Medicine and Health Sciences Commons^™

Short- And Long-Term Outcomes Of Third Liver Transplantation At Single Centre, Hideyi Tanaka, Mamoun Al Basheer, Jeffrey Shum, Michael Bloch, Roberto Hernandez Alejandro, Vivian Mcalister, William Wall, Douglas Quan

Data and Test Instruments

Purpose Although three or more liver transplantation (LT)s in the same patient arouse not only medical but also ethical issues in the context of organ shortage, it is a fact that additional liver retransplantation (reLT) is the only lifesaving treatment option for those with graft failure after a second LT. However, little is known regarding the risks and benefits associated with a third LT. Methods We analyzed fifteen cases of third LT and 48 of second LT performed between January 2000 and December 2010. Clinical outcomes were compared with those of second LT cases performed during the same period. Results …

Making Meaning In The Legacy Of Tissue Donation For Donor Families, Nancy S. Hogan, Lee A. Schmidt, Maggie Coolican

Nursing: School of Nursing Faculty Publications and Other Works

Context-Individuals needing lifesaving (heart valves, skin grafts for repair of critical burn injuries) and life-enhancing (corneas, bone and tendon grafts, skin, and veins) tissue donations outnumber the tissues available for transplant. Objective-To describe the grief family members experienced 6 months after donation and to learn how family decision makers gained meaning from the decision to donate a loved one's tissues. This is phase 1 of a longitudinal study in which family decision makers will be surveyed again at 13 and 25 months after donation. Design-Qualitative descriptive. Participants-One hundred seven family decision makers whose family member died a traumatic sudden death …

Diseases At The Livestock–Wildlife Interface: Status, Challenges, And Opportunities In The United States, Ryan S. Miller, Mathew L. Farnsworth, Jennifer L. Malmberg

Zoonotics and Wildlife Disease: Publications

In the last half century, significant attention has been given to animal diseases; however, our understanding of disease processes and how to manage them at the livestock–wildlife interface remains limited. In this study, we conduct a systematic review of the scientific literature to evaluate the status of diseases at the livestock–wildlife interface in the United States. Specifically, the goals of the literature review were three fold: first to evaluate domestic animal diseases currently found in the United States where wildlife may play a role; second to identify critical issues faced in managing these diseases at the livestock–wildlife interface; and third …

Myofascial Pain Syndrome: A Treatment Review, Mehul J. Desai, Vikramjeet Saini, Shawnjeet Saini

Anesthesiology and Critical Care Medicine Faculty Publications

Myofascial pain syndrome (MPS) is defined as pain that originates from myofascial trigger points in skeletal muscle. It is prevalent in regional musculoskeletal pain syndromes, either alone or in combination with other pain generators. The appropriate evaluation and management of myofascial pain is an important part of musculoskeletal rehabilitation, and regional axial and limb pain syndromes. This article reviews the current hypotheses regarding the treatment modalities for myofascial trigger points and muscle pain. Through a critical evidence-based review of the pharmacologic and nonpharmacologic treatments, the authors aim to provide clinicians with a more comprehensive knowledge of the interventions for myofascial …

The Effect Of Visual Suggestion On Exercise Motivation And Outcomes, Thomas G. Plante, Ashley Morisako, Justine Folk, Elizabeth Kay, Caroline Read, Ashley Dunn, Angel Perez, Eleanor Willemsen

Psychology

Theories of suggestion and motivation were used to examine if college students exercising in an environment with low or high motivation posters would affect mood, perceived exertion, and exercise workload (i.e., RPM and speed). A total of 134 students (62 males, 72 females) were randomly assigned to one of three conditions while exercising: relaxing posters (i.e., tropical nature), motivational posters (i.e., competitive bikers), or no posters (i.e., control). Participants completed 20 minutes of exercise at their own pace. Measures of mood were taken immediately prior to and following exercise. Exercise workload was recorded throughout. Results indicate that participants in the …

Progressive Hair Coil Strangulation Of Penis, Shahzad Ms, Mohammed Shamim

Section of General Surgery

Strangulation of penis by hair strands is a well-known, but uncommon clinical entity. We report two cases occurring in circumcised boys causing progressive painless disfigurement of penis with strands of hair coiled around the penile shafts, strangulating the penis. Primary repair was done in one case and delayed primary repair was done in the other, both with satisfactory results.

Data On The Diversion, Nonmedical Use And Adverse Outcomes Associated With Pharmaceutical Opioids, Amanuel Zimam, Teresa D. Schmidt, Alexandra Nielsen, Wayne W. Wakeland

Complex Systems Faculty Publications and Presentations

Background: Recent increases in the nonmedical use of pharmaceutical opioids and the adverse outcomes associated with them have stimulated a large amount of research and data collection on this public health problem. Systematic organization of the available data sources is needed to facilitate ongoing research, analysis, and evaluation.

Method: A list of keywords associated with diversion, nonmedical use, and adverse outcomes of pharmaceutical opioid use generated 94 peer-reviewed academic articles and a number of governmental and nongovernmental sources. All sources were in English, contained quantitative data, and were published between January 1995 and April 2012. A list of 20 topics …

A Discursive Analysis Of A Pregnancy Center: How Pregnant Women Are Encouraged To Develop A Sense Of Self-Worth And Emotional Wellbeing Through The Use Of Rhetoric And Imagery, Jessica Postma

Masters Theses

This study presents and alternative approach to how pregnancy is interpreted in western society and how settings such as a pregnancy center both challenges and reinforces these social standards. The promotion of abstinence, the aversion to abortion, notions of truth and morality, religious narratives, and the standard of care are all integral components to this analysis of pregnancy, language, and culture.

A Preliminary Study Of The Articulatory And Acoustic Features Of Forward And Backward Tone Placement In Singing, Krista Wyllys

Masters Theses

A variety of terms exist for describing tone quality in singing, and voice scientists, voice therapists, teachers of singing, and students of singing use different terms to describe the same sound. One aspect of tone quality is tone placement. Teachers of singing often rely on imagery and imitation to elicit correct tone placement from students of singing. More concrete data about what produces forward and backward tone placement could supplement singing teachers’ current practice of using imagery and imitation to elicit a desirable tone quality. This study examined forward and backward tone placement to determine the articulatory gestures and acoustic …

The Role Of Transcendence In A Holistic View Of Successful Aging : A Concept Analysis And Model Of Transcendence In Maturation And Aging., Valerie Lander Mccarthy, Amanda Bockweg

Faculty and Staff Scholarship

BACKGROUND: Although successful aging is most often defined by the absence of disease and disability, older adults consistently report aging successfully even in the presence of chronic illness and functional limitations. A more holistic way of looking at old age suggests transcendence may be an important missing criterion for successful aging.

AIM: Transcendence, a late life developmental process, appears to have a profound effect within the spiritual domain, but is an abstract, complex and unfamiliar concept. A clear understanding of the meaning of transcendence is necessary to explore the concept’s usefulness as a potential basis for future interventions to increase …

Alaska Winter's Relationship To Domestic Violence And Alcohol Abuse, Jennifer Marie Read

Geography and the Environment: Graduate Student Capstones

Alaska is known for its long, dark, cold winter months. Daylight savings time exists to cope with months that have little sunlight, but that still leaves on average, five hours of daylight. Special light bulbs exist to help with the darkness by providing light that tricks the body into thinking it is getting more sun than it really is. As daylight decreases, the weather turns colder; depression, alcohol, and domestic violence begin to rise. Studies show alcohol related crime and domestic violence occur more during the winter months in Alaska. This research paper will analyze the data pertaining to alcohol …

Exploring Volatile General Anesthetic Binding To A Closed Membrane-Bound Bacterial Voltage-Gated Sodium Channel Via Computation., S G Raju, Annika F Barber, David N Lebard, Michael L Klein, Vincenzo Carnevale

Department of Neuroscience Faculty Papers

Despite the clinical ubiquity of anesthesia, the molecular basis of anesthetic action is poorly understood. Amongst the many molecular targets proposed to contribute to anesthetic effects, the voltage gated sodium channels (VGSCs) should also be considered relevant, as they have been shown to be sensitive to all general anesthetics tested thus far. However, binding sites for VGSCs have not been identified. Moreover, the mechanism of inhibition is still largely unknown. The recently reported atomic structures of several members of the bacterial VGSC family offer the opportunity to shed light on the mechanism of action of anesthetics on these important ion …

Acetylation Of The Cell-Fate Factor Dachshund Determines P53 Binding And Signaling Modules In Breast Cancer., Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Jing Wang, Wei Zhang, Jie Zhou, Gabriele Disante, Zhiping Li, Hallgeir Rui, Andrew A Quong, Steven B Mcmahon, Haiteng Deng, Michael P Lisanti, Chenguang Wang, Richard G Pestell

Department of Cancer Biology Faculty Papers

Breast cancer is a leading form of cancer in the world. The Drosophila Dac gene was cloned as an inhibitor of the hyperactive epidermal growth factor (EGFR), ellipse. Herein, endogenous DACH1 co-localized with p53 in a nuclear, extranucleolar compartment and bound to p53 in human breast cancer cell lines, p53 and DACH1 bound common genes in Chip-Seq. Full inhibition of breast cancer contact-independent growth by DACH1 required p53. The p53 breast cancer mutants R248Q and R273H, evaded DACH1 binding. DACH1 phosphorylation at serine residue (S439) inhibited p53 binding and phosphorylation at p53 amino-terminal sites (S15, S20) enhanced DACH1 binding. DACH1 …

Craniocerebral Injuries In War Against Terrorism --- A Contemporary Series From Pakistan, Muhammad-Umair Bashir, Muhammad-Zubair Tahir, Ehsan Bari, Sehreen Mumtaz

Section of Neurosurgery

Objective: Terrorism-related bomb attacks on civilian population have increased dramatically over the last decade. Craniocerebral injuries secondary to improvised explosive devices have not been widely reported in the context of unarmored civilians. This series intends to report the spectrum of these injuries secondary to suicidal and implanted bombs as encountered at the Aga Khan University Hospital, Pakistan (AKUH). Further, a few pertinent management guidelines have also been discussed.
Methods: The hospital database and clinical coding during a 5-year period were examined for head injuries secondary to terrorism-associated blasts. In addition to patient demographics, data analysis for our series included initial …

Validity And Reliability Testing: Urdu Translated Modified Response To Symptoms Questionnaire, Saleema Allana, Tazeen S. Ali, Khurshid Khowaja, Aamir Hameed, Debra Kay Moser

School of Nursing & Midwifery

Objective: To determine validity and reliability of the Urdu translated, modified "Response to symptoms questionnaire" (RSQ) among acute coronary syndrome (ACS) patients in Karachi.
Study Design: A qualitative, tool validation study.
Place and Duration of Study: Two tertiary care hospitals in Karachi, the Aga Khan University Hospital, Karachi and the Karachi Institute of Heart Diseases, from December 2010 to April 2011.
Methodology: After making certain modifications, the original tool in English was translated into Urdu. Next, five cardiology experts evaluated the tool for its content and face validity. Test retest and inter rater reliabilities were computed for the RSQ using …

Presenting Budget In A Research Grant Application, Junaid Ahmed Bhatti, Umbreen Akhtar, Bilal Arshed Butt, Naveed Zafar Janjua

Department of Emergency Medicine

No abstract provided.

A Comparison Of Who Guidelines Issued In 1997 And 2009 For Dengue Fever - Single Centre Experience., Munawar Khursheed, Uzma R. Khan, Kiran Ejaz, Jabeen Fayyaz, Irum Qamar, J. Razzak

Department of Emergency Medicine

Objective: To compare the original (1997) and revised (2009) versions of World Health Organization guidelines for dengue patients
Methods: Adult patients with a positive dengue Immunoglobulin M serology, and a diagnosis of dengue were included in the study at Aga Khan University Hospital during a three-year period from January 2005 to December 2007. Data related to these dengue patients was collected from their medical records. Guidelines were then applied by the research assistant and correlation among these guidelines was computed. SPSS 19 was used for statistical analysis.
Results: A total of 612 patients were found with a diagnosis of dengue, …

The Twenty-First Century Black Bag: Mobile Delivery Of Health Care Information And Implications For Health Science Library Collection Development, Elizabeth Retzel Bucciarelli

Graduate Capstone Projects

Mobile devices such as electronic tablets and smart phones have had a tremendous impact on the delivery of health and medically-related information for health care professionals. These innovative information tools are now used regularly at the patient bedside and in clinical care settings to enhance patient education and to access information regarding best practices, and point-of-care diagnostics and treatments. Presumably, then, institutions which educate students in the health sciences must also teach and acclimate them throughout their allied health programs to integrate and apply these health information delivery tools into clinical practice. This project will review the last five years …

Cyclic Peptides Containing Tryptophan And Arginine As Src Kinase Inhibitors, Amir Nasrolahi Shirazi, Rakesh Tiwari, Alex Brown, Dindyal Mandal, Gongqin Sun, Keykavous Parang

Pharmacy Faculty Articles and Research

A number of cyclic and linear peptides containing various combinations of amino acids were evaluated for their Src kinase inhibitory potency. Among all the peptides, cyclic decapeptide C[RW]5 containing alternative arginine (R) and tryptophan (W) residues was found to be the most potent Src kinase inhibitor. C[RW]5 showed higher inhibitory activity (IC50=2.8 μM) than C[KW]5, L(KW)5, C[RW]4, and C[RW]3 with IC50 values of 46.9, 69.1, 21.5, and 25.0 μM, respectively, as determined in a fluorescence intensity-based assay. Thus, the cyclic nature, the presence of arginine, ring size, and the number of amino acids in the structure of the peptide were …

Uchunguzi (Journal Watch/Montre De Journal) June 2013, Benjamin Wachira

Family Medicine, East Africa

No abstract provided.

Tobacco Treatment Outcomes From A Specialist Smoking Cessation Clinic Based Within Cardiology Services, Milan Khara, Chizimuzo T.C. Okoli

Nursing Presentations

BACKGROUND: Populations with cardiac conditions often continue to smoke at high rates (up to 62%), even after experiencing life-threatening cardiac events. The purpose of our study is to examine pilot treatment outcomes of an outpatient Smoking Cessation Clinic (SCC) provided within Cardiology Services.

METHODS: This study is based on a retrospective review of the charts of 118 participants of the SCC (between Sept 2010 and May 2012). The primary components of intervention include tailored pharmacotherapy and behavioural counselling. The main outcome of interest is self-reported 7-day point-prevalence of smoking abstinence verified by expired CO level (when available).

RESULTS: 34.7% …

Visionary Summer 2013, College Of Optometry

Visionary

No abstract provided.

Helping Haiti's Transportation Issues: Increasing Haiti's Medical Liabilities., Nancy Mclaughlin, Hannah Rogers

PCOM Scholarly Works

No abstract provided.

Use Of A Specific Alpha7 Nicotinic Acetylcholine Receptor Agonist Can Prevent Loss Of Retinal Ganglion Cells In An In Vivo Rat Glaucoma Model, David Mata

Masters Theses

Acetylcholine (ACh) has been shown to have a neuroprotective effect against glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs) through activation of α7 nicotinic ACh receptors (nAChRs). In this study, the neuroprotective effects of the α7 nAChR agonist, PNU-282987, were investigated using an in vivo model of glaucoma in adult Long Evans rats. Hypertonic saline injections were used to induce a glaucoma model. After one month, retinas were removed, flat mounted, fixed and labeled with an antibody against Thy 1.1 to label RGCs and fluorescently tagged for visualization. Eye drop application of PNU-282987 resulted in neuroprotection against RGC loss in …

Commencement Program 2013, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2013 Events of Commencement

5 | The Academic Procession

7 | Significance of Academic Regalia

9 | The Good Samaritan

10 | University History Highlights

12 | Loma Linda University Song - "Healing Love"

13 | The Speakers

23 | The University Honorees

45 | The School Honorees

64 | The Programs

• School of Medicine, 65
• School of Pharmacy, 83
• School of Dentistry, 90
• School of Behavioral Health and School of Religion, 107
• School of Nursing, 120
• School of Pubic Health, 129
• School of Allied Health Professions - Physical Therapy, 145 …

The Case For Conscientiousness: Evidence And Implications For A Personality Trait Marker Of Health And Longevity, Tim Bogg, Brent W. Roberts

Psychology Faculty Research Publications

Purpose Recent initiatives by major funding agencies have emphasized translational and personalized approaches (e.g., genetic testing) to health research and health management. While such directives are appropriate, and will likely produce tangible health benefits, we seek to highlight a confluence of several lines of research showing relations between the personality dimension of conscientiousness and a variety of health-related outcomes.

Methods Using a modified health process model, we review the compelling evidence linking conscientiousness to health and disease processes, including longevity, diseases, morbidity-related risk factors, health-related psycho-physiological mechanisms, health-related behaviors, and social environmental factors related to health.

Conclusion We argue the …

Block Copolymer Self-Assembled And Cross-Linked Nanoassemblies For Combination Delivery Of Iron Oxide And Doxorubicin, Daniel Scott, Yihwa Beabout, Robert J. Wydra, Mo Dan, Robert A. Yokel, J. Zach Hilt, Younsoo Bae

Pharmaceutical Sciences Faculty Publications

We describe the development of nanoscale polymer drug carriers for the combinational delivery of an anticancer drug (doxorubicin: DOX) along with super paramagnetic iron oxide nanoparticles (IONPs). The drug molecules were electrostatically loaded into both block copolymer self-assembled nanoassemblies (SNAs) and cross-linked nanoassemblies (CNAs). Both nanoassemblies entrapped DOX and IONPs either individually or in tandem, maintaining sub-100 nm diameter. The IONP-loaded nanoassemblies generated heat in the presence of an alternating magnetic field (AMF). Incorporation of the drug payload, DOX, showed no adverse effects on the heating profile. Drug release from the SNAs and CNAs was accelerated as temperature increased from …

Oncolog, Volume 58, Number 06, June 2013, Joe Munch, Amelia Scholtz, Luanne Jorewicz

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Addressing Emerging Survivorship Issues in Glioblastoma Patients: An increasing number of glioblastoma patients are becoming '' long-term'' survivors-living 3 or more years after diagnosis
• Prediction Tool Helps Determine Whether Older Breast Cancer Patients will benefit from Radiation: A statistical tool is now available to predict the likely individual benefit of radiation therapy for older women who have undergone breast-conserving surgery for breast cancer
• Sequential Multidrug Regiman May Offer an Alternative to Standard Cisplatin-Based Therapy for Urothelial Cancer: Cisplatin-based chemotherapy is the standard neoadjuvant treatment for high-risk, surgically resectable, invasive urothelial cancer. But some patients are not good candidates for this …

Impact Of Finger Position On Pinch Strength, Rachel Boerema, Jamie Powers, Kelsey Walukonis

Hand and Upper Extremity

The purpose of this study was to assess for differences in the amount of tip, lateral, and three-jaw-chuck pinch force generated when fingers are placed on the groove or bridge of a B&L pinch gauge. Thirty-six healthy volunteers (9 males, 27 females), ages 19-49, participated in the study. Using a quantitative crossover design, each participant pinched six times: one for each type of pinch with fingers placed on the groove and bridge. Although no significant differences were found, results revealed slightly higher three-jaw- chuck and lateral pinch strength when fingers were placed on the groove, whereas tip pinch strength was …

Expression Of The Chemokine Receptor, Cxcr4, And Its Ligand, Sdf-1, Are Increased In Purkinje Cells Of The Multiple System Atrophy Cerebellum, Megan Welter

Masters Theses

Multiple System Atrophy (MSA) is a sporadic, neurodegenerative disease that consists of three conditions: autonomic dysfunction, Parkinsonism and cerebellar ataxia. Our lab conducted an Affymetrix global gene expression analysis using pons tissue of MSA patients to determine genes that are differentially expressed when compared to non- MSA controls. This study identified upregulated genes, including the C-X-C chemokine receptor type 4, CXCR4, to which stromal cell-derived factor-I (SDF-1) is the natural ligand. The CXCR4/SDF-1 signaling pair has been sho.wn to play multiple roles in the brain, such as inducing neuronal apoptosis and promoting leukocyte recruitment during inflammation. The MSA cerebellum presents …