Medicine and Health Sciences Commons^™

When You Can't Watch What You Eat: Examining The Fda’S Recall Process For Food Allergies, Jacob Passy

Capstones

Over a third of all recalls for food products in the United States occur due to an undeclared allergen. In these situations, a food product is often mislabeled or contaminated in some way, resulting in the unknown presence of allergen. For food-allergic consumers, a company's mistake can become life-threatening. By investigating data from the Food and Drug Administration, I found that supermarket chains are responsible for about a fifth of all recalls, and that many recalls occur past the product's expiration date. These factors point to the need to improve the FDA's handling of food allergies in food manufacturing.

Therapeutic Effect And Predictors Of The Effectiveness Of Custom-Made Foot Orthoses For Common Foot Pain, Yan-Ren Lin, Chen-Yu Hung, Chun-Chieh Lee, Yu-Ting Hsieh, Tyng-Guey Wang

Rehabilitation Practice and Science

Purpose: Custom-made foot orthoses are commonly used to treat foot pain by modifying the distribution of foot pressure. The therapeutic effect of custom-made foot orthoses on specific foot pain such as pes cavus, rheumatoid arthritis, and plantar fasciitis has been established. However, the therapeutic effect of custom-made foot orthoses on common foot pain remains unclear, and the foot characteristics with which patients are most likely to benefit from this intervention have not been adequately explored. The purposes of this study were to investigate the therapeutic effect of custom-made foot orthoses on common foot pain and to determine potential predictors of …

Associations Between Physical Fitness And Health-Related Quality Of Life Of Nurses, Chia-Huei Lin, Li-Chi Chiang, Wen-Chii Tzeng, Liang-Cheng Chen, Shin-Tsu Chang, Shang-Lin Chiang

Rehabilitation Practice and Science

Background: Little is known regarding health-related quality of life (HRQOL) and its association with physical fitness among nurses. Purpose: To investigate whether physical fitness was associated with HRQOL among nurses. Methods: A cross-sectional study was conducted on 232 volunteer nurses who were 31 years of age and free of disease-related disability. Physical fitness was assessed using a cws28 health-related physical fitness system which measured body composition (BMI and percentage body fat), balance, flexibility, muscle strength, muscular endurance, and cardiorespiratory fitness. SF-36®, a structured self-reporting questionnaire, was used to evaluate HRQOL. The association between physical fitness and HRQOL (independent of potential …

The Effect Of Static Wrist Position On Median Nerve Over Six Hours, Ching-Ning Hsu, Yu-Sheng Yang, Jui-Jen Hsu, Yi-Chun Tsai, Pei-Hua Lin, Chia-Ling Lee

Rehabilitation Practice and Science

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, caused by the compression of the median nerve in the carpal tunnel over the wrist. The purpose of this study is to demonstrate how different wrist positions change median nerve image and their corresponding results of nerve conduction study (NCS). In this study, we investigated 40 normal wrists and 32 wrists with CTS. In both groups, subjects were randomly assigned to wear a splint, and the wrist was placed at 0, 15, 30 and 45 degrees of extension. Ultrasonography was performed before splinting, immediately after splinting and repeated again 2, …

Disability And Rehabilitation -The Challenge And Opportunity Of Physiatrists In Disability, Kwang-Hwa Chang, Tsan-Hon Liou

Rehabilitation Practice and Science

Disability, a long-standing problem affecting mankind, is associated with medical, social welfare, political, and human rights problems and, therefore, is complex. The World Health Organization (WHO) promulgated the International Classification of Functioning, Disability, and Health (ICF) in 2001, facilitating the study of disability in recent years. According to the WHO Disability Report, the worldwide prevalence of disability is 15%, and the minimal worldwide prevalence is estimated to be 1 billion cases. Before 2012, disability evaluation was based mainly on the medical model in Taiwan, and, therefore, the prevalence was lower than 5%, which is much lower than the international level. …

The Prevalence And Related Factors Of Posttraumatic Stress Disorder Among Subjects With Spinal Cord Injury, Ching-Chi Chang, Yu-Ting Yang, Shu-Han Yu, Nai-Yin Chang, Vincent Chin-Hung Chen, Su-Ju Tsai

Rehabilitation Practice and Science

There are approximately 1200 new cases of traumatic spinal cord injury (SCI) each year in Taiwan. Traumatic SCI often results from motor vehicle crashes, acts of violence or sports injuries. These are potentially leading patients to suffer from posttraumatic stress disorder (PTSD). The characteristic symptoms of PTSD include persistent re-experiencing of the event, increased arousal and avoidance of stimuli associated with the trauma and numbing of general responsiveness. The symptoms must cause clinically significant distress or impairment in social, occupational or other important areas of functioning. Our purpose was to identify the prevalence and related factors of posttraumatic stress disorder …

Weakness Of Bilateral Upper Limbs Since Birth Caused By Encephalocraniocutaneous Lipomatosis: A Casereport, I-Hsien Wu, Chia-Chi Wang, Ling-Jung Lee, Hui-Chun Juan

Rehabilitation Practice and Science

Encephalocraniocutaneous lipomatosis (ECCL) is a very rare neurocutaneous syndrome with hallmark lesions including cranial lipomas, ocular lipodermoids and brain abnormalities. ECCL was first described by Haberland and Perou in 1970, and it is sometimes referred to as Haberland syndrome. The genetics of ECCL are unknown, however it is generally considered to be a genetically mosaic condition. Herein, we report the case of a 20-day-old infant girl who presented with weakness of bilateral upper limbs since birth. Subcutaneous masses over her right cheek, eye, inguinal area and limbs were also noted on examination. Brain and spinal magnetic resonance imaging revealed intradural …

Biomechanical Analysis Of Lower Limb Muscle Power In Elderly Individuals, I-Chung Cheng, Shun-Hwa Wei, Fu-Kong Lieu, Pei-Chen Tsai

Rehabilitation Practice and Science

Background: The aging process may contribute to a decrease in lower extremity function in elderly individuals, which in turn often causes a functional decrease in activities of daily living, loss in quality of life, and increase in risk of accidental falls. In the last few decades, numerous studies in elderly individuals have reported the relation between a high incidence of accidental falls and inadequate muscle strength. Unfortunately, few studies have provided insight about their individual muscle performance, such as the explosive muscle power, from a biomechanical prospective. Quantitative analysis of the sit- to- stand (STS) ability is a useful method …

Cardiac Rehabilitation Among Patients With Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention After Acute Myocardial Infarction Indicator Was Activated, Yu-Yang Hung, Su-Ying Hung, Chen-Liang Chou, Shih-Ann Chen

Rehabilitation Practice and Science

Background and Purpose: Cardiac rehabilitation (CR) is effective in improving mortality and morbidity outcomes and may favorably influence cardiac risk factors in patients with coronary heart disease. Despite the proven benefits, CR remains considerably under-utilized worldwide. The aim of this study was to research the current status of CR for patients with acute myocardial infarction (AMI) receiving percutaneous coronary intervention (PCI) after the Taiwan Clinical Performance Indicator executes was activated in a medical center in Taiwan. Methods: The medical records of 174 patients with AMI at our hospital from January to December 2012 were retrospectively reviewarticleed to investigate the consultation …

Ultrasonography In The Diagnosis Of Carpal Tunnel Syndrome And Measurement Of Gliding Of The Median Nerve, Yi-Wei Chang, Yi-Chieh Lien, Yi-Shiung Horng

Rehabilitation Practice and Science

The main purpose of the diagnostic ultrasound examination for carpal tunnel syndrome (CTS) is to compensate for the inadequacies of physical examinations and nerve conduction studies and thereby reduce the false negative rate of CTS diagnosis. The cross-sectional area of the median nerve, swelling ratio, flattening ratio, and palmar bowing of the flexor retinaculum have been reported as the diagnostic criteria for CTS in ultrasonographic examinations. In addition, Doppler ultrasound has been applied to measure the blood flow of the median nerve, and dynamic ultrasound combined with a cross-correlation algorithm has been developed to measure the gliding of the median …

Association Between The Amount Of Inpatient Rehabilitation Therapy And The Risk Of Disability And Mortality In Patients With Ischemic Stroke, Yu-Ju Chang, Gwo-Chi Hu, Yi-Pin Chiang, Yao-Chia Chuang, Chih-Lin Kuo

Rehabilitation Practice and Science

Background and Purpose: Most studies have demonstrated that rehabilitation program is able to improve functional recovery and reduce the risk of disability in patients with acute stroke. However, the relationship between the amount of the inpatient rehabilitation therapy and the risk of disability and mortality among patients with acute ischemic stroke is still unknown. The present study was undertaken to investigate the relationship between the amount of inpatient rehabilitation therapy and the risk of disability and mortality among patients with acute ischemic stroke, as well as to assess whether the association varies with respect to stroke severity Methods: We designed …

Gender Difference In Acute Myocardial Infarction Patients Receiving Phase 1 Cardiac Rehabilitation, Chi-Che Ho, Yi-Ru Chen, Chung-Han Ho, Wen-Chih Lin, Shu-Han Yang, Hui-Chun Juan, Willy Chou

Rehabilitation Practice and Science

Purpose: The effects of gender difference on the pathogenesis, epidemiology, diagnosis, treatment, and prognosis of cardiovascular diseases have been widely examined. In addition, gender differences influence cardiac rehabilitation; however, few studies have investigated the effect of gender difference on phase 1 cardiac rehabilitation patients. Therefore, this study explored gender difference in acute myocardial infarction patients who received phase 1 cardiac rehabilitation based on data collected from the National Health Insurance Research Database. For our analysis, we focused on the age distribution, comorbidities, and medical treatment of these patients. The study results are expected to serve as a reference for cardiac …

Effects Of Low-Level Laser Therapy On Matrix Metalloproteinase And Collagen Expression Of Tendon Cells, Chien-Hung Chen, Shih-Wei Hung, Jong-Hwei S. Pang, Wen-Chung Tsai, Miao-Sui Lin, Tung-Yang Yu, Hsiang-Ning Chang

Rehabilitation Practice and Science

Objective: Low-level laser therapy (LLLT) is commonly used to treat sports-related tendinopathy or tendon injury. However, scientific evidence of the effects and underlying molecular mechanisms of tendinopathy treatment remained limited. Tendon healing requires tenocyte migration to the repair site, followed by proliferation and synthesis of the extracellular matrix, including collagens. The study was designed to determine the effect of laser on the metabolism of collagen for injuried tendon repair, furthermore, become a foundation of the LLLT for tendon repair. Methods: Tendon cells from rat Achilles tendons were obtained to investigate the effect of LLLT on collagen metabolism in tendon repair. …

Pengembangan Multimedia Pendidikan Jasmani Materi Budaya Hidup Sehat Untuk Sekolah Menengah Atas, Arief Fitriadi, Hari Amirullah Rachman

Jurnal Keolahragaan

Penelitian ini bertujuan untuk menghasilkan sebuah produk berupa multimedia pembelajaran pendidikan jasmani materi budaya hidup sehat dalam bentuk buku dan CD (Compact Disk). Jenis penelitian adalah Research and Development (R and D) dengan pendekatan survei melalui tes pengukuran. Penelitian pengembangan ini melalui empat tahapan, yaitu pendahuluan, tahap pengembangan, tahap uji lapangan dan tahap desiminasi produk. Populasi penelitian adalah siswa kelas X dan kelas XI SMA Negeri se-Kabupaten Yogyakarta sebanyak 83 orang. Instrumen pengumpulan data adalah lembar validasi untuk ahli materi dan ahli media, serta lembar kuesioner untuk siswa SMA. Hasil penelitian menunjukkan sebagai berikut: (1) Hasil validasi oleh …

Neural Biomarkers For Assessing Different Types Of Imagery In Pictorial Health Warning Labels For Cigarette Packaging: A Cross-Sectional Study, Roger D. Newman-Norlund, Jim Thrasher, Johann Fridriksson, William Brixius, Brett Froeliger, David Hammond, Michael K. Cummings

Faculty Publications

Objective Countries around the world have increasingly adopted pictorial health warning labels (HWLs) for tobacco packages to warn consumers about smoking-related risks. Research on how pictorial HWLs work has primarily analysed self-reported responses to HWLs; studies at the neural level comparing the brain's response to different types of HWLs may provide an important complement to prior studies, especially if self-reported responses are systematically biased. In this study we characterise the brain's response to three types of pictorial HWLs for which prior self-report studies indicated different levels of efficacy.

Methods Current smokers rated pictorial HWLs and then observed the same HWLs …

Pengaruh Diayogarobik Dan Kgd Awal Terhadap Kapasitas Fisik Dan Kimiawi Darah Penderita Dm Tipe 2, Intan Imawati, B.M. Wara Kushartanti

Jurnal Keolahragaan

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh latihan diayogarobik terhadap kapasitas fisik dan kimiawi darah, (2) perbedaan pengaruh latihan diayogarobik terhadap kapasitas fisik dan kimiawi darah antara penderita diabetes mellitus tipe 2 dengan kadar glukosa darah awal di bawah 250 mg/dl dan di atas 250 mg/dl. Metode penelitian ini adalah eksperimen. ata penelitian ini diperoleh melalui tes dan pengukuran terhadap fleksibilitas dengan menggunakan fleksometer, kekuatan otot lengan dengan Push & Pool Dinamometer, kekuatan otot tungkai dengan Leg & Back Dinamometer, serta kadar glukosa darah dan kadar kolesterol darah dengan Glukometer. Hasil penelitian ini menunjukkan bahwa: (1) diayogarobik …

Research News: 2014, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants and contracts recently awarded

Hiv Symptom Burden And Anemia Among Hiv-Positive Individuals: Cross-Sectional Results Of A Community-Based Positive Living With Hiv (Polh) Study In Nepal, Catherine Martin, Kalpana Poudel-Tandukar, Krishna C. Poudel

Krishna C. Poudel

Kinomic Profiling Of Electromagnetic Navigational Bronchoscopy Specimens: A New Approach For Personalized Medicine, Joshua C. Anderson, Douglas J. Minnich, M. Christian Dobelbower, Alexander J. Denton, Alex M. Dussaq, Ashley N. Gilbert, Timothy Rohrbach, Waleed Arafat, Karim Welaya, James A. Bonner, Christopher D. Willey

Richard Bland Faculty Works

Purpose

Researchers are currently seeking relevant lung cancer biomarkers in order to make informed decisions regarding therapeutic selection for patients in so-called “precision medicine.” However, there are challenges to obtaining adequate lung cancer tissue for molecular analyses. Furthermore, current molecular testing of tumors at the genomic or transcriptomic level are very indirect measures of biological response to a drug, particularly for small molecule inhibitors that target kinases. Kinase activity profiling is therefore theorized to be more reflective of in vivo biology than many current molecular analysis techniques. As a result, this study seeks to prove the feasibility of combining a …

Jefferson Digital Commons Quarterly Report: October-December 2014, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Jefferson Digital Commons Reports

This Jefferson Digital Commons quarterly report will cover the following:

• Assorted statistics
• New assets added to the JDC
• Historical Materials
• What people are saying about the JDC

Left Ventricular Assist Device As Destination Therapy, Maya Guglin, Leslie W. Miller

The VAD Journal

Mechanical circulatory support is the most rapidly evolving strategy in heart failure management. The growing number of patients who need better results than medical therapy can offer, the limited pool of donors for cardiac transplantation, and several technological breakthroughs have all made the option of implanting a left ventricular assist device (LVAD) as destination therapy more important.

In this review, we outline the indications and decision making process of considering a patient for a destination therapy LVAD, as well as outcomes, complications, and issues related to management of patients on currently approved devices. The future direction of the field will …

Primary Health Centres And Patients Satisfaction Level In Haripad Community Development Block Of Kerala, India, Sarath Chandran

SARATH CHANDRAN

The main objectives of the present study were to show the spatial distribution of Primary Health Centres in the Haripad Block of Kerala and to investigate the patients’ perception regarding the services provided by the Primary Health Centres. Spatial distribution of Primary Health centres was shown with the help of GIS mapping. Out of eight Primary Health Centres of the Block, five of them were selected by lottery method of simple random sampling for the present study. A pre designed schedule was used for t tabulated and analysed by using of primary health care services in Haripad The major problems …

Classification Of Current Anticancer Immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer

Journal Articles: Pathology and Microbiology

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification …

Hemagglutinin-Based Polyanhydride Nanovaccines Against H5n1 Influenza Elicit Protective Virus Neutralizing Titers And Cell-Mediated Immunity., Kathleen A. Ross, Hyelee Loyd, Wuwei Wu, Lucas Huntimer, Shaheen Ahmed, Anthony R. Sambol, Scott Broderick, Zachary Flickinger, Krishna Rajan, Tatiana K. Bronich, Surya Mallapragada, Michael J. Wannemuehler, Susan Carpenter, Balaji Narasimhan

Journal Articles: Pharmaceutical Sciences

H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to traditional vaccine technologies. In particular, polyanhydride nanoparticles encapsulating subunit proteins have been shown to enhance humoral and cell-mediated immunity and provide protection upon lethal challenge. In this work, a recombinant H5 hemagglutinin trimer (H5₃) was produced and encapsulated into polyanhydride nanoparticles. The studies performed indicated that the recombinant H5₃ antigen was a robust immunogen. Immunizing mice with H5₃ encapsulated into polyanhydride nanoparticles induced high neutralizing antibody titers and enhanced CD4(+) T …

The Bubbling Aorta, Hesham R. Omar, Maya Guglin

The VAD Journal

We are presenting the image of the bubbles in the descending aorta in a patient on VA ECMO.

Promoting Self-Management Through Adherence Among Heart Failure Patients Discharged From Rural Hospitals: A Study Protocol., Lufei Young, Sue Barnason, Van Do

Journal Articles: College of Nursing

UNLABELLED: Background Heart failure is one of the most prevalent chronic conditions in adults, leading to prolonged morbidity, repeated hospitalizations, and placing tremendous economic burden on the healthcare system. Heart failure patients discharged from rural hospitals, or primarily critical access hospitals, have higher 30-day readmission and mortality rates compared to patients discharged from urban hospitals. Self-management improves heart failure patients' health outcomes and reduces re-hospitalizations, but adherence to self-management guidelines is low. We propose a home based post-acute care service managed by advanced practice nurses to enhance patient activation and lead to the improvement of self-management adherence in heart failure …

Classification Of Current Anticancer Immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P Colombo, Lisa Coussens, Madhav V Dhodapkar, Alexander M Eggermont, Douglas T Fearon, Wolf H Fridman, Jitka Fučíková, Dmitry I Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M Kirkwood, Eva Klein, Alexander Knuth, Claire E Lewis, Roland Liblau, Michael T Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J Melief, Elizabeth A Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E Peter, Kenneth J Pienta, Angel Porgador, George C Prendergast, Gabriel A Rabinovich, Nicholas P Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J Smyth, Daniel E Speiser, Radek Spisek, Pramod K Srivastava, James E Talmadge, Eric Tartour, Sjoerd H Van Der Burg, Benoît J Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S Weber, Theresa L Whiteside, Jedd D Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer

Kimmel Cancer Center Faculty Papers

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification …

Continuing To Confront Copd International Physician Survey: Physician Knowledge And Application Of Copd Management Guidelines In 12 Countries, Kourtney J. Davis, Sarah H. Landis, Yeon-Mok Oh, David M. Mannino, Meilan K. Han, Thys Van Der Molen, Zaurbek Aisanov, Ana M. Menezes, Masakazu Ichinose, Hana Muellerova

Preventive Medicine and Environmental Health Faculty Publications

AIM: Utilizing data from the Continuing to Confront COPD (chronic obstructive pulmonary disease) International Physician Survey, this study aimed to describe physicians' knowledge and application of the GOLD (Global initiative for chronic Obstructive Lung Disease) Global Strategy for the Diagnosis, Management and Prevention of COPD diagnosis and treatment recommendations and compare performance between primary care physicians (PCPs) and respiratory specialists.

MATERIALS AND METHODS: Physicians from 12 countries were sampled from in-country professional databases; 1,307 physicians (PCP to respiratory specialist ratio three to one) who regularly consult with COPD, emphysema, or chronic bronchitis patients were interviewed online, by telephone or face …

Efek Fraksi N-Heksana Kulit Hylocereus Polyhizus Terhadap Kadar Malondialdehida Tikus Stres Oksidatif, Wirna Maya Sari, Sri Wahdaningsih, Eka Kartika Untari

Pharmaceutical Sciences and Research

Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential used natural exogenous antioxidant. The aim of this research was to study the effect of n-hexane fraction of H.polyhizus peel on MDA level and to determine the dose that could reduce the MDA level. H.polyhizus peel was macerated with chloroform, fractionated with n-Hexane. Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H.polyhizus peel extract group treated with dose I (10mg/ 200gbw), …

Efek Fraksi N-Heksana Kulit Hylocereus Polyrhizus Terhadapaktivitas Katalase Tikus Stres Oksidatif, Eka Kartika Untari, Sri Wahdaningsih, Agustia Damayanti

Pharmaceutical Sciences and Research

Production of excess free radicals cause oxidative damage and degenerative diseases. Catalase enzyme is one of the endogenous intracellular antioxidant that can be reduced by oxidative stress conditions. The peel of red dragon fruit (Hylocereus polyrhizus) as a potent exogenous antioxidants could support the internal enzyme activity to prevent free radicals. The aim of this research was to determine the effect of n-hexane fraction of H.polyrhizus’s peel and the dose that could increase activity of catalase. The peel was maserated with chloroform, then fractionated by n-hexane. Stress condition was achieved by five days fasting and swimming for 10 mins/day to …