Medicine and Health Sciences Commons^™

Asbestos Exposure In The Research Laboratory, Ediberto D. Garcia

USF Tampa Graduate Theses and Dissertations

Introduction: Asbestos has been employed in a myriad of industrial applications for more than a century. Of the 181 Mt of asbestos produced worldwide, over 31 Mt was consumed in the U.S. The production and consumption of this mineral eventually was found to cause asbestosis, lung cancer and mesothelioma. While the brunt of the human exposure to asbestos occurred in insulation work, many more workers in other jobs were expose to asbestos fibers. Very little is known about the potential exposure to asbestos in research labs.

Goal: In order to investigate potential research lab work exposures, we simulated lab work …

Effects Of Speech Production Ability On A Measure Of Speech Perception Capacity In Young Children With Cochlear Implants And Their Articulation-Matched Peers, Victoria Beatriz Gonzalez

USF Tampa Graduate Theses and Dissertations

With reductions in the age criterion for cochlear implantation, the need for age-appropriate measures of speech perception skills has increased. One recently developed tool that shows great promise for the clinical assessment of auditory speech perception capacity in young children with cochlear implants is the On-Line Imitative Test of Speech-Pattern Contrast Perception (OlimSpac). The OlimSpac requires a child to imitate nonword utterances by providing a verbal response. The child's perceptual abilities are inferred from the child's productions through having a listener, who is masked to the stimulus select the utterance produced by the child in an eight-alternative force-choice task. Although …

Practitioners' Use Of Clinical Practice Guidelines: An Evidence-Based Approach, Sondra Michelle Phipps Santana

UNF Graduate Theses and Dissertations

Pre-diabetes is a serious health problem in the United States. Distinguished by plasma glucose levels that are above the normal threshold, patients with pre-diabetes are 10 times more likely to develop type 2 diabetes. Patients with pre-diabetes suffer the same complications as patients with diabetes including diabetic retinopathy, nephropathy, and microalbuminuria.

There is considerable evidence to support the idea that early identification and aggressive treatment of pre-diabetes has the potential to delay disease progression. The American Diabetes Association’s clinical practice guideline recommends management of with lifestyle modification and metformin for patients who are at risk for developing type 2 diabetes. …

Het Gebruik Van Risicotaxatie Instrumenten Onder Spv-En (The Use Of Risk Assessment Instruments Among Community Psychiatric Nurses), Sophie De Valk, Corine De Ruiter, Jorge Folino, Matthew Large, Thierry Pham, Kim Reeves, Carolina Condemarin, Louise Nielsen, Martin Rettenberger, Robyn Mei Yee Ho, Verónica Godoy-Cervera, Kimberlie Dean, Maria Francisca Rebocho, Karin Arbach-Lucioni, Martin Grann, Katharina Seewald, Michael W. Doyle, Sarah Desmarais, Richard Van Dorn, Randy Otto, Jay Singh

Faculty Scholarship

Dutch Abstract: Auteur en een groot aantal alumni-collega's van de Universiteit van Maastricht, hebben gekeken welke risicotaxatie-instrumenten SPV-en gebruiken om het risico van recidive in te schatten bij clienten uit de forensische psychiatrie. Met behulp van START kan volgens hen het risico voor anderen, het risico op victimisatie, risico op zelfbeschadigend gedrag, suïcidegevaar, ongeoorloofde afwezigheid, middelenmisbruik en zelfverwaarlozing bij deze forensische groep vastgesteld worden.

English Abstract: The author and colleagues from the University of Maastricht investigated the use of structured risk assessment instruments in forensic psychiatry. Using instruments such as the START may aid in the assessment of violence, victimization, …

Time-Stepping For Laser Ablation, Harihar Khanal, David Autrique, Vasilios Alexiades

Publications

Nanosecond laser ablation is a popular technique, applied in many areas of science and technology such as medicine, archaeology, chemistry, environmental and materials sciences. We outline a computational model for radiative and collisional processes occurring during ns-laser ablation, and compare the performance of various low and high order time-stepping algorithms.

Hydrodynamic Modeling Of Ns-Laser Ablation, David Autrique, Vasilios Alexiades, Harihar Khanal

Publications

Laser ablation is a versatile and widespread technique, applied in an increasing number of medical, industrial and analytical applications. A hydrodynamic multiphase model describing nanosecond-laser ablation (ns- LA) is outlined. The model accounts for target heating and mass removal mechanisms as well as plume expansion and plasma formation. A copper target is placed in an ambient environment consisting of helium and irradiated by a nanosecond-laser pulse. The effect of variable laser settings on the ablation process is explored in 1-D numerical simulations.

Sites Of Alcohol Action At The Glun1/Glun2b Nmda Receptor M3-M4 Domain Intersubunit Interfaces, Yuanhao Zhao, M. Wu, Hong Ren, Robert W. Peoples

Biomedical Sciences Faculty Research and Publications

The N-methyl-D-aspartate (NMDA) receptor has been shown to be one of the most important target sites of alcohol in the central nervous system. We and others have identified positions in the third and fourth membrane-associated (M) domains of both GluN1 and GluN2A subunits that influence alcohol sensitivity. In the structural model of the NMDA receptor based upon the related GluA2 receptor, the outward face of the M3 domain of one subunit type is oriented toward the M4 domain of the other subunit type. We recently reported that four pairs of alcohol-sensitive amino acid positions in GluN1/GluN2A NMDA receptors interact at …

Oxysterols And Parkinson´S Disease. Evidence That Levels Of 24s-Hydroxycholesterol In Cerebrospinal Fluid Correlates With The Duration Of The Disease., Steve Meaney, Anita Lovgren-Sandblom, Lovisa Brodin, Lisette Salveson, Valerio Leoni, Kristian Winge, Sven Palhagen, Per Svenninson

Articles

Oxysterols are important for cholesterol homeostasis in the brain and may be affected in neurodegenerative diseases. The levels of the brain-derived oxysterol 24S-hydroxycholesterol (24S-OH) have been reported to be markedly reduced in the circulation of patients with Parkinson's disease (PD) (Lee et al., Antioxid. Redox Signal. 11 (2009) 407–420). The finding is surprising in view of the fact that other neurodegenerative diseases are associated with relatively modest effects on the circulating levels of 24S-OH. We determined the plasma and cerebrospinal fluid (CSF) levels of 24S-OH and 27-hydroxycholesterol (27-OH) in patients with PD with different disease duration using a highly accurate …

Urban Indian Perspectives Of Traditional Indian Medicine, Annette Squetimkin-Anquoe

Antioch University Dissertations & Theses

American Indians (AI) represent two percent of the United States population with over five hundred and sixty federally recognized tribes. In comparison to mainstream society AI show disparate rates for a number of health conditions. While some AI use traditional forms of medicine and healing practices that encompass mind-body-spirit approaches, studies conducted on the topic of Traditional Indian Medicine (TIM) among American Indians are sparse. Considering the fact that two thirds of the entire AI population currently lives in urban areas, it is timely to learn more about how TIM is seen by them. The purpose of this study was …

Existential Concerns Of Individuals Living With Chronic Mental Illness In Guam, Christina Maria B. Dela Cruz

Antioch University Dissertations & Theses

Individuals living with chronic mental illness experience a host of challenges associated with the symptoms of their illness. In an effort to help restore healthy functioning, mental health treatment for individuals with chronic mental illness thus focuses primarily on symptom reduction and management. Recent research exploring the lived experience of individuals with chronic mental illness suggests that apart from their symptoms, these individuals also encounter existential issues related to the self, relationships with others, temporality, making meaning out of the illness experience, and managing life with the illness. At the same time, however, this research has tended to focus on …

The Role Of Agency In Community Health Outcomes: Local Health Departments And Childhood Immunization Coverage Rates, James Anthony Ransom

Antioch University Dissertations & Theses

Organizational culture is defined as a system of shared meaning held by members of an organization that distinguishes it from other organizations. How organizational culture is experienced in the public sector, particularly local health departments (LHDs), is not well understood. The purpose of this study was to determine whether LHD organizational culture impacts childhood immunization coverage rates. I used a modified organizational culture survey tool, the Organizational Management Survey, to quantify organizational culture and determine whether an LHD's organizational culture helps explain variations in childhood immunization coverage rates. In addition, qualitative data from an earlier study of LHD immunization staff …

The Two-Phase Arterial Blood Flow With Or Without A Catheter And In The Presence Of A Single Or Multi Stenosis, Ani E. Garcia, Daniel N. Riahi

School of Mathematical & Statistical Sciences Faculty Publications

We consider the problem of blood flow in an artery with or without a catheter and in the presence of single or multi stenosis whose shape is based on the available experimental data for the stenosis in a human’s artery. The presence of stenosis in the artery, which locally narrows portion of the artery, can be a result of fatty materials such as cholesterol in the blood. The use of catheter is important as a standard tool for diagnosis and treatment in patience whose blood flow passage in the artery is affected adversely by the presence of the stenosis within …

Plain Packaging For Cigarettes Improves Retail Transaction Times, Owen B. Carter, Matthew Welch, Brennen W. Mills, Tina Phan, Paul Chang

Research outputs 2013

No abstract provided.

Association Between Γ-Glutamyl Transferase And Metabolic Syndrome: A Cross-Sectional Study Of An Adult Population In Beijing, Lixin Tao, Xia Li, Huiping Zhu, Yue Gao, Yanxia Luo, Wei Wang, Zhaoping Wang, Dongning Chen, Lijuan Wu, Xiuhua Guo

Research outputs 2013

The relationship between liver enzymes and clustered components of metabolic syndrome (MetS) is explored and the predictive power of γ-glutamyl transferase (GGT) for the diagnosis of MetS in an adult population in Beijing is investigated. A total of 10,553 adults aged 20-65 years who underwent health examinations at Beijing Tongren Hospital in 2012 were enrolled in the study. Multivariate logistic regression analysis is conducted to determine the associations between the levels of various liver enzymes and clustered components of MetS. A receiver operating characteristic analysis is used to determine the optimal cut-off value of GGT for the diagnosis of MetS. …

The Ecology Of Medical Care In Beijing, Shuang Shao, Feifei Zhao, Jing Wang, Lei Feng, Xiaoqin Lu, Juan Du, Yuxiang Yan, Chao Wang, Yinghong Fu, Jingjing Wu, Xinwei Yu, Kaykeng Khoo, Youxin Wang, Wei Wang

Research outputs 2013

Background: We presented the pattern of health care consumption, and the utilization of available resources by describing the ecology of medical care in Beijing on a monthly basis and by describing the socio-demographic characteristics associated with receipt care in different settings. Methods: A cohort of 6,592 adults, 15 years of age and older were sampled to estimate the number of urbanresident adults per 1,000 who visited a medical facility at least once in a month, by the method of three-stage stratified and cluster random sampling. Separate logistic regression analyses assessed the association between those receiving care in different types of …

Tackling Overweight And Obesity: Does The Public Health Message Match The Science?, Katherine Hafekost, David Lawrence, Francis Mitrou, Therese O'Sullivan, Stephen Zubrick

Research outputs 2013

Background: Despite the increasing understanding of the mechanisms relating to weight loss and maintenance, there are currently no validated public health interventions that are able to achieve sustained long-term weight loss or to stem the increasing prevalence of obesity in the population. We aimed to examine the models of energy balance underpinning current research about weight-loss intervention from the field of public health, and to determine whether they are consistent with the model provided by basic science. EMBASE was searched for papers published in 2011 on weight-loss interventions. We extracted details of the population, nature of the intervention, and key …

A Review Of Cricket Fielding Requirements, D Macdonald, John B. Cronin, J Mills, Michael Mcguigan, R Stretch

Research outputs 2013

Cricket is played in three formats at elite level: Test, One Day and Twenty20. Fielding is an important component of cricket, as all players are obliged to field. However, there is a paucity of literature on fielding compared with that on batting and bowling. We review the available literature in terms of technical, mental, physiological and physical factors important to fielding, to identify knowledge gaps and better understand the performance requirements of fielding in cricket.

Characteristics And Quality Of Life Of Patients Presenting To Cancer Support Centres: Patient Rated Outcomes And Use Of Complementary Therapies, Bonnie J. Furzer, Kemi E. Wright, Anna S. Petterson, Karen E. Wallman, Timothy R. Ackland, David Jl Joske

Research outputs 2013

Background: In order to effectively target and provide individualised patient support strategies it is crucial to have a comprehensive picture of those presenting for services. The purpose of this study was to determine the characteristics and patient rated outcomes of individuals presenting to SolarisCare cancer support centres and their choices regarding complementary and integrated therapies (CIT).Methods: A cohort with a current or previous cancer diagnosis aged 18 - 87 years presenting to a SolarisCare centre during a 5-day period completed a questionnaire. Four SolarisCare centres participated in the trial including regional and metropolitan locations. Outcomes included medical and demographic characteristics, …

Retinal Vascular Biomarkers For Early Detection And Monitoring Of Alzheimer's Disease, Shawn Frost, Yogi Kanagasingam, Hamid Sohrabi, J Vignarajan, P Bourgeat, Olivier Salvado, Victor Villemagne, Christopher Rowe, S Lance Macaulay, Cassandra Szoeke, Kathryn A. Ellis, David Ames, Colin L. Masters, Stephanie Rainey-Smith, Ralph N. Martins

Research outputs 2013

The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes …

Multiplex Biomarkers In Blood, Veer Bala Bala Gupta, Ramani Sundaram, Ralph N. Martins

Research outputs 2013

Advances in the field of blood biomarker discovery will help in identifying Alzheimer's disease in its preclinical stage, allowing treatment to be initiated before irreversible damage occurs. This review discusses some recent past and current approaches being taken by researchers in the field. Individual blood biomarkers have been unsuccessful in defining the disease pathology, progression and thus diagnosis. This directs to the need for discovering a multiplex panel of blood biomarkers as a promising approach with high sensitivity and specificity for early diagnosis. However, it is a great challenge to standardize a worldwide blood biomarker panel due to the innate …

Lifestyle Factors, Medication Use And Risk For Ischaemic Heart Disease Hospitalisation: A Longitudinal Population-Based Study, Anthony S. Gunnell, K Einarsdottir, Daniel A. Galvao, S Joyce, S Tomlin, Vicki J. Graham, Caroline Mcintyre, Robert U. Newton, T Briffa

Research outputs 2013

Background:Lifestyle factors have been implicated in ischaemic heart disease (IHD) development however a limited number of longitudinal studies report results stratified by cardio-protective medication use.Purpose:This study investigated the influence of self-reported lifestyle factors on hospitalisation for IHD, stratified by blood pressure and/or lipid-lowering therapy.Methods:A population-based cohort of 14,890 participants aged 45+ years and IHD-free was identified from the Western Australian Health and wellbeing Surveillance System (2004 to 2010 inclusive), and linked with hospital administrative data. Adjusted hazard ratios for future IHD-hospitalisation were estimated using Cox regression.Results:Current smokers remained at higher risk for IHD-hospitalisation (adjusted HR=1.57; 95% CI: 1.22-2.03) after adjustment …

Rationale, Design And Methods For A Community-Based Study Of Clustering And Cumulative Effects Of Chronic Disease Processes And Their Effects On Ageing: The Busselton Healthy Ageing Study, A James, M Hunter, L Straker, J Beilby, R Bucks, T Davis, R H. Eikelboom, D Hillman, J Hui, J Hung, M Knuiman, D A. Mackey, Robert U. Newton, L J. Palmer, A W. Musk, Investigator Group Busselton Healthy Ageing Study

Research outputs 2013

Background: The global trend of increased life expectancy and increased prevalence of chronic and degenerative diseases will impact on health systems. To identify effective intervention and prevention strategies, greater understanding of the risk factors for and cumulative effects of chronic disease processes and their effects on function and quality of life is needed.The Busselton Healthy Ageing Study aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. Longitudinal (3-5 yearly) follow-up is planned. Methods/design. Phase I (recruitment) is a cross-sectional community-based prospective cohort study involving up to 4,000 'Baby Boomers' …

The Emotional Intelligence Of A Group Of Critical-Care Nurses In South Africa, Amanda Towell, Elzabe Nel, Ann Muller

Research outputs 2013

Critical-care nurses often look after three or more critically-ill patients during a shift. The workload and emotional stress can lead to disharmony between the nurse’s body, mind and spirit. Nurses with a high emotional intelligence have less emotional exhaustion and psychosomatic symptoms; they enjoy better emotional health; gain more satisfaction from their actions (both at work and at home); and have improved relationships with colleagues at work. The question arises: what is the emotional intelligence of critical-care nurses? A quantitative survey was conducted. The target population was registered nurses working in critical-care units who attended the Critical Care Congress 2009 …

Immune Response To Snake Envenoming And Treatment With Antivenom; Complement Activation, Cytokine Production And Mast Cell Degranulation, Shelley Stone, Geoffrey K. Isbister, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Ariaranee Ariaratnam, Tamara E. Jacoby-Alner, Claire L. Cotterell, Simon G A Brown

Research outputs 2013

Background:Snake bite is one of the most neglected public health issues in poor rural communities worldwide. In addition to the clinical effects of envenoming, treatment with antivenom frequently causes serious adverse reactions, including hypersensitivity reactions (including anaphylaxis) and pyrogenic reactions. We aimed to investigate the immune responses to Sri Lankan snake envenoming (predominantly by Russell's viper) and antivenom treatment.Methodology/Principal Findings:Plasma concentrations of Interleukin (IL)-6, IL-10, tumor necrosis factor α (TNFα), soluble TNF receptor I (sTNFRI), anaphylatoxins (C3a, C4a, C5a; markers of complement activation), mast cell tryptase (MCT), and histamine were measured in 120 Sri Lankan snakebite victims, both before and …

Brief Oral Health Promotion Intervention Among Parents Of Young Children To Reduce Early Childhood Dental Decay, Peter Arrow, Joseph Raheb, Margaret Miller

Research outputs 2013

Background: Severe untreated dental decay affects a child's growth, body weight, quality of life as well as cognitive development, and the effects extend beyond the child to the family, the community and the health care system. Early health behavioural factors, including dietary practices and eating patterns, can play a major role in the initiation and development of oral diseases, particularly dental caries. The parent/caregiver, usually the mother, has a critical role in the adoption of protective health care behaviours and parental feeding practices strongly influence children's eating behaviours. This study will test if an early oral health promotion intervention through …

A Systematic Review Of The Impact Of Powered Mobility Devices On Older Adults' Activity Engagement, Ryan W. Fomiatti, Janet E. Richmond, Lois K. Moir, Jeannine L. Millsteed

Research outputs 2013

Purpose: To systematically review the impact powered mobility devices have on engagement in independent occupations for adults with acquired mobility limitations.

Method: Electronic search of CINAHL Plus, Medline, PsychInfo, OT Seeker, Joanna Briggs Institute, and Physiotherapy Evidence Database. Search terms included combinations of words to encompass all terms most likely used for powered mobility.

Results: Eleven studies were eligible for inclusion. One study was a true experimental design; four studies were pre-experimental, and six were nonexperimental. Studies indicated positive improvements to occupational engagement and independence while environmental barriers were identified as negatively impacting occupation and increasing risk of injury or …

Markers Of Circulating Tumour Cells In The Peripheral Blood Of Patients With Melanoma Correlate With Disease Recurrence And Progression, Anna L. Reid, M Millward, Robert Pearce, M Lee, M Frank, A Ireland, L Monshizadeh, Tapan Rai, P Heenan, Sandra Medic, P Kumarasinghe, Melanie R. Ziman

Research outputs 2013

Background: Multimarker quantitative real-time polymerase chain reaction (qRT-PCR) represents an effective method for detecting circulating tumour cells in the peripheral blood of patients with melanoma.

Objectives: To investigate whether the phenotype of circulating melanoma cells represents a useful indicator of disease stage, recurrence and treatment efficacy.

Methods: Peripheral blood was collected from 230 patients with melanoma and 152 healthy controls over a period of 3 years and 9 months. Clinical data and blood samples were collected from patients with primary melanoma (early stages, 0-II, n = 154) and metastatic melanoma (late stages, III-IV, n = 76). Each specimen was examined …

The Economic Benefits Of Increased Levels Of Nursing Care In The Hospital Setting, Diane E. Twigg, Elizabeth Geelhoed, Alexandra Bremner, Christine M. Duffield

Research outputs 2013

Aim: To assess the economic impact of increased nursing hours of care on health outcomes in adult teaching hospitals in Perth, Western Australia.

Background: Advancing technology and increased availability of treatment interventions are increasing demand for health care while the downturn in world economies has increased demand for greater efficiency. Nurse managers must balance nurse staffing to optimize care and provide efficiencies.

Design: This longitudinal study involved the retrospective analysis of a cohort of multi-day stay patients admitted to adult teaching hospitals.

Methods: Hospital morbidity and staffing data from September 2000 until June 2004, obtained in 2010 from a previous …

Myocardial Infarction: Sex Differences In Symptoms Reported To Emergency Dispatch, Linda L. Coventry, Alexandra Bremmer, Ian Jacobs, Judith Finn

Research outputs 2013

Background: Emergency management of myocardial infarction (MI) is time-critical, because improved patient outcomes are associated with reduced time from symptom onset to definitive care. Previous studies have identified that women are less likely to present with chest pain.

Objective: We sought to measure the effect of sex on symptoms reported to the ambulance dispatch and ambulance times for MI patients.

Methods: The Western Australia Emergency Department Information System (EDIS) was used to identify patients with emergency department (ED) diagnoses of MI (ST-segment elevation MI and non–ST-segment elevation MI) who arrived by ambulance between January 1, 2008, and October 31, 2009. …

Having A Greater Proportion Of Registered Nurses In A Respiratory Care Centre Is Associated With Fewer Urinary Infections And Increased Successful Ventilator Weaning, Diane E. Twigg

Research outputs 2013

This study explored the impact of skill mix model changes on patient outcomes in a critical care environment, specifically, a respiratory care centre based in a southern Taiwan medical centre. It identified that the cost of ventilator-dependent patients in Taiwan in 1999 was 3.5 billion New Taiwan dollars, equivalent to US$ 121 million. In this context, controlling the costs of healthcare while maintaining quality care became critical. This research examined two skill mix staffing models, a mixed registered nurse (RN) and nursing aid model and a 100% RN model, and their impact on patient outcomes. Patient outcomes were pressure ulcers, …