Medicine and Health Sciences Commons^™

Synthesis And Biological Evaluation Of Novel Folic Acid Receptor-Targeted, Β-Cyclodextrin-Based Drug Complexes For Cancer Treatment., Juan-Juan Yin, Sonali Sharma, Stepan P. Shumyak, Zhi-Xin Wang, Zhi-Wei Zhou, Yangde Zhang, Peixuan Guo, Chen-Zhong Li, Jagat R. Kanwar, Tianxin Yang, Shyam S. Mohapatra, Wanqing Liu, Wei Duan, Jian-Cheng Wang, Qi Li, Xueji Zhang, Jun Tan, Lee Jia, Jun Liang, Ming Q. Wei, Xiaotian Li, Shu-Feng Zhou

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Drug targeting is an active area of research and nano-scaled drug delivery systems hold tremendous potential for the treatment of neoplasms. In this study, a novel cyclodextrin (CD)-based nanoparticle drug delivery system has been assembled and characterized for the therapy of folate receptor-positive [FR(+)] cancer. Water-soluble folic acid (FA)-conjugated CD carriers (FACDs) were successfully synthesized and their structures were confirmed by 1D/2D nuclear magnetic resonance (NMR), matrix-assisted laser desorption ionization time-of-flight mass spectrometer (MALDI-TOF-MS), high performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), and circular dichroism. Drug complexes of adamatane (Ada) and cytotoxic doxorubicin (Dox) with FACD were readily …

Continuous Correction Of Differential Path Length Factor In Near-Infrared Spectroscopy, Tanveer Talukdar, Jason H. Moore, Solomon G. Diamond

Dartmouth Scholarship

In continuous-wave near-infrared spectroscopy (CW-NIRS), changes in the concentration of oxyhemoglobin and deoxyhemoglobin can be calculated by solving a set of linear equations from the modified Beer-Lambert Law. Cross-talk error in the calculated hemodynamics can arise from inaccurate knowledge of the wavelength-dependent differential path length factor (DPF). We apply the extended Kalman filter (EKF) with a dynamical systems model to calculate relative concentration changes in oxy- and deoxyhemoglobin while simultaneously estimating relative changes in DPF. Results from simulated and experimental CW-NIRS data are compared with results from a weighted least squares (WLSQ) method. The EKF method was found to effectively …

The Development And Applications Of The Hint Scoring Function: Exploring Colchicine-Site Anticancer Agents And Tautomerism, Chenxiao Da

Theses and Dissertations

The overall aim of this work was to apply HINT, an empirical scoring function based on the understanding of hydrophobicity, to analyze and predict the binding affinities and biological activities of colchicine-site anticancer agents. The second, concurrent aim was to improve the scoring function by incorporating tautomerism within the modeling process. Our belief is that proper evaluation of tautomeric forms for small molecules will improve performance of virtual screening. The novel pyrrole-based compounds targeting the colchicine site were docked into the receptor using HINT as a rescoring function. Two distinct binding modes dictated by the size and shape of a …

Comparative Analysis Of Waveone And Lightspeed Lsx For The Residual Dentin Thickness Of The Bifurcated Maxillary First Premolar Buccal Root Utilizing Limited Field Cone Beam Computed Tomography, Manpreet Singh Sarao

Theses and Dissertations

The purpose of this study was to compare the thickness of dentin removed from the buccal root of bifurcated maxillary first premolars (BMFP) in the area of furcation groove after instrumentation with WaveOne and LightSpeed LSX files utilizing limited field cone beam computerized tomography. All data was analyzed using repeated-measured mixed-model ANOVA and differences were described using Tukey’s multiple comparison procedure. The thickness of dentin removed with LightSpeed LSX files (0.1 mm) was significantly less than the thickness of dentin removed with WaveOne files (0.2 mm). To conclude, LSX files remove a more predictable and consistent thickness of dentin from …

Qol In Child Lqts Patients Compared To Cardiac Patients, Elizabeth A. Waldron, Stephanie H. Felgoise, Carmella Tress, Katherine Lawrence, Victoria L. Vetter

Research Day

Introduction:

• Long QT Syndrome (LQTS) is a life threatening geneticallyinherited cardiac arrhythmia disorder affecting approximately 1:2500 persons1, often diagnosed in childhood.

• Management of LQTS changes patients’ lifestyles which can affect quality of life (QoL). Patients have restrictions in physical activity, diet, treatment of noncardiac conditions; take daily doses of medicine and/or have implantable cardiac devices (pacemaker/defibrillator).

• General pediatirc cardiac patients show significantly worse QoL in comparison to healthy controls2,3.

• Nearly 1 in 5 with other cardiac disorders reported impaired psychosocial functioning3.

• The effects of implanted cardiac rhythm devices in cardiac patients demonstrated a significant effect …

Estimating The Impact Of Lost To Follow-Up On Breast Cancer Patients' Disease-Free Survival, Debbie Yan Qun Huang

Statistics

Background The 5-year survival rate for patients with breast cancer is much higher than patients with other types of cancer. Due to this longer survival period, breast cancer patients also tend to have increased rates of lost to follow-up, when compared to other cancers. When a patient becomes lost, the occurrence of distant metastasis cannot be reliably ascertained, unless the patient had a breast cancer-specific (BC) death. The impact of lost patients on recurrence rates and disease-free survival (DFS) was explored in breast cancer patients seen at the City of Hope from 1997 to 2012.

Methods Female breast cancer patients …

Effects Of Noise On Cognitive Function During Dual Tasks Across Normally Aging Adults, Jennine Harvey

Theses and Dissertations (ETD)

This study expands upon methods used to investigate cognition and speech perception which have been limited by lack of (a) pre-screening of cognitive function in participants, (b) reporting visual or auditory accuracy and reaction time measures across experimental conditions that examine reaction times, and (c) comprehensive test battery that includes performance across multiple levels of dual task paradigms (DTPs). This study aims to examine group performance on dual tasks (DT) increasing in cognitive (task difficulty) and perceptual load (noise) with age. Participants were divided into two groups based upon age. Group 1 consisted of 14 listeners (Female=11) who were 40-59 …

Mmp-3 Mediates Psychosine-Induced Globoid Cell Formation: Implications For Leukodystrophy Pathology, Kumiko Ijichi, Graham D. Brown, Craig S. Moore, Paige N. Winokur, Roberto Pagarigan, Stephen J. Crocker

UCHC Articles - Research

Globoid cell leukodystrophy (GLD) or Krabbe disease, is a fatal demyelinating disease attributed to mutations in the galactocerebrosidase (GALC) gene. Loss of function mutations in GALC result in accumulation of the glycolipid intermediate, galactosylsphingosine (psychosine). Due to the cytotoxicity of psychosine, it has been hypothesized that accumulated psychosine underlie the pathophysiology of GLD. However, the cellular mechanisms of GLD pathophysiology remain unclear. Globoid cells, multinucleated microglia/macrophages in the central nervous system (CNS), are a defining characteristic of GLD. Here we report that exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase …

Place Events 2012-2013, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for 2012-2013.

Homelessness: Relationships Between Program Completion At A Transformational Shelter And Mental Illness, Substance Abuse, And Trauma, Richard T. Mccutcheon

Theses & Dissertations

Each and every evening many people do not have a home to return to. Solving the epidemic problem of homelessness is an ongoing pursuit. Analyzing issues related to homelessness will help solve the problem of homelessness for some individuals and families. Data was gathered, prioritized and analyzed to determine correlations and relationships between completion of a transformational shelter’s program and mental illness, substance abuse, and trauma. Demographic variables were assessed as well. A person is more likely to complete the program if they have a substance abuse issue. Females are more likely than males to complete the program. Program completion …

Linking And Retaining Hiv Patients In Care: The Importance Of Provider Attitudes And Behaviors, Manya Magnus, Jane Herwehe, Michelli Murtaza-Rossini, Petera Reine, Damien Cuffie, Deann Gruber, Michael Kaiser

Epidemiology Faculty Publications

Retention in HIV treatment may reduce morbidity and mortality, as well as slow the epidemic. Myriad barriers to retention include stigma, homophobia, structural barriers, transportation, and insurance. The purpose of this study was to evaluate patient perceptions of provider attitudes among HIV-infected persons within a state-wide public hospital system in Louisiana. A convenience sample of patients attending HIV clinics throughout the state participated in an anonymous interview. Factors associated with negative perceptions of care were evaluated in conjunction with a validated stigma measure. Factors associated with having a delayed entry into or break in care were evaluated in conjunction with …

The Acute Effects Of Yoga On Executive Function, Neha Gothe, Matthew B. Pontifex, Charles Hillman, Edward Mcauley

Kinesiology, Health and Sport Studies

Despite an increase in the prevalence of yoga exercise, research focusing on the relationship between yoga exercise and cognition is limited. The purpose of this study was to examine the effects of an acute yoga exercise session, relative to aerobic exercise, on cognitive performance. Methods: A repeated measures design was employed where 30 female college-aged participants (Mean age = 20.07, SD = 1.95) completed 3 counterbalanced testing sessions: a yoga exercise session, an aerobic exercise session, and a baseline assessment. The flanker and n-back tasks were used to measure cognitive performance. Results: Results showed that cognitive performance after the yoga …

Concussion Management, Education, And Return-To-Play Policies In High Schools: A Survey Of Athletic Directors, Athletic Trainers, And Coaches, Amanda Esquivel, Sadiq Haque, Patrick Keating, Stephanie Marsh, Stephen Lemos

Kinesiology, Health and Sport Studies

Background: Concussions represent 8.9% to 13.2% of all high school athletic injuries. How these injuries are managed is currently unknown.

Hypothesis: There are differences in concussion management and awareness between boys football, boys ice hockey, and boys and girls soccer.

Study Design: Descriptive epidemiologic study.

Methods: High school athletic directors were contacted via email and asked to complete an online survey with four separate sections for athletic directors, head coaches, team physicians, or certified athletic trainers.

Results: According to coaches, concussion awareness education was provided for football (97%), hockey (65%), and boys and girls soccer …

Phenethylisothiocyanate Alters Site- And Promoter-Specific Histone Tail Modifications In Cancer Cells, Yi Liu, Suvobrata Chakravarty, Moul Dey

Chemistry and Biochemistry Faculty Publications

Site-specific histone modifications are important epigenetic regulators of gene expression. As deregulation of genes often results in complex disorders, corrective modulation of site-specific histone marks could be a powerful therapeutic or disease-preventive strategy. However, such modulation by dietary compounds and the resulting impact on disease risk remain relatively unexplored. Here we examined phenethylisothiocyanate (PEITC), a common dietary compound derived from cruciferous vegetables with known chemopreventive properties under experimental conditions, as a possible modulator of histone modifications in human colon cancer cells. The present study reports novel, dynamic, site-specific chemical changes to histone H3 in a gene-promoter-specific manner, associated with PEITC …

Explorations Into Continuity: An Heuristic, Artistic Inquiry Into The Interplay Between Work As A Dance/Movement Therapist And Service Within The Bahá’Í Community, Elena M. Rezai

Creative Arts Therapies Theses

The purpose of this thesis was to explore the concept of integration between two main aspects of my life: my professional career as a dance/movement therapist on an inpatient adolescent behavioral health unit, and service guided by Bahá’í teachings in a neighborhood-based setting. Literature reviewed encompassed instances of Rudolf von Laban’s Effort elements found in the Bahá’í Writings, as well as research on the integration between the mind, body and spirit, the history of religion and mental health, and the current relationship between religion and mental health. Both artistic inquiry and heuristic methodologies were used to guide my research. Through …

Breaking The Silence And Moving Voices: Dance/Movement Therapy In The Treatment Of Male And Female Sexual Trauma Survivors, Sarah A. Winkler

Creative Arts Therapies Theses

The purpose of this research was to decipher the benefits and challenges of using a body-based therapy on male and female survivors of sexual trauma, to explore how dance/movement therapy is a therapeutic intervention that facilitates recovery within this population, and to illuminate whether gender socialization practices have an impact on how trauma is processed and emoted within the male and female bodies. The thesis provides information about common presenting problems, treatment models, and case studies for both sexes of this population. Using a loosely structured eleven count questionnaire, case studies, anecdotes, and movement observations employing Laban Movement Analysis terminology …

Performance As Therapy: An Intervention For Adults With Developmental Disabilities, Emily A. D'Annunzio

Creative Arts Therapies Theses

The research thesis titled, “Performance as therapy: An intervention for adults with developmental disabilities” examined how adults with developmental disabilities (DD) respond to this specific dance/movement therapy intervention. It shows how this intervention method addresses the psychosocial goal of increasing interpersonal skills. The research took place at a day rehabilitation center, located in Chicago, IL. The co-researchers are participants of a day rehabilitation program, which offers creative arts therapies. The co-researchers are both male and female who range in age from 21 to 60. Caucasian, African American and Hispanic ethnic backgrounds are represented. Co-researchers have DD, which include diagnoses of …

Rapid 13(C) Urea Breath Test To Identify Helicobacter Pylori Infection In Emergency Department Patients With Upper Abdominal Pain, Andrew C. Meltzer, Rebecca Pierce, Derek A.T. Cummings, Jesse M. Pines, Larissa May, Meaghan A. Smith, Joseph Marcotte, Melissa L. Mccarthy

Emergency Medicine Faculty Publications

Introduction: In emergency department (ED) patients with upper abdominal pain, management includes ruling out serious diseases and providing symptomatic relief. One of the major causes of upper abdominal pain is an ulcer caused by Helicobacter pylori (H. pylori), which can be treated and cured with antibiotics. We sought to estimate the prevalence of H. pylori infection in symptomatic patients using a convenience sample at a single urban academic ED and demonstrate the feasibility of ED-based testing.

Methods: We prospectively enrolled patients with a chief complaint of pain or discomfort in the upper abdomen for 1 year from February …

From Qualitative Work To Intervention Development In Pediatric Oncology Palliative Care Research, Terrah Foster Akard, Mary Jo Gilmer, Debra L. Friedman, Barbara Given, Verna L. Hendricks-Ferguson, Pamela S. Hinds

Pediatrics Faculty Publications

Qualitative methods can be particularly useful approaches to use with individuals who are experiencing a rare disease and thus who comprise a small sample (such as children with cancer) and are at points in care that few experience (such as end of life). This data-based methods article describes how findings from a qualitative study were used to guide and shape a pediatric oncology palliative care intervention. Qualitative data can lay a strong foundation for subsequent pilot intervention work by facilitating the development of an underlying study conceptualization, providing recruitment feasibility estimates, helping establish clinically meaningful inclusion criteria, establishing staff acceptability …

Literature Review Of Early And Precocious Puberty In Girls, Denise R. Tate

Graduate Research Projects

No abstract provided.

Chhs May/June 2013 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

The Effect Of Skeletal Muscle Mass On Basal Metabolic Rate In College-Age Males 2013, Chase Vaughn

Master's Theses

There are many misconceptions within the fitness community. One such misconception is that an increase in muscle mass will have a large increase in basal metabolic rate, yet this may not be the best way for successful weight loss. The purpose of this study was to determine the strength of the correlation between skeletal muscle mass and basal metabolic rate. The hypothesis tested was that basal metabolic rate is strongly correlated with skeletal muscle mass. The participants were college-aged males (n =17). Skeletal muscle mass (SMM) was estimated using the skin-fold circumference model (SFCM): SMM (kg) = Ht (0.00744 CAG2 …

The Presence Of Coups D'État Within Revolutions: Effects On Population Health, Rose E. Facchini

Master's Theses

The present study is a comparative approach to revolutions and their effect on population health during the post-conflict period. Specifically, it attempts to determine whether revolutions that are accompanied by a coup d'état have a significant negative impact on post-revolution population health. Degree of revolutionary violence, governmental structures, and pre-revolution health systems is of particular interest as relevant variables. The study focuses on the Latin American countries of Nicaragua and Chile due to their similar region and timeframe. The revolutions and accompanying coup d'état in both of these countries do not demonstrate different patterns on public health in the post-conflict …

History And Hope: The International Humanitarian Reader, Kevin M. Cahill, M.D.

Institute of International Humanitarian Affairs

History and Hope: The International Humanitarian Reader provides a better understanding—both within and outside academia—of the multifaceted demands posed by humanitarian assistance programs. The Reader is a compilation of the most important chapters in the twelve-volume International Humanitarian Affairs book series published by Fordham University Press. Each selected chapter has been edited and updated. In addition, the series editor, Kevin M. Cahill, M.D., has written, among other chapters, an introductory essay explaining the academic evolution of the discipline of humanitarian assistance. It focuses on the “Fordham Experience”: its Institute of International Humanitarian Affairs (IIHA) has developed practical programs for training …

เนื้องอกฮีแมงจิโอเพอริไซโทมาและโซลิทารี ไฟบรัสทูเมอร์: ข้อพิจารณาในการวินิจฉัย, พรภพ รัตนอาภา, เอกรัฐ ภัทรธราธิป

Chulalongkorn University Dental Journal

ฮีแมงจิโอเพอริไซโทมาเป็นเนื้องอกชนิดไม่ร้ายแรงที่มีจุดกําเนิดมาจากเพอริไซต์ซึ่งเป็นเซลล์ยืดหดได้ รอบหลอดเลือดเล็ก ในอดีตการให้การวินิจฉัยฮีแมงจิโอเพอริไซโทมาทางจุลพยาธิวิทยา ขึ้นกับการตรวจพบกลุ่ม หลอดเลือดผนังบางแตกแขนงคล้ายเขากวาง ล้อมรอบด้วยเซลล์เนื้องอกกายสัณฐานเดียว รูปร่างกลมหรือกระสวย อย่างไรก็ตามหลายการศึกษาตั้งข้อสังเกตหลายประการเกี่ยวกับธรรมชาติของเพอริไซต์และการดํารงอยู่ของ เนื้องอกชนิดนี้ ปัจจุบันแนวคิดของการวินิจฉัยเนื้องอกกลุ่มนี้ได้เปลี่ยนแปลงไป ดังเช่นการจําแนกเนื้องอกของเนื้อเยื่ออ่อนจากองค์การอนามัยโลกครั้งล่าสุด เนื้องอกที่ได้รับการวินิจฉัยเป็นฮีแมงจิโอเพอริไซโทมาได้ถูกจําแนก เป็นเนื้องอกกลุ่มอื่น ๆ โดยเฉพาะโซลิทารีไฟบรัสทูเมอร์ เนื้อหาของบทความปริทัศน์ฉบับนี้จะอภิปรายข้อถกเถียง เกี่ยวกับฮีแมงจิโอเพอริไซโทมา รวมถึงนําเสนอลักษณะทั่วไป และลักษณะในช่องปากของผู้ป่วยโซลิทารีไฟบรัส ทูเมอร์ที่มีรายงานทั้งหมด (ว ทันต จุฬาฯ 2556;36:129-42)

The Influence Of Respiratory Muscle Training On Exercise Endurance 2013, Justin Vanderbeck

Master's Theses

Exercise endurance in multiple populations has been shown to increase after bouts of respiratory muscle training (RMT) (Bailey, Romer, Kelly, Wilkerson, Dimenna & Jones, 2010; Brown, Sharpe, Graham & Johnson, 2008; Griffiths & McConnell, 2007; Kilding, Brown & McConnell, 2007; Laoutaris et al., 2012; Markov, Spengler, Stuessi, Boutellier & Knöpfli-Lenzin, 2001; Spengler & Boutellier, 2000; Stuessi, Spengler, Knöpfli-Lenzin, Markov & Boutellier, 2001; Volianitis et al., 2000). The use of resistance via respiratory muscle strength training (RMST) has been shown to produce greater increases in endurance than with no resistance, but the method of RMST that produces the greatest increases in …

Organized Camp And Character Development 2013, Veronica Ripp

Master's Theses

The purpose of this study was to examine the relationship between organized camp and character development. In particular, it looked to determine to what extent organized camp affected campers' character, including how much change in character campers' experienced in a week at camp, what aspects of character were most influenced, and what factors about camp had the most impact on campers' character. The study was multimodal in design, using the Values in Action Inventory for Youth (VIA-Youth) as a pre and posttest for quantitative analysis and camper interviews, staff interviews, and researcher observations for qualitative analysis. Seven completed VIA-Youth pre …

Section Abstracts: Medical Science

Virginia Journal of Science

Abstracts of the Medical Science Section for the 91st Annual Virginia Journal of Science Meeting, May 2013

Diabetic Db/Db Mice Exhibit Central Nervous System And Peripheral Molecular Alterations As Seen In Neurological Disorders., A. Ernst, Ajaykumar Narayan Sharma, Khalid M. Elased, P. C. Guest, H. Rahmoune, S. Bahn

Pharmacology and Toxicology Faculty Publications

The db/db mouse is a widely used preclinical model in diabetes research. Recent studies have shown that these mice also display aspects of psychosis and depression-like behaviors as seen in some psychiatric disorders. Here, we have performed multiplex immunoassay and liquid chromatography mass spectrometry profiling of the plasma and brain samples from db/db and control mice to identify altered pathways, which could be related to these behavioral abnormalities. This is the first study to carry out profiling of the brain proteome in this model. Plasma from the db/db mice had increased levels of leptin and insulin, decreased levels of peptide …

Community Building Through A Recovery Oriented Sytems Of Care Model For Tobacco Cessation In The Elderly, Ginny L. Hamolsky

Senior Honors Projects

Abstract

Community building is an important concept for all healthcare providers to understand in order to implement effective health promotion and empower members of a community. The World Health Organization (WHO) states that community building involves action at three levels to improve health. These actions include the advancement of skills among practitioners, expansion of support and infrastructure for health promotion, and the development of cohesiveness and partnerships within communities. If implemented effectively, the benefits of community building include enhancing quality of life, promoting health and well being, empowering individuals, and creating sustainable health care organizations that conduct and maintain successful …