Medicine and Health Sciences Commons^™

Efficacy Of Homoeopathic Treatment For Diabetic Distal Symmetric Polyneuropathy: A Multicentric Randomised Double-Blind Placebo-Controlled Clinical Trial, Raj Manchanda, Bindu Sharma, Pritha Mehra

Indian Journal of Research in Homoeopathy

Background: There are limitations in the management of Diabetic Distal Symmetric Polyneuropathy (DDSP) in conventional system but in Homoeopathy the research studies have shown positive results. These studies were not robust enough to prove the efficacy of individualized homoeopathy, thus this protocol has been developed to assess the efficacy of these individualized homoeopathic drugs in this disease. Material and Methods: It shall be a double blind randomised placebo controlled clinical trial. On the basis of earlier observational studies and repertorial anamnesis of DDSP symptoms, 15 homoeopathic medicines have been identified. The validated scales are being used for evaluating the outcomes …

Homoeopathic Management Of Attention Deficit Hyperactivity Disorder: A Randomised Placebo-Controlled Pilot Trial, Praveen Oberai, S Gopinadhan, Roja Varanasi, Alok Mishra, Vikram Singh, Chaturbhuja Nayak

Indian Journal of Research in Homoeopathy

Objective: To evaluate the usefulness of individualised homoeopathic medicines in treatment of Attention Deficit Hyperactivity Disorder (ADHD). Design: Randomised placebo-controlled single-blind pilot trial. Setting: Central Research Institute (Homoeopathy), Kottayam, Kerala, India from June 2009 to November 2011. Participants: Children aged 6-15 years meeting the Diagnostic Statistical Manual of mental disorders (DSM-IV) criteria for ADHD. Interventions: A total of 61 patients (Homoeopathy = 30, placebo = 31) were randomised to receive either individualised homoeopathic medicine in fifty millesimal (LM) potency or placebo for a period of one year. Outcome measures: Conner′s Parent Rating Scale-Revised: Short (CPRS-R (S)), Clinical Global Impression-Severity Scale …

Preliminary Study To Evaluate Analgesic And Behavioural Effects Of Lycopodium Clavatum In Experimental Animals, Echur Sundaram, Kushal Singh, Pratap Reddy, Sunil Kumar, Kainikkara Nair, Anil Khurana, Hari Singh, Chaturbhuja Nayak

Indian Journal of Research in Homoeopathy

Background and Aim: In Homoeopathy, the drug Lycopodium clavatum is prescribed for digestive upset, inflammations of urinary organs and dermal problems, but not for the treatment of central nervous system disorders unlike its use in traditional and folk medicine for central nervous system conditions. The present study was, therefore, undertaken with an aim to explore the possible analgesic and behavioural activities of the homoeopathic formulations of Lycopodium clavatum in animal models. Material and Methods: Wistar albino rats (120-140 g) of either sex were used to evaluate analgesic effect by using hot plate, ice plate and Randall-Selitto tests and behavioural effect …

A Characterization Of Gold Nanoparticle Uptake By Mammalian Cells, Thomas Garner

All Dissertations

Over the past decade, there has been an exponential growth in products and applications that utilize nanotechnology, as these materials present exciting opportunities for the development of new products, enhancement of existing products, and the evolution of innovative procedures. However, this recent growth has occurred in the absence of detailed knowledge concerning the interactions of nanoparticles with biological systems. Nanoparticles must usually be bioavailable in order to elicit a biological response, and to reach an active site they must usually cross a membrane. As a result, cell culture studies have proven to be beneficial and are generally one of the …

Building The Science Of Healthcare Public Reporting: Integrating Anecdotal Information To Enhance Sensemaking, Kapil Chalil Madathil

All Dissertations

Anecdotal information about a healthcare consumers' interaction with care providers and hospital facilities is becoming increasingly available to the public in the form of YouTube videos and as discussion posts on peer-support groups. This form of information can potentially jeopardize the utility of reports generated by Federal entities as it potentially diverts consumer attention from more reliable measures of quality. This dissertation investigates how a health consumer's choice of care is influenced by anecdotal information on the care process available on YouTube. This research then investigates the effect of information presentation methods such as narratives and active engagement with quality …

Phosphate Esters, Thiophosphate Esters And Metal Thiophosphates As Lubricant Additives, David W. Johnson, John E. Hils

Chemistry Faculty Publications

Phosphate esters, thiophosphate esters and metal thiophosphates have been used as lubricant additives for over 50 years. While their use has been extensive, a detailed knowledge of how they work has been a much more recent development. In this paper, the use of phosphate esters and thiophosphate esters as anti-wear or extreme pressure additives is reviewed with an emphasis on their mechanism of action. The review includes the use of alkyl phosphates, triaryl phosphates and metal containing thiophosphate esters. The mechanisms of these materials interacting with a range of iron and steel based bearing material are examined.

Membrane-Protein Dynamics: New Perspectives In Fcepsilonri Signaling Through Single Particle Tracking, Patrick J. Cutler

Biomedical Sciences ETDs

Under physiological conditions IgE binds to its high affinity receptor, FcεRI. The aggregation of IgE-FcεRI by crosslinker initiates intracellular signaling resulting in the release of histamines and other cellular mediators that are the basis for allergic disease. In the field of IgE-FcεRI, receptor immobilization was thought to trigger signaling. Recent single particle tracking (SPT) experiments presented evidence supporting the hypothesis that small mobile aggregates are signaling competent. SPT is an important method for investigating spatio-temporal relationships at the subcellular level. New SPT tools are necessary to adequately investigate this hypothesis. The studies presented here both develop and apply tools for …

Safety Of Botulinum Toxin For Dysphagia In Oculopharyngeal Muscular Dystrophy, Sarah Youssof

Biomedical Sciences ETDs

Despite multiple studies reporting marked benefit of botulinum toxin (BTX) for treatment of cricopharyngeal dysphagia, little is known about its safety for this indication. We examined the safety of cricopharyngeal BTX for dysphagia in oculopharyngeal muscular dystrophy (OPMD). We reviewed records of patients with OPMD who received cricopharyngeal BTX. Twenty-four patients underwent 66 procedures. Overall adverse event frequency was 44%. The most common adverse events were dysphonia (24%) and worsened dysphagia (14%). Logistic regression demonstrated that dose was a significant predictor of worsened dysphagia (P=0.036) and of the composite event of dysphonia or worsened dysphagia (P=0.009). There was a non-significant …

Labrad : Vol 39, Issue 2 - December 2013, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• Diagnosis of Inborn Errors of Metabolism in Pakistan
• Inherited Metabolic Disorders-Presenting as Metabolic Emergencies
• Role of Biochemical Genetics Laboratary in Evaluation of IEM
• Amino Acid Chromatography for the Diagnosis of Inborn Error of Metabolism
• Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Gene
• Diagnosis of Tyrosinemia Type I
• Congential Hypothyroidism
• Congential Adrenal Hyperplasia, An Insight of Laboratory
• Inaugration Ceremony of Section of biochemical Genetics Laboratory

Patients’ Attitudes Towards Patient Involvement In Safety Interventions: Results Of Two Exploratory Studies, Rachel Davis, Nick Sevdalis, Anna Pinto, Ara Darzi, Charles A. Vincent

Faculty Publications

BACKGROUND: In recent years, patient-focused interventions have been introduced aimed at increasing patient involvement in safety-related behaviours. However, patients' attitudes towards these interventions and comfort in participating in the recommended behaviours remain largely unexplored. OBJECTIVE: To evaluate patients' attitudes towards a video and leaflet aimed at encouraging patient involvement in safety-related behaviours. DESIGN: Two exploratory studies employing a within-subjects mixed-methods design. SETTING: Six hospital wards on an inner-city London teaching hospital. PARTICIPANTS: Medical and surgical inpatients: 80 patients in study 1 (mean age 55; 69% men) and 80 patients in study 2 (mean age 52; 60% men). INTERVENTION: Patients watched …

Assessing Certified Registered Nurse Anesthetists’ Attitudes Toward And Barriers To The Use Of Evidence-Based Anesthesia Practice, Laurie E. Parkman

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Evidence-based practice is the integration and synthesis of the best research evidence with clinical expertise and patient values. Use of evidence-based practice decreases variability in care and improves patient outcomes. This research project assessed variables that inhibit the adoption of evidence-based practice into individual CRNAs’ practice. Ninety-two CRNAs in Georgia participated in an email survey to assess attitudes and perceived barriers to evidence-based practice. Attitudes toward evidence-based practice were assessed with the Evidence-Based Practice Questionnaire (EBPQ), and perceived barriers to the use of evidence-based practice were assessed with the BARRIERS scale. A Pearson product-moment correlation coefficient was computed to assess …

Exploration Of Ethnic Differences Between Hispanic And Marshallese Mothers' Child Body Perceptions And Factors That Impact Childhood Obesity, Ashley Paige Latimer

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Childhood obesity is on the rise in the United States, especially among the Southern states and in minority ethnic groups. This condition is a known contributor to many chronic diseases, such as diabetes and cardiovascular disease, which develop in early adulthood. The Marshallese people - whose population is higher in Northwest Arkansas than anywhere else in the contiguous United States - have a high incidence of obesity and diabetes. Additionally, the Hispanic population per capita in Northwest Arkansas is more than triple that of the state of Arkansas, and have comparable obesity rates to the Marshallese population. The purposes of …

What Is The Relationship Between Maternal Bmi > 30 And Method Of Delivery?, Jessica Carol Wehmeyer

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Maternal obesity and its correlation to method of delivery are important when determining risk factors and examining adverse events and complications during pregnancy and labor. This study was completed as a retrospective review of the Uniform Data Set (UDS) of midwifery deliveries. It examined maternal body mass indexes (BMIs) pre-pregnancy as well as the impact these BMIs had on the method of delivery. Results of this study determined that there was a relationship between maternal BMI > 30 and the method of delivery. Women with a maternal BMI > 30 are 1.93% more likely to have a Cesarean delivery rather than a …

Assessing The Indoor Tanning Behaviors And Risk Of Skin Cancer Among Illinois Wesleyan University Students, Ellen Cornelius '14

Outstanding Senior Seminar Papers

The purpose of this research is to assess the indoor tanning behaviors of students at Illinois Wesleyan University (IWU) in Bloomington, Illinois and formulate strategies to reduce students’ risk of skin cancer. Skin cancer is widespread, and is the second most common cancer among people aged 15-24 years. There is strong evidence to support that many skin cancer cases seen today could have been avoided if the individual had never used an indoor tanning device. Research suggests the use of indoor tanning devices is popular among college-aged females in the US, thus persuading this demographic to reduce their indoor tanning …

Introduction: A Global Approach To Reproductive Justice—Psychosocial And Legal Aspects And Implications, Joan C. Chrisler

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Adequate Assurance Or Medical Mediocrity: An Analysis Of The Limits On The Affordable Care Act's Application To Women's Health, Nicole M. Hartz

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Bad Medicine: Abortion And The Battle Over Who Speaks For Women's Health, Andrea D. Friedman

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Effect Of Functional Starch In Brown Rice And Grain Sorghum On Plasma Glucose And Insulin Responses In Humans, Nicole Marie Poquette

Graduate Theses and Dissertations

Diabetes and obesity are chronic illnesses increasing at dramatic rates in the U.S. and around the world. Research has looked to prevent or control diabetes and obesity through functional ingredients such as healthy-dietary carbohydrates to control blood glucose levels. Starch is a principle carbohydrate, which influences blood glucose levels, and measuring starch digestibility fractions can help predict the glucose response in the body. The objectives of this study were to investigate the functional starch content of parboiled brown rice flour and grain sorghum flour, and measure the effects on postprandial plasma glucose and insulin levels of 14 and 10 healthy …

Shear Force At Failure And Stiffness Of All-Inside Meniscal Repair Devices, William K. Kesto, Amanda O. Esquivel, David C. Markel

Kinesiology, Health and Sport Studies

The purpose of this study was to determine the failure load and stiffness of various meniscal repair devices. A total of 61 fresh-frozen porcine menisci (medial and lateral) were used for the study. A 30-mm vertical, full-thickness tear was created and repaired using one of three all-inside fixation devices and one inside–out repair in the vertical mattress pattern. We used the MaxBraid (Biomet, Warsaw, IN) inside–out suture as a control. The other devices tested were the Meniscal Cinch (Arthrex, Naples, FL), Ultra FasT-Fix (Smith & Nephew, Andover, MA), and the MaxFire MarXmen (Biomet, Warsaw, IN). In addition, two devices, MaxFire …

Sepsis Bundled Care - An Early Goal Directed Therapy Application Study, Deven Arora

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Introduction: Septicemia is a severe disease affecting our healthcare system. A local hospital implemented a treatment protocol based on recent national standards to better treat this condition. The purpose of this study was to see if this protocol had any effect on patient outcomes in key variables. Methods: Pre and post design with pre-implementation (of the treatment protocol) sample group being all patients admitted to the Emergency Department (ED) at the test hospital with initial diagnosis of sepsis from May - October of 2012 while the post sample group was all patients admitted to the ED at the test hospital …

Department Of Surgery Update, December 2013, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains information about the new Chair of Family medicine, a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Surface-Enhanced Raman Spectroscopy (Sers) Tracking Of Chelerythrine, A Na+ K+ Pump Inhibitor, Into Cytosol And Plasma Membrane Fractions Of Human Lens Epithelial Cell Cultures, Kevin M. Dorney, Ioana E.P. Sizemore, Tariq Alqahtani, Norma C. Adragna, Peter K. Lauf

Pharmacology and Toxicology Faculty Publications

Background/aims: The quaternary benzo-phenanthridine alkaloid (QBA) chelerythrine (CET) is a pro-apoptotic drug and Na(+)/K(+) pump (NKP) inhibitor in human lens epithelial cells (HLECs). In order to obtain further insight into the mechanism of NKP inhibition by CET, its sub-cellular distribution was quantified in cytosolic and membrane fractions of HLEC cultures by surface-enhanced Raman spectroscopy (SERS). Methods: Silver nanoparticles (AgNPs) prepared by the Creighton method were concentrated, and size-selected using a one-step tangential flow filtration approach. HLECs cultures were exposed to 50 μM CET in 300 mOsM phosphate-buffered NaCl for 30 min. A variety of cytosolic extracts, crude and purified membranes, …

Developmental Characterization Of The Choroid Plexus In Sialidosis (Neu1 Deficient) Mice, Danielle Lee Helton

Theses and Dissertations (ETD)

The lysosomal sialidase Neuraminidase-1 (Neu1) initiates the hydrolysis of sialoglycoconjugates by cleaving their terminal sialic acid residues. Neu1 creates a complex with the carboxypeptidase protective protein/cathepsin A (PPCA), which is necessary for its catalytic activation and its transport to the lysosomal compartment. In humans, a primary deficiency of this enzyme leads to a pediatric, catastrophic, neurodegenerative lysosomal storage disorder called sialidosis. Mice deficient in Neu1 exemplify the early-onset severe form of sialidosis. Our laboratory has recently discovered that loss of Neu1 exacerbates the process of lysosomal exocytosis (LyEXO) in various cell types by influencing the sialic acid content of lysosomal …

Cost Of Illness Study Of Anxiety Disorders For The Ambulatory Adult Population Of The United States, Elaheh Shirneshan

Theses and Dissertations (ETD)

Background: Anxiety disorders are the most common psychiatric illness in the United States. However, economic burdens of this category of mental illnesses have not been well studied yet. The objective of this study was to estimate the societal cost of anxiety disorders for the ambulatory adult population of the U.S.

Data and Method: Data was collected from the 2009 and 2010 Medical Expenditure Panel Survey (MEPS), Bureau of Labor Statistics (BLS), and National Vital Statistics System (NVSS). Cost components included in the analyses were direct medical costs (i.e. cost for inpatient visits, outpatient visits, emergency room visits, office-based visits, prescription …

Determinants Of Upper Genital Tract Complications In A Chlamydial Urogenital Mouse Model, Enitra N. Jones

Theses and Dissertations (ETD)

Genital Chlamydia trachomatis infection is a major public health concern. Chlamydia is the most commonly reported infection in the United States and the most common bacterial sexually transmitted infection worldwide. Unrecognized infection endangers female reproductive health by serious complications such as Pelvic Inflammatory Disease, ectopic pregnancy, and involuntary infertility. Widespread Chlamydia control programs were implemented more than two decades ago to improve women's reproductive health but, despite initial success, the number of chlamydial infections reported have increased.

One of the hypotheses put forth to explain increased chlamydial reporting suggests that a longterm caveat of control initiatives is interference with the …

The Risks And Benefits Of Running Barefoot Or In Minimalist Shoes: A Systematic Review, Kyle Perkins

HIM 1990-2015

The popularity of running barefoot or in minimalist shoes has notably increased in the last decade due to claims of injury prevention, enhanced running efficiency, and improved performance when compared to running in shoes (shod). A systematic review of the literature was performed using the Downs and Black checklist to assess the methodological quality of studies proposing risks or benefits between running barefoot, shod, or in minimalist shoes. The databases Ovid MEDLINE, SPORTDiscus, and CINAHL were searched using keywords or "Booleans" including: "Barefoot", "Running" and "Minimalist," exclusively. All included articles were obtained from peer reviewed journals in the English language …

Economic Impact Of Medical Education Expansion In Nevada: Economic Impact Assessment And Recommended Approach, Tripp Umbach

Lincy Institute Reports and Briefs

In May 2013, The Lincy Institute1 commissioned, Tripp Umbach2 to prepare an economic impact report to show the value of a new, four-year allopathic medical school (hereinafter referred to as the new four-year medical school) in Las Vegas. To accomplish this task, Tripp Umbach evaluated multiple medical school development models in order to recommend the optimal model that would provide the greatest economic impact to the state of Nevada and the Las Vegas Metropolitan area.

Barriers To Membership In The American Dental Hygienists’ Association In The State Of Georgia, Brandy Henderson

Electronic Theses and Dissertations

Professional associations must have a significant level of membership to be effective. Georgia membership is increasingly low; therefore, ADHA cannot represent dental hygienists’ interests. This study determined factors that caused dental hygienists to continue to forgo membership in the ADHA. Several theoretical views of professional membership were considered. The sample was acquired from an unbiased systematic sampling of 50% (3,270) of registered dental hygienists and a convenience sampling of ADHA nonmembers at 2 continuing education seminars in Georgia. Data collection procedures included an electronic cover letter, consent form, and survey via Survey Monkey or hard copies for seminars. Three hundred …

Intrahypothalamic Pituitary Adenylate Cyclase-Activating Polypeptide Regulates Energy Balance Via Site-Specific Actions On Feeding And Metabolism, Jon Resch, Brian Maunze, Adriana K. Gerhardt, Samuel K. Magnuson, Kailynn A. Phillips, Sujean Choi

Biomedical Sciences Faculty Research and Publications

Numerous studies have demonstrated that both the hypothalamic paraventricular nuclei (PVN) and ventromedial nuclei (VMN) regulate energy homeostasis through behavioral and metabolic mechanisms. Receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) are abundantly expressed in these nuclei suggesting PACAP may be critical for the regulation of feeding behavior and body weight. To characterize the unique behavioral and physiological responses attributed to select hypothalamic cell groups, PACAP was site-specifically injected into the PVN or VMN. Overall food intake was significantly reduced by PACAP at both sites, however meal pattern analysis revealed only injections into the PVN produced significant reductions in meal size, …

Effect Of Asthma And Cystic Fibrosis On Health Utilization And Education Progress In Children And Adolescents., Bradlee A. Jenkins

Undergraduate Honors Theses

Aims. To determining the effect of asthma, cystic fibrosis (CF), and both on healthcare utilization, absences from school, and rate of progress in school.

Background. Previous studies on academic progression and health care utilization in children with the respiratory diseases of asthma and CF have been limited or conflicting.

Design. Non experimental, cross-sectional, secondary data analysis using a multilevel probability sample.

Methods. The response of all persons under 18 years of age in the U.S. 1997-2012 National Health Interview Survey to interviewer questions on demographic, educational, and health care utilization items were analyzed. The mean and 95% confidence intervals for …