Medicine and Health Sciences Commons^™

Acute To Subchronic Toxicity And Reproductive Effects Of Aqueous Ethanolic Extract Of Rhizomes Of Lasia Spinosa Thw. In Male Rats, Theerayuth Kaewamatawong, Wanwipa Suthikrai, Anong Bintvihok, Wijit Banlunara

The Thai Journal of Veterinary Medicine

Acute and subchronic tests on the toxicity and reproductive effects of aqueous ethanolic extract of rhizomes of Lasia spinosa Thw. was studied in male rats. In the acute test, oral administration of 5, 10, 20, 40 g/kg of the extract showed no mortality or behavioral changes. In the subchronic test, administration of 5 or 20 g/kg of the extract for 28 days revealed no mortality of the animals. No differences in hematological parameters were observed in either control or treatment groups of both tests. For blood chemistry analysis in both tests, triglycerides in treatment rats were significantly decreased compared to …

Sds-Page Electrophoresis For Urinary Protein Analysis In Dogs With Chronic Kidney Disease And Urinary Tract Infection, Orapun Jaturakan, Manisin Vanichwatanaramlouk, Arunrat Kornkaew, Monkon Trisiriroj, Winai Chansaisakorn, Siripen Komolvanich, Kittipong Tachampa, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

The objective of the present study was to investigate urinary protein profiles in dogs with chronic kidney disease (CKD) in comparison to dogs with urinary tract infection (UTI). Animals were divided into 4 groups: control, CKD stages II+III, CKD stage IV and UTI. Blood pressure was measured using oscillometric method. Blood was collected for determinations of packed cell volume (PCV), blood urea nitrogen (BUN) and plasma creatinine concentrations. Urine was collected for urinalysis and protein determination. Total urinary proteins were measured using semi-quantitative method by precipitation with sulfosalicylic acid and a standard SDS-polyacrylamide gel electrophoresis (SDS-PAGE) which were presented as …

Changing The View On Specialized Treatment: The Interdisciplinary Approach, Ginger Bailey Mba, Rn, Cnor

Patient Care Services / Nursing

No abstract provided.

Decreasing Turnover Time In The Operating Room: A Multidisciplinary Challenge, Patricia Cressman, Denise M. Lawyer Rn, Deborah Schantzenbach Rn, Cnor

Patient Care Services / Nursing

No abstract provided.

Suggestive Evidence For Association Between L-Type Voltage-Gated Calcium Channel (Cacna1c) Gene Haplotypes And Bipolar Disorder In Latinos: A Family-Based Association Study, Suzanne Gonzalez, Chun Xu, Mercedes Ramirez, Juan Zavala, Regina Armas, Salvador A. Contreras, Javier Contreras, Albana Dassori, Robin J. Leach, Michael A. Escamilla

Health & Biomedical Sciences Faculty Publications

Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and bipolar disorder (BP) in European and European-American cohorts. We performed a family-based association study to determine whether CACNA1C is associated with BP in the Latino population.

Methods: This study included 913 individuals from 215 Latino pedigrees recruited from the USA, Mexico, Guatemala, and Costa Rica. The Illumina GoldenGate Genotyping Assay was used to genotype 58 single-nucleotide polymorphisms (SNPs) that spanned a 602.9-kb region encompassing the CACNA1C gene including two SNPs (rs7297582 and rs1006737) previously …

Personal And Relationship Challenges Of Adults With Type 1 Diabetes, Paula M. Trief Phd, Jonathan G. Sandberg, Jacqueline A. Dimmock Phd, Patricia J. Forken Ba, Ruth S. Weinstock Md, Phd

Faculty Publications

Little is known about the psychosocial challenges of adults living with type 1 diabetes or its impact on partner relationships. This qualitative study was undertaken to gain better understanding of these issues.

Expressing Emotions Through Participation In Painting, Molly Bathje

The Open Journal of Occupational Therapy

The cover of the Winter 2013 Open Journal of Occupational Therapy, titled Miles eMOTION, was created by Miles Scharfenberg, an 18-year-old young man with multiple developmental impairments. Miles’ story and his artwork provide a reflection on the ways in which creativity and art can enhance the lives of people with disabilities and their families. Miles’ art exists because of his drive toward engagement and participation in life, but also essential is his mother’s commitment to providing opportunities for him to be creative. The Miles eMOTION series of paintings can inspire occupational therapists, families, caregivers, and people with disabilities to …

Online Learning Of Safe Patient Transfers In Occupational Therapy Education, Cynthia L. Hayden

The Open Journal of Occupational Therapy

Online higher education is steadily increasing. For programs in allied health to be offered effectively in an e-learning format, clinical psychomotor skills need to be addressed. The aim of this research was to design, implement, and evaluate an online safe patient transfers module for occupational therapy assistant (OTA) students. The efficacy of teaching safe patient transfers in an e-learning environment was appraised using both quantitative and qualitative analysis. The applied research project was completed at a Tennessee community college. A convenience sample of eighteen students participated in the pilot study. Twenty-five students participated in the subsequent study. The instructional design …

The Training And Use Of Service Dogs In Occupational Therapy Education, Mary Isaacson

The Open Journal of Occupational Therapy

The purpose of this study is to describe the role of occupational therapy fieldwork students in the training of service dogs. Ethnography is an approach that strives to explore and describe the point of view of people. Ethnographers view the researcher as an instrument to gain insight into the subject. This researcher utilized her own experiences as an occupational therapist, an occupational therapy educator, and as a volunteer dog trainer of service dogs. She then validated the process through interviews with key informants. The results indicate that occupational therapists and occupational therapy students are capable of playing a significant role …

International Occupational Therapists Continuing Education Needs And Opportunities: A Survey, Husny Amerih

The Open Journal of Occupational Therapy

Occupational therapists (OTs) are expected to maintain up-to-date knowledge and clinical competence by engaging in continuing professional education (CPE). The objective of this research was to obtain information on CPE needs and opportunities in developed and developing countries. A survey was created and emailed to 520 OTs in various countries, asking questions about CPE requirements, opportunities, and the avenues of CPE available to OTs. One hundred-nineteen OTs from 17 different countries responded. Of the 119 OTs, 28 practice in developing countries and 91 practice in developed countries. Thirty-nine percent of the OTs in developing countries stated that they have certain …

An Evaluation Of The Potential Effectiveness Of A Tai Chi Program For Health Promotion Among People With Severe Mental Illness, Ann M. Chapleau, Diane Powers Dirette

The Open Journal of Occupational Therapy

In response to the significant health disparities among persons with severe mental illness (SMI), this pilot study was developed to evaluate the potential effectiveness of a Tai Chi program provided to adults who are members of a psychosocial clubhouse program. A non-randomized, controlled pretest-posttest design was used, and qualitative data from a program evaluation survey is shared to provide insight into the strengths and limitations of this explorative study. A simplified, beginner-level Tai Chi program was provided twice a week for 12 weeks. Changes in cardiac and pulmonary function and perceived quality of health were measured. Results support the potential …

Functional Improvement In Older Adults After A Falls Prevention Pilot Study, Pei-Fen J. Chang, Yong-Fang Kuo

The Open Journal of Occupational Therapy

Falls are a costly, disabling, and life-threatening risk in the elderly. Improvements in physical function, balance, lower extremity strength, and health-related quality of life are hypothesized to help mitigate fall risk. In this pilot study, six women and men with an average age of 81 years participated in a 6-week exercise and education program created to reduce risk of falls. Evaluations were made at baseline and at 6 weeks on four tests: the Functional Status Questionnaire, the Berg Balance Scale (BBS), the Six-minute Walk Test, and the World Health Organization Quality of Life–BREF 26-question test. Scores indicated significant improvement in …

A Survey To Determine The Reliability Of Dynamometer And Pinch Gauge Dial Readings Among Certified Hand Therapists, Theodore I. King Ii

The Open Journal of Occupational Therapy

Using a cross-sectional descriptive study design, surveys were mailed to 200 randomly selected certified hand therapists of the American Society of Hand Therapists (ASHT) to determine how they document analog dynamometer and pinch gauge dial readings. Three different needle settings for the dynamometer and pinch gauge were presented in picture format. For each instrument, one needle setting was just above a gauge marker, one was just below a gauge marker, and one was set exactly between two gauge markers. A total of 126 out of 200 surveys were returned for a participation rate of 63%. For the dynamometer readings, therapists …

Letter From The Editor: The Importance Of Frames Of Reference, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

The Santa Clara, 2013-02-28, Santa Clara University

The Santa Clara

No abstract provided.

Importance Of New Technologies For Diabetes Monitoring, David P. Paul Iii, Joey Preast, Zach Garrett, Alberto Coustasse

Management Faculty Research

Diabetes and its ramifications and treatments are presented, followed by discussion of the importance of communication between patient and clinician. Improved communication approaches, including telephone consultations, blood glucose communications to a provider with feedback, and active electronic diaries on smartphones for both type 1 and type 2 diabetes mellitus, are reviewed.

Icd-10 In The United States: Better Late Than Never, Holly Johns, Cara Havens, Danielle Robinson, Bala S. Pothakamuri, David P. Paul Iii, Alberto Coustasse

Management Faculty Research

The United States faces a revolution in the healthcare system soon, when the present coding system (ICD-9) will be replaced with what has for some years been the international standard: ICD-10. ICD-10 will provide a tremendous opportunity for better capturing the information in the increasingly complex delivery of healthcare. Although the transition to ICD-10 will undoubtedly result in substantial short-term costs, the long term benefits make the transition imperative.

Medical Tourism And International Healthcare Options, David Conley, Andrew Sikula Sr., William Willis, Alberto Coustasse

Management Faculty Research

Medical tourism has evolved from traveling to the United States (U.S.) and a select few other countries, such as India and Thailand, to a global trend in affordable alternative healthcare. Medical tourism in the U.S. and in other countries has evolved because of cost and lengthy waiting periods. Some insurance companies are marketing kidney transplants and joint replacements through medical choice programs in order to save overall expense. As an economical approach to controlling rising health care costs in the U.S., medical tourism is becoming a valid alternative.

Elevated Chemerin Levels In Pakistani Men: An Interrelation With Metabolic Syndrome Phenotypes, Syeda Sadia Fatima, Kiymet Bozaoglu, Rehana Rehman, Faiza Alam, Abdul Shakoor Memon

Department of Biological & Biomedical Sciences

Chemerin is a novel protein linked to adipocyte differentiation and the development of metabolic imbalances. We sought to examine the relationship of chemerin with metabolic syndrome disturbances including body fat percentage, serum lipid, glucose, insulin levels and body fat percentage in lean and obese volunteers. A cross-sectional study of 90 randomly selected healthy males from Pakistan were divided into three groups as per Body Mass Index (BMI) criteria for South Asian Population. Anthropometric measurements were taken for BMI, waist circumference, hip circumference and body fat percentage, while serum analyses were performed for fasting blood glucose, fasting insulin, fasting lipid profile …

Mir203 Mediates Subversion Of Stem Cell Properties During Mammary Epithelial Differentiation Via Repression Of Δnp63Α And Promotes Mesenchymal-To-Epithelial Transition, A J. Decastro, K A. Dunphy, J Hutchinson, A L. Balboni, P Cherukuri, D J. Jerry, J Direnzo

Dartmouth Scholarship

During reproductive life, the mammary epithelium undergoes consecutive cycles of proliferation, differentiation and apoptosis. Doing so relies on the retained proliferative capacity, prolonged lifespan and developmental potency of mammary stem cells (MaSCs). ΔNp63α, the predominant TP63 isoform in mammary epithelia, is robustly expressed in MaSCs and is required for preservation of self-renewing capacity in diverse epithelial structures. However, the mechanism(s) underlying subversion of this activity during forfeiture of self-renewing capacity are poorly understood. MicroRNAs (miRNAs) govern critical cellular functions including stem cell maintenance, development, cell cycle regulation and differentiation by disrupting translation of target mRNAs. Data presented here …

The Effect Of Statins On Testosterone In Men And Women, A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Mary Schooling, Shiu Lun Au Yeung, Guy Freeman, Benjamin J. Cowling

Publications and Research

Background
Statins are extensively used for cardiovascular disease prevention. Statins reduce mortality rates morethan other lipid-modulating drugs, although evidence from randomized controlled trials also suggests that statinsunexpectedly increase the risk of diabetes and improve immune function. Physiologically, statins would beexpected to lower androgens because statins inhibit production of the substrate for the local synthesis of androgens and statins’ pleiotropic effects are somewhat similar to the physiological effects of lowering testosterone, so we hypothesized that statins lower testosterone.

Methods
A meta-analysis of placebo-controlled randomized trials of statins to test the a priori hypothesis that statins lower testosterone. We searched the PubMed, …

Kinetic And Thermodynamic Studies Of Thrombin Inhibitors, Aziz May Abdel

Theses and Dissertations

Sulfated low molecular weight lignins (LMWLs), CDSO3 and FDSO3, designed recently as macromolecular mimetics of heparin, were found to exhibit potent anticoagulant activity. Small molecules based on the same scaffold, SBD and SBT, showed promising thrombin inhibition. We were able to address the mechanism of the inhibition using Michaelis-Menten kinetics. All the molecules were found to be allosterically impairing thrombin activity using either noncompetitive or uncompetitive mechanism. Absence of competition with hirugen, an exosite 1 ligand, and competition with polymeric heparin points to exosite 2 as the site of interaction for these inhibitors. Yet mixed competition results with other exosite …

The Return Of The Huntington’S Whirlwind, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

March 27 & April 3, 2013, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting minutes of the March 27 & April 3, 2013 Faculty Committee meeting.

February 27, 2013, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting minutes of the February 6, 2013 Faculty Committee meeting.

Hemodialysis Access: Initial Considerations And The Difficult Patient, Laura Peterson, Maria Litzendorf, Hooman Khabiri, Stanislaw P. Stawicki

Department of Surgery Faculty Publications

The population requiring hemodialysis (HD) in the United States continues to grow, with recent studies reporting over 370,000 Americans with end stage renal disease (ESRD) who are HD-dependent. The creation of functional HD access is often the limiting step in utilization of renal replacement therapy (RRT). Since the 1960s, the creation of hemodialysis access has become one of the most commonly performed procedures in the United States with over 500,000 vascular access procedures performed per year. This represents approximately 8% of the annual Medicare budget allocated to patients with ESRD. The magnitude of the associated economic and human costs is …

Young Athletes Must Learn To Balance Health, Challenges, Lisa Barkley

UCF Forum

We all want sports heroes and we all want to win – but that desire comes with a price. Just as there will always be winners in sports, there will always be injuries and losers. Often the lines are blurred between what is in the best interest of an athlete’s health and well-being and what it takes to win.

An Acacb Variant Implicated In Diabetic Nephropathy Associates With Body Mass Index And Gene Expression In Obese Subjects, Lijun Ma, Mariana Murea, James A. Snipes, Alejandra Marinelarena, Jacqueline Krüger, Pamela J. Hicks, Kurt A. Langberg, Meredith A. Bostrom, Jessica N. Cooke, Daisuke Suzuki, Tetsuya Babazono, Takashi Uzu, Sydney C. W. Tang, Ashis K. Mondal, Neeraj K. Sharma, Sayuko Kobes, Peter A. Antinozzi, Matthew Davis, Swapan K. Das, Neda Rasouli, Philip A. Kern, Nathan J. Shores, Lawrence L. Rudel, Matthias Blüher, Michael Stumvoll, Donald W. Bowden, Shiro Maeda, John S. Parks, Peter Kovacs, Robert L. Hanson, Steven C. Elbein, Barry I. Freedman

Clinical and Translational Science Faculty Publications

Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (BMI) and gene expression in multiple populations, with and without T2DM. Among subjects without T2DM, rs2268388 DN risk allele (T) associated with higher BMI in Pima Indian children (n = 2021; p-additive = 0.029) and African Americans (AAs) (n = 177; p-additive = 0.05), with a trend in European Americans (EAs) (n = 512; p-additive = 0.09), but not …

An Acacb Variant Implicated In Diabetic Nephropathy Associates With Body Mass Index And Gene Expression In Obese Subjects, Lijun Ma, Mariana Murea, James A. Snipes, Alejandra Marinelarena, Jacqueline Krüger, Pamela J. Hicks, Kurt A. Langberg, Meredith A. Bostrom, Jessica N. Cooke, Daisuke Suzuki, Tetsuya Babazono, Takashi Uzu, Sydney C. W. Tang, Ashis K. Mondal, Neeraj K. Sharma, Sayuko Kobes, Peter A. Antinozzi, Matthew Davis, Swapan K. Das, Neda Rasouli, Philip A. Kern, Nathan J. Shores, Lawrence L. Rudel, Matthias Blüher, Michael Stumvoll, Donald W. Bowden, Shiro Maeda, John S. Parks, Peter Kovacs, Robert L. Hanson, Leslie J. Baier, Steven C. Elbein, Barry I. Freedman

Internal Medicine Faculty Publications

Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (BMI) and gene expression in multiple populations, with and without T2DM. Among subjects without T2DM, rs2268388 DN risk allele (T) associated with higher BMI in Pima Indian children (n = 2021; p-additive = 0.029) and African Americans (AAs) (n = 177; p-additive = 0.05), with a trend in European Americans (EAs) (n = 512; p-additive = 0.09), but not Germans (n …

Molecular Basis Of Differential Sensitivity Of Myeloma Cells To Clinically Relevant Bolus Treatment With Bortezomib, Tamer B. Shabaneh, Sondra L. Downey, Ayrton L. Goddard, Michael Screen, Marcella M. Lucas, Alan Eastman, Alexei F. Kisselev

Dartmouth Scholarship

The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause less than 85% inhibition of the chymotrypsin-like activity of the proteasome, but little attention has been paid as to whether in vitro studies are representative of this level of inhibition. Patients receive bortezomib as an intravenous or subcutaneous bolus injection, resulting in maximum proteasome inhibition within one hour followed by a gradual recovery of activity. In contrast, most in vitro studies use continuous treatment so that activity never recovers. Replacing continuous treatment with 1 h-pulse treatment increases differences in sensitivity in …