Medicine and Health Sciences Commons^™

Consequences Of Prenatal Ethanol Exposure And Maternal Stress On Offspring, Miranda C. Staples

Biomedical Sciences ETDs

Extensive evidence in humans suggests that exposure to insults during gestation, such as ethanol or maternal stress, can negatively impact the developing fetus in manners which can last into adulthood. These deleterious effects can include various behavioral challenges including cognitive impairments and increases in anxiety. These findings have been replicated in animal models of prenatal ethanol exposure and prenatal stress exposure, but little work has been conducted on measuring the interactive effects of the two prenatal insults in combination. Currently, there is no animal model of combined prenatal ethanol and prenatal stress exposures which has been utilized to systematically evaluate …

The Voice Of Latino Adolescent Parents: A Focus Group Approach, Brenda Pereda

Biomedical Sciences ETDs

Background Adolescent Latina mothers are at high risk of rapid repeat pregnancy with poor economic, educational and health outcomes. Identifying barriers to use of the most effective contraception—long acting reversible contraceptives (LARC)—in adolescent Latino parents may help in the development of strategies to reduce unintended pregnancy in this high risk group. Objectives Primary Aim: • To identify the barriers to use of LARC by Latina adolescent mothers. Secondary Aims • Understand the context of contraceptive conversations and decision making. • Explain factors that influence contraceptive adoption and adherence. • Explore the Latino adolescent males perspective on contraception. Methods A sequential, …

Gene-Environment Interactions Affect Long-Term Depression (Ltd) Through Changes In Dopamine D2 Receptor Affinity In Snap25 Haplodeficient Mice, Michael J. Baca

Biomedical Sciences ETDs

Genes and environmental conditions interact in the development of cognitive capacities and each plays an important role in neuropsychiatric disorders such as attention deficit/hyperactivity disorder (ADHD) and schizophrenia. Multiple studies have indicated that the gene for the SNARE protein, SNAP-25 is a candidate susceptibility gene for ADHD, as well as schizophrenia, while maternal smoking is a candidate environmental risk factor for ADHD. In this study, mice heterozygous for a Snap25 allele and deficient in SNAP-25 expression were utilized to model genetic effects in combination with prenatal exposure to nicotine to explore genetic and environmental (G x E) factors and interactions. …

C-Rel Is A Transcriptional Target Of Mesoderm Inducer In Xenopus Like 1 (Mixl1), Aaron C. Raymond

Dissertations and Theses (Open Access)

MIXL1, an evolutionarily conserved, paired-type homeobox transcription factor induced by BMP4/TGFb signaling, is a critical regulator of embryonic and adult hematopoiesis. Several lines of evidence implicate MIXL1 in hematopoietic transformation: (i) Aberrant MIXL1 expression is seen in human CML ( Chronic Myelogenous Leukemia) in blast crisis, AML (Acute myelogenous leukemia), B cell lymphomas and pediatric ALL (Acute lymphocytic leukemia). (ii) Retroviral transduction of Mixl1 induces AML in murine models. Nonetheless, mechanisms underlying MIXL1 mediated proliferative, survival advantages are unknown.

The goal of my studies is to understand if and how aberrant MIXL1 expression contributes to leukemogenesis. As a first step, …

The Efficacy Of Partial Squats On Measures Of Strength And Explosiveness: An Exploratory Study, Caleb D. Bazyler, Kimitake Sato, Craig A. Wassinger, Hugh S. Lamont, Michael H. Stone

ETSU Faculty Works

Abstract available in the 8th Annual Coaches and Sport Science College.

Identification Of Biomarkers Associated With Ascites Incidence In Broilers, Kaylee Rowland

Graduate Theses and Dissertations

Poultry is key in genetic research due to breeding feasibility, relatively short generation interval, and distinct phenotypes. It is estimated that 8% of broiler deaths annually can be attributed to ascites, an economically important disease that has been challenging the industry for the past 2 decades. Genetically selected ascites resistant (RES) and susceptible (SUS) chicken lines have been established and maintained by the University of Arkansas, Fayetteville. Intensive research efforts have been made to reveal physiological and biochemical characteristics for the incidence of ascites. Since the whole genome of the major ancestral chicken, the Red Jungle Fowl, has been sequenced, …

Tuberculosis Affecting The Nervous System: Can We Trace The Source Of Infection?, Naila Shahbaz, Saima Kashif, Hina Mushtaq

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Treatment Goals For Patients Who Elect Surgical Vs. Pessary Treatment For Symptomatic Pelvic Organ Prolapse, Mamta Muralidhar Mamik

Biomedical Sciences ETDs

Objective: The objective of this study is to assess differences in self-described goals for treating symptomatic pelvic organ prolapse for women that choose surgery compared to women who choose pessary. Methods: Women who had symptomatic stage 2 prolapse or greater presenting for care of pelvic organ prolapse to the Urogynecology Clinic at the University of New Mexico were recruited. These patients listed up to three goals they had of their treatment and rated the goals from 0 to 10, with 10 being the most important. In addition, patients completed the short forms of the established Pelvic Floor Distress Inventory (PFDI-20), …

Creative Products In A Service Industry: A Look Into The Health Insurance Industry, Aaron Michael Lepsch

Creativity and Change Leadership Graduate Student Master's Projects

The purpose of this project is to look into products within the health insurance industry within New York State and determine whether current models can identify whether the insurance products are creative. With the advent to healthcare exchanges starting January 1, 2014, the healthcare industry is making tremendous changes within the industry. Federal and State regulators are mandating more coverage, implementing more rules and regulations as well with standardizing products. Due to this standardization, how might you classify one insurer’s product more creative to another insurer with the exact same product? Models like the Creative Product Analysis Model (CPAM) and …

Neurovascular Unit Dysfunction With Blood-Brain Barrier Hyperpermeability Contributes To Major Depressive Disorder: A Review Of Clinical And Experimental Evidence, Souhel Najjar, Daniel M. Pearlman, Orrin Devinsky, Amanda Najjar, David Zagzag

Dartmouth Scholarship

About one-third of people with major depressive disorder (MDD) fail at least two antidepressant drug trials at 1 year. Together with clinical and experimental evidence indicating that the pathophysiology of MDD is multifactorial, this observation underscores the importance of elucidating mechanisms beyond monoaminergic dysregulation that can contribute to the genesis and persistence of MDD. Oxidative stress and neuroinflammation are mechanistically linked to the presence of neurovascular dysfunction with blood-brain barrier (BBB) hyperpermeability in selected neurological disorders, such as stroke, epilepsy, multiple sclerosis, traumatic brain injury, and Alzheimer’s disease. In contrast to other major psychiatric disorders, MDD is frequently comorbid with …

Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor And Promotes Invasion And Metastasis In Lung Adenocarcinoma, Erminia Massarelli

Dissertations and Theses (Open Access)

CXC chemokine receptor 2 (CXCR2) is a G-protein coupled receptor which mediates signaling by binding to CXC chemokines CXCL1-3 and 5-8. In non-small cell lung cancer CXCR2 has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. However, there is controversial data in the literature about CXCR2 expression in tumor cells and its role in the tumor microenvironment. We hypothesized that tumoral expression of CXCR2 and its ligands promote tumor invasion and metastasis in non-small cell lung cancer. The effect of CXCR2 expression on tumor cells was studied using stable knockdown clones derived from …

Staphylococcus Aureus Sara Regulates Inflammation And Colonization During Central Nervous System Biofilm Formation, Jessica N. Snowden, Matthew K. Beaver, Karen Beenken, Alexander R. Horswill, Tammy L. Kielian

Journal Articles: Pediatrics

Infection is a frequent and serious complication following the treatment of hydrocephalus with CSF shunts, with limited therapeutic options because of biofilm formation along the catheter surface. Here we evaluated the possibility that the sarA regulatory locus engenders S. aureus more resistant to immune recognition in the central nervous system (CNS) based on its reported ability to regulate biofilm formation. We utilized our established model of CNS catheter-associated infection, similar to CSF shunt infections seen in humans, to compare the kinetics of bacterial titers, cytokine production and inflammatory cell influx elicited by wild type S. aureus versus an isogenic sarA …

Characterization Of Prophylactic Antiemetic Regimens In Pediatric Patients Receiving Moderately And Highly Emetogenic Chemotherapy, Jessica Degiacomo Pharmd, Kristin M. Held Pharmd, Bcop

Department of Pharmacy

No abstract provided.

Locking Compression Plate In Musculoskeletal Oncology'a Nriend In Need', Masood Umer, Kashif Abbas, Shahid Khan, Haroon Ur Rashid

Department of Surgery Docs

Abstract

BACKGROUND:

We are presenting our experience in the use of locking compression plate (LCP) after juxta-articular oncological resections in addition to its use in pathologic fracture.

METHODS:

A retrospective audit of skeletal reconstruction using LCP in 25 cases of long bone tumors was performed from 2008 to 2010. Reconstruction following limb salvage surgery was done in 17 patients and internal fixation of pathological fracture was done in 8 patients. All patients were available for > 12 months of follow-up, and thus assessed for union at the resected ends.

RESULTS:

There were 8 males and 17 females in the study. The …

Rectal Carcinoma Under 40 Years Of Age: Seven-Year Post-Treatment Follow-Up At A Tertiary Care Hospital In Pakistan, Naveed Haroon, Salma Khan, Rehman Alvi

Department of Surgery Docs

Objectives: To determine epidemiological characteristics, clinical presentation, histopathological features, and long-term follow-up of patients below 40 years of age with carcinoma rectum.Methods: The retrospective case series comprised all patients presenting with histopathological diagnosis of carcinoma rectum with age 15-40 years at the Aga Khan University Hospital between January 1994 and December 2004. Details regarding patient demographics, pre-operative assessment, management and tumour grade and stage were obtained from a prospectively maintained database. Continuous and categorical variables in the data were analysed.Results: Of the 23 patients in the study, 14 (60.89%) were male and 9 (39.13%) were female. Mean age of the …

Investigation Of Commercial Milk Enzyme-Linked Immunosorbent Assay (Elisa) Kits: Specificity And Utility For Residues Of Foods Subjected To Proteolysis During Processing, Katherine O. Ivens

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Analytical methods, such as enzyme-linked immunosorbent assays (ELISA), are used to detect and quantify residues from allergenic sources in food products. However, ELISAs have not been validated for use in foods that have been exposed to proteolysis. This thesis explores the specificities, sensitivities, and capabilities of commercially-available milk ELISA kits for detecting milk residues in cheeses that have undergone varying degrees of proteolysis.

The specificity, accuracy, and consistency of twelve commercially-available milk ELISA kits for individual milk proteins and commonly used milk-derived ingredients, including α-,β-, and κ-casein, β-lactoglobulin, α-lactalbumin, non-fat dry milk, sodium caseinate, and whey protein concentrate were evaluated. …

Effects Of Messages Emphasizing Environmental Determinants Of Obesity On Intentions To Engage In Diet And Exercise Behaviors, Jeff Niederdeppe, Sungjong Roh, Michael A. Shapiro, Hye Kyung Kim

Research Collection Lee Kong Chian School Of Business

Reducing rates of obesity will require interventions that influence both individual decisions and environmental factors through changes in public policy. Previous work indicates that messages emphasizing environmental determinants increases support for public policies, but some suspect this strategy may undermine motivation to engage in diet and exercise. Emphasizing factors outside of personal control appears to enhance rather than undermine motivations to engage in healthy diet and exercise behavior.

Hearing-Aid Safety: A Comparison Of Estimated Threshold Shifts For Gains Recommended By Nal-Nl2 And Dsl M[I/O] Prescriptions For Children, Teresa Y. C. Ching, Earl E. Johnson, Mark Seeto, John H. Macrae

ETSU Faculty Works

Objective: To investigate the predicted threshold shift associated with the use of nonlinear hearing aids fitted to the NAL-NL2 or the DSL m[i/o] prescription for children with the same audiograms. For medium and high input levels, we asked: (1) How does predicted asymptotic threshold shifts (ATS) differ according to the choice of prescription? (2) How does predicted ATS vary with hearing level for gains prescribed by the two prescriptions? Design: A mathematical model consisting of the modified power law combined with equations for predicting temporary threshold shift (Macrae, 1994b) was used to predict ATS. Study sample: Predicted threshold shift were …

The Journey To Becoming-Authentic From The Voices Of Nursing Students Living With Attention Deficit Hyperactivity Disorder, Sheryl Lynn Allen

Dissertations

Research and literature on nursing students living with attention deficit hyperactivity disorder (ADHD) in higher education is deficient in supporting the needs of a growing population. The aim of this study sought to uncover the essence of nursing students’ experiences through a hermeneutic phenomenological approach and promote deeper understanding of the meaning of lifeworld experiences through the lens of critical social theory (CST). CST sustains freedom from ideological restraints to allow exploration into individual experiences. The voices of student participants provide the medium for articulating meaning. An integrative approach using van Manen’s (1990) and Munhall’s (2012) methods guided this study. …

Group Empowerment Capacity And Capability In Schools Of Nursing, Mary Louanne Friend

Dissertations

Nursing education is experiencing rapid changes as nurses are expected to transform and lead health care delivery within the United States. The ability to produce graduates who can promote a culture of safety, and provide patient centered care in collaboration with others will require nursing administrators and faculty who are empowered and able to achieve goals. The Sieloff Theory of Group Empowerment within Organizations (Sieloff & Bularzik, 2011) provided the theoretical basis for this exploratory correlational study examining group empowerment capacity and empowerment in administrators and faculty within the United States. Empowerment was conceptualized as the ability of the group …

Editorial, R Manchanda

Indian Journal of Research in Homoeopathy

No abstract provided.

Standardisation Of Ficus Carica L.: In Homoeopathic Perspective, P Subramanian, P Rao, T Reddy, P Sudhakar, P Reddy, Santhosh Sharma, D Baburaj

Indian Journal of Research in Homoeopathy

Background: Ficus carica L. known as ′Common Fig′ in English and ′Anjir′ in Hindi, is a well known tree belonging to the family Moraceae. The unripe fruits are used as medicine in Homoeopathy. Objective: The pharmacognostic and physico-chemical studies are carried out to facilitate use of correct species and standard raw materials. Material and Methods: Pharmacognostic studies on unripe fruits of authentic samples of Ficus carica L. have been carried out; Physico-chemical parameters of raw drug viz., extractive value, ash values, formulation, besides weight per mL, total solids, alcohol content along with High Performance Thin Layer Chromatography (HPTLC) and Ultra …

Experience With Homoeopathy In A Case Of Large Urethral Calculus, Soma Sharma, Gyandas Wadhwani

Indian Journal of Research in Homoeopathy

Calculus in the male urethra is a rare clinical presentation and case reports of urethral calculi in the medical literature are likewise scant. We report a case of a 33-year-old male who presented at Delhi Govt Homoeopathic Dispensary at Aali Village with intense pain and scanty urination. Ultrasonography confirmed the diagnosis of urethral calculus in prostatic part of urethra. On the basis of keynotes, Lyssin prescribed in LM potencies improved urinary flow immediately and provided pain relief, which were objectively assessed as per pre-defined scales, and the 11 mm calculus was expelled in 8 days. No complication was observed during …

Ccrh Quarterly Bulletin Volume 8 (1-4), 1986, V Gupta

Indian Journal of Research in Homoeopathy

No abstract provided.

Diabetes Mellitus: Homoeopathic Approach. (Disease Monograph-4), Kanjaksha Ghosh

Indian Journal of Research in Homoeopathy

No abstract provided.

Multicenter Study Of Pectus Excavatum, Final Report: Complications, Static/Exercise Pulmonary Function, And Anatomic Outcomes., Robert E. Kelly, Robert B. Mellins, Robert C. Shamberger, Karen K. Mitchell, M Louise Lawson, Keith T. Oldham, Richard G. Azizkhan, Andre V. Hebra, Donald Nuss, Michael J. Goretsky, Ronald J. Sharp, George W. Holcomb, Walton K T Shim, Stephen M. Megison, R Lawrence Moss, Annie H. Fecteau, Paul M. Colombani, Dan Cooper, Traci Bagley, Amy Quinn, Alan B. Moskowitz, James F. Paulson

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: A multicenter study of pectus excavatum was described previously. This report presents our final results.

STUDY DESIGN: Patients treated surgically at 11 centers were followed prospectively. Each underwent a preoperative evaluation with CT scan, pulmonary function tests, and body image survey. Data were collected about associated conditions, complications, and perioperative pain. One year after treatment, patients underwent repeat chest CT scan, pulmonary function tests, and body image survey. A subset of 50 underwent exercise pulmonary function testing.

RESULTS: Of 327 patients, 284 underwent Nuss procedure and 43 underwent open procedure without mortality. Of 182 patients with complete follow-up (56%), …

The Effect Of Perceived Parental Style On Hispanic Adults Receiving Outpatient Substance Abuse Treatment In South Texas, Elizabeth C. Palacios

Theses and Dissertations - UTB/UTPA

Hirschi's (1969) Social Control Theory proposes that parental relationships serve as a shielding factor and has positive impact in the decreasing delinquency (i.e. substance use/abuse) in young people. This theory provides a framework for understanding substance use/abuse in young adult populations. Other factors including gender, cultural influences, family composition and birth order were also examined in this study. The Drug Abuse Screening Test - 20 (Skinner, 1982), the Parental Authority Questionnaire (Buri, 1991), and a demographic scale were utilized in a population of 182 adults in outpatient substance abuse treatment centers in South Texas, Texas Gulf Coast and areas in …

Us Medical Specialty Global Health Training And The Global Burden Of Disease, Vanessa B. Kerry, Rochelle P. Walensky, Alexander C. Tsai, Regan W. Bergmark, Brian A. Bergmark, Chaturia Rouse, David R. Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Rapid growth in global health activity among US medical specialty education programs has lead to heterogeneity in types of activities and global health training models. The breadth and scope of this activity is not well chronicled.

Methods: Using a standardized search protocol, we examined the characteristics of US medical residency global health programs by number of programs, clinical specialty, nature of activity (elective, research, extended curriculum based field training), and geographic location across seven different clinical medical residency education specialties. We tabulated programmatic activity by clinical discipline, region and country. We calculated the Spearman's rank correlation coefficient to estimate …

Smooth Muscle-Specific Myosin Phosphatase Target Subunit 1 (Mypt1): An Important Piece Of The Puzzle., Satish Rattan

Division of Gastroenterology and Hepatology Faculty Papers

Dear Sir:

We have read with great interest a recent article by Dr. He et al. in the June issue of Gastroenterology.¹ The studies provide strong evidence in favor of the concept that smooth muscle–specific myosin phosphatase target subunit 1 (MYPT1) of myosin light chain phosphatase (MLCP) plays a critical role in the agonist-induced contraction/relaxation of the smooth muscle. This was shown in their studies using animals with knocked out MYPT1^-/-. The investigators employed the Cre-loxP system in which they used the promoter region and exon 1 of Mypt1 flanked by 2 loxP sites …

Acquisition Of Medication For Short-Term Medical Mission Trips, Christine R. Birnie

Pharmacy Faculty/Staff Publications

In lieu of an abstract, here is the article's first paragraph:

Each year, increasing numbers of pharmacists and pharmacy students participate in medical mission trips around the world. The Christian Pharmacist Fellowship International (CPFI) partners with Global Health Outreach (GHO) to ensure that one or two pharmacists are included on each of their multi-disciplinary medical trips. Over the past years, the number of pharmacists participating on these trips has increased from 20 pharmacists in 2002 to 78 pharmacists in 2012.¹ In recent years, pharmacy students have also become active team members, and several schools are now organizing medical mission …