leads Important Effort For Animal Health Diagnostics
[Page] 10 4-H Philanthropy: Supporters Continue Campaign For New 4-H Exhibit Hall [Page] 11 Growing Global Citizens: AgBio Courses Offer International Learning Opportunities
[Page] 12 Guidance For Gardeners: Several …

Geospatial Relationships Of Air Pollution And Acute Asthma Events Across The Detroit–Windsor International Border: Study Design And Preliminary Results, Lawrence D. Lemke, Lois E. Lamerato, Xiaohong Xu, Jason C. Booza, John J. Reiners Jr., Delbert M. Raymond Iii, Paul J. Villeneuve, Eric Lavigne, Dana Larkin, Helene J. Krouse

School of Medicine Publications

The Geospatial Determinants of Health Outcomes Consortium (GeoDHOC) study investigated ambient air quality across the international border between Detroit, Michigan, USA and Windsor, Ontario, Canada and its association with acute asthma events in 5- to 89-year-old residents of these cities. NO2, SO2, and volatile organic compounds (VOCs) were measured at 100 sites, and particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) at 50 sites during two 2-week sampling periods in 2008 and 2009. Acute asthma event rates across neighborhoods in each city were calculated using emergency room visits and hospitalizations and standardized to the overall age and gender distribution of …

Safety Of Hexaminolevulinate For Blue Light Cystoscopy In Bladder Cancer. A Combined Analysis Of The Trials Used For Registration And Postmarketing Data., J Alfred Witjes, Leonard G. Gomella, Arnulf Stenzl, Sam S. Chang, Dirk Zaak, H Barton Grossman

Department of Urology Faculty Papers

OBJECTIVE: To detail and put into perspective, safety of hexaminolevulinate blue light cystoscopy (HAL-BLC), including repeated use, based on combined data of controlled trials used for registration of HAL and postmarketing experience.

METHODS: Safety data of 2 randomized comparative studies (group 1) and 4 within patient control studies (group 2) were combined. Postmarketing data from >200,000 patients were analyzed.

RESULTS: In group 1, 533 patients were examined with HAL-BLC and 499 with white light (WL) cystoscopy. In group 2, 791 patients were examined with both WL and HAL-BLC. Between 73% and 93% of these patients had concomitant diseases. Between 41% …

Mechanisms Of Isometric Exercise-Induced Hypoalgesia In Young And Older Adults, Kathy J. Lemley

Dissertations (1934 -)

Pain reduction following exercise (exercise-induced hypoalgesia; EIH) is well-established in young adults. Specific to isometric exercise, the greatest EIH follows low intensity contractions held for long duration. The EIH response of older adults is not known; and the mechanisms for EIH are unclear at any age. This dissertation aimed to address these unknowns through a series of three studies. In study one, repeatability of pressure pain reports (pain threshold and pain ratings) was assessed in healthy older adults, including the impact of psychological factors. Pain reports, measured before and after quiet rest, did not change following quiet rest. Higher state …

Posaconazole Tablet Pharmacokinetics: Lack Of Effect Of Concomitant Medications Altering Gastric Ph And Gastric Motility In Healthy Subjects., Walter K. Kraft, Peter S. Chang, Marlou L P S Van Iersel, Hetty Waskin, Gopal Krishna, Wendy M Kersemaekers

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Posaconazole oral suspension is an extended-spectrum triazole that should be taken with food to maximize absorption. A new posaconazole tablet formulation has demonstrated improved bioavailability over the oral suspension in healthy adults in a fasting state. This study evaluated the effects of concomitant medications altering gastric pH (antacid, ranitidine, and esomeprazole) and gastric motility (metoclopramide) on the pharmacokinetics of posaconazole tablets. This was a prospective open-label 5-way crossover study in 20 healthy volunteers. In each treatment period, a single 400-mg dose (4 100-mg tablets) of posaconazole was administered alone or with 20 ml antacid (2 g of aluminum hydroxide and …

Asa Section On Teaching Of Statistics In The Health Sciences: 25 Years Later, Constantine Daskalakis, Scd

Department of Pharmacology and Experimental Therapeutics Faculty Papers

ASA's Section on Teaching of Statistics in the Health Sciences was established as a subsection of the Section on Statistical Education in 1970, and became an independent section in 1991. Stephen Looney, Todd Nick, Ralph O'Brien, Bob Oster and others led the section's early growth in the mid-to-late 1990s. Sessions and continuing education courses were organized at JSM, the newsletter was modernized, and a first website was established. In the early-to-mid 2000s, Ruth Mickey, Walter Ambrosius, Cyndy Long, Ed Gracely, the late Patrick Arbogast, Jodi Lapidus, and Scott Evans added their own efforts in strengthening section activities. It was during …

Trends And Determinants Of Up-To-Date Status With Colorectal Cancer Screening In Tennessee, 2002-2008, Sreenivas P. Veeranki, Shimin Zheng

ETSU Faculty Works

BACKGROUND:

Screening rates for colorectal cancer (CRC) are increasing nationwide including Tennessee (TN); however, their up-to-date status is unknown. The objective of this study is to determine the trends and characteristics of TN adults who are up-to-date status with CRC screening during 2002-2008.

METHODS:

We examined data from the TN Behavioral Risk Factor Surveillance System for 2002, 2004, 2006 and 2008 to estimate the proportion of respondents aged 50 years and above who were up-to-date status with CRC screening, defined as an annual home fecal occult blood test and/or sigmoidoscopy or colonoscopy in the past 5 years. We identified trends …

Antifungal Activity Of Cationic Conjugated Polyelectrolytes And Oligomers Against Candida Albicans, Laura Jane Ingersol

Biomedical Sciences ETDs

Candida albicans is a human fungal commensal and an opportunistic pathogen. It is a polymorphic fungus that is able to invade host cells and disseminate through tissues. C. albicans also form biofilms on medical devices and mucosal surfaces, which aid in the development of drug resistance, tissue colonization and evasion of host immunity. Disseminated candidiasis is associated with high mortality rates, especially in immunocompromised hosts. Concern about resistance to current antifungal therapies has led to a push to develop novel, alternative treatments. In this study, we investigated the antifungal activities of two agents: PPE-DABCO, a poly(phenylene ethynylene) (PPE)-based cationic conjugated …

Cold Inducible Rna Binding Protein Is Disrupted In Er+Pr+Her2- Tumors, Grace Anyango Okello

Biomedical Sciences ETDs

RNA binding proteins (RBPs) and microRNAs (miRNAs) control gene expression post-transcriptionally by targeting mRNAs for translational activation, repression, or degradation. To date, aberrant expression of RBPs and miRNAs has been observed in many types of human cancers. We have shown the overexpression of Cold Inducible RNA binding protein (CIRP) in human breast cancer cell lines as compared to nontumorigenic and nontransformed breast epithelial cells. Others have shown cytoplasmic CIRP to be upregulated in a subset of breast tumors. Little is known about CIRP targets or its role in breast cancer. RBP Human antigen R (HuR), whose cytoplasmic localization is associated …

Evaluation Of The Association Between Exposure To Different Forms Of Electronic Media With Dietary Intake And Body Mass Index Percentile In Hispanic And American Indian Pre-Schoolers In Rural New Mexico, Kevin Patrick Vlahovich

Biomedical Sciences ETDs

BACKGROUND: Obesity is a problem for Hispanic and American Indian children. Sedentary behavior has been linked to increased body weight and poor dietary quality. The purpose of this study was to evaluate the associations between different forms of sedentary behavior involving exposure to electronic media with dietary intake and body mass index (BMI) Percentile. METHODS: My cross-sectional study used baseline anthropomorphic measures and parent survey data collected as part of the Child Health Initiative for Lifelong Eating and Exercise (CHILE) study. I used multivariate linear regression to evaluate the relationship between different forms of sedentary behavior (time per week spent …

Engineering Catalytic Molecular Logic Devices For Biodetection, Carl W. Brown Iii

Biomedical Sciences ETDs

This dissertation describes the development of DNA computing techniques and molecular logic devices specifically engineered for direct translation to biological sample detection. As disease states originate at the molecular level, it is critical to design diagnostic and therapeutic devices that are capable of molecular-scale sensing and decision-making in the cellular environment. The predictable nature of DNA hybridization and secondary structure formation enables programmable interactions, providing a stable, cost-effective, and biocompatible mechanism for making decisions on the molecular scale. The incorporation of DNAzymes, DNA strands that can perform a variety of chemical reactions, adds innate catalysis and a rich biochemical diversity …

Changes In Peak Acceleration In The Snatch Across Multiple - Attempts In Training: A Case Study, George K. Beckham, Kimitake Sato, Timothy J. Suchomel, William A. Sands, Michael H. Stone

ETSU Faculty Works

Accelerometers are devices that have been recently used to assess the performance of weightlifters in training. This case study used vertical acceleration data to assess multiple snatch attempts in a single lifter during a training session. The lifter exhibited variability in a number of measures, including peak acceleration and peak velocity. The measures calculated from the acceleration-time data did not show consistent trends between made and missed lifts. More work is needed identify variables of interest for snatch performance.

Longitudinal Monitoring Of Countermovement Jump Mechanical Variables: A Preliminary Investigation, Christopher J. Sole, Satoshi Mizuguchi, Timothy J. Suchomel, William A. Sands, Michael H. Stone

ETSU Faculty Works

The purpose of this study was to examine the influence of accumulated volume load on countermovement jump (CMJ) mechanical variables. Eight athletes underwent weekly CMJ testing using a force plate. Statistical changes were observed in certain CMJ variables over the observation period. Jump height (0.42±0.05 m) and allometrically scaled peak power (88.86±7.49 W·kg-0.67) exhibited multiple statistical changes. These changes appeared to exhibit a delayed effect in response to accumulated volume load. Specifically, following several weeks of large accumulated volume loads these variables declined. In addition subsequently decreasing accumulated volume loads resulted in an increase in both variables. The findings of …

The Interplay Of Trait Anger, Childhood Physical Abuse, And Alcohol Consumption In Predicting Intimate Partner Aggression, Rosalita C. Maldonado, Laura E. Watkins, David Dilillo

Department of Psychology: Faculty Publications

The current study examined three well-established risk factors for intimate partner aggression (IPA) within Finkel and Eckhardt’s I³ model, including two impellance factors—trait anger and childhood physical abuse history—and the disinhibiting factor of alcohol consumption. Participants were 236 male and female college students in a committed heterosexual dating relationship who completed a battery of self-report measures assessing childhood physical abuse, trait anger, alcohol consumption, and IPA perpetration. Results revealed a significant three-way interaction showing that as the disinhibition factor alcohol consumption increased, the interaction of the two impelling factors, trait anger and childhood physical abuse, became increasingly more positive. …

Feasibility Of Diagnosis Of Postcardiotomy Tamponade By Miniaturized Transesophageal Echocardiography., Hitoshi Hirose, Md, Shreya Gupta, Bs, Harrsion Pitcher, Md, Joseph Miessau, Ms, Qiong Yang, Md, Jenny Yang, Md, Nicholas Cavarhocchi, Md

Department of Surgery Faculty Papers

BACKGROUND: Pericardial tamponade after cardiac surgery is a critical diagnosis that can be difficult to diagnose using conventional cardiac monitoring. Transesophageal echocardiography can provide comprehensive information to make the diagnosis but is not always available, whereas transthoracic echocardiography has its utility limited because of the body habitus or other surgical effects. New monitoring devices, miniaturized hemodynamic transesophageal echocardiography (hTEE), which allows point of care assessment of cardiac filling and functions, may aid in diagnosis of postcardiotomy tamponade.

METHODS: From May 2011 to July 2013, 21 patients underwent hTEE to rule out pericardial tamponade for clinical suspicion of tamponade after open …

Cost-Effective Practice Of Neurology: An Idea Whose Time Has Come, Rashid Jooma

Pakistan Journal of Neurological Sciences (PJNS)

Pakistanis spent $ 7.2 billion on healthcare in 2013 (3.1% of our Gross Domestic Product), representing a per capita expenditure of $ 39.4. The government contribution to this was no more than 31.4% ($ 12.4 per capita). The public allocations to health thus represent a paltry 4.7% of total government expenditure and are just shy of 1% of our GDP.

To Determine The Frequency Of Depression In Patients With Primary Epilepsy, Wazir Akber, Noor Ahmed Khosa, Amanullah Sarangzai

Pakistan Journal of Neurological Sciences (PJNS)

Depression is well known common co-morbid psychiatric condition associated with primary epilepsy. This study showed that frequency of depression was 62% in primary epilepsy patient presenting to the Neurology outpatient clinic of a tertiary care hospital. Female gender, high seizures frequency, polytherapy with AEDs and long duration of primary epilepsy were found to be the factors leading to frequent occurrence of depression in primary epilepsy patients Objective: To determine the frequency of depression in patients with primary epilepsy presenting to the Neurology outpatient clinic of Aga Khan University Hospital Karachi.Study Design: Cross-sectional study. Study Setting: Neurology outpatient department at Aga …

Coil Embolization Of Wide Neck Cerebral Aneurysms Using Balloon Remodeling Technique-Initial Experience In Pakistan, Qasim Bashir, Hina Nabi Ahmed

Pakistan Journal of Neurological Sciences (PJNS)

The balloon remodeling technique [BRT] was developed for neuroendovascular treatment of wide-necked cerebral aneurysms. Herein, we describe our initial experience of aneurysm embolization using BRT in Pakistan with the new double-lumen balloon catheters (Sceptor C and Ascent) and Hyperform balloon micro catheter and discuss its benefits.

Clippers (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive To Steroids)–Case Report With Neuroimaging, Abdul Salam, Farah Sana, Rashed Nazir, M. Azhar Saeed, Yasir Iqbal, Arsalan Ahmad

Pakistan Journal of Neurological Sciences (PJNS)

Background: CLIPPERS syndrome (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is an inflammatory disease process primarily involving the pons and adjacent structures. Clinically, the patient may present with cerebellar signs such as dysarthria, gait ataxia and with cranial nerve palsies. It shows good response to steroids / immunosuppressive therapy. Pathologically, there is infiltration of T lymphocytes into the perivascular spaces of brainstem. The disease follows a relapsing and a remitting course and the earlier the treatment is started with high dose steroids and the more prolonged it is, the better the clinical outcome will be.

Sporadic Cjd And Retinitis Punctata Albescansa Case Report And Literature Review, Quratulain Khan, Yusra Hanif Khan

Pakistan Journal of Neurological Sciences (PJNS)

Introduction Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of CJD causing 85% of all cases. Various phenotypes of sCJD have been identified including Heidenhain variant which has early and predominant visual symptoms with most pronounced neuropathological changes in occipital lobe. Methodology. We are reporting a case of sCJD with Retinitis Punctata Albescens (RPA), a variant of Retinitis Pigmentosa (RP), which to our knowledge has not been reported before. A 51 year old, married, right handed, Pakistani woman presented with dementia and gait problems for 3 months and visual hallucinations for 2 months. Ophthalmological examination 3 years prior to …