Medicine and Health Sciences Commons^™

Reliability And Reproducibility Of Spectral And Time Domain Optical Coherence Tomography Images Before And After Correction For Patients With Age-Related Macular Degeneration., Mohammad A. Sadiq, Aymen Rashid, Roomasa Channa, Elham Hatef, Diana V. Do, Quan Dong Nguyen, Yasir J. Sepah

Journal Articles: Ophthalmology

PURPOSE: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus (TM) OCT, and the Spectral Domain (SD-OCT) Spectralis (TM) and Cirrus (TM) OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration.

DESIGN: Prospective observational study.

SETTING: University-based retina practice.

PATIENTS: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD.

PROCEDURE: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices.

MAIN OUTCOME MEASURES: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for …

Functional Study Of Hemogen Knockout Mouse Model, Peng Gao

Theses and Dissertations (ETD)

Mouse Hemogen (Hemgn) is regarded as a homologue of human Erythroid Differentiation Associated Gene (EDAG). EDAG overexpression has been postulated for association with some leukemia cases. Meanwhile, Hemgn has been found to contribute to Hoxb4 mediated hematopoietic stem cell expansion. Based on these postulations and evidences, a Hemgn knockout mouse model has been generated to study its function in normal and stress hematopoiesis. I confirmed the Hemgn expression in hematopoietic organs including bone marrow and spleen, as well as round spematids in testis. Hemgn is expressed in mouse hematopoietic stem cells and erythroid progenitor cells. Moreover, Hemgn was also found …

Treatment Effects Of The Mandibular Anterior Repositioning Appliance (Mara) And Conventional Orthodontic Mechanics On Temporomandibular Joint Morphology: A Comparison Using Cone Beam Computed Tomography, Brenton E. Glassell

Theses and Dissertations (ETD)

Introduction: An ongoing debate exists in orthodontics about the amount of condylefossa remodeling and growth seen in Class II patients using functional appliance therapy. Some clinicians and researchers have found that that the use of functional appliances increases the amount of condylar growth and subsequent Class II skeletal correction; others believe that the mandible has a preset amount of growth and that conventional orthodontics will result in a similar amount of condylar growth to functional appliance therapy. Purpose: The aim of this study was to compare condylar remodeling in functional appliance treatment using the mandibular anterior repositioning appliance (MARA) to …

A Series Of Pharmaceutical Technology Concepts Applied To Pediatric Formulations, Hao Lou

Theses and Dissertations (ETD)

Pediatric formulations have received great attention from regulatory agencies in the United States and Europe. Since solid dosage forms such as tablets and capsules will not be able to improve pediatric patients’ compliance, customized pediatric formulations are needed. In response, formulators in the pharmaceutical industry have made significant effort into developing various pediatric formulations. However, developing satisfactory pediatric formulations is a process that is guided by case by case basis. The objective of this current study was to apply the scientific pharmaceutical technology concepts into developing modern pediatric formulations. We have shown that the drug delivery design will be affected …

The Development And Application Of A Custom Robotic Biomechanical Testing Platform Employing Real-Time Load-Control To Compare Spinal Biomechanical Testing Protocols: Pure Moment, Ideal Follower Load, And A Novel Trunk Weight Protocol, Charles Ramsey Bennett

Theses and Dissertations (ETD)

The human lumbar spine has been the subject of biomechanical study for many decades owing to the numerous medical cases resulting in the development of various corrective surgical procedures and medical devices intended to relieve patient discomfort. Spinal biomechanics is a broad field containing but not limited to the in vitro study of cadaveric tissue utilizing testing platforms used to apply motion- or load-profiles to tissue in the investigation of the various kinetic or kinematic responses, respectively. The particular arena field of this research concerns the field of robotics as it applies to testing platforms and how they are applied …

Dare To…. Defy C Diff, Lourdes C. Fernandez Rn, Bsn, Ccrn, Csc, Roslyn M. Harris Ms, Bsn, Rn, Ccrn-Cmc

Patient Care Services / Nursing

No abstract provided.

Nutritional Status Of Patients With End Stage Liver Disease: An Outpatient Assessment, Anna Marie Cumming-Browne Hefner Phd, Msn, Cpnp, Rn

Dissertations

Cirrhosis is the 12th leading cause of death in the United States. It is well documented end stage liver disease drives a patient to a catabolic state thus depleting them of essential nutrients. Malnutrition is often unrecognized and untreated in outpatients. Though BMI, nutritional intake, anthropometric measurements have been used in clinical trials, there still remains no standard nutritional assessment. The purpose of this dissertation was to (1) identify the incidence of malnutrition in patients with compensated and decompensated liver disease utilizing defined nutritional parameters (Subjective Global Assessment, anthropometric measurements, hand grip strength, and laboratory values) and (2) correlate with …

Psychometric Properties Of Standardized Patient And Faculty Rater's Evaluations Of Pre-Licensure Nursing Student Competencies, Karen A. Macauley Phd, Dnp, Fnp-Bc, Gnp, Bc

Dissertations

The use of simulation as a teaching modality has been rooted in the military, aviation, space, and engineering for centuries (Bradley, 2006). Clinical simulation allows for training of healthcare providers that might be too costly, risky, or hazardous in the clinical setting (Bradley, 2006). A variety of simulation modalities are used including virtual learning, task trainers, mannequins, and standardized patients (SPs). External demands for improved accountability of clinical performance is requiring nursing educators to reevaluate methods of teaching and how we measure nursing competence (Nehring & Lashley, 2010). Standardized patients have been used in medical school curricula to teach and …

Description Of Medical-Surgical Nurses Care Of Patients At Risk For Pressure Ulcers, Barbara Jean Mayer Phd

Dissertations

Aim: The purpose of this qualitative study was to explore and describe the level of understanding of PU development and prevention and perceptions of implementing PU prevention measures in nurses caring for patients in medical-surgical units. Method: The study was conducted in three (3) community hospitals within the same healthcare system using an Interpretive Description approach. Six (6) focus groups were conducted including thirty (30) participants. Findings: Participants described their knowledge of PU development and prevention as good and perceived continuing education as important in maintaining knowledge levels. Two (2) methods of identifying patients at risk for PU development were …

Risk-Appropriate Maternal Care: Identifying Risk Factors That Effect Maternal Outcome, Lucy R. Van Otterloo Phd, Msn, Rnc, Cns

Dissertations

Although maternal deaths are the most tragic of obstetric events it continues to be a rare event. Maternal morbidity, on the other hand, is increasing and poses a greater impact on the economic, psychological, and physical health of the woman and her family, yet it has not been the focus of measurement or research since there is no systematic collection of data available. As complications increase, the likelihood of adverse maternal outcomes such as longer postpartum stays due to the need for more extensive care will also increase. Nurses are being challenged to use their knowledge and skills to identify …

The Karabus Affair Speaks To Larger Issues For American Academic And Medical Centers., Leonard A Zwelling, Md, Mba, Razelle Kurzrock, Md, Philip R Cohen, Md, Bernard Levin, Md, Ch, Lawrence Parish, Md

Department of Dermatology and Cutaneous Biology Faculty Papers

Finally, on March 12, 2013, a major American newspaper, The Wall Street Journal, reported on the plight of Dr. Cyril Karabus (1,2). Dr. Karabus is the 78 year old pediatric oncologist from Claremont, Capetown, South Africa who is well known as the retired head of the Oncology and Hematology Unit of the Red Cross Children’s Hospital, University of Cape Town, as well as for his devoted service to poor children in the apartheid era. In 2002, he cared for a three-year old Yemeni girl with acute myelogenous leukemia during a locum tenens in the United Arab Emirates (UAE).

Efficacy Of Probiotics For Reducing The Incidence Of Lameness In Broilers Grown On Wire Flooring, John Matthew Stark

Graduate Theses and Dissertations

Growing broilers on wire flooring provides an excellent experimental model for reproducibly triggering significant levels of lameness. In Pilot Study #1 using broilers from Line C grown on wire flooring, adding the Biomin probiotic PoultryStar® to the feed reduced the percentage of lameness by half when compared with broilers that received the control diet alone. In Pilot Study # 2 using broilers from Line B grown on wire flooring, adding the PoultryStar® probiotic reduced the percentage of lameness to 8% when compared with 28% lameness in broilers that received the control diet alone. The objective of this study was to …

Efficacy Of Selected Disinfectants Against Salmonella Isolates From Broiler Breeders, Arslan Aslam

Graduate Theses and Dissertations

Salmonella have been causing huge losses in the poultry industry and have been a major cause food borne illness for many years. Salmonella infections in humans from poultry have been increasing. Good hygiene and biosecurity measures can reduce the incidence of Salmonella infections at poultry farms. Disinfection is a most important measure taken to prevent Salmonellosis in poultry. This research was conducted to determine the efficacy of 12 disinfectants against seven Salmonella isolates in the presence and absence of organic matter. A bacterial solution of a specific optical density value was prepared and .05x, .1x and .2x concentrations of disinfectants …

Landscape Epidemiology And Machine Learning: A Geospatial Approach To Modeling West Nile Virus Risk In The United States, Sean Gregory Young

Graduate Theses and Dissertations

The complex interactions between human health and the physical landscape and environment have been recognized, if not fully understood, since the ancient Greeks. Landscape epidemiology, sometimes called spatial epidemiology, is a sub-discipline of medical geography that uses environmental conditions as explanatory variables in the study of disease or other health phenomena. This theory suggests that pathogenic organisms (whether germs or larger vector and host species) are subject to environmental conditions that can be observed on the landscape, and by identifying where such organisms are likely to exist, areas at greatest risk of the disease can be derived. Machine learning is …

A Profile Of The Characteristics And Professional Development Needs Of National Collegiate Athletic Association Division Ii Athletic Directors, Dustin Smith

Graduate Theses and Dissertations

The purpose for conducting the study was to identify the personal, professional, and educational backgrounds of NCAA Division II athletic directors. The study was designed to detail the professional development opportunities that existed among the population, and determine how frequently the NCAA Division II athletic directors took advantage of the opportunities that were available to them. The significance of the study rested on the ability to identify the NCAA Division II athletic director population and describe the qualities and characteristics that comprised the target population. Since little data existed detailing this population, the study provided an opportunity to describe a …

Oxidation Of Thrombomodulin Methionine 388 In Cigarette Smokers, Samrat B. Thapa

Graduate Theses and Dissertations

This work tested the hypothesis that oxidation of methionine 388 in thrombomodulin is higher in cigarette smokers, and thus a likely contributor towards the hypercoagulable state in smokers. Thrombomodulin, a protein cofactor found on endothelial cell surfaces, regulates the activity of thrombin. Thrombin bound to thrombomodulin no longer converts fibrinogen to fibrin, but instead activates Protein C which, in turn, stops the coagulation cascade by inactivation of clotting factors. The oxidation of methionine 388 of thrombomodulin has been shown in vitro to dramatically decrease the anticoagulant cofactor activity of thrombomodulin. The blood of cigarette smokers is more prone to clot …

Qcm Aptasensor For Rapid And Specific Detection Of Avian Influenza Virus, Luke Brockman

Graduate Theses and Dissertations

There has been a need for rapid detection of avian influenza virus (AIV) H5N1 due to it being a potential pandemic threat. Most of the current methods, including culture isolation and PCR, are very sensitive and specific but require specialized laboratories and trained personnel in order to complete the tests and are time-consuming. The goal of this study was to design a biosensor that would be able to rapidly detect AIV H5N1 using aptamers as biosensing material and a quartz crystal microbalance (QCM) for transducing method. Specific DNA aptamers against AIV H5N1 were immobilized, through biotin and streptavidin conjugation, onto …

Development Of The Cultural Appreciation Of Martial Arts Scale, John Roderick Malmo

Graduate Theses and Dissertations

The purpose of this study was to develop a reliable and valid Social sciences instrument designed to measure the construct of Cultural Appreciation of Martial Arts. Data were collected from 114 adult martial arts participants. Study participants represented Taekwondo schools located in Arkansas and Filipino martial arts schools located in Arkansas, Missouri, Oklahoma, and Texas. Development of the instrument involved the use of an expert panel, a Q-sort, test-retest reliability test, Exploratory Factor Analysis, and Cronbach's alpha.

The study resulted in a 20-item, 3-factor scale that measures Cultural Knowledge, Cultural Sensitivity, and Cultural Awareness and is named the Cultural Appreciation …

Master Physician Scheduling Problem, Aldy Gunawan, Hoong Chuin Lau

Research Collection School Of Computing and Information Systems

We study a real-world problem arising from the operations of a hospital service provider, which we term the master physician scheduling problem. It is a planning problem of assigning physicians’ full range of day-to-day duties (including surgery, clinics, scopes, calls, administration) to the defined time slots/shifts over a time horizon, incorporating a large number of constraints and complex physician preferences. The goals are to satisfy as many physicians’ preferences and duty requirements as possible while ensuring optimum usage of available resources. We propose mathematical programming models that represent different variants of this problem. The models were tested on a real …

Pre-Operative Angiotensin Converting Enzyme Inhibitors And Angiotensin Receptor Blockers On The Occurrence Of Post Operative Atrial Fibrillation After Cardiac Valve Department Of Surgery, Nasir Shariff, Matthew W. Martinez Md, Ravi V. Desai Md, Michael J. Weiss, Vadim Levin Md, Larry E. Jacobs Md, Martin E. Matsumura Md, Ronald S. Freudenberger Md

Department of Medicine

No abstract provided.

The Impact Of Dementia Of The Alzheimer’S Type On Drawing Style: A Comparison Between Human Figure Drawings Completed By Elderly Adults With And Without Dementia Of The Alzheimer’S Type, Kate Cronjé

EVMS School of Health Professions Theses & Dissertations

This study utilized a descriptive and comparative non-experimental design in order to examine differences between Human Figure Drawings (HFDs) completed by 25 adults between the age of 65-100with a known diagnosis of Dementia of the Alzheimer’s Type (DAT), and 22 adults in the same age range with no known diagnosis of DAT. Instrumentation included the Mini-Mental State Examination (MMSE) paired with the modified Formal Elements Art Therapy Scale (FEATS) and the Human Figure Drawing (HFD). The MMSE was applied in order to screen for cognitive impairment, and the FEATS/HFD quantified drawing characteristics across five scales: Prominence of Color, Color Fit, …

Body Image: Indicators And Concern As Demonstrated In A Brief Art Therapy Group, Ashley Busch

EVMS School of Health Professions Theses & Dissertations

Research indicates that adolescent girls are prone to partake in pathological eating habits and internalization of the “thin ideal,” which increases their predisposition for developing a negative body image. Negative body image, in turn, increases the risk of developing an eating disorder. This study examined art therapy’s effectiveness in identifying body image concern in a group of pre-adolescent girls. Three girls participated in the single-session art therapy intervention that contained three art tasks related to body image. Two qualitative measures and one qualitative pretest/posttest measures were included to evaluate body image concern and the overall effectiveness of the intervention. Each …

The Three Dimensions Of Cultural Competency In Art Therapy Education: Awareness, Knowledge, And Skills, Evans Baker

EVMS School of Health Professions Theses & Dissertations

The subject of multicultural competent practice has gained attention from the mental health professions for the last few decades. Many health profession’s associations took actions to ensure that cultural competent practice is one of the major focuses in the educational setting. The American Art Therapy Association understood the necessity of multicultural competency education and in December 2011, announced the Multicultural / Diversity Competencies as a guideline for practicing art therapists and educators to establish cultural competency standards. Lack of research in the subject of multicultural competency inspired this study to examine the art therapy education program in a wide range …

Improving Health Outcomes For Children (Ihoc): Summary Of Pediatric Quality Measures For Children Enrolled In Mainecare Ffy 2009 - Ffy 2012, Nathaniel J. Anderson Ms, Mph, Tracey Meagher

Population Health & Health Policy

his report, authored by USM Muskie School research staff, presents the results of the 16 CHIPRA Core Measures that were collected using MaineCare claims or Vital Statistics data and reported in the State of Maine’s FFY 2012 CHIP Annual Report to the Centers for Medicare and Medicaid Services (CMS). Also included in this report are an additional three measures from the Improving Health Outcomes for Children (IHOC) project’s Master List of Pediatric Measures. In addition to presenting results in graphs and narrative, this report also provides measure definitions and background information about each measure topic.

The goal of this document …

2013 April 30 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Rosiglitazone Treatment Of Type 2 Diabetic Db/Db Mice Attenuates Urinary Albumin And Angiotensin Converting Enzyme 2 Excretion, Harshita Chodavarapu, Nadja Grobe, Hari Krishna Somineni, Esam Said Busah Salem, Malav Navinchandra Madhu, Khalid M. Elased

Pharmacology and Toxicology Faculty Publications

Alterations within the renal renin angiotensin system play a pivotal role in the development and progression of cardiovascular and renal disease. Angiotensin converting enzyme 2 (ACE2) is highly expressed in renal tubules and has been shown to be renoprotective in diabetes. The protease, a disintegrin and metalloprotease (ADAM) 17, is involved in the ectodomain shedding of several transmembrane proteins including ACE2. Renal ACE2 and ADAM17 were significantly increased in db/db mice compared to controls. We investigated the effect of the insulin sensitizer, rosiglitazone, on albuminuria, renal ADAM17 protein expression and ACE2 shedding in db/db diabetic mice. …

Physical Activity And Exercise During Adolescence And Young Adulthood Can Act As Preventative Measures Against The Development Of Osteoporosis In Elderly People, Christine C. Center

Honors College Theses

Osteoporosis, “the silent killer,” is responsible for 8.9 million annual fractures. Although not bound to these factors, osteoporosis typically targets females that are post-menopausal and have a family history of the disease. Osteoporosis is caused by a decrease in bone mass density. Physical activity and exercise and often spoken about when the topic of osteoporosis is discussed because of the impact they have on maintaining bone mass density in an effort to delay osteoporosis. This paper first provides an overview of osteoporosis, explanation of methods of diagnosing osteoporosis, risk factors, complications and treatment for osteoporosis. Topics covered include, bone mass …

Impacting The Tdap Acceptance Rate Among Postpartum Women, Amie Burns-Scharnke

Evidence-Based Practice Project Reports

Pertussis, also known as Whooping Cough, is a contagious disease that affects children more than adults, especially children under the age of 12 months. In the United States in 2009, there were more than 16,000 cases of pertussis in infants less than 6 month of age (National Network for Immunizations and Information, 2011). At a local Midwestern community hospital, a revised Tdap policy that consisted of an education component and standardization of when the vaccine was administered was implemented to increase the acceptance rate of Tdap vaccines among postpartum mothers due to their significantly low Tdap acceptance rate. The purpose …

Three-Dimensional Soft Tissue Changes Upon Smiling, Clayton Mcentire

Theses and Dissertations

As esthetic improvement continues to be a primary goal of orthodontic patients and practitioners, it is important to understand the soft tissue movements that occur during the transition from rest to smile. Advances in technology allow capture of 3-dimesional photographs. The purpose of this study was to quantify the soft tissue changes that occur upon smiling and to compare changes between males and females using 3-dimensional photography. Fifty-four participants had resting and smiling photographs taken with the 3dMDface camera system. The two images were registered on stable facial surfaces, landmarks were placed, and measurements were recorded. Three-dimensional changes occurred in …

Service-Learning Programs Impact On Dental Students' Confidence In Treating Pediatric Population, Bushra Bhatti

Theses and Dissertations

Purpose: In 2011, Clinical Service-Learning (DENS 762) became a formal university-designated course required to all senior dental students at VCU School of Dentistry. The interest of this study was to measure students' experience in treating pediatric patients and to determine the effect the course had on students' self-perceived confidence in treating the pediatric population. Methods: This was an observational study of the VCU class of 2012 who were enrolled in the clinical service-learning class. Following their service-learning rotations, fourth-year dental students were surveyed about their experiences on their service-learning rotation. Out of 105 students, 76 completed the survey. Results: The …