Medicine and Health Sciences Commons^™

Neuromyelitis Optica In Child: Diagnostic And Therapeutic Challenges, Karolina Dembinski, Maria Gieron-Korthals, Carlos R. Martinez, Lisa Rodriguez

Pediatrics Faculty Publications

Neuromyelitis optica (NMO) is a rare syndrome of severe inflammatory demyelination of the central nervous system, causing attacks of optic neuritis and transverse myelitis. Although uncommon, attention should be given to the proper identification and management of the affected patients. We present a case of a 13-year-old girl with severe neuromyelitis optica. The patient’s initial presentation consisted of encephalopathy and optic neuritis. Approximately 2 months later, coinciding with the weaning of steroid treatment, she presented with ascending paralysis and respiratory failure. She was seropositive for NMO-IgG. Treatment included intravenous immune globulin, steroids, plasmapheresis, and rituximab and was complemented with proper …

Chiral Polarization Scale Of Qcd Vacuum And Spontaneous Chiral Symmetry Breaking, Andrei Alexandru, Ivan Horváth

Anesthesiology Faculty Publications

It has recently been found that dynamics of pure glue QCD supports the low energy band of Dirac modes with local chiral properties qualitatively different from that of a bulk: while bulk modes suppress chirality relative to statistical independence between left and right, the band modes enhance it. The width of such chirally polarized zone – chiral polarization scale Λch – has been shown to be finite in the continuum limit at fixed physical volume. Here we present evidence that Λch remains non–zero also in the infinite volume, and is therefore a dynamical scale in the theory. Our experiments in …

Barriers To Consuming Healthy Food And The Role Of Food Pantries In Improving Diets On Low Income Families, Antoinette M. Sangye

Master of Public Health Program Student Publications

Background: Poor diet and physical inactivity are among the leading preventable causes of deaths in the United States which disproportionately affect people with low income. A healthy diet rich in fruits and vegetables may prevent the most common diet-related chronic conditions.

Objective: This study explores factors that affect the ability of low income American families to consume a healthy diet. It also addresses the role of food pantries in providing nutritious food to families at risk of food insecurity.

Methods: An online survey was emailed to 50 food pantries that are members of The Foodbank Inc., Dayton Ohio. Thirty three …

A Comparison Of Food Inspection Practices Of The U.S. Air Force And Ohio Local Public Health, Danny R. Pizzino, Karen A.N. Rupp

Master of Public Health Program Student Publications

Objective: As Americans consume more meals outside the home, food safety of restaurants is more critical. The purpose of this study is to examine the effect of food service establishment (FSE) inspection frequency on FSE performance. In this study, the U.S. Air Force (USAF) public health system is compared to Ohio local public health departments (Ohio LPHDs). The USAF inspects FSEs more frequently than Ohio LPHDs do. The goal is to determine if this increased frequency leads to higher food safety in the FSEs.

Methods: We reviewed 1482 reports from three USAF bases and 1909 reports from six Ohio LPHDs …

Food Limitation As A Potentially Emerging Contributor To The Asian Vulture Crisis, Fakhar -I- Abbas, Thomas P. Rooney, Jibran Haider, Afsar Mian

Biological Sciences Faculty Publications

It was believed that the reason for decline in Asian vulture population is the drug, Diclofenac sodium (DFS), used in livestock. Even after declaring the DFS use banned by the government, apparent decrease in the population of vultures was reported. Alternate hypothesis was suggested that food limitation may be a cause of Asian vulture crisis in Pakistan. Very recent shifts in livestock utilization observed in Pakistan may present a significant barrier to vulture recovery. Increased livestock utilization is translated to fewer carcasses. Since 2005, no livestock carcasses were found in 1650 km transect in the habitat of vultures. Carcasses recorded …

Game-Based Curricula In Biology Classes: Multi-Level Assessment Of Science Learning, Troy D. Sadler, William L. Romine, Parker E. Stuart

Biological Sciences Faculty Publications

Video games played on computers, game consoles, tablets and smart phones have become a very popular medium in our society. A growing body of scholarship suggests that video games can support substantial learning (for reviews see Gee, 2007; Honey & Hilton, 2011; Squire, 2011). Research has documented ways in which games engage students deeply in thinking, learning, and collaboration (Gee, 2005). Evidence suggests that games can support development of critical thinking (Squire, 2006), creativity (Annetta, Cheng, & Holmes, 2010), and mastery and application of target concepts (Squire, 2011).

Detecting Fatigue In Commercial Flight Operations Using Physiological Measures, Lisa C. Thomas, Kimberly Craig, Christopher Gast, Robert Grube, Mike Muhm, Emma Romig

International Symposium on Aviation Psychology - 2013

The purpose of this study is to determine whether any technology exists to unobtrusively, reliably, and accurately detect symptoms of fatigue in real time before fatigue affects performance. Airline pilots are fitted with a variety of physiological measurement devices (e.g. EEG, blink rate, etc.) that have been demonstrated in the literature to be related to fatigue. Each crew of two pilots performs simulated gate-to-gate flight operations under rested and fatigued conditions, during which physiologic and performance parameters are continuously monitored. In addition, audio, video, and simulator data are recorded for post-session evaluation. Ultimately, if one or more technologies proves effective, …

Enhancing Helicopter-Pilot Obstacle Avoidance Using A Binocular Head-Mounted Display, Dennis B. Beringer, Gena Drechsler

International Symposium on Aviation Psychology - 2013

Twenty-three helicopter pilots flew a simulated Bell 206 in Helicopter Emergency Medical Service (HEMS) scenarios with obstructions present. In Study 1, the head-mounted display (HMD) showed highway-in-the-sky guidance but not obstructions. Study 2 added obstructions (broadcast towers, power lines) in the HMD. Pilots detected and avoided HMD-depicted obstructions earlier than those only shown out the window. Wire strikes were frequent without HMD depictions of obstructions but were greatly reduced when these objects were shown in the HMD. They were completely eliminated when a red warning fence was overlaid on the power-line graphic at the point it transected the flight path. …

Supervisory Control State Diagrams To Depict Autonomous Activity, Michael Patzek, Clayton Rothwell, George Bearden, Benjamin Ausdenmoore, Allen Rowe

International Symposium on Aviation Psychology - 2013

As capabilities of autonomous systems expand, traditional geospatial information displays used for supervisory control will likely need to be augmented with more explicit information on higherorder autonomous activities, such as goal-directed task selection, situation assessment, decisionmaking, and planning. We present a supervisory control interface for higher-order autonomy based on finite state machine diagrams called Layered Pattern Recognizable Interfaces for State Machines (L-PRISM). L-PRISM is a hierarchically arranged set of nested state diagrams coupled with a temporal control and payload viewer. The mission goals and tasks are at the top-most layer and sub-tasks and states at lower layers, providing varying levels …

The Effects Of Stereoscopic Radar Displays On Air Traffic Controller Performance, Jason G. Russi, Brent T. Langhals, Michael E. Miller, Eric Heft

International Symposium on Aviation Psychology - 2013

Controllers identify vertical separation in aircraft depicted on 2-D radar displays by calculating altitude from numerical values. This is used to create a 3-D mental image to determine vertical spacing; a mentally fatiguing practice. Current stereoscopic display technology exists that may allow reduction of this aspect of controller workload. With a near doubling of traffic expected within the next two decades (FAA, 2012), controllers’ abilities to rapidly interpret spacing and maintain awareness will become increasingly imperative to safety. A stereoscopic radar simulator was developed and field-tested with 35 USAF controllers. It presented a top-down view, similar to traditional radar displays, …

Does Supplementary Computer Generated Cueing Enhance Controller Efficiency In A Congested Communication Environment?, Laurienne C.R.A. Santana, Brent T. Langhals, Michael E. Miller, Vic Finomore

International Symposium on Aviation Psychology - 2013

Air traffic controllers are often required to simultaneously communicate with several aircraft over multiple radio frequencies. As a result, during peak loading, it is common for the controller to receive multiple concurrent communications, each from a different aircraft, making it difficult to discern all necessary auditory communications. To address this problem, a modified air traffic control (ATC) interface was prototyped with the goal of increasing controller-to-pilot communication efficiency. This prototype involved an automated text to speech system which displayed supplementary text in an on-screen text box, echoing aircraft transmissions in the event of an indiscernible radio call. The prototype was …

Exploring The Effects Of Working Memory Capacity, Attention, And Expertise On Situation Awareness In A Flight Simulation Environment, Orçun Orkan Özcan, Murat Perit Çakır, Bilge Say

International Symposium on Aviation Psychology - 2013

Simulator pilots are subject to some of the constraints of a real flight situation in a PC based flight simulation. Situation awareness (SA) for simulator pilots was explored in terms of underlying cognitive aspects by analyzing the compound effects of expertise, working memory, inhibition and divided attention. Online and Offline SA measurements were analyzed with expertise and scores of Automated Operation Span Task, Stroop and Coşkunöz visual attention tasks. Regression analyses revealed the expected relationships of simulator pilots’ SA with expertise and inhibition capacity but not with working memory and divided attention capacity. Obtained results were also compared to those …

Review Of Pilot Performance And Pilot-Automation Interaction Models In Support Of Nextgen, Angelia Sebok, Christopher D. Wickens

International Symposium on Aviation Psychology - 2013

Computational models of aircraft pilot performance will gain importance over the next decades, as major evolutions in the national airspace continue to emerge with the NextGen program. Evaluating new technology, or procedures such as self-separation, requires time and resourceconsuming pilot-in-the-loop (PITL) simulations. Models can augment PITL findings and they can help to constrain the scope of PITL simulations. If they are validated, such computational models may actually answer some design questions in place of PITL simulations. This paper summarizes a review of modeling efforts to address pilot performance, and elaborates on pilot-automation interaction models.

Disclosure In Times Of Art: A Relational Analysis Of Social Practices, Anita Hardon, Alice Desclaux, Joe Lugalla

Institute for Educational Development, East Africa

The reach of HIV counseling and testing has grown rapidly since the 2000s, particularly since 2007 when provider-initiated counseling and testing was implemented alongside voluntary counseling and testing and testing for the prevention of mother-to-child transmission. Nevertheless, we still know little about the attendant practices of disclosing HIV-positive status. Persistently high rates of non-disclosure raise difficult ethical, public health and human rights issues. The articles in this special issue show that disclosure practices in Africa not only follow the public health rationality but are shaped by fears of stigma that favor secrecy. They show how practices of disclosure are embedded …

Tracking Transplanted Bone Marrow Stem Cells And Their Effects In The Rat Mcao Stroke Model., Gregory V Goldmacher, Rena Nasser, Daniel Y Lee, Sargon Yigit, Robert Rosenwasser, Lorraine Iacovitti

Farber Institute for Neuroscience Faculty Papers

In this study, rat bone marrow stromal stem cells (BMSCs) were tracked after IV administration to rats with experimental stroke caused by middle cerebral artery occlusion (MCAO). In addition, the effects of BMSC treatment on blood cell composition, brain glia and sensorimotor behavior was studied and compared to that which occurred spontaneously during the normal recovery process after stroke. We found that the vast majority of radiolabeled or fluorescently labeled BMSCs traveled to and remained in peripheral organs (lungs, spleen, liver) 3 days after IV injection in the MCAO rat. Once in the circulation, BMSCs also produced rapid alterations in …

Effect Of Gps Feedback On Lactate Threshold Pacing In Intercollegiate Distance Runners, Jacob W. Smith, Matthew F. Moran, John T. Foley

All PTHMS Faculty Publications

In their roles as coaches, the authors have observed that first-year collegiate distance runners often have difficulty running at prescribed training paces during lactate threshold (LT) training runs. Previous research has validated the accuracy of global positioning system (GPS) devices in providing distance and velocity feedback during running. The purpose of this study was to determine the efficacy of using the Garmin Forerunner 305 GPS watch (Garmin) to reduce deviations from prescribed training paces during LT runs with first-year collegiate runners. Participants were two groups of varsity cross country runners who completed a three-week LT training intervention either with (n …

Graduate-Level Nursing Ph.D. In Nursing Education Entering Class 2013, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Supervisee Experiences Of Corrective Feedback In Clinical Supervision: A Consensual Qualitative Research Study, David Lyle Phelps

Dissertations (1934 -)

Clinical supervision plays an integral role in counselor development, assisting supervisees to transition from educational coursework to clinical practice. Feedback, including that which is corrective, allows supervisors to transmit knowledge to supervisees and communicate evaluations of supervisee performance. Despite the central role of feedback in clinical supervision, surprisingly little empirical attention has focused on supervisee experiences of corrective feedback in clinical supervision. This study sought to provide a deeper understanding of supervisee experiences of corrective feedback in clinical supervision. Twelve participants were interviewed regarding their experience of corrective feedback in clinical supervision during predoctoral psychology internship. Participants expected to receive …

Public Health Bill Draft Requests - 2013 Nv Legislative Session, Nevada Institute For Children's Research And Policy Reports

Nevada Institute for Children's Research and Policy Reports

Public Health Bill Draft Requests - 2013 NV Legislative Session

Impairment Of Trkb-Psd-95 Signaling In Angelman Syndrome, Cong Cao, Mengia S. Rioult-Pedotti, Paolo Migani, Crystal J. Yu, Rakesh Tiwari, Keykavous Parang, Mark R. Spaller, Dennis J. Goebel, John Marshall

Pharmacy Faculty Articles and Research

Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal expression of the maternally inherited Ube3A ubiquitin protein ligase, required for the proteasomal degradation of proteins implicated in synaptic plasticity, such as the activity-regulated cytoskeletal-associated protein (Arc/Arg3.1). Mice deficient in maternal Ube3A express elevated levels of Arc in response to synaptic activity, which coincides with severely impaired long-term potentiation (LTP) in the hippocampus and deficits in learning behaviors. In this study, we sought to test whether elevated levels of Arc interfere with brain-derived neurotrophic factor (BDNF) …

Acute Coronary Syndromes: Current Treatment Guidelines And Updates, Bernard Lau, Michael Lee, Thien Tran, Laura Tsu

Pharmacy Faculty Articles and Research

This home-study CPE activity has been developed to educate pharmacists on acute coronary syndrome (ACS) and its medical management.

What Evidence Is Available On Aldosterone Antagonists For Use In Heart Failure With Preserved Ejection Fraction?, Vivian Loo, Laura Tsu

Pharmacy Faculty Articles and Research

This drug information question and answer sheet discusses the use of aldosterone antagonists for use in heart failure with preserved ejection fraction.

Calcium Phosphate Nanoparticles: A Future Therapeutic Platform For The Treatment Of Osteomyelitis?, Tejal A. Dasai, Vuk Uskoković

Pharmacy Faculty Articles and Research

No abstract provided.

Chikungunya Virus Infection Results In Higher And Persistent Viral Replication In Aged Rhesus Macaques Due To Defects In Anti-Viral Immunity, Ilhem Messaoudi, Jennifer Totonchy, Thomas Totonchy, Craig N. Kreklywich, Kristen Haberthur, Laura Springgay, James D. Brien, Michael S. Diamond, Victor R. Defilippis, Daniel N. Streblow

Pharmacy Faculty Articles and Research

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne Alphavirus that causes a clinical disease involving fever, myalgia, nausea and rash. The distinguishing feature of CHIKV infection is the severe debilitating poly-arthralgia that may persist for several months after viral clearance. Since its re-emergence in 2004, CHIKV has spread from the Indian Ocean region to new locations including metropolitan Europe, Japan, and even the United States. The risk of importing CHIKV to new areas of the world is increasing due to high levels of viremia in infected individuals as well as the recent adaptation of the virus to the mosquito species Aedes …

Aberrant Proliferation In Cxcr7+ Endothelial Cells Via Degradation Of The Retinoblastoma Protein, Jennifer Totonchy, Jessica M. Osborn, Sara Botto, Lisa Clepper, Ashlee V. Moses

Pharmacy Faculty Articles and Research

Angiogenesis is a critical factor in the growth and dissemination of solid tumors. Indeed, tumor vasculature is abnormal and contributes to the development and spread of malignancies by creating a hostile microenvironment. The alternative SDF-1/CXCL12 receptor, CXCR7, is frequently and specifically expressed in tumor-associated vessels. In this study, we examine the role of endothelium-expressed CXCR7 in tumor vascular dysfunction by specifically examining the contribution of CXCR7 to endothelial cell (EC) proliferation. We demonstrate that CXCR7 expression is sufficient to drive post-confluent growth in EC cultures. Further, we provide a novel mechanism for CXCR7-mediated proliferation via proteasomal degradation of the tumor …

Corneal Gene Therapy: Basic Science And Translational Perspective, Rajiv R. Mohan, Jason T. Rodier, Ajay Sharma

Pharmacy Faculty Articles and Research

Corneal blindness is the third leading cause of blindness worldwide. Gene therapy is an emerging technology for corneal blindness due to the accessibility and immune-privileged nature of the cornea, ease of vector administration and visual monitoring, and ability to perform frequent noninvasive corneal assessment. Vision restoration by gene therapy is contingent upon vector and mode of therapeutic gene introduction into targeted cells/tissues. Numerous efficacious vectors, delivery techniques, and approaches have evolved in last decade for developing gene-based interventions for corneal diseases. Maximizing the potential benefits of gene therapy requires efficient and sustained therapeutic gene expression in target cells, low toxicity, …

The Psychology Of Mediation, David A. Hoffman, Richard N. Wolman

Cardozo Journal of Conflict Resolution

The purpose of this article is to provide an overview and summary of a broad range of psychological phenomena and examine their application to mediation. Our goal is to provide mediators-as well as the lawyers and disputants who use mediation-with a guide to navigating the powerful psychological and emotional currents that flow through the mediation process.

Cutaneous Asthenia (Ehlers–Danlos Syndrome) In A Cat, Banu Dokuzeylül, Eli̇f Demet Altun, Tamer Hali̇t Özdoğan, Hasan Hakan Bozkurt, Seçki̇n Serdar Arun, Mehmet Erman Or

Turkish Journal of Veterinary & Animal Sciences

Ehlers-Danlos syndrome (EDS), or dermatosparaxis, is a rare hereditary disease of the connective tissue, which is characterized by skin hyperextensibility and laxity. In the present article, the case of a crossbred female spayed cat, at the age of 2 years, was presented with hyperelasticity of the skin, alopecia, and an ulcerative wound on the left hind leg. The animal's dorsum was hyperextensible, smooth to the touch, and could be easily torn with minor traumas. To the best of the authors' knowledge, the present report is the first documented feline case of cutaneous asthenia in Turkey.

In Vivo Regulation Of Brain-Derived Neurotrophic Factor In Dorsal Root Ganglia Is Mediated By Nerve Growth Factor-Triggered Akt Activation During Cystitis, Li-Ya Qiao, Sharon Yu, Jarren C. Kay, Chun-Mei Xia

Physiology and Biophysics Publications and Presentations

Abstract

The role of brain-derived neurotrophic factor (BDNF) in sensory hypersensitivity has been suggested; however the molecular mechanisms and signal transduction that regulate BDNF expression in primary afferent neurons during visceral inflammation are not clear. Here we used a rat model of cystitis and found that the mRNA and protein levels of BDNF were increased in the L6 dorsal root ganglia (DRG) in response to bladder inflammation. BDNF up-regulation in the L6 DRG was triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reduced BDNF levels during cystitis. The neutralizing NGF antibody also …

Wicking: A Rapid Method For Manually Inserting Ion Channels Into Planar Lipid Bilayers, Justin A. Costa, Dac A. Nguyen, Egdar Leal-Pinto, Ronald E. Gordon, Basil Hanss

Physiology and Biophysics Publications and Presentations

The planar lipid bilayer technique has a distinguished history in electrophysiology but is arguably the most technically difficult and time-consuming method in the field. Behind this is a lack of experimental consistency between laboratories, the challenges associated with painting unilamellar bilayers, and the reconstitution of ion channels into them. While there has be a trend towards automation of this technique, there remain many instances where manual bilayer formation and subsequent membrane protein insertion is both required and advantageous. We have developed a comprehensive method, which we have termed “wicking”, that greatly simplifies many experimental aspects of the lipid bilayer system. …