Medicine and Health Sciences Commons^™

Roadmap...Setting The Course For Patient And Family Involvement In Their Plan Of Care (Poster), Kristina Holleran, Tracie Heckman Msn, Rn, Cmsrn

Patient Care Services / Nursing

No abstract provided.

Establishment Of A Comprehensive Network-Wide Pressure Ulcer Assessment Process: Enhancing Patient Care While Embracing The New Centers For Medicare And Medicaid Services Standards, Carolyn L. Davidson Rn, Phd, Courtney Vose Rn, Msn, Mba, Aprn

Patient Care Services / Nursing

No abstract provided.

Relationship Of Internet-Delivered Mantram Repetition Program To Burnout, Stress Of Conscience, Spiritual Wellbeing, And Mindfulness In Healthcare Workers, Sheryl Leary Phd

Dissertations

This study evaluated the effect of the Mantram Repetition Program (MRP), an internet-delivered stress management course on burnout, stress of conscience, spiritual wellbeing, and mindfulness on a self-selected group of healthcare workers (HCWs). A quasi-experimental repeated measures design was used. Participants enrolled in a six-session MRP delivered over three months and completed baseline, post-course, and three-month post-course assessments. Measurement tools included the Maslach Burnout Inventory-General Survey (MBI-GS), the Stress of Conscience Questionnaire (SCQ), the Functional Assessment of Chronic Illness Therapy Spiritual Wellbeing Scale (FACIT-12), and the Mindfulness Awareness Attention Scale (MAAS). Statistically significant effects of the MRP showed a decrease …

Elevated Blood Glucose Levels In The Emergency Department: Missed Opportunity For Informing And Referring, Melissa D. Rouse Phd, Rn, Cns-Bc, Cen, Hacp, Cphq

Dissertations

The purpose of this research was to examine (1) the rates of elevated blood glucose ≥ 150 mg/dL in adults without a prior history of diabetes, receiving care for a non-diabetes related visit to the ED and (2) Emergency Department provider patterns for informing and referring discharged Emergency Department patients for follow-up of elevated random blood glucose levels. A descriptive, correlational, cross-sectional design, with purposive sample was used. Retrospective chart review was done for patients age 18 and older, treated in two EDs from March 1, 2010 through March 22, 2010. Significant relationships were found between blood glucose level and …

Adjusting Medical School Admission: Assessing Interpersonal Skills Using Situational Judgement Tests, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Context: Todays formal medical school admission systems often include only cognitively oriented tests, although most medical school curricula emphasise both cognitive and non-cognitive factors. Situational judgement tests (SJTs) may represent an innovative approach to the formal measurement of interpersonal skills in large groups of candidates in medical school admission processes. This study examined the validity of interpersonal video-based SJTs in relation to a variety of outcome measures. Methods: This study used a longitudinal and multiple-cohort design to examine anonymised medical school admissions and medical education data. It focused on data for the Flemish medical school admission examination between 1999 and …

The Santa Clara, 2013-01-31, Santa Clara University

The Santa Clara

No abstract provided.

Family Violence Quality Assessment Tool For Primary Care Offices, Therese M. Zink

Family Medicine Faculty Publications

Dr. Zink will discuss the Family Violence Quality Assessment Tool for Primary Care Offices, a modified version of Dr. Coben's Delphi Instrument. The tool may be used to assess family violence efforts in primary care at the beginning and intermittently. It is meant to be a tool for identifying deficiencies so they can be remedied and the care to patients living with violence and abuse can be improved.

Agenda Of 01/31/2013 Hsc Board Of Directors Mtg, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Minutes Of 01/31/2013 Hsc Board Of Directors Mtg, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Two Semis Collide - Fire Ensues; Both Drivers Perish, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

One summer’s night, a 49 year-old semi-truck driver (D1), pulling a flatbed loaded with salvage cars for recycling traveled north on a three-lane state highway. D1 topped a hill, drove through a right curve when the unit rolled onto the driver’s side, slide across the center line and entered a straight stretch approximately half way to the bottom of a hill. As D1’s unit was sliding down the hill in the south bound lanes, a 52 year-old semi-truck driver (D2) hauling bottled beverages was traveling south in the straight stretch up the hill. As D1 slide down the hill, D2 …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Barriers to Cervical Cancer Screening

Imatinib Reverses Doxorubicin Resistance By Affecting Activation Of Stat3-Dependent Nf-Κb And Hsp27/P38/Akt Pathways And By Inhibiting Abcb1, Jonathan T. Sims, Sourik S. Ganguly, Holly Bennett, J. Woodrow Friend, Jessica Tepe, Rina Plattner

Pharmacology and Nutritional Sciences Faculty Publications

Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either resistant to chemotherapy (conventional or targeted) or develop resistance during treatment, and residual chemoresistant cells are highly metastatic. Metastatic cancer cells resist the effects of chemotherapeutic agents by upregulating drug transporters, which efflux the drugs, and by activating proliferation and survival signaling pathways. Previously, we found that c-Abl and Arg non-receptor tyrosine kinases are activated in breast cancer, melanoma, and glioblastoma cells, and promote cancer progression. In this report, we demonstrate that the c-Abl/Arg inhibitor, …

Evaluating Audio Computer Assisted Self-Interviews In Urban South African Communities: Evidence For Good Suitability And Reduced Social Desirability Bias Of A Cross-Sectional Survey On Sexual Behaviour, Roxanne Beauclair, Fei Meng, Nele Deprez, Marleen Temmerman, Alex Welte, Wim Delva, Niel Hens

Obstetrics and Gynaecology, East Africa

Background: Efficient HIV prevention requires accurate identification of individuals with risky sexual behaviour. However, self-reported data from sexual behaviour surveys are prone to social desirability bias (SDB). Audio Computer-Assisted Self-Interviewing (ACASI) has been suggested as an alternative to face-to-face interviewing (FTFI), because it may promote interview privacy and reduce SDB. However, little is known about the suitability and accuracy of ACASI in urban communities with high HIV prevalence in South Africa. To test this, we conducted a sexual behaviour survey in Cape Town, South Africa, using ACASI methods.

Methods: Participants (n = 878) answered questions about their sexual relationships on …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Barriers to Cervical Cancer Screening

Notice Of 01/31/2013 Hsc Board Of Directors Mtg, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Tissue Metabolic Responses To Salt Stress In Wild And Cultivated Barley, Dezhi Wu, Shengguan Cai, Mingxian Chen, Lingzhen Ye, Zhonghua Chen, Haitao Zhang, Fei Dai, Feibo Wu, Guoping Zhang

Publications

A thorough understanding of the mechanisms underlying barley salt tolerance and exploitation of elite genetic resource are essential for utilizing wild barley germplasm in developing barley varieties with salt tolerance. In order to reveal the physiological and molecular difference in salt tolerance between Tibetan wild barley (Hordeum spontaneum) and cultivated barley (Hordeum vulgare), profiles of 82 key metabolites were studies in wild and cultivated barley in response to salinity. According to shoot dry biomass under salt stress, XZ16 is a fast growing and salt tolerant wild barley. The results of metabolite profiling analysis suggested osmotic adjustment was a basic mechanism, …

The Biodiversity Hypothesis And Allergic Disease: World Allergy Organization Position Statement., Tari Haahtela, Stephen Holgate, Ruby Pawankar, Cezmi A. Akdis, Suwat Benjaponpitak, Luis Caraballo, Jeffrey Demain, Jay M. Portnoy, Leena Von Hertzen, Wao Special Committee On Climate Change And Biodiversity

Manuscripts, Articles, Book Chapters and Other Papers

Biodiversity loss and climate change secondary to human activities are now being associated with various adverse health effects. However, less attention is being paid to the effects of biodiversity loss on environmental and commensal (indigenous) microbiotas. Metagenomic and other studies of healthy and diseased individuals reveal that reduced biodiversity and alterations in the composition of the gut and skin microbiota are associated with various inflammatory conditions, including asthma, allergic and inflammatory bowel diseases (IBD), type1 diabetes, and obesity. Altered indigenous microbiota and the general microbial deprivation characterizing the lifestyle of urban people in affluent countries appear to be risk factors …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Barriers to Cervical Cancer Screening

Gut Hormones, Appetite Suppression And Cachexia In Patients With Pulmonary Tb, Suzanne W. Chang, William S. Pan, Daniel Lozano Beltran, Lizet Oleyda Baldelomar, Marco Antonio Solano, Iskra Tuero, Faustino Torrico, Robert H. Gilman

Medicine Faculty Publications

Background

Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unknown.

Methods and Findings

41 subjects with newly-diagnosed pulmonary TB (cases) were compared to 82 healthy controls. We measured appetite, body mass index (BMI), % body fat (BF), plasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects. Measurements were taken at baseline for controls and at treatment days 0, 30, and 60 for cases. Baseline appetite, BMI, and BF were …

Rv Dysfunction By Mri Is Associated With Elevated Transpulmonary Gradient And Poor Prognosis In Patients With Sickle Cell Associated Pulmonary Hypertension, Kim-Lien L. Nguyen, Shoaib Alam, Xin Tian, Steve W. Leung, Catherine Seamon, Caterina P. Minniti, James G. Taylor, Vandana Sachdev, Andrew E. Arai, Gregory J. Kato

Internal Medicine Presentations

Patients with sickle cell disease (SCD) and pulmonary hypertension (PH) have increased mortality. SCD-PH is often complicated by high cardiac output (CO) related to anemia. The transpulmonary gradient (TPG) reflects a pressure differential across the pulmonary vascular bed without the confounding effect of CO (PVR=TPG/CO). Based on the cardiac transplant literature, a TPG ≥ 12 mmHg indicates significant pulmonary arterial hypertension (PAH). With PH, there is often morphologic adaptation by the right ventricle (RV). In idiopathic PAH, RV dilation and decreased function have been correlated with poor prognosis. We hypothesize that patients with SCD and a TPG ≥ 12 mmHg …

Properties Of Ribbon And Non-Ribbon Release From Rod Photoreceptors Revealed By Visualizing Individual Synaptic Vesicles., Minghui Chen, Matthew J. Van Hook, David Zenisek, Wallace B. Thoreson

Journal Articles: Pharmacology & Experimental Neuroscience

Vesicle release from rod photoreceptors is regulated by Ca(2+) entry through L-type channels located near synaptic ribbons. We characterized sites and kinetics of vesicle release in salamander rods by using total internal reflection fluorescence microscopy to visualize fusion of individual synaptic vesicles. A small number of vesicles were loaded by brief incubation with FM1-43 or a dextran-conjugated, pH-sensitive form of rhodamine, pHrodo. Labeled organelles matched the diffraction-limited size of fluorescent microspheres and disappeared rapidly during stimulation. Consistent with fusion, depolarization-evoked vesicle disappearance paralleled electrophysiological release kinetics and was blocked by inhibiting Ca(2+) influx. Rods maintained tonic release at resting membrane …

Genetic Diversity In The Modern Horse Illustrated From Genome-Wide Snp Data, Jessica L. Petersen, James R. Mickelson, E. Gus Cothran, Lisa S. Andersson, Jeanette Axelsson, Ernie Bailey, Danika Bannasch, Matthew M. Binns, Alexandre S. Borges, Pieter Brama, Artur Da Câmara Machado, Ottmar Distl, Michela Felicetti, Laura Fox-Clipsham, Kathryn T. Graves, Gérard Guérin, Bianca Haase, Telhisa Hasegawa, Karin Hemmann, Emmeline W. Hill, Tosso Leeb, Gabriella Lindgren, Hannes Lohi, Maria Susana Lopes, Beatrice A. Mcgivney, Sofia Mikko, Nicholas Orr, M. Cecilia T. Penedo, Richard J. Piercy, Marja Raekallio, Stefan Rieder, Knut H. Røed, Maurizio Silvestrelli, June Swinburne, Teruaki Tozaki, Mark Vaudin, Claire M. Wade, Molly E. Mccue

Veterinary Science Faculty Publications

Horses were domesticated from the Eurasian steppes 5,000-6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits and fitness, has resulted in diverse populations distributed across the world, many of which have become or are in the process of becoming formally organized into closed, breeding populations (breeds). This report describes the use of a genome-wide set of autosomal SNPs and 814 horses from 36 breeds to provide the first detailed description of equine breed diversity. F(ST) calculations, parsimony, and distance analysis demonstrated relationships among the breeds that largely reflect …

Junior Seau, Super Sunday, And Our Most Important Natural Resource, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

2013 January 29 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Nanotubes As Mitochondrial Uncouplers, Patrick G. Sullivan

Neuroscience Faculty Patents

A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca²⁺ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.

Lack Of Resveratrol Neuroprotection In Developing Rats Treated With Kainic Acid, L K. Friedman, B Goldstein, A Rafiuddin, P Roblejo, S Friedman

NYMC Faculty Publications

In adult rats, trans-resveratrol attenuates kainic acid (KA)-induced convulsions and the associated hippocampal neurotoxicity. Increased neuronal survival was correlated with reduced lipid peroxidation. Since free radical generation after KA is age dependent and does not correlate with the onset of seizure-induced injury, the present study investigated whether daily trans-resveratrol treatment in development could protect the juvenile hippocampus from seizures and onset of damage at postnatal (P) day 21. Rat pups were treated with daily injections of trans-resveratrol under three dosage regimens (1-15 mg/kg and 20-50mg/kg). Weight, electroencephalography (EEG), histology, and N-methyl-d-aspartate (NMDA) receptor expression were determined. Malondialdehyde (MDA) concentration was …

Role Of Deregulated Micrornas In Breast Cancer Progression Using Ffpe Tissue, Liang Chen, Youhuai Li, Yebo Fu, Jin Peng, Meng-Hsuan Mo, Michael Stamatakos, Christine B. Teal, Rachel F. Brem, Alexander Stojadinovic, Michael Grinkemeyer, Timothy A. Mccaffrey, Yan-Gao Man, Sidney W. Fu

Pathology Faculty Publications

MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition. Intraductal epithelial proliferations of the breast are histologically and clinically classified into normal, atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). To better understand the progression of ductal breast cancer development, we attempt to identify deregulated miRNAs in this process using Formalin-Fixed, Paraffin-Embedded (FFPE) tissues from breast cancer patients. Following tissue microdissection, we obtained 8 normal, 4 ADH, 6 DCIS and 7 IDC samples, which were subject to RNA isolation …

Assisted Living: Facilities, Financing, And Oversight, Carol O'Shaughnessy

National Health Policy Forum

This publication briefly describes assisted living facilities that provide long-term services and supports to people with functional or cognitive impairments who do not need the level of skilled nursing care offered in nursing homes but cannot live independently. It also describes selected resident characteristics, reviews cost and financing arrangements, and reviews state responsibilities for regulation and oversight of assisted living facilities.

Food Venue Choice, Consumer Food Environment, But Not Food Venue Availability Within Daily Travel Patterns Are Associated With Dietary Intake Among Adults, Lexington Kentucky 2011, Alison A. Gustafson, Jay W. Christian, Sarah Lewis, Kate Moore, Stephanie Jilcott

Dietetics and Human Nutrition Faculty Publications

OBJECTIVE: The retail food environment may be one important determinant of dietary intake. However, limited research focuses on individuals' food shopping behavior and activity within the retail food environment. This study's aims were to determine the association between six various dietary indicators and 1) food venue availability; 2) food venue choice and frequency; and 3) availability of healthy food within food venue.

METHODS: In Fall, 2011, a cross-sectional survey was conducted among adults (n=121) age 18 years and over in Lexington, Kentucky. Participants wore a global position system (GPS) data logger for 3-days (2 weekdays and 1 weekend day) to …

Control Of Candida Albicans Metabolism And Biofilm Formation By Pseudomonas Aeruginosa Phenazines, Diana K. Morales, Nora Grahl, Chinweike Okegbe, Lars E. P. Dietrich, Nicholas J. Jacobs, Deborah A. Hogan

Dartmouth Scholarship

Candidaalbicanshasdevelopmentalprogramsthatgoverntransitionsbetweenyeastandfilamentousmorphologies and between unattached and biofilm lifestyles. Here, we report that filamentation, intercellular adherence, and biofilm develop- ment were inhibited during interactions between Candida albicans and Pseudomonas aeruginosa through the action of P. aeruginosa-produced phenazines. While phenazines are toxic to C. albicans at millimolar concentrations, we found that lower concentrations of any of three different phenazines (pyocyanin, phenazine methosulfate, and phenazine-1-carboxylate) allowed growth but affected the development of C. albicans wrinkled colony biofilms and inhibited the fungal yeast-to-filament transition. Phenazines impaired C. albicans growth on nonfermentable carbon sources and led to increased production of fer- mentation products (ethanol, glycerol, and …