Medicine and Health Sciences Commons^™

An Simplified Comprehensive Assessment Tool For Long-Term Care Residents In Taiwan, Pay-Shin Lin, Ting-Chin Lin, Chih-Chung Chen, Sun-Fen Chi, Chih-Kuang Chen, Alice May-Kuen Wong

Rehabilitation Practice and Science

Background and purpose: Along with the population and mean age of the older adults increase steadily, the prevalence of ADL impairment is getting higher which would increase the needs for elderly care. Therefore, how to evaluate patients’ care needs and resource utilization has become an important issue recently. The purposes of this study are to test the reliability and validity of a newly developed comprehensive assessment tool for care need-PRABC, hoping that it could be a easy, quick and clinical usable tool to assess the level of residents’ long-term care needs. Method: This is a cross-sectional study. Subjects were recruited …

Disability And Rehabilitation -The Challenge And Opportunity Of Physiatrists In Disability, Kwang-Hwa Chang, Tsan-Hon Liou

Rehabilitation Practice and Science

Disability, a long-standing problem affecting mankind, is associated with medical, social welfare, political, and human rights problems and, therefore, is complex. The World Health Organization (WHO) promulgated the International Classification of Functioning, Disability, and Health (ICF) in 2001, facilitating the study of disability in recent years. According to the WHO Disability Report, the worldwide prevalence of disability is 15%, and the minimal worldwide prevalence is estimated to be 1 billion cases. Before 2012, disability evaluation was based mainly on the medical model in Taiwan, and, therefore, the prevalence was lower than 5%, which is much lower than the international level. …

Influence Of Pain On Depression And Quality Of Life In Patients With Spinal Cord Injury, Yao-Jen Chen, Hong-Ye Chen

Rehabilitation Practice and Science

Objective: To assess pain prevalence in a spinal cord injury (SCI) population and the influence of pain on depression and quality of life in patients with SCI. Methods: Two hundred twenty six SCI patients were asked to participate in this study after completing a questionnaire. The questionnaire included demographic data, clinical characteristics of SCI, performance of daily activities and pain intensity on a Numerical Rating Scale (NRS). The Chinese version of Identification (ID) of pain questionnaire was used to detect the neuropathic form of pain. The Taiwanese Depression Questionnaire (TDQ) was used for screening of depression and the Taiwan version …

The Prevalence And Related Factors Of Posttraumatic Stress Disorder Among Subjects With Spinal Cord Injury, Ching-Chi Chang, Yu-Ting Yang, Shu-Han Yu, Nai-Yin Chang, Vincent Chin-Hung Chen, Su-Ju Tsai

Rehabilitation Practice and Science

There are approximately 1200 new cases of traumatic spinal cord injury (SCI) each year in Taiwan. Traumatic SCI often results from motor vehicle crashes, acts of violence or sports injuries. These are potentially leading patients to suffer from posttraumatic stress disorder (PTSD). The characteristic symptoms of PTSD include persistent re-experiencing of the event, increased arousal and avoidance of stimuli associated with the trauma and numbing of general responsiveness. The symptoms must cause clinically significant distress or impairment in social, occupational or other important areas of functioning. Our purpose was to identify the prevalence and related factors of posttraumatic stress disorder …

Overview Of The Reporting Of Developmentally-Delayed Children In Taiwan Between 2007 And 2012, Chun-Wei Kang, Chun-Lung Chen, Jiun-Yih Lee, Sung-Hui Tseng

Rehabilitation Practice and Science

Successful early intervention (EI) depends on the early detection of children who exhibit a delay in development or are at risk for developmental problems and providing these children and their families with timely integrated services delivered by social welfare, health, and educational professionals. To understand the difference in reporting rates among cities and counties, we analyzed registry data on the reported number of early intervention services (EISs) provided to developmentally delayed children from 2007 to 2012 published annually by the Department of Statistics, Ministry of the Interior. The information included the number of new cases reported each year according to …

Weakness Of Bilateral Upper Limbs Since Birth Caused By Encephalocraniocutaneous Lipomatosis: A Casereport, I-Hsien Wu, Chia-Chi Wang, Ling-Jung Lee, Hui-Chun Juan

Rehabilitation Practice and Science

Encephalocraniocutaneous lipomatosis (ECCL) is a very rare neurocutaneous syndrome with hallmark lesions including cranial lipomas, ocular lipodermoids and brain abnormalities. ECCL was first described by Haberland and Perou in 1970, and it is sometimes referred to as Haberland syndrome. The genetics of ECCL are unknown, however it is generally considered to be a genetically mosaic condition. Herein, we report the case of a 20-day-old infant girl who presented with weakness of bilateral upper limbs since birth. Subcutaneous masses over her right cheek, eye, inguinal area and limbs were also noted on examination. Brain and spinal magnetic resonance imaging revealed intradural …

Therapeutic Effect And Predictors Of The Effectiveness Of Custom-Made Foot Orthoses For Common Foot Pain, Yan-Ren Lin, Chen-Yu Hung, Chun-Chieh Lee, Yu-Ting Hsieh, Tyng-Guey Wang

Rehabilitation Practice and Science

Purpose: Custom-made foot orthoses are commonly used to treat foot pain by modifying the distribution of foot pressure. The therapeutic effect of custom-made foot orthoses on specific foot pain such as pes cavus, rheumatoid arthritis, and plantar fasciitis has been established. However, the therapeutic effect of custom-made foot orthoses on common foot pain remains unclear, and the foot characteristics with which patients are most likely to benefit from this intervention have not been adequately explored. The purposes of this study were to investigate the therapeutic effect of custom-made foot orthoses on common foot pain and to determine potential predictors of …

Cardiac Rehabilitation Among Patients With Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention After Acute Myocardial Infarction Indicator Was Activated, Yu-Yang Hung, Su-Ying Hung, Chen-Liang Chou, Shih-Ann Chen

Rehabilitation Practice and Science

Background and Purpose: Cardiac rehabilitation (CR) is effective in improving mortality and morbidity outcomes and may favorably influence cardiac risk factors in patients with coronary heart disease. Despite the proven benefits, CR remains considerably under-utilized worldwide. The aim of this study was to research the current status of CR for patients with acute myocardial infarction (AMI) receiving percutaneous coronary intervention (PCI) after the Taiwan Clinical Performance Indicator executes was activated in a medical center in Taiwan. Methods: The medical records of 174 patients with AMI at our hospital from January to December 2012 were retrospectively reviewarticleed to investigate the consultation …

Effects Of Acetaminophen, Etodolac And Indomethacin On Migration, Proliferation And Collagen Expression Of Tendon Cells, Yun-Ming Yang, Hsiang-Ning Chang, S Jong-Hwei Pang, Chung-Bao Hou, Wen-Chung Tsai

Rehabilitation Practice and Science

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy. Tendon healing requires migration of tendon cells to the repair site, followed by proliferation of these cells and collagen synthesis. Purpose: This study evaluated the effects of acetaminophen, etodolac, and indomethacin on tenocyte migration, proliferation, and synthesis of type I and III collagen. Methods: Rat Achilles tendon cells were treated with acetaminophen, etodolac, and indomethacin. Tendon cell migration and proliferation were assessed using transwell filter migration assay and MTT assay, respectively. The expression of collagen I and III mRNA were evaluated by quantitative real-time polymerase chain reaction. Results: Unlike …

Visual Restoration In Vertebral Artery Dissection With Cortical Blindness: A Casereport, Wen-Chih Lin, Yi-Ru Chen, Pin-Hsiu Chen, Pei-Chi Hsiao, Daniel Chiung-Jui Su, Jung-Tai Liu, Willy Chou

Rehabilitation Practice and Science

The annual incidence of vertebral artery dissection is 1 in 100,000. The clinical manifestations are diverse, including dizziness, occipital headache, neck pain and posterior circulation ischemia. One fourth of patients with vertebral artery dissection develop posterior circulation stroke, so vertebral artery dissection is considered one of the common causes of young stroke. The most common ophthalmic signs after posterior circulation ischemia are blurry vision followed by diplopia, whereas complete visual loss is uncommon. This report describes a 34-year-old woman who presented with complete cortical blindness caused by spontaneous vertebral artery dissection with ischemic stroke in the posterior circulation. In addition …

Ultrasonography In The Diagnosis Of Carpal Tunnel Syndrome And Measurement Of Gliding Of The Median Nerve, Yi-Wei Chang, Yi-Chieh Lien, Yi-Shiung Horng

Rehabilitation Practice and Science

The main purpose of the diagnostic ultrasound examination for carpal tunnel syndrome (CTS) is to compensate for the inadequacies of physical examinations and nerve conduction studies and thereby reduce the false negative rate of CTS diagnosis. The cross-sectional area of the median nerve, swelling ratio, flattening ratio, and palmar bowing of the flexor retinaculum have been reported as the diagnostic criteria for CTS in ultrasonographic examinations. In addition, Doppler ultrasound has been applied to measure the blood flow of the median nerve, and dynamic ultrasound combined with a cross-correlation algorithm has been developed to measure the gliding of the median …

Association Between The Amount Of Inpatient Rehabilitation Therapy And The Risk Of Disability And Mortality In Patients With Ischemic Stroke, Yu-Ju Chang, Gwo-Chi Hu, Yi-Pin Chiang, Yao-Chia Chuang, Chih-Lin Kuo

Rehabilitation Practice and Science

Background and Purpose: Most studies have demonstrated that rehabilitation program is able to improve functional recovery and reduce the risk of disability in patients with acute stroke. However, the relationship between the amount of the inpatient rehabilitation therapy and the risk of disability and mortality among patients with acute ischemic stroke is still unknown. The present study was undertaken to investigate the relationship between the amount of inpatient rehabilitation therapy and the risk of disability and mortality among patients with acute ischemic stroke, as well as to assess whether the association varies with respect to stroke severity Methods: We designed …

Gender Difference In Acute Myocardial Infarction Patients Receiving Phase 1 Cardiac Rehabilitation, Chi-Che Ho, Yi-Ru Chen, Chung-Han Ho, Wen-Chih Lin, Shu-Han Yang, Hui-Chun Juan, Willy Chou

Rehabilitation Practice and Science

Purpose: The effects of gender difference on the pathogenesis, epidemiology, diagnosis, treatment, and prognosis of cardiovascular diseases have been widely examined. In addition, gender differences influence cardiac rehabilitation; however, few studies have investigated the effect of gender difference on phase 1 cardiac rehabilitation patients. Therefore, this study explored gender difference in acute myocardial infarction patients who received phase 1 cardiac rehabilitation based on data collected from the National Health Insurance Research Database. For our analysis, we focused on the age distribution, comorbidities, and medical treatment of these patients. The study results are expected to serve as a reference for cardiac …

Effects Of Low-Level Laser Therapy On Matrix Metalloproteinase And Collagen Expression Of Tendon Cells, Chien-Hung Chen, Shih-Wei Hung, Jong-Hwei S. Pang, Wen-Chung Tsai, Miao-Sui Lin, Tung-Yang Yu, Hsiang-Ning Chang

Rehabilitation Practice and Science

Objective: Low-level laser therapy (LLLT) is commonly used to treat sports-related tendinopathy or tendon injury. However, scientific evidence of the effects and underlying molecular mechanisms of tendinopathy treatment remained limited. Tendon healing requires tenocyte migration to the repair site, followed by proliferation and synthesis of the extracellular matrix, including collagens. The study was designed to determine the effect of laser on the metabolism of collagen for injuried tendon repair, furthermore, become a foundation of the LLLT for tendon repair. Methods: Tendon cells from rat Achilles tendons were obtained to investigate the effect of LLLT on collagen metabolism in tendon repair. …

Effect Of Celecoxib On Hemophilic Arthropathyof Knee Joint With Synovitis, Ching-Yueh Lin, Chih-Ya Chang, Ming-Jen Ke, Yin-Yin Wu, Yung-Tsan Wu, Yeu-Chin Chen, Tsung-Ying Li

Rehabilitation Practice and Science

Introduction: Recurrent hemoarthrosis leads to synovitis, bone erosion, and subsequent hemoarthropathy in hemophilia. Few clinical trials have focused on the efficacy and adverse effects of nonsteroidal antiinflammatory drugs (NSAIDs), specifically cyclooxygenase-2-selective NSAIDs, in treating hemoarthropathy in patients with hemophilia. This study investigated the effect and safety of celecoxib in treating hemophilic arthropathy with synovitis. Materials and method: A total of 15 patients with hemophilic arthropathy were prescribed 200 mg of celecoxib twice per day for 30 days. Out come measurements regarding before and after treatment, joint range of motion, pain score (visual analogue scale), bleeding frequency, synovial thickness measured using …

Well-Born: Black Women And The Infertility Crisis No One Is Talking About, Kaara Baptiste

Capstones

Black women are twice as likely to experience infertility than white women, but are less likely to seek treatment or to have successful fertility results once treated. Despite this alarming number, this topic is not often discussed, even among the black community. My narrative piece t tells the story of a black woman confronting her infertility diagnosis and the role her race played in her fertility treatment, while exploring the role racism and sexuality have had in keeping this issue in the shadows.

Lady Luck: The Rise Of Women Problem Gamblers, Antonia Massa

Capstones

Gambling addiction, once considered a nearly exclusively male affliction, is becoming more common among women. This story looks at the lives and addictions of two women problem gamblers. The project includes text, audio, images and a web app for smartphones, designed to help women who think they may have a gambling problem.

Hemagglutinin-Based Polyanhydride Nanovaccines Against H5n1 Influenza Elicit Protective Virus Neutralizing Titers And Cell-Mediated Immunity., Kathleen A. Ross, Hyelee Loyd, Wuwei Wu, Lucas Huntimer, Shaheen Ahmed, Anthony R. Sambol, Scott Broderick, Zachary Flickinger, Krishna Rajan, Tatiana K. Bronich, Surya Mallapragada, Michael J. Wannemuehler, Susan Carpenter, Balaji Narasimhan

Journal Articles: Pharmaceutical Sciences

H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to traditional vaccine technologies. In particular, polyanhydride nanoparticles encapsulating subunit proteins have been shown to enhance humoral and cell-mediated immunity and provide protection upon lethal challenge. In this work, a recombinant H5 hemagglutinin trimer (H5₃) was produced and encapsulated into polyanhydride nanoparticles. The studies performed indicated that the recombinant H5₃ antigen was a robust immunogen. Immunizing mice with H5₃ encapsulated into polyanhydride nanoparticles induced high neutralizing antibody titers and enhanced CD4(+) T …

Classification Of Current Anticancer Immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer

Journal Articles: Pathology and Microbiology

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification …

Promoting Self-Management Through Adherence Among Heart Failure Patients Discharged From Rural Hospitals: A Study Protocol., Lufei Young, Sue Barnason, Van Do

Journal Articles: College of Nursing

UNLABELLED: Background Heart failure is one of the most prevalent chronic conditions in adults, leading to prolonged morbidity, repeated hospitalizations, and placing tremendous economic burden on the healthcare system. Heart failure patients discharged from rural hospitals, or primarily critical access hospitals, have higher 30-day readmission and mortality rates compared to patients discharged from urban hospitals. Self-management improves heart failure patients' health outcomes and reduces re-hospitalizations, but adherence to self-management guidelines is low. We propose a home based post-acute care service managed by advanced practice nurses to enhance patient activation and lead to the improvement of self-management adherence in heart failure …

Global Medical Education Partnerships To Expand Specialty Expertise: A Case Report On Building Neurology Clinical And Research Capacity, Marco A. Costa, Anthony Furlan, Chris T. Longenecker, Shirley Moore, Svetlana Pundik, Daniel I. Smith, Kathleen A. Smyth, Martha Sajatovic

Faculty Scholarship

Background: Neurological disorders are a common cause of morbidity and mortality in sub-Saharan African, but resources for their management are scarce. Collaborations between training institutions in developed and resource-limited countries can be a successful model for supporting specialty medical education and increasing clinical and research capacity. Case report: This report describes a US National Institutes of Health (NIH) funded Medical Education Partnership Initiative (MEPI) to enhance expertise in neurology, developed between Makerere University College of Health Sciences in Kampala, Uganda, and Case Western Reserve University School of Medicine in Cleveland, OH, USA. This collaborative model is based on a successful …

Jefferson Digital Commons Quarterly Report: October-December 2014, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Jefferson Digital Commons Reports

This Jefferson Digital Commons quarterly report will cover the following:

• Assorted statistics
• New assets added to the JDC
• Historical Materials
• What people are saying about the JDC

Left Ventricular Assist Device As Destination Therapy, Maya Guglin, Leslie W. Miller

The VAD Journal

Mechanical circulatory support is the most rapidly evolving strategy in heart failure management. The growing number of patients who need better results than medical therapy can offer, the limited pool of donors for cardiac transplantation, and several technological breakthroughs have all made the option of implanting a left ventricular assist device (LVAD) as destination therapy more important.

In this review, we outline the indications and decision making process of considering a patient for a destination therapy LVAD, as well as outcomes, complications, and issues related to management of patients on currently approved devices. The future direction of the field will …

Continuing To Confront Copd International Physician Survey: Physician Knowledge And Application Of Copd Management Guidelines In 12 Countries, Kourtney J. Davis, Sarah H. Landis, Yeon-Mok Oh, David M. Mannino, Meilan K. Han, Thys Van Der Molen, Zaurbek Aisanov, Ana M. Menezes, Masakazu Ichinose, Hana Muellerova

Preventive Medicine and Environmental Health Faculty Publications

AIM: Utilizing data from the Continuing to Confront COPD (chronic obstructive pulmonary disease) International Physician Survey, this study aimed to describe physicians' knowledge and application of the GOLD (Global initiative for chronic Obstructive Lung Disease) Global Strategy for the Diagnosis, Management and Prevention of COPD diagnosis and treatment recommendations and compare performance between primary care physicians (PCPs) and respiratory specialists.

MATERIALS AND METHODS: Physicians from 12 countries were sampled from in-country professional databases; 1,307 physicians (PCP to respiratory specialist ratio three to one) who regularly consult with COPD, emphysema, or chronic bronchitis patients were interviewed online, by telephone or face …

The Bubbling Aorta, Hesham R. Omar, Maya Guglin

The VAD Journal

We are presenting the image of the bubbles in the descending aorta in a patient on VA ECMO.

Classification Of Current Anticancer Immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P Colombo, Lisa Coussens, Madhav V Dhodapkar, Alexander M Eggermont, Douglas T Fearon, Wolf H Fridman, Jitka Fučíková, Dmitry I Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M Kirkwood, Eva Klein, Alexander Knuth, Claire E Lewis, Roland Liblau, Michael T Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J Melief, Elizabeth A Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E Peter, Kenneth J Pienta, Angel Porgador, George C Prendergast, Gabriel A Rabinovich, Nicholas P Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J Smyth, Daniel E Speiser, Radek Spisek, Pramod K Srivastava, James E Talmadge, Eric Tartour, Sjoerd H Van Der Burg, Benoît J Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S Weber, Theresa L Whiteside, Jedd D Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer

Kimmel Cancer Center Faculty Papers

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification …

Efek Fraksi N-Heksana Kulit Hylocereus Polyhizus Terhadap Kadar Malondialdehida Tikus Stres Oksidatif, Wirna Maya Sari, Sri Wahdaningsih, Eka Kartika Untari

Pharmaceutical Sciences and Research

Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential used natural exogenous antioxidant. The aim of this research was to study the effect of n-hexane fraction of H.polyhizus peel on MDA level and to determine the dose that could reduce the MDA level. H.polyhizus peel was macerated with chloroform, fractionated with n-Hexane. Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H.polyhizus peel extract group treated with dose I (10mg/ 200gbw), …

Efek Fraksi N-Heksana Kulit Hylocereus Polyrhizus Terhadapaktivitas Katalase Tikus Stres Oksidatif, Eka Kartika Untari, Sri Wahdaningsih, Agustia Damayanti

Pharmaceutical Sciences and Research

Production of excess free radicals cause oxidative damage and degenerative diseases. Catalase enzyme is one of the endogenous intracellular antioxidant that can be reduced by oxidative stress conditions. The peel of red dragon fruit (Hylocereus polyrhizus) as a potent exogenous antioxidants could support the internal enzyme activity to prevent free radicals. The aim of this research was to determine the effect of n-hexane fraction of H.polyrhizus’s peel and the dose that could increase activity of catalase. The peel was maserated with chloroform, then fractionated by n-hexane. Stress condition was achieved by five days fasting and swimming for 10 mins/day to …

Formulasi Krim Antioksidan Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea Batatas (L.) Lamk) Sebagai Anti Aging, Damaranie Dipahayu, Widji Soeratri, Mangestuti Agil

Pharmaceutical Sciences and Research

No abstract provided.

Antibakteri Fraksi N-Heksana Kulit Hylocereus Polyrhizus Terhadap Staphylococcus Epidermidis Dan Propionibacterium Acnes, Sri Wahdaningsih, Eka Kartika Untari, Yunita Fauziah

Pharmaceutical Sciences and Research

Acne can be caused by Staphylococcus epidermidis and Propionibacterium acnes. By using antibiotic for the acne theraphy in a long term period can cause resistance, organ detriment and imunohypersensitivity. Red dragon fruit’s peel (Hylocereus polyrhizus) is one of natural materials which can be used for alternative antibacterial. This study aims to determine the antibacterial activity of n-Hexane fraction of red dragon fruit’s peel against S. epidermidis dan P. acnes by the method of disc diffusion Kirby-Bauer. Red dragon fruit’s peel powder macerated within chloroform, and macerate then fractionated with n-Hexane. Phytochemical screening result red dragon fruit’s peel contains terpenoid and …