Medicine and Health Sciences Commons^™

Family Acculturation And Asthma Outcomes In Latino Children, Tania M. Barreno

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Asthma is the primary chronic disease diagnosed in children. California has had some of the highest asthma prevalence rates within the nation. The literature indicates that there is a poor understanding of asthma outcome and management. However, studies exploring the role of acculturation on such outcomes are limited. Thus, the goal of this research was to conduct a secondary analysis of the Child Questionnaire from the California Health Interview Survey (CHIS) 2007 and 2009 cross-sectional data to explore the determinants of asthma outcomes as it relates to family acculturation.

Methodology: The quantitative data were analyzed using Stata. Descriptive statistics, …

Small Molecule Inhibitors Of Hpv16 E6, Chung-Hsiang Yuan

Loma Linda University Electronic Theses, Dissertations & Projects

High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the interactions between HPV E6 and its partners using small molecules had the potential to re-sensitize HPV+ cells to apoptosis. To test this prediction, we screened libraries of small molecules for candidates that could block E6/caspase 8 binding, and identified several candidates from different chemical classes. Testing hits for dose-dependency and specificity in vitro and for toxicity …

The Public Health Impact Of Maternal Smoking Cessation During Pregnancy : The San Bernardino County Experience, Michael Batech

Loma Linda University Electronic Theses, Dissertations & Projects

Most studies of maternal tobacco cessation during pregnancy have estimated measures of effect that can be useful in identifying the exposure as an etiologic risk factor in maternal and child health. However, in the case of maternal tobacco use there is overwhelming evidence for a causal role in adverse infant outcomes, and public health needs to focus on measures of potential impact in order to better prioritize and allocate resources toward interventions. The aims of this dissertation were: 1) to investigate the public health impact of smoking cessation during pregnancy among mothers giving birth in San Bernardino County, California; and …

Role Of Igf-Ii, Prl, And Fabps In The Breast Cancer Disparity Among Aa Women, Teleka Cassandra Patrick

Loma Linda University Electronic Theses, Dissertations & Projects

It is well documented that African-American (AA) patients present with more advanced states of breast cancer and have lower survival rates than Caucasian-Americans (CA). Epidemiological data have shown that pregnancy and lactation at an early age in humans reduce the risk of breast cancer. Studies in mice and rats have shown that lactation stimulates the expression of intracellular fatty-acid binding protein 3 (FABP3). FABP3 is detected in human breast tissue and is known as mammary-derived growth inhibitor (MDGI) because it has a strong inhibitory effect on cell proliferation. FABP5 is also expressed in the breast, and has been associated with …

Stress, Depression, Quality Of Life, And Language Recovery In Constraint Induced Aphasia Therapy (Ciat), Brian Sharp

Loma Linda University Electronic Theses, Dissertations & Projects

Traditional aphasia treatment approaches focus initially on restoration of language, but quickly move to use of alternative modes of communication when progress is slow. Constraint Induced Aphasia Therapy (CIAT), a more intensive form of treatment, is based on the concept of frequent, long sessions and forced use of the impaired language system. Prior to the present study, the relationship between CIAT and stress had not been explored; therefore, this study compared cortisol stress levels and improvement of language skills in two groups of subjects, all of whom presented with expressive aphasia. Ten subjects participated in CIAT, and received 10 days …

Microglia And Complement In Alzheimer's Disease With Cerebral Amyloid Angiopathy, Matthew K. Zabel

Loma Linda University Electronic Theses, Dissertations & Projects

Alzheimer’s disease (AD) is the most common form of dementia and completely lacks any viable, long-term therapeutic intervention. This is partly due to an incomplete understanding of AD etiology and the possible confounding factors associated with its genotypic and phenotypic heterogeneity. Cerebral amyloid angiopathy (CAA) is a common, yet frequently overlooked, pathology associated with AD. A pathological hallmark of AD consists of extracellular amyloid-beta (Aβ) deposits, while CAA

manifests with deposition Aβ within the smooth muscle layer of cerebral arteries and arterioles. The role of Aβ in AD and CAA pathophysiology has long been controversial. Although it may have toxic …

Physician Couples: A Qualitative Inquiry Focused On Gendered Power And Marital Equality, Sarah C. Stuchell

Loma Linda University Electronic Theses, Dissertations & Projects

How couples “do” gender and power in their marriages is a relevant topic for today’s couples. Despite social changes toward equality in many realms, gender continues to organize relationships in ways that give husbands more power than wives. However, some contemporary couples make conscious decisions to resist forces toward organizing according to stereotypical gender ideals and to “do” gender differently in their relationships. For couples in which one or both is a physician, power is also deeply embedded in the physician status, with families tending to organize around the physician’s demands. While these effects reinforce male dominance when the husband …

Ontogeny Of Venom Use And Venom Composition In The Western Widow Spider Latrodectus Hesperus, David Roger Nelsen

Loma Linda University Electronic Theses, Dissertations & Projects

I investigated the behavioral ecology of venom and venom use by the western widow spider (Latrodectus hesperus), emphasizing the role of ontogeny. In an introductory paper, I reviewed existing definitions of venom and poison, and refined these by adding a third category of toxic biological secretions: toxungen. These three can be distinguished by mode of toxin delivery and presence of a wound. In the first of four empirical studies, I investigated venom use by adult females in the context of threat assessment. A single brief poke at the lowest threat level elicited primarily avoidance responses ("move" and "retract"), repeated prodding …

Expanding Roles Of Medical Assistants In The Patient Centered Medical Home, Christopher W. Eldridge

Muskie School Capstones and Dissertations

The Patient Centered Medical Home (PCMH) is a new model of care endorsed in 2007 by the four major primary care physician associations. The PCMH is an approach to providing comprehensive primary care for children, youth, and adults. The PCMH is a health care setting that facilitates partnerships between individual patients and their personal physicians, and, when appropriate, the patient’s family as defined in the 2007 document Joint Principles of the Patient-Center Medical Home. The five key principles as defined in the article are:
1) Physician Directed Medical Practice
2) Whole Person Orientation
3) Care is Coordinated and/or Integrated across …

Maternal Smoking, Weight Status And Preecalmpsia And Eclampsia Risk Among Women Living In San Bernardino County, Fiona Bedelia Lewis

Loma Linda University Electronic Theses, Dissertations & Projects

Preeclampsia is defined as pregnancy-induced hypertension affecting between 2% and 8% of pregnancies and accounting for about 10-15% of maternal deaths worldwide. Eclampsia is defined as the occurrence of one or more episodes of seizures in a pregnant woman related only to a preeclampsia diagnosis. Preeclampsia, if poorly managed, can progress to eclampsia resulting in injury and death to both mother and infant. The etiology of preeclampsia is not completely understood. Oxidative stress leading to abnormal placenta development and endothelial dysfunction are thought to be key components in the biological mechanism of preeclampsia.

Modifiable risk factors include maternal body weight …

Perinatal Nicotine Exposure And Programming Of Hie Sensitive Phenotype In Neonatal Rat Brains, Yong Li

Loma Linda University Electronic Theses, Dissertations & Projects

Large epidemiological and animal studies have revealed a clear association of adverse intrauterine environment with the increased risk of metabolic, cardiovascular and neurological diseases. Maternal smoking is the single most widespread perinatal insult in the world and has been associated with adverse pregnancy outcomes for mother, fetus and the newborn. Our study aims to test the hypothesis that perinatal nicotine exposure induces reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model …

Evaluation Of Degradation Of The Chicken Egg Over Time By Method Of Haugh Unit Score, Serena Gurley

Animal Science

The purpose of this senior project was to measure the degradation of the chicken egg over time under different treatments. 864 eggs were collected and divided into six treatment groups. The six groups of study were refrigerated: unwashed, washed, washed and oiled as well as room temperature: unwashed, washed, washed and oiled. The Haugh unit score was measured individually for one dozen eggs taken randomly from each of the six groups once a week for twelve weeks. The Haugh unit score statistical assessment of the eggs found washed and oiled eggs held in refrigeration maintain freshness longer than the other …

Reproductive Tract Infections Among Married Women In Peri-Urban Areas Of Karachi, Pakistan: A Population-Based Study, Neelofar Sami, Tazeen S. Ali, E. Khan

Community Health Sciences

Background: Reproductive Tract Infections (RTIs) is a major public health problem. In Pakistan, there is dearth of information about the prevalence of RTIs among women and their health seeking behavior. A study was conducted to determine the prevalence, number and types of RTIs among women residing in squatter settlements in Karachi and their health seeking behavior.
Methods: The respondents were married non-pregnant women aged 15–49 years residing in peri-urban areas of Karachi, Pakistan. The interviews with women were followed by their physical and pelvic examinations. Samples swabs collected from vagina and endocervix were tested in laboratory.
Results: Overall, 23.8% of …

Lower Extremity Functional Tests And Risk Of Injury In Division Iii Collegiate Athletes, Jason Brumitt, Bryan C. Heiderscheit, Robert C. Manske, Paul E. Niemuth, Mitchell J. Rauh

Faculty Publications - College of Physical Therapy

Purpose/Background: Functional tests have been used primarily to assess an athlete’s fitness or readiness to return to sport. The purpose of this prospective cohort study was to determine the ability of the standing long jump (SLJ) test, the single-leg hop (SLH) for distance test, and the lower extremity functional test (LEFT) as preseason screening tools to identify collegiate athletes who may be at increased risk for a time-loss sports-related low back or lower extremity injury.

Methods: A total of 193 Division III athletes from 15 university teams (110 females, age 19.1 ± 1.1 y; 83 males, age 19.5 ± 1.3 …

B Cell Response And Hemagglutinin Stalk-Reactive Antibody Production In Different Age Cohorts Following 2009 H1n1 Influenza Virus Vaccination, Mark Y. Sangster, Jane Baer, Felix W. Santiago, Theresa T. Fitzgerald, Natalia A. Ilyushina

Dartmouth Scholarship

The 2009 pandemic H1N1 (pH1N1) influenza virus carried a swine-origin hemagglutinin (HA) that was closely related to the HAs of pre-1947 H1N1 viruses but highly divergent from the HAs of recently circulating H1N1 strains. Consequently, prior ex- posure to pH1N1-like viruses was mostly limited to individuals over the age of about 60 years. We related age and associated dif- ferences in immune history to the B cell response to an inactivated monovalent pH1N1 vaccine given intramuscularly to subjects in three age cohorts: 18 to 32 years, 60 to 69 years, and >70 years. The day 0 pH1N1-specific hemagglutination inhibition (HAI) …

Uv Radiation And The Skin, John A. D'Orazio, Stuart G. Jarrett, Alexandra Amaro-Ortiz, Timothy Scott

Toxicology and Cancer Biology Faculty Publications

UV radiation (UV) is classified as a "complete carcinogen" because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and …

Bioactive Lipids And Cationic Antimicrobial Peptides As New Potential Regulators For Trafficking Of Bone Marrow-Derived Stem Cells In Patients With Acute Myocardial Infarction, Anush V. Karapetyan, Yuri M. Klyachkin, Samy Selim, Manjula Sunkara, Khaled M. Ziada, Donald A. Cohen, Ewa K. Zuba-Surma, Janina Ratajczak, Susan S. Smyth, Mariusz Z. Ratajczak, Andrew J. Morris, Ahmed Abdel-Latif

Internal Medicine Faculty Publications

Acute myocardial infarction (AMI) triggers mobilization of stem cells from bone marrow (BM) into peripheral blood (PB). Based on our observation that the bioactive sphingophospholipids, sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HSCs), we explored whether they also direct trafficking of non-hematopoietic stem cells (non-HSCs). We detected a 3–6-fold increase in circulating CD34+, CD133+, and CXCR4+ lineage-negative (Lin−)/CD45− cells that are enriched in non-HSCs [including endothelial progenitors (EPCs) and very small embryonic-like stem cells (VSELs)] in PB from AMI patients (P<0.05 vs. controls). Concurrently, we measured a 3-fold increase in S1P and C1P levels in plasma from AMI patients. At the same time, plasma obtained at hospital admission and 6 h after AMI strongly chemoattracted human BM-derived CD34+/Lin− and CXCR4+/Lin− cells in Transwell chemotaxis assays. This effect of plasma was blunted after depletion of S1P level by charcoal stripping and was further inhibited by the specific S1P1 receptor antagonist such as W146 and VPC23019. We also noted that the expression of S1P receptor 1 (S1P1), which is dominant in naïve BM, is reduced after the exposure to S1P at concentrations similar to the plasma S1P levels in patients with AMI, thus influencing the role of S1P in homing to the injured myocardium. Therefore, we examined mechanisms, other than bioactive lipids, that may contribute to the homing of BM non-HSCs to the infarcted myocardium. Hypoxic cardiac tissue increases the expression of cathelicidin and β-2 defensin, which could explain why PB cells isolated from patients with AMI migrated more efficiently to a low, yet physiological, gradient of stromal-derived factor-1 in Transwell migration assays. Together, these observations suggest that while elevated S1P and C1P levels early in the course of AMI may trigger mobilization of non-HSCs into PB, cathelicidin and β-2 defensin could play an important role in their homing to damaged myocardium.

Challenges And Opportunities For Improving Mental Health Services In Rural Long-Term Care, Jean A. Talbot Phd, Andrew F. Coburn Phd

Long Term Services and Supports

Despite high levels of need, individuals in long-term care often fail to receive appropriate mental health services, especially in rural areas. In this report (and accompanying Research & Policy Brief), we consider challenges and opportunities for improving mental health treatment delivered to long-term care recipients in rural settings. As background, we note the prevalence of mental health problems in long-term care populations, describe deficiencies in the mental health care afforded to long-term care recipients, and identify barriers that hinder the remediation of these deficiencies in rural settings. We also outline a rationale for enhancing mental health services in long-term …

A Review Of Serum 25-Hydroxyvitamin D Levels In Alaska Native And Non-Natives In Southwest Alaska, Melanee Tiura

Master's Theses and Doctoral Dissertations

Background: Vitamin D insufficiency and deficiency have been documented throughout the world, correlating with disease processes including: cancers, bone disorders, autoimmune diseases, and cardiovascular disease. Factors affecting people of Southwest Alaska, such as northern latitude (above 34ºN), low dietary intake of vitamin D, reduced sun exposure, high body mass index, and darker skin pigmentation increase risk for Serum 25-hydroxyvitamin D [25(OH)D] deficiency and insufficiency.

Purposes of the Study: To evaluate the incidence of 25(OH)D insufficiency and deficiency in Southwest Alaska, differences in deficiency rates between Alaska Natives and non-Natives, and seasonal trends in 25(OH)D levels.

Subjects: Forty-nine adults with 25(OH)D …

School Of Nursing Newsletter June 2013, Southern Adventist University School Of Nursing

Southern Nursing - School of Nursing Newsletter

The June 2013 issue of the newsletter features articles on Linda Marlowe's retirement, senior recognition, mission trips, a simulated disaster, a visit from Japanese nursing students, and the debut of a standardized patient program.

Visual Outcome Of Cataract Surgery, Farzeen Khalid Hashmi, Qazi Assad Khan, Tanveer Anjum Chaudhry, Khabir Ahmad

Department of Surgery Docs

The aim of this study was to assess whether the visual outcome of cataract surgery in the institution was in accordance with the World Health Organization recommendations. In this retrospective case series, all patients who underwent cataract surgery by a single surgeon from January 2009 till June 2011 were included. Date were collected from medical records on age, gender, visual acuity and causes of sub-optimal outcome. The main outcome was best-corrected visual acuity in the operated eye, measured 4 – 6 weeks after surgery. Data on visual outcome was grouped using WHO's classification. Of the 495 eyes that underwent cataract …

Benzodiazepine Use In Medical Out-Patient Clinics: A Study From A Developing Country, Muhammad Junaid Patel, Syed Ahmer, Faheem Khan, Abdullah Waqar Ahmed Qureshi, Muhammad Farrukh Shehzad, Sania Muzaffar

Section of Internal Medicine

Objective: To estimate the prevalence of Benzodiazepine use in the outpatient setting of general medicine clinics at a single tertiary care centre.

Methods: The prospective prevalence study was conducted in the outpatient setting of Internal Medicine Clinics at Aga Khan University Hospital, Karachi, from November to December 2009. All subjects were interviewed after informed consent and variables were recorded on a specially-designed proforma. Apart from basic demographics and comorbid conditions, duration, frequency and route of benzodiazepine use, as well as the reason and who initiated it was noted. Chi-square test and t test was applied to see the …

Standardization Of Homoeopathic Drug: Buxus Sempervirens L., P Subramanian, P Rao, T Reddy, P Sudhakar, P Reddy

Indian Journal of Research in Homoeopathy

Background: Buxus sempervirens L. (Buxaceae), is a small tree, used in Homoeopathy for acute pain, increase in pulse rate and nausea. Leaves and stems are used in the preparation of medicine. Objective : The pharmacognostic and physico-chemical studies are carried out to facilitate use of correct species and standard raw materials. Material and Methods: Pharmacognostic studies of leaf and stem of authentic samples of Buxus sempervirens have been carried out. Physico-chemical parameters of the raw drug, namely, extractive values, ash value, formulation besides weight per milliliter, total solids, alcohol content, High Performance Thin Layer Chromatography (HPTLC) and Ultraviolet (UV) studies …

Hydroquinone: Homoeopathic Pathogenetic Trial, Rajesh Shah

Indian Journal of Research in Homoeopathy

Background: A double-blind, randomized, placebo-controlled Homoeopathic Pathogenetic Trial (HPT/Drug Proving) of Hydroquinone was conducted, using the accepted guidelines, ethical approval and scientific documentation The potentization method was standardized. Toward enhancing the quality of HPT, the investigator proposed and evaluated the data using the Quantitative Pathogenetic Index and Qualitative Pathogenetic Index. Usable symptoms were derived from the study. The medicine was suggested for the treatment of vitiligo, based on its known toxicological effects. HPT of a new medicinal substance, using the established parameters, to evaluate symptoms in healthy volunteers was carried out using a controlled experiment. Aims: The aim of the …

Effect Of Homoeopathic Lm Potencies In Acute Attacks Of Haemorrhoidal Disease: A Multicentric Randomized Single-Blind Placebo-Controlled Trial, P Chakraborty, Roja Varanasi, A Majumdar, Kishan Banoth, Sunil Prasad, M Ghosh, M Sinha, G Reddy, Vikram Singh

Indian Journal of Research in Homoeopathy

Background and Objectives: Anecdotal data on the usefulness of homoeopathic medicines in acute haemorrhoids shows grade V evidence. So, the efficacy of individualized homoeopathic medicines in LM potencies, in Acute Haemorrhoidal Attacks (AHAs), was investigated in this study against placebo. Material and Methods: In a multicenter randomized controlled single-blind parallel group trial conducted at six centers under the Central Council for Research in Homoeopathy, patients who presented with any symptom such as bleeding, pain, discharge, heaviness, and itching were included. The patients were randomized to receive either individualized homoeopathic medicine or placebo for a period of 90 days. Changes in …

Antidiabetic Effect Of Cephalandra Indica Q In Diabetic Rats, Arindam Pal, Biswapriya Misra, Shibendu Das, Samiran Gauri, Moumita Patra, Satyahari Dey

Indian Journal of Research in Homoeopathy

Background: Diabetes mellitus is an emerging global epidemic, taking its toll in developing countries as India. Presently, the treatment for diabetes using allopathic drugs gives only a temporary relief. A combination of right medicine and potency, on other hand has given Homoeopathy a high success rate in the treatment of this disease. Objective: The aim of this study was to investigate the effects of Cephalandra indica mother tincture and potencies on blood glucose level, cholesterol level, body weight, and beta-cells of pancreatic islets of Langerhans, in streptozotocin (STZ)-induced diabetic Wistar rats. Material and Methods: Glucose uptake was monitored in mother …

Treatment Of Post-Burn Hypertrophic Scar With Homoeopathic Medicine, Bhopal Arya, Vaqar Siddiqui, Rupali Dixit

Indian Journal of Research in Homoeopathy

Hypertrophic scar (HSc) is a dermal fibro proliferative disorder that occurs following trauma, inflammation, surgery, burns, and sometimes spontaneously. This is a case report of a 23 year old male with post-burn HSc after acid burn injury on his left jaw. The homoeopathic medicine Silicea was prescribed in 30 th potency on the basis of the totality of symptoms followed by repertorization; though only three doses of Silicea were prescribed at baseline during the course of treatment followed by placebo, there was a marked improvement in HSc as well as in associated complaints.

Glimpses From The Past, Ccrh Quarterly Bulletin Review, Volume 6 (1-4), 1984, Chaturbhuja Nayak, Harleen Kaur

Indian Journal of Research in Homoeopathy

No abstract provided.

Samuel Hahnemann: The Founder Of Homoeopathy, R Manchanda, Pritha Mehra

Indian Journal of Research in Homoeopathy

No abstract provided.

Editorial, R Manchanda

Indian Journal of Research in Homoeopathy

No abstract provided.