Medicine and Health Sciences Commons^™

What's Happening: February, 2013, Maine Medical Center

What's Happening

No abstract provided.

Assuring Access To Data For Chemical Evaluations, Lynn R. Goldman, Ellen K. Silbergeld

Environmental and Occupational Health Faculty Publications

Background: A database for studies used for U.S. Environmental Protection Agency (EPA) pesticide and chemical reviews would be an excellent resource for increasing transparency and improving systematic assessments of pesticides and chemicals. There is increased demand for disclosure of raw data from studies used by the U.S. EPA in these reviews.

Objectives: Because the Information Quality Act (IQA) of 2001 provides an avenue for request of raw data, we reviewed all IQA requests to the U.S. EPA in 2002–2012 and the U.S. EPA’s responses. We identified other mechanisms to access such data: public access databases, the Freedom of Information Act …

Cytoplasmic Localization Of Alteration/Deficiency In Activation 3 (Ada3) Predicts Poor Clinical Outcome In Breast Cancer Patients., Sameer Mirza, Emad A. Rakha, Alaa Alshareeda, Shakur Mohibi, Xiangshan Zhao, Bryan J. Katafiasz, Jun Wang, Channabasavaiah B. Gurumurthy, Aditya Bele, Ian O. Ellis, Andrew R. Green, Hamid Band, Vimla Band

Journal Articles: Genetics, Cell Biology & Anatomy

Transcriptional activation by estrogen receptor (ER) is a key step to breast oncogenesis. Given previous findings that ADA3 is a critical component of HAT complexes that regulate ER function and evidence that overexpression of other ER coactivators such as SRC-3 is associated with clinical outcomes in breast cancer, the current study was designed to assess the potential significance of ADA3 expression/localization in human breast cancer patients. In this study, we analyzed ADA3 expression in breast cancer tissue specimens and assessed the correlation of ADA3 staining with cancer progression and patient outcome. Tissue microarrays prepared from large series of breast cancer …

Sickle Cell Disease In Pregnancy: Trend And Pregnancy Outcomes At A Tertiary Hospital In Tanzania, Projestine S. Muganyizi, Hussein Kidanto

Faculty of Health Sciences, East Africa

SCD in pregnancy is associated with increased adverse fetal and maternal outcomes. In Tanzania where the frequency of sickle cell trait is 13% there has been scanty data on SCD in pregnancy. With progressive improvement in childhood survival the burden of SCD in pregnancy will increase. We analyzed all deliveries at Muhimbili National Hospital (MNH) from 1999 to 2011. Fetal and maternal outcomes of SCD deliveries were compared with non-SCD. Data were analyzed using IBM SPSS statistics version 19. Chi square and Fisher Exact tests were used to compare proportions and the independent t-test for continuous data. To predict risks …

Pterygium Recurrence Related To Its Size And Corneal Involvement, Pir Salim Mahar, Nabeel Manzar

Section of Ophthalmology

Objective: To establish the usefulness of grading system based on the size and extent of corneal involvement in predicting recurrence in patients undergoing primary pterygium excision with intraoperative use of adjunctive topical Mitomycin-C (MMC).
Study Design: A case series.
Place and Duration of Study: Section of Ophthalmology, the Aga Khan University Hospital, Karachi, from 2005 till 2010.
Methodology: One hundred and twenty male patients (120 eyes) underwent surgical removal of pterygium using bare sclera method with MMC in concentration of 0.2 mg/ml (0.02%) with exposure time of 3 minutes. Classification of subjects was done according to the grading of pterygium. …

Contemporary Therapeutic Aquatics: Interprofessional Course, Marcia Levinson, Pt, Phd, Mft, Martha Langley Ankeny, M.Ed. M.Ed., E. Adel Herge, Otd, Otr/L

Academic Commons and Scott Memorial Library Staff Papers and Presentations

Aquatic therapy can meet the needs of individuals from childhood to older adulthood with a variety of health conditions, and, in certain situations, is preferable to land-based therapy. Information on this specialized area of practice is minimally covered in entry-level occupational and physical therapy curricula, yet aquatic therapy is a rapidly expanding area of practice.

Inflammatory Biomarker Changes And Their Correlation With Framingham Cardiovascular Risk And Lipid Changes In Antiretroviral-Naive Hiv-Infected Patients Treated For 144 Weeks With Abacavir/Lamivudine/Atazanavir With Or Without Ritonavir In Aries., Benjamin Young, Kathleen E Squires, Lisa L Ross, Lizette Santiago, Louis M Sloan, Henry H Zhao, Brian C Wine, Gary E Pakes, David A Margolis, Mark S Shaefer

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Propensity for developing coronary heart disease (CHD) is linked with Framingham-defined cardiovascular risk factors and elevated inflammatory biomarkers. Cardiovascular risk and inflammatory biomarkers were evaluated in ARIES, a Phase IIIb/IV clinical trial in which 515 antiretroviral-naive HIV-infected subjects initially received abacavir/lamivudine + atazanavir/ritonavir for 36 weeks. Subjects who were virologically suppressed by week 30 were randomized 1:1 at week 36 to either maintain or discontinue ritonavir for an additional 108 weeks. Framingham 10-year CHD risk scores (FRS) and risk category of

Alcohol And Prescription Drug Safety In Older Adults, Faika Zanjani, Aasha I. Hoogland, Brian G. Downer

Graduate Center for Gerontology Faculty Publications

BACKGROUND: The objectives of this study were to investigate older adults' knowledge of prescription drug safety and interactions with alcohol, and to identify pharmacists' willingness to disseminate prescription drug safety information to older adults.

METHODS: The convenience sample consisted of 48 older adults aged 54-89 years who were recruited from a local pharmacy and who completed surveys addressing their alcohol consumption, understanding of alcohol and prescription drug interactions, and willingness to change habits regarding alcohol consumption and prescription drugs. To address pharmacist willingness, 90 pharmacists from local pharmacies volunteered and answered questions regarding their willingness to convey prescription drug safety …

Drivers Killed Due To Tire Failures, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To Prevent Tire Failures,

Employers should:

• Ensure that routine maintenance is performed on work vehicles
• Implement and enforce an employer seat belt safety program

Employees should:

• Be properly trained in safe work vehicle operation
• Perform routine pre-trip and post-trip inspections, including inspection of the tires
• Ensure that tires do not run below 80% of the recommended pressure

Clinical Application Of Nightingale’S Environmental Theory, Shirin Rahim

School of Nursing & Midwifery

Florence Nightingale (1820-1910) the first nursing theorist and the first one to lay the foundation of modern nursing has based her philosophy on spiritualism. Selanders (2010) quotes (Cook, 1913, Vol. 1, p. 15) in saying, that “She records in her diary an interaction with God at age 16 when He “called her to His service” (p.82). Her devotion towards God and her belief of spirituality was the foundation of almost all that Nightingale did as a nurse and for nursing profession. (Allighood and Tommy 2010). Nightingale has taken the same premise for her environmental theory. In this theory Nightingale (1860) …

Mindfulness-Based Relapse Prevention For Substance Craving., Katie Witkiewitz, Sarah Bowen, Haley Douglas, Sharon H Hsu

Articles, Abstracts, and Reports

Craving, defined as the subjective experience of an urge or desire to use substances, has been identified in clinical, laboratory, and preclinical studies as a significant predictor of substance use, substance use disorder, and relapse following treatment for a substance use disorder. Various models of craving have been proposed from biological, cognitive, and/or affective perspectives, and, collectively, these models of craving have informed the research and treatment of addictive behaviors. In this article we discuss craving from a mindfulness perspective, and specifically how mindfulness-based relapse prevention (MBRP) may be effective in reducing substance craving. We present secondary analyses of data …

Future Competencies Needed For The Direct Service Workforce, William Spears, Carla Clasen, Katherine L. Cauley

Population and Public Health Sciences Faculty Publications

The aging of the baby boom generation and health care policy changes represented by the Affordable Care act create challenges for the long term care industry in America. In 2011 the first of the baby boomers turned 65 years old. By 2030 a total of 78 million baby boomers, 19% of the population, will be 65 or more years old and eligible for Medicare (U.S. Census Bureau 2010). Discussions of potential health care worker shortages often focus on the need for more physicians and nurses to care for an aging population. These changes are putting pressure on long term care …

Acute Respiratory Distress Syndrome-A Concise Clinical Review, Erfan Hussain, Fahad Hamid

Department of Medicine

Acute Respiratory Distress Syndrome (ARDS) is a challenging and deadly disease faced by critical care specialists. The literature concerning ARDS has been increasing for the last 12 years and there are now many options available to treat this disease. However, not all of these options work and some may even be harmful to patients. The purpose of this paper is to provide the reader with a review of the new criteria for ARDS definition and to discuss the pros and cons of the various treatment options now available.

蓬瀛仙館 : 探討患有「抑鬱症」長者的服務提供狀況 - 早期防治工作的成效評估, Asia-Pacific Institute Of Ageing Studies, Lingnan University 嶺南大學亞太老年學研究中心

APIAS Research Report 研究報告

是次計劃希望全面地評估蓬瀛仙館現時為長者所提供的抑鬱症前期服務，並提出服務建議，作日後改善及發展長者抑鬱症服務之參考，計劃目標如下：

一. 評估機構現時對長者抑鬱症前期服務提供的狀況；

二. 了解服務使用者對長者抑鬱症服務的期望與現時機構提供的前期服務兩者之間的差距，作為日後服務改進以及發展之參考；

三. 對機構提供之長者抑鬱症前期服務提出改善方案，以及為將來機構發展全方位的長者抑鬱症服務提供發展框架；

四. 為機構提供系統性之長者抑鬱症服務評估框架，以便機構日後作定期的服務評估。

Caveolin-1 Deficiency Induces Spontaneous Endothelial-To-Mesenchymal Transition In Murine Pulmonary Endothelial Cells In Vitro., Zhaodong Li, Peter J. Wermuth, Bryan S. Benn, Michael P. Lisanti, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

It was previously demonstrated that transforming growth factor β (TGF-β) induces endothelial-to-mesenchymal transition (EndoMT) in murine lung endothelial cells (ECs) in vitro. Owing to the important role of caveolin-1 (CAV1) in TGF-β receptor internalization and TGF-β signaling, the participation of CAV1 in the induction of EndoMT in murine lung ECs was investigated. Pulmonary ECs were isolated from wild-type and Cav1 knockout mice using immunomagnetic methods with sequential anti-CD31 and anti-CD102 antibody selection followed by in vitro culture and treatment with TGF-β1. EndoMT was assessed by semiquantitative RT-PCR for Acta2, Col1a1, Snai1, and Snai2; by immunofluorescence for α-smooth muscle actin; and …

Characteristics, Sexual Behaviour And Risk Factors Of Female, Male And Transgender Sex Workers In South Africa, Marlise L. Richter, M. Chersich, Marleen Temmerman, Stanley Luchters

Obstetrics and Gynaecology, East Africa

Background. In South Africa, information on sex workers’ characteristics, sexual behaviour and health needs is limited. Current social, legal and institutional factors impede a safe working environment for sex workers and their clients.

Objectives. To describe characteristics and sexual behaviour of female, male and transgender sex workers, and assess their risk factors for unprotected sex.

Methods: Repeat cross-sectional surveys among sex workers were conducted in Hillbrow, Sandton, Rustenburg and Cape Town in 2010. Sex workers were interviewed once; any re-interviews were excluded from analysis. Unprotected sex was defined as any unprotected penetrative vaginal or anal sex with last two clients. …

Block Copolymer Cross-Linked Nanoassemblies Improve Particle Stability And Biocompatibility Of Superparamagnetic Iron Oxide Nanoparticles, Mo Dan, Daniel F. Scott, Peter A. Hardy, Robert J. Wydra, J. Zach Hilt, Robert A. Yokel, Younsoo Bae

Pharmaceutical Sciences Faculty Publications

PURPOSE: To develop cross-linked nanoassemblies (CNAs) as carriers for superparamagnetic iron oxide nanoparticles (IONPs).

METHODS: Ferric and ferrous ions were co-precipitated inside core-shell type nanoparticles prepared by cross-linking poly(ethylene glycol)-poly(aspartate) block copolymers to prepare CNAs entrapping Fe(3)O(4) IONPs (CNA-IONPs). Particle stability and biocompatibility of CNA-IONPs were characterized in comparison to citrate-coated Fe(3)O(4) IONPs (Citrate-IONPs).

RESULTS: CNA-IONPs, approximately 30 nm in diameter, showed no precipitation in water, PBS, or a cell culture medium after 3 or 30 h, at 22, 37, and 43°C, and 1, 2.5, and 5 mg/mL, whereas Citrate-IONPs agglomerated rapidly (> 400 nm) in all …

Compliant Head Probe For Positioning Electroencephalography Electrodes And Near-Infrared Spectroscopy Optodes, Paolo Giacometti, Solomon G. Diamond

Dartmouth Scholarship

A noninvasive head probe that combines near-infrared spectroscopy (NIRS) and electroencephalography (EEG) for simultaneous measurement of neural dynamics and hemodynamics in the brain is presented. It is composed of a compliant expandable mechanism that accommodates a wide range of head size variation and an elastomeric web that maintains uniform sensor contact pressure on the scalp as the mechanism expands and contracts. The design is intended to help maximize optical and electrical coupling and to maintain stability during head movement. Positioning electrodes at the inion, nasion, central, and preauricular fiducial locations mechanically shapes the probe to place 64 NIRS optodes and …

Sex And Hormonal Influences On Seizures And Epilepsy, Jana Velíšková, Kara A. Desantis

NYMC Faculty Publications

Epilepsy is the third most common chronic neurological disorder. Clinical and experimental evidence supports the role of sex and influence of sex hormones on seizures and epilepsy as well as alterations of the endocrine system and levels of sex hormones by epileptiform activity. Conversely, seizures are sensitive to changes in sex hormone levels, which in turn may affect the seizure-induced neuronal damage. The effects of reproductive hormones on neuronal excitability and seizure-induced damage are complex to contradictory and depend on different mechanisms, which have to be accounted for in data interpretation. Both estradiol and progesterone/allopregnanolone may have beneficial effects for …

Oncolog, Volume 58, Number 02, February 2013, Bryan Tutt, Jill Delsigne

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Chronic Viral Hepatitis in Cancer Patients Requires Personalized Management: Chronic viral hepatitis is life-threatening for many patients but curable or manageable for others. But in patients who have both viral hepatitis and cancer, cancer treatment may exacerbate the viral infection and lead to other complications, such as liver failure or even death
• Managing Sleep Disorders in Cancer Patients: Quality sleep is essential to healing, to proper immune function, and even to mental health. Conversely, lack of sleep has been associated with depression, anxiety, and decreased cognitive function. In cancer patients, poor sleep reduces quality of life; nevertheless, most cancer patients …

Management Of Upper Aerodigestive Tract Bleeding In Patients On Ecmo., Hitoshi Hirose, Md, Phd, Meredith Harrison, Md, Adam I. Baker, Md, Nicholas C. Cavarocchi, Md

Department of Surgery Faculty Papers

Introduction: Bleeding complications on Extracorporeal Membrane Oxygenation (ECMO) are often encountered. In a review of our own series, it was found that upper aero digestive tract bleeding was common and management was often difficult. We propose an algorithm to help manage upper aero digestive tract bleeding in the anticoagulated, ECMO patient. Hypothesis: Once an ECMO patient fails conservative management for upper aero digestive bleeding, more aggressive measures will prove successful, which will provide benefit to the patient. Methods: A retrospective chart review was performed of the patients who underwent venovenous or veno-arterial ECMO at our institution between July 2010 and …

Time Management Strategies For Research Productivity, Jo-Ana D. Chase, Robert V. Topp, Carol E. Smith, Marlene Z. Cohen, Nancy Fahrenwald, Julie Zerwic, Lazelle E. Benefield, Cindy M. Anderson, Vicki Conn

College of Nursing Faculty Research and Publications

Researchers function in a complex environment and carry multiple role responsibilities. This environment is prone to various distractions that can derail productivity and decrease efficiency. Effective time management allows researchers to maintain focus on their work, contributing to research productivity. Thus, improving time management skills is essential to developing and sustaining a successful program of research. This article presents time management strategies addressing behaviors surrounding time assessment, planning, and monitoring. Herein, the Western Journal of Nursing Research editorial board recommends strategies to enhance time management, including setting realistic goals, prioritizing, and optimizing planning. Involving a team, problem-solving barriers, and early …

Principles Of Periodontology, Andrew R. Dentino, Seokwoo Lee, Jason Mailhot, Arthur F. Hefti

School of Dentistry Faculty Research and Publications

Periodontal diseases are among the most common diseases affecting humans. Dental biofilm is a contributor to the etiology of most periodontal diseases. It is also widely accepted that immunological and inflammatory responses to biofilm components are manifested by signs and symptoms of periodontal disease. The outcome of such interaction is modulated by risk factors (modifiers), either inherent (genetic) or acquired (environmental), significantly affecting the initiation and progression of different periodontal disease phenotypes. While definitive genetic determinants responsible for either susceptibility or resistance to periodontal disease have yet to be identified, many factors affecting the pathogenesis have been described, including smoking, …

Examining Advances In Technology And Hospitality Information Strategy, Robert J. Kauffman, P. Oconnor

Research Collection School Of Computing and Information Systems

Hospitality managers have turned to IT to streamline reservations, capture new customer data, and build market share. Internet-based reservations, advertising and communication, social media, and mobile phones offer technology-led opportunities for value cocreation with customers. We aim to stimulate sharing of new ideas, current applications and emerging managerial know-how for the hospitality industry, while bringing new submissions to CQ.

Osteochondritis Dissecans Development After Bone Contusion Of The Knee In The Skeletally Immature: A Case Series, Kevin G. Shea, John C. Jacobs Jr., Nathan L. Grimm, Ronald P. Pfeiffer

Kinesiology Faculty Publications and Presentations

Osteochondritis dissecans (OCD) is thought to be an acquired osteochondral disorder, and its etiology may be multi-factorial. Trauma, both acute and repetitive events, has previously been proposed as a potential cause for OCD development. We present two cases of skeletally immature males who developed a symptomatic OCD lesion following a femoral condyle bone contusion. These cases suggest that an acute traumatic event may lead to the development of OCD of the knee.

An Intervention To Improve Adherence And Management Of Symptoms For Patients Prescribed Oral Chemotherapy Agents: An Exploratory Study, Sandra L. Spoelstra, Barbara A. Given, Charles W. Given, Marcia Grant, Alla Sikorskii, Mei You, Veronica Decker

Peer Reviewed Articles

Background: The use of oral chemotherapy agents to treat cancer has increased. Patients are responsible for adhering to complex dosing regimens, while monitoring and managing symptoms from side effects of the chemotherapy at home.

Objective: This study examined an intervention to manage symptoms and promote adherence to oral chemotherapy agents.

Intervention and Methods: A 3 group exploratory pilot study determined how an Automated Voice Response (AVR) system alone (N=40), or the AVR with strategies to manage symptoms and adherence (N=40), or the AVR with strategies to manage adherence (N=39) reduced symptom severity and improved adherence. Participants received a Symptom Management …

Distribution Of Dyssynchrony In Subjects With No Known Cardiac Disease And Comparison Of Velocity Vector Imaging To Color-Coded Tissue Doppler Imaging., Anoop C Parameswaran, Bhaskar Purushottam, Aman Amanullah, Vincent M. Figueredo, M.D.

Division of Cardiology Faculty Papers

Data on the distribution of dyssynchrony in subjects with normal ejection fraction (EF) and normal QRS are scarce. We studied 100 subjects with no known cardiac disease (52% male, mean age 60 ± 17 years) using velocity vector imaging (VVI). Seventeen percent had septal to lateral (S-L) wall longitudinal delay >75 msec, 63% of subjects had S-L wall radial delay >75 msec, and 25% had a circumferential opposing wall delay >100 msec. Those with circumferential opposing wall delay of >100 msec had a lower EF (57 ± 5% vs. 62 ± 5%, P < 0.05). In an additional group of 33 patients, we compared the longitudinal dyssynchrony parameters as assessed by VVI and tissue Doppler imaging (TDI) and found them to be comparable. In conclusion, we find significant variation in time to peak velocities in subjects with no known cardiac disease, who had a normal left ventricular ejection fraction and QRS duration. VVI is comparable to TDI.

Comparison Of Clinical And Csf Profiles In Children With Tuberculous And Pyogenic Meningitis; Role Of Csf Protein: Glucose Ratio As Diagnostic Marker Of Tuberculous Meningitis, Farah Naz Qamar, Arshalooz Jamila Rahman, Sania Iqbal, Khadija Humayun

Department of Paediatrics and Child Health

Objectives: To compare the clinical and laboratory features of tuberculous meningitis with bacterial meningitis and to determine if protein glucose ratio in the cerebrospinal fluid can be predictive of the condition.
Methods: It was a retrospective descriptive study at the Paediatric Ward of Aga Khan University Hospital, Karachi, for which records of 46 patients with tuberculous meningitis and 33 with bacterial meningitis were reviewed. All records related to the study period that was from January 2005 to October 2010. The records were retrieved in December 2010. Tuberculous meningitis was defined as illness > or = 14 days, basal enhancement or tuberculoma …

Visual Performance In Patients With Neovascular Age Related Macular Degeneration Undergoing Treatment With Intravitreal Ranibizumab, Sarah Sabour-Pickett, James Loughman, John M. Nolan, Jim Stack, Pesudovs Pesudovs, Katherine A. Meagher, Stephen Beatty

Articles

Purpose. To assess visual function and its response to serial intravitreal ranibizumab (Lucentis, Genentech) in patients with neovascular age-related macular degeneration (nv-AMD).

Methods. Forty-seven eyes of 47 patients with nv-AMD, and corrected distance visual acuity (CDVA) logMAR 0.7 or better, undergoing intravitreal injections of ranibizumab, were enrolled into this prospective study. Visual function was assessed using a range of psychophysical tests, while mean foveal thickness (MFT) was determined by optical coherence tomography (OCT).

Results. Groupmean (±sd)MFT reduced significantly frombaseline (233±59)) to exit (205±40)) (p = 0.001). CDVA exhibited no change between baseline and exit visits (p = 0.48 …

Comparison Of Manual Versus Automated Data Collection Method For An Evidence-Based Nursing Practice Study, Matthew D. Byrne, T R. Jordan, Tamara Welle

Articles

OBJECTIVE:

The objective of this study was to investigate and improve the use of automated data collection procedures for nursing research and quality assurance.

METHODS:

A descriptive, correlational study analyzed 44 orthopedic surgical patients who were part of an evidence-based practice (EBP) project examining post-operative oxygen therapy at a Midwestern hospital. The automation work attempted to replicate a manually-collected data set from the EBP project.

RESULTS:

Automation was successful in replicating data collection for study data elements that were available in the clinical data repository. The automation procedures identified 32 "false negative" patients who met the inclusion criteria described in …