Medicine and Health Sciences Commons^™

Marked Improvement Of Cytotoxic Effects Induced By Docetaxel On Highly Metastatic And Androgen-Independent Prostate Cancer Cells By Downregulating Macrophage Inhibitory Cytokine-1., M Mimeault, Sonny L. Johansson, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Overexpression of macrophage inhibitory cytokine-1 (MIC-1) frequently occurs during the progression of prostate cancer (PC) to androgen-independent (AI) and metastatic disease states and is associated with a poor outcome of patients.

METHODS: The gain- and loss-of-function analyses of MIC-1 were performed to establish its implications for aggressive and chemoresistant phenotypes of metastatic and AI PC cells and the benefit of its downregulation for reversing docetaxel resistance.

RESULTS: The results have indicated that an enhanced level of secreted MIC-1 protein in PC3 cells is associated with their acquisition of epithelial-mesenchymal transition features and higher invasive capacity and docetaxel resistance. Importantly, …

What's Happening: March 18, 2013, Maine Medical Center

What's Happening

No abstract provided.

Loss Of Fbp1 By Snail-Mediated Repression Provides Metabolic Advantages In Basal-Like Breast Cancer, Chenfang Dong, Tingting Yuan, Yadi Wu, Yifan Wang, Teresa W-M Fan, Sumitra Miriyala, Yiwei Lin, Jun Yao, Jian Shi, Tiebang Kang, Pawel Lorkiewicz, Daret St. Clair, Mien-Chie Hung, B. Mark Evers, Binhua P. Zhou

Toxicology and Cancer Biology Faculty Publications

The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells with cancer stem cell (CSC)-like characteristics. We show that the Snail-G9a-Dnmt1 complex, which is critical for E-cadherin promoter silencing, is also required for the promoter methylation of fructose-1,6-biphosphatase (FBP1) in basal-like breast cancer (BLBC). Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and maintenance of ATP production under hypoxia. Loss of FBP1 also inhibits oxygen consumption and reactive oxygen species production by suppressing mitochondrial complex I activity; this metabolic reprogramming results in an increased CSC-like property and tumorigenicity by enhancing …

Ada News - 03/18/2013, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

An Investigation Of Dialysis Patients' Medication Compliance And The Relationship Of Physician Ordering Practices, Adele Curtis

Master's Theses and Doctoral Dissertations

In-center dialysis patients have multiple physicians involved in their care related to complications of end stage renal disease and the start of dialysis. This study reviewed the number of physicians involved in the participants’ (n=41) care and determined if it was associated with medication compliance and additionally assessed the in-center dialysis facility staff’s ability to keep up-to-date home medication orders. Participant interviews, home medication reviews, and reconciliations were completed. The average number of medications ordered per participant was 11.58, and 37% of all medications ordered needed corrections made to the home medication orders. The average number of physicians per participant …

Online Survey System For Image-Based Clinical Guideline Studies Using The Delphi Method, Todd Martin Harper

Theses and Dissertations

The increasing use of health information technology (HIT) is due to a rising interest in improving the quality of health care. HIT has the potential to reduce cost and transform services. Proper clinical support systems will contribute to the meaningful use of HIT systems by providing a wide array of data to clinicians for the diagnosis and treatments. Clinical guidelines, created by a consensus of experts, can be put in place to assist physicians in making clinical decisions. Delphi methods are commonly used to create consensus from surveys completed by a team of experts. Image-based studies could create guidelines that …

Medical School Watercooler Newsletter - March 17, 2013, Lindsey Lyle

Watercooler Newsletter

This is the March 17, 2013 edition of the Frederick P. Whiddon College of Medicine's newsletter, watercooler.

Contents Include

• High School Students Learn about Field of Neurology

• USA Mitchell Cancer Institute Hosts 2013 Oncology Outlook

• March 28th DSS to Feature Dr. Basil Rigas

• USA College of Medicine to Host 5th Annual Gumbo Chili Showdown

• USA Family Medicine Focusing on Quality Improvement

• Register Now: 22nd Annual Obstetrics & Gynecology Conference

Drugs, Devices, And Desires: A Problem-Based Learning Course In The History Of Medicine, Sarah Levitt, Anne Mckeage, P. K. Rangachari

Interdisciplinary Journal of Problem-Based Learning

Problem-based learning (PBL) is well suited for courses in the history of medicine, where multiple perspectives exist and information has to be gleaned from different sources. A student, an archivist, and a teacher offer three perspectives about a senior level course where students explored the antecedents and consequences of medical technology. Two active learning strategies were used: (a) PBL to explore the historical basis of procedures used to diagnose, prevent and treat a single disease, tuberculosis, and (b) a concurrent inquiry-based component that permitted individual exploration of other medical technologies and demonstration of learning through diverse options (book reviews, conversations, …

Commentary For The Special Issue: Pbl Scholarship: Building On The Educational Vision Of Howard Barrows, Peggy A. Ertmer

Interdisciplinary Journal of Problem-Based Learning

In this commentary, I discuss each of the seven articles included in this special issue, which, as a collection, honor the impact of Howard Barrows’ vision on the scholarship and practice of problem-based learning (PBL). Collectively, these articles represent a variety of contexts, content areas, delivery formats, and structures in PBL implementations and research. Each article is examined and evaluated for specific information that practitioners and researchers may use in their future PBL efforts.

Creating A Learning Space In Problem-Based Learning, Cindy E. Hmelo-Silver

Interdisciplinary Journal of Problem-Based Learning

An important aspect of PBL problems is the affordances that they hold for engaging students in discussion of important content knowledge. In this paper, I argue that one can analyze a problem in terms of a deep problem space and a broader learning space to identify the conceptual ideas for potential engagement. The problem space refers to the specific ideas and concepts that are part of the goals of the problem at hand. The learning space includes those aspects of the problem space and also includes the broader space of related conceptual ideas such as the anatomy and physiology related …

Disseminating Childhood Home Injury Risk Reduction Information In Pakistan: Results From A Community-Based Pilot Study, Aruna Chandran, Uzma Rahim Khan, Nukhba Zia, Asher Feroze, Sarah Stewart De Ramirez, Cheng-Ming Huang, Junaid A. Razzak, Adnan A. Hyder

Department of Emergency Medicine

Background: Most childhood unintentional injuries occur in the home; however, very little home injury prevention information is tailored to developing countries. Utilizing our previously developed information dissemination tools and a hazard assessment checklist tailored to a low-income neighborhood in Pakistan, we pilot tested and compared the effectiveness of two dissemination tools.

Methods: Two low-income neighborhoods were mapped, identifying families with a child aged between 12 and 59 months. In June and July 2010, all enrolled households underwent a home hazard assessment at the same time hazard reduction education was being given using an in-home tutorial or a pamphlet. …

Calpain 1 Knockdown Improves Tissue Sparing And Functional Outcomes After Spinal Cord Injury In Rats, Chen Guang Yu, Yanzhang Li, Kashif Raza, Xin Xin Yu, Sarbani Ghoshal, James W. Geddes

Spinal Cord and Brain Injury Research Center Faculty Publications

To evaluate the hypothesis that calpain 1 knockdown would reduce pathological damage and functional deficits after spinal cord injury (SCI), we developed lentiviral vectors encoding calpain 1 shRNA and eGFP as a reporter (LV-CAPN1 shRNA). The ability of LV-CAPN1 shRNA to knockdown calpain 1 was confirmed in rat NRK cells using Northern and Western blot analysis. To investigate the effects on spinal cord injury, LV-CAPN1shRNA or LV-mismatch control shRNA (LV-control shRNA) were administered by convection enhanced diffusion at spinal cord level T10 in Long-Evans female rats (200–250 g) 1 week before contusion SCI, 180 kdyn force, or sham surgery at …

Student-Athlete Perceptions Of Increased Internationalization In College Athletics, Erica Zonder

Master's Theses and Doctoral Dissertations

This study examined the effect of the increase in the number of international student-athletes in Division I college athletics on the experience of international and domestic student-athletes, specifically by investigating the perceptions of female athletes participating in sports that have high percentages of international student-athlete involvement. Scholarship opportunities, school choice, playing time, and recruiting areall areas that were explored through a questionnaire. This study potentially fills a gap in the research regarding the increased participation by international student-athletes on both the domestic and international student-athlete experience. Results indicated that international and domestic student-athletes had different perceptions of their recruiting experience …

The Community As A Learner Group, Cathyann Feher Rn,Msn, Karen L. Kutner Mba, Robert Ruhf, Charles Scagliotti Md,Facs, Michael M. Badellino Md

Department of Surgery

No abstract provided.

A Biodistribution And Toxicity Study Of Cobalt Dichloride–Nacetyl Cysteine (C4) As An Implantable Mri Marker For Prostate Cancer Treatment, Steven J. Frank, Mary J. Johansen, Karen S. Martirosyan, Mihai Gagea, Carolyn S. Van Pelt

Physics & Astronomy Faculty Publications

Purpose—C4, a cobalt dichloride–N-acetyl cysteine complex, is being developed as a positivesignal magnetic resonance imaging (MRI) marker to localize implanted radioactive seeds in prostate brachytherapy. We evaluated the toxicity and biodistribution of C4 in rats with the goal of simulating systemic effects of potential leakage from C4 MRI markers within the prostate.

Methods—9 μl doses (equivalent to leakage from 120 markers in a human) of control (0.9% sodium chloride), 1% (proposed for clinical use) and 10% C4 solution were injected into the prostates of male Sprague-Dawley rats via laparotomy. Organ toxicity and cobalt disposition in plasma, tissues, feces …

Today - March 15, 2013, Loma Linda University Health

TODAY

Inside this issue:

-- 'Cirque du Jubilee' gala raises more than $846,000 for LLU Children's Hospital
-- For cancer survivor Dawn Scott and her Loma Linda University Cancer Center surgeon, 'Failure is not an option'
-- Board of Trustees appoints new School of Dentistry dean
-- LLUMC senior vice president and LLU Printing Services honored by Loma Linda Chamber of Commerce
-- Chance encounter leads to creation of Serenity Square, tranquil place for employees
-- Free weight loss help available for LLUH employees
-- 'The power of inclusion' highlights challenges and synergies opportunities of diversity
-- Integrated Wayfinding Project starts …

Pharmacovigilance: A Comparative Study About The Knowledge Of Adverse Drug Reaction (Adr) Reporting That Private Practitioners And Government Doctors Gained In A Random Locality In India, Shanthan B. Pingili

Master's Theses and Doctoral Dissertations

The present pilot study aims to compare the knowledge pertaining to ADR reporting systems that government doctors and private practitioners gained in a random, tier-II city in India, by conducting a questionnaire based survey. Their knowledge of ADR reporting, related guidelines and/or regulations, the frequency of ADRs they observe and diagnose, their opinion on mandatory reporting by doctors, type of ADRs they would generally report, and to whom ADRs should be reported are discussed besides evaluating the attributable reasons for underreporting, if any. A total of 47 (21.36%) responded to this random survey, of whom 27 (57.4%) were government doctors …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Luque Joins CSI Executive Board

Lymphotoxin-Α Is A Novel Adiponectin Expression Suppressor Following Myocardial Ischemia/Reperfusion., Wayne Bond Lau, Yanqing Zhang, Jianli Zhao, Baojiang Liu, Xiaoliang Wang, Yuexing Yuan, Theodore A. Christopher, Bernard Lopez, Erhe Gao, Walter J. Koch, Xin L. Ma, Yajing Wang

Department of Emergency Medicine Faculty Papers

Recent clinical observations demonstrate adiponectin (APN), an adipocytokine with potent cardioprotective actions, is significantly reduced following myocardial ischemia/reperfusion (MI/R). However, mechanisms responsible for MI/R-induced hypoadiponectinemia remain incompletely understood. Adult male mice were subjected to 30-min MI followed by varying reperfusion periods. Adipocyte APN mRNA and protein expression and plasma APN and TNFα concentrations were determined. APN expression/production began to decline 3 h after reperfusion (reaching nadir 12 h after reperfusion), returning to control levels 7 days after reperfusion. Plasma TNFα levels began to increase 1 h after reperfusion, peaking at 3 h and returning to control levels 24 h after …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Luque Joins CSI Executive Board

Rehabilitation Service Utilization Among African American Women Living With Hiv/Aids: Using The Behavioral Model For Vulnerable Populations, Aisha Shamburger-Rousseau

Theses and Dissertations

African American women represent one of the largest groups disproportionately living with and affected by HIV/AIDS yet African American women have largely been unrepresented in the federal-state rehabilitation system. As pharmaceutical treatment options improve and individuals with HIV/AIDS are living longer and healthier lives, research exploring the appropriateness of rehabilitation services has increased. Accordingly, it has become more necessary to address the needs of this population. As the largest service provider for people with disabilities, the state-federal rehabilitation system has the potential to be a vital resource for African American women living with HIV/AIDS. The purpose of this study is …

Uncovering The Molecular Pathways Of Mbd5 In Neurodevelopmental Disorders, Sureni Mullegama

Theses and Dissertations

Neurodevelopmental disorders (NDs) are a growing public health concern. These complex disorders cause failure of normal brain development, which leads to intellectual disability (ID) or autism in 3% of children. Accurate diagnosis of NDs is difficult due to complex overlapping phenotypes. Moreover, associations between phenotypically similar NDs and their overlapping molecular mechanisms remain unidentified. The chromosome 2q23.1 region is a newly discovered disease region. We have recently identified a novel ND, 2q23.1 deletion syndrome. The phenotype includes severe ID, significantly delayed speech, behavioral problems, seizures and short stature. This syndrome shares characteristics in common with other genetic syndromes, including Smith-Magenis …

Global Prefrontal And Fronto-Amygdala Dysconnectivity In Bipolar I Disorder With Psychosis History, Alan Anticevic, Margaret S. Brumbaugh, Anderson M. Winkler, Lauren E. Lombardo, Jennifer Barrett, Phillip R. Corlett, Hedy Kober, June Gruber, Grega Repovs, Michael W. Cole

School of Medicine Publications

BACKGROUND: Pathophysiological models of bipolar disorder postulate that mood dysregulation arises from fronto-limbic dysfunction, marked by reduced prefrontal cortex (PFC) inhibitory control. This might occur due to both disruptions within PFC networks and abnormal inhibition over subcortical structures involved in emotional processing. However, no study has examined global PFC dysconnectivity in bipolar disorder and tested whether regions with within-PFC dysconnectivity also exhibit fronto-limbic connectivity deficits. Furthermore, no study has investigated whether such connectivity disruptions differ for bipolar patients with psychosis history, who might exhibit a more severe clinical course. METHODS: We collected resting-state functional magnetic resonance imaging at 3T in …

Navigating Diversity And Inclusion In Veterinary Medicine, Lisa M. Greenhill, Kauline Cipriani Davis, Patricia M. Lowrie, Sandra F. Amass

New Directions in the Human-Animal Bond

This book addresses the continued lack of the diversity in veterinary medicine, the least inclusive of all medical professions. Effective navigation of the complexity of diversity and inclusion in veterinary medicine requires clear enumeration, recognition, and understanding of key issues, challenges, and opportunities. In a nation with rapidly changing demographics, public needs and expectations of the veterinary profession will continue to evolve. A more diverse scientific workforce is required to feed the veterinary profession, not just for the purposed of equity, but as necessity for its sustainability and relevance.The book lays out the history of diversity in the veterinary profession, …

The Value Of Bleeding Scans In The Evaluation Of Acute Lower Gastrointestinal Bleeding, K Beiermeister, L Smith, Robert J. Sinnott, John S. Park Md

Department of Surgery

No abstract provided.

Embedded Assessment And Evidence-Based Curriculum Mapping: The Promise Of Learning Analytics, Jane M. Souza

Pharmacy Faculty/Staff Publications

At Wegmans School of Pharmacy, we have adopted an embedded assessment approach to curriculum mapping and data collection on student learning outcomes achievement. In essence, we capture the data from the course level exams that our faculty members craft to measure student learning.

Resolution Of Clinical And Laboratory Abnormalities After Diagnosis Of Ventilator-Associated Pneumonia In Trauma Patients, Joseph M. Swanson, Kathryn A. Connor, Louis J. Magnotti, Martin A. Croce, Jessica Johnson, G. Christopher Wood, Timothy C. Fabian

Pharmacy Faculty/Staff Publications

Background: Guidelines advise that patients with ventilator-associated pneumonia (VAP) should respond clinically by Day 3 of antibiotics. White blood cell (WBC) count, maximum temperature (Tmax), and PaO2:FIO2 ratio are all said to respond significantly by Day 6. Resolution of abnormalities has not been evaluated in trauma patients.

Methods: Retrospective review of trauma patients with VAP. The WBC count, Tmax, and PaO2:FIO2 were evaluated for 16 days after diagnosis. Patients were grouped into uncomplicated VAP, complicated VAP (those with inadequate empirical therapy [IEAT], VAP relapse/superinfection, or acute respiratory distress syndrome), and concurrent infection +VAP (those also infected at another site).

Results: …

A Comparison Of Daily Consumption Of Artificial Dye-Containing Foods By American Children And Adults, Carol Christine Bell

Master's Theses and Doctoral Dissertations

Children with developing nervous systems might be at greater risk for any potential neurobehavioral effects of color additives widespread in many foods. This study thus examined whether children consumed foods containing color additives more frequently than adults. Twenty-one adults (aged 18-60) and parents of 14 children (aged 4-7) with regular eating patterns kept detailed food records for five days. Diets were analyzed for foods containing the dyes Red #3, Red #40, Yellow #5, Yellow #6, Blue #1, Blue #2 and Green #3 by comparing ingredient labels found in grocery stores and online. The number of daily dye exposures was significantly …

Facilitating Social Integration For People With Severe Mental Illness, Sheila Linz

Seton Hall University Dissertations and Theses (ETDs)

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Just Beautiful Portrays Of The Mind? The Relevance Of Aesthetic Strategies On Knowledge Creation In Neuroscience, Valerie Kummer

The Transdisciplinary STEAM+ Journal

We live in the age of big data. All types of data are being generated at an increasing rate but theories about the strategies and methods to visualize them is lagging. One of the main challenges we face today in research is to keep up with the massive amounts of data we produce (Allen, Elena A. et.al, 2012). Especially in the field of neuroscience and its use of imaging technologies, the vast array of data has risen to such a high number that it is impossible to grasp the inherent information without additional software tools and intelligent interfaces. Only through …