Medicine and Health Sciences Commons^™

Alopecia Areata: An Overview, Chaya Gestetner

The Science Journal of the Lander College of Arts and Sciences

This review seeks to find the most efficient treatment for alopecia areata. Alopecia is not very well understood as demonstrated by the unsatisfactory treatment options. The author reviewed many studies with different treatment options and concluded that treatment with Diphenylcyclopropenone (DPCP), a topical sensitizer, has the best results and that extensive research into the pathogenesis of alopecia areata is still necessary and may result in better treatment options for those afflicted with the disease.

The Pathogenesis And Treatment Of Gout, Daniel Silberstein

The Science Journal of the Lander College of Arts and Sciences

In the past, the etiology of gout was simplistically believed to be based in the generous indulgence of rich foods and alcohol. However, research has revealed that gout has complex environmental and genetic origins. Specifically, researchers have begun to focus attention on the molecular basis of gout and its related features. These features include hyperuricemia, the stages of gout, and the decreased solubility of uric acid. Furthermore, with epidemiologic evidence indicating that the prevalence of gout is consistently rising, it is imperative that medical providers understand the research-based guidelines for treatment. This includes what medications to administer, monitoring for drug-induced …

Efficacy Of Probiotics Lactobacillus Rhamnosus Gg And Saccharomyces Boulardii In The Treatment Of Antibiotic-Associated Diarrhea And Clostridium Diffiicile-Associated Disease, Estie Klugmann

The Science Journal of the Lander College of Arts and Sciences

Antibiotic therapy may cause serious side effects. Two disturbing effects of antibiotic administration are antibiotic-associated diarrhea and Clostridium difficile-associated disorder. Antibiotic-associated diarrhea occurs as a direct result of the normal flora destruction due to the antibiotics - which do not discriminate against pathogens or healthy forms of bacteria. C. diff disorder also occurs as an indirect result of antibiotic administration, because the destruction of the normal flora prevents people from having healthy bacteria to prevent disease. There have been studies conducted to determine if replacing the destroyed normal flora with probiotics, or beneficial microorganisms will prevent or treat these conditions. …

What Is The Role Of Incretin Mimetics In The Treatment Of Type 2 Diabetes?, Isaac Silberstein

The Science Journal of the Lander College of Arts and Sciences

Type 2 diabetes mellitus (DM) is an intricate disorder defined by insulin resistance, impaired insulin secretion, hyperglycemia, and both microvascular and macrovascular complications. Standard antidiabetic agents like metformin, insulin, sulfonylureas and thiazolidinediones are often insufficient at glucoregulation and do not address the decline in beta cell function that characterizes type 2 diabetes. Moreover, the adverse effects of some of these pharmaceuticals, such as hypoglycemia and weight gain, are disappointing and further limit their clinical utility. Research demonstrates that the actions of two potent incretins. Glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), address these concerns as they stimulate beta …

The Effects Of Emotional Experiences On Memory Processing, Naomi Berkowitz

The Science Journal of the Lander College of Arts and Sciences

Neural regions, specifically the amygdala, hippocampus, and prefrontal cortex overlap in functions of emotion and memory, indicating a degree of interrelatedness between the two functions. Lesions in medial temporal lobe regions result in an impairment of memory processes specific to emotional stimuli. Additionally, amygdala activity is increased for all valence memory as opposed to neutral. Arousal levels of high and low valence memories affect the pathway for encoding in the brain, and determine the vividness and episodic detail with which a memory will be recorded. The amygdala-hippocampal network is involved in high arousal memory, while a prefrontal cortex-hippocampal network is …

Is There An Alternative Way Of Treating Drug Resistant Epilepsy? The Effects Of The Ketogenic Diet In Children With Intractable Epilepsy, Chaya M. Weinberg

The Science Journal of the Lander College of Arts and Sciences

Many children with epilepsy experience seizures that cannot be resolved with medication. Since surgical intervention is not always an option, the ketogenic diet (KD). a high fat, low carbohydrate and protein diet, offers a chance for seizure reduction and in some cases freedom from seizures and medication. Side effects do exist, although none are serious. Efficacy has been proven through many studies. The mechanism of the KD's effectiveness is still unknown, although several hypotheses exist, including the theory that ketone bodies themselves are anticonvulsant, and the hypothesis that glucose restriction stops seizures. Adenosine A1 receptors are also thought to have …

The Common Allergic Mechanism Of Rhinitis And Asthma, Esther Feinstein

The Science Journal of the Lander College of Arts and Sciences

Allergic rhinitis and asthma are closely linked diseases which are very prevalent within the population, affecting millions. They are both characterized by chronic airway inflammation. They are often present in the same patients and rhinitis is even considered an independent risk factor for asthma. Treating allergic rhinitis can reduce the severity of asthma. Mechanisms connecting the two have been researched for many years. Studies show that they have a similar allergic mechanism that is mediated by the same cells. The allergic inflammation is characterized by the presence of eosinophils and is mediated by T-helper type 2 lymphocytes. The circulation of …

Cytoplasmic Actin: Structure And Function, Justin Konig

The Science Journal of the Lander College of Arts and Sciences

Cytoplasmic actin plays a crucial role in cellular structure, cell motility, intracellular transportation, and the cell cycle. Two isoforms of cytoplasmic actin have been identified, β and γ. Although their amino acid sequence is nearly identical, these two isoforms are encoded by different genes located on different chromosomes. Recent research has found that, despite their similarities, the two isoforms of cytoplasmic actin have distinct functions. This paper will review the structural and functional differences between the two isoforms, concluding with a discussion of some mutations that have been linked to disease.

Huntington's Disease And Its Effect On The Brain, Shaina Rivkin-Drizin

The Science Journal of the Lander College of Arts and Sciences

Huntington's disease is a neurodegenerative disease that leads to gradual extensive brain damage, especially in the striatum and the cerebral cortex. Initial symptoms are cognitive difficulties, loss of motor contra and sudden mood imbalances. Cognitive function slowly declines into dementia, coupled with behavioral and psychiatric problems. Sufferers die within 20 years due to illness complications: a fall, pneumonia, or heart disease (Walker, 2007). This paper reviews the principle biological cause of the disease, its effect on the brain, diagnosis, and treatment.

Are Epidermal Barrier Defects Responsible For The Underlying Pathology Of Atopic Dermatitis?, Naomi Davis

The Science Journal of the Lander College of Arts and Sciences

Atopic dermatitis, often referred to as eczema, is a chronic inflammatory skin condition frequently seen in young children. It is a complex disease involving environmental factors, genetics and immune dysregulation. There is currently no cure with conflicting opinions from physicians regarding treatment and management. A clearer understanding of pathogenesis of atopic dermatitis can hopefully lead to new and improved treatment options for patients. Current evidence seems to support epidermal skin barrier defects as the cause of this disease. This paper seeks to investigate if this out-in hypothesis can be responsible as the sole pathogenesis of atopic dermatitis. To write this …

Microparticle Function, Leorra Kohen

The Science Journal of the Lander College of Arts and Sciences

Microparticles are emerging as an integral part of the vascular system. The microparticles are derived from stimulated or apoptotic endothelial cells, platelets, and leukocytes. They are involved in coagulation and regular cell function. Excessive numbers of microparticles contribute to artherosclerosis, chronic renal failure, and metabolic syndrome. Microparticle levels may be reduced by medications, relieving symptoms for awhile. Studies are being done to predict disease by counting microparticles. Further research must be done to understand and make use of microparticles.

Role Of Microrna-155 In A Mouse Model Of Colon Cancer., Claire Mitchell Midyette

Theses and Dissertations

Colorectal cancer remains the third most common malignancy and the fourth most common cause of cancer mortality worldwide. Dysregulated miRNA levels are associated with several types of malignancies and may serve as important biomarkers and/or therapeutic targets in colorectal cancer. We examined the role of miRNA-155 on tumorigenesis and associated symptoms using a well-characterized mouse model of colorectal cancer. C57BL/6 wild-type mice and miRNA-155-/- mice (n=7-13 group) were given a single injection of AOM (10mg/Kg) followed by 3 cycles of DSS (2% in the water for 1 week followed by 2 weeks of plain water). A C57BL/6 wild-type group that …

Description And Service Innovation In Adolescent Transition Within Kentucky State Agency Education Programs, Amy C. Marshall

Theses and Dissertations--Rehabilitation Sciences

Of all Kentucky youth, state agency children are at the highest risk of making unsuccessful post-secondary transitions to adulthood. The intent of both studies comprising this dissertation was to understand and guide transition planning to make future improvements to transitions of adolescents in state agency programs.

The Kentucky Youth at Risk in Transition Study was a mixed methods study that identified and described the understandings of student transitions in state agency education programs from the perspectives of youth and administrators. The study included 105 nontraditional education programs funded and supervised by the Kentucky Educational Collaborative for State Agency Children (KECSAC). …

Developing The Rehabilitation Education For Caregivers And Patients (Recap) Model: Application To Physical Therapy In Stroke Rehabilitation, Megan M. Danzl

Theses and Dissertations--Rehabilitation Sciences

Patient and caregiver education is recognized as a critical component of stroke rehabilitation and physical therapy practice yet the informational needs of stroke survivors and caregivers are largely unmet and optimal educational interventions need to be established. The objective of this dissertation was to develop a theory and model of “Rehabilitation Education for Caregivers and Patients” (RECAP) in the context of physical therapy and stroke rehabilitation, grounded in the experiences and perceptions of stroke survivors, their caregivers, and physical therapists.

Qualitative research methods with a novel grounded theory approach were used. Potential constructs of RECAP were identified from existing research. …

A Comparison Of Upper Extremity Function Between Female Breast Cancer Survivors And Healthy Controls: Typical Self- Report Of Function, Motion, Strength And Muscular Endurance, Mary Insana Fisher

Theses and Dissertations--Rehabilitation Sciences

Many women who have experienced breast cancer (BC) report continued impairments in upper extremity (UE) function beyond the time required for normal healing after surgical treatment. Most research supporting this has not made comparisons between survivors of breast cancer (BCS) to a sample of healthy women. This lack of comparison to a healthy cohort prevents an understanding of whether continued deficits in UE function are due to normal aging or the BC treatment.

The purpose of this research was to compare quality of life (QOL) and UE function among long term breast cancer survivors and similar aged women without cancer. …

Predictors Of Outcome Following Standardized Rehabilitation For Patients With Shoulder Pain, Stephanie D. Moore

Theses and Dissertations--Rehabilitation Sciences

Shoulder dysfunction is frequently treated and persistent symptoms are common. Differential diagnosis of shoulder injuries can be challenging and knowledge of a diagnosis alone does not appear to be enough information to predict outcomes. Determination of a set of factors that predict outcome would assist clinicians in making the most effective treatment decision for patients with shoulder pain. The purposes of this dissertation were to investigate patient-clinician agreement in an orthopedic population of patients with shoulder pain and to determine what combination of factors best predicts positive patient-reported outcome following standardized rehabilitation in patients with shoulder pain.

In the first …

Anterior Cruciate Ligament Prevention: Effect Of Neuromuscular Training Compliance On Muscular Strength Development, Daisuke Sugimoto

Theses and Dissertations--Rehabilitation Sciences

The anterior cruciate ligament (ACL) originates from posterior part of the medial side of the lateral condyle of femur to anterior intercondylar notch between a transverse meniscal ligament and medial side of medial meniscus of tibia. Once ACL is disrupted, pain, effusion and atrophy are commonly observable and cause functional disability. Because of the functional limitations, athletic participation is severely restricted. ACL injury is more prevalent in physically active females compared to their male counterparts in the sports of basketball and soccer in high school and collegiate levels.

Several attributes of females are considered risk factors for the higher ACL …

Impact Of Computer Experience On The Viability And Repeatablity Of The Moorfields Motion Displacement Test In A Developing And Underserved African Setting, James Loughman, Carmen Gonzalez Alvarez, Gay Mary Verdon-Roe, Roger Anderson, Ramos Antonio Manuel, Kovin Naidoo

Articles

Background: The current study was designed to explore the effect of computer experience on the viability and testretest repeatability of the Moorfields Motion Displacement Test (MMDT), a novel computer-driven glaucoma screening device, in an African community setting. Methods: 164 healthy subjects were recruited from a semi-rural Mozambican environment, and stratified according to computer experience (computer naïve: n=85, computer familiar: n=79). A suprathreshold screening test algorithm was employed, and the global probability of true damage (GPTD), testing time (TT) and false positive (FP) response rate were recorded. The visual field test was conducted twice on the same eye, and results compared …

Relationship Between Fear Of Falling And Mobility Varies With Visual Function Among Older Adults, Orna Donoghue, Harriet Ryan, Eoin Duggan, Ciaran Finucane, George Sava, Hilary Cronin, James Loughman, Rose Anne Kenny

Articles

Aim: The present study examined the association between vision, fear of falling and fear-related activity restriction, and assessed the effect of vision on the relationship between fear of falling and mobility, using data from a nationally representative sample of community-dwelling adults aged ≥50 years. Methods: Participants (n = 5003) completed an interview and health assessment (including Timed Up-and-Go, vision and cognitive tests). Visual acuity and contrast sensitivity were assessed using an Early Treatment Diabetic Retinopathy Study logMAR chart and Functional Vision Analyzer, respectively. Participants self-reported their vision as excellent, very good, good, fair or poor. They were assigned to no …

A Reference Manual For Caregivers Of Individuals With Als, Jessica Pastir, Brianna Woodard

Occupational Therapy Capstones

No abstract provided.

Occupational Therapy In Oncology: A Guide For The Occupational Therapist Working On The Oncology Care Team, Kaitlyn Radi, Anna Schumacher

Occupational Therapy Capstones

No abstract provided.

An Exploratory Study Investigating The Quality Of Life In Parents Of Children With Disabilities, Jeffrey Crain, Rebecca Lang

Occupational Therapy Capstones

The purpose of the study is to investigate caregivers' of children with disabilities perceptions related to their quality of life through engagement in meaningful occupations. Researchers hope that data from this study will contribute to the growing body of literature on caregivers of children with disabilities. Quality of life is an outcome measure that occupational therapists utilize in their practice.

Throughout the course of the study data was collected through the use of a semi structured interview tool. Researchers developed this tool to allow participants to openly express their thoughts, emotions, and experiences related to having a child with a …

A Manual For Caregivers Of Infants And Young Children Who Are At Risk For Or Have Experienced A Tbi: Prevention And Education, Meghan Enabnit, Stephanie Gubbels

Occupational Therapy Capstones

The prevalence of infant TBI, 0 to 4 years of age, is one of the highest population groups to experience TBI (Faul, Xu, Wald, & Coronado, 2010). The age group between 0-4 years old has contributed to 251,546 emergency department visits, 15,239 hospital visits, and 998 deaths (Faul et aI., 2010). The purpose of this scholarly project is to increase awareness and knowledge of infant and young child traumatic brain injury across all contexts, to reduce incidence of traumatic brain injury and re-injury and to promote development for the vulnerable, at-risk, infant and young child population through the creation and …

Motivating The Unmotivated Child: Using Psychosocial Intervention Methods In The School, Kristi Fickes, Kelsey Hoffmann

Occupational Therapy Capstones

Problem: School-based occupational therapists have reported barriers to working with children with psychosocial needs including a limited knowledge of psychosocial methods (Barnes, Beck, Vogel, Grice, & Murphy, 2003; Case-Smith & Archer, 2008). These issues prevent children with motivational and behavioral issues from receiving the best care possible and, in some cases, from receiving therapy at all.

Methods: An extensive literature review was conducted to understand current utilization of psychosocial strategies in school-based occupational therapy practice, barriers therapists experience in applying these strategies, and effective psychosocial strategies for children with motivational issues. Findings of the literature suggested that continuing education was …

Adolescents With Fetal Alcohol Spectrum Disorder: Program For Prevention Of Juveniles Entering The Criminal Justice System, Erin Sykora, René Warzecha

Occupational Therapy Capstones

Purpose: The purpose of the product is to provide adolescents with fetal alcohol spectrum disorder (FASD) who are in a youth juvenile detention center the opportunity to participate in group sessions that will increase their functional occupational performance and decrease behaviors associated with their disorder.

Methodology: An extensive literature review was completed in order to determine the need for services and the information to include within the product. The authors looked at websites related to programming already implemented in Juvenile Centers to gather an idea of how to organize the product. A review of Cole’s 7 Steps was done in …

The Role Of Occupational Therapy In Skilled Dementia Care: Improving Quality Of Life, Kelly Bainbridge, April Benoit

Occupational Therapy Capstones

The occurrence of dementia has been increasing over the years. It is estimated that the number of people with dementia will increase to more than 45 million within the next 20 years (Ferri et al., 2005). This increase will lead to an increased demand for occupational therapists to work with individuals with dementia within skilled care units to meet the vast needs of this population and promote quality of life. Occupational therapists are skilled in working with people with dementia; yet, most occupational therapists do not feel confident in their role with skilled dementia care. This has been found to …

An Intergenerational Leisure Activity Program To Promote Successful Aging, Rachel Becker, Jason Zacharias

Occupational Therapy Capstones

PROBLEM: By the year 2030, older adults who are 65 years of age or older will account for 20% of the US population (Center for Disease Control, 2008); however, the rate of successful aging has decreased 25% from 1998 to 2004 (McLaughlin, Connell, Heeringa, Li, &Roberts, 2009).

PURPOSE: The purpose of this scholarly project is to develop an intergenerational program that will promote successful aging of older adults. METHOD: A literature review was conducted on older adults and successful aging using PubMed, OT search, CINAHL, AJOT, Google scholar, and textbooks. RESULTS: Researchers indicated that intergenerational programs promote successful aging and …

Occupational Therapy For Adolescents: A Nature-Based Interventions Approach, Amanda Cruze, Myrtyce Remus

Occupational Therapy Capstones

PURPOSE: The first purpose of this scholarly project was to address current trends in relation to adolescents’ increased reliance on technology, decreased exposure to natural settings, and utilization of nature in adolescent occupational therapy care. The second purpose of the scholarly project was to provide occupational therapists with an interventions guide for nature-based activities to be used with the adolescent population.

METHOD: A literature review was conducted on adolescents, technology and nature using PubMed, CINAHL, AJOT, OT Search, MESH, Google Scholar, and textbooks.

RESULTS: A review of the literature indicated that the target population, Generation Z, had grown up with …

An Occupation-Based Protocol For Treatment Of Adults With Burn Injury, Lyndsey Felber, Megan Metelak

Occupational Therapy Capstones

People are occupational beings. Occupations build the structure of a client’s day. Thus, occupations give life it’s meaning (Hocking, 2001). Occupational therapists have a holistic viewpoint of clients that focuses on improving their quality of life through meaningful occupations. There is a lack of literature supporting the use of occupationbased intervention with adults with burn injuries. Throughout the literature preparatory and purposeful interventions are prominent for burn rehabilitation. (Holavanahalli et al. 2011, Fung et al., 2010, Parry et al., 2012). According to Richard et al. (2008), current techniques to treat burn injuries have remained unchanged for centuries. They suggest that …

An Occupational Therapy Guide To Assessment Of Executive Function Of Rural Agriculture Workers, Cayleigh Gerstner, Alyssa Lopez

Occupational Therapy Capstones

Purpose: Develop a guide for occupational therapists working with rural agricultural-based individuals’ experiencing cognitive deficits. Methodology: A comprehensive literature review was completed with major topics including the definition of executive functioning, common duties of ranch/farm workers, relationship between executive functioning and work, rural agriculture culture. The goal of the literature review was to gain an understanding of the influence of executive functioning skills on engagement within occupational duties and tasks of rural agriculture workers. Results: An occupational therapy guide was developed to provide a list of common tasks/duties of ranchers/framers and the associated executive functioning skills as well as client …