Medicine and Health Sciences Commons^™

Impact Of Vulvovaginal Health On Postmenopausal Women: A Review Of Surveys On Symptoms Of Vulvovaginal Atrophy, Sharon J. Parish, Rossella E. Nappi, Michael L. Krychman, Susan Kellogg-Spadt, James A. Simon, Jeffrey A. Goldstein, Sheryl A. Kingsberg

Obstetrics and Gynecology Faculty Publications

Several recent, large-scale studies have provided valuable insights into patient perspectives on postmenopausal vulvovaginal health. Symptoms of vulvovaginal atrophy, which include dryness, irritation, itching, dysuria, and dyspareunia, can adversely affect interpersonal relationships, quality of life, and sexual function. While approximately half of postmenopausal women report these symptoms, far fewer seek treatment, often because they are uninformed about hypoestrogenic postmenopausal vulvovaginal changes and the availability of safe, effective, and well-tolerated treatments, particularly local vaginal estrogen therapy. Because women hesitate to seek help for symptoms, a proactive approach to conversations about vulvovaginal discomfort would improve diagnosis and treatment.

Analgesic Effect Of A Mixed T-Type Channel Inhibitor/Cb2 Receptor Agonist, Vinicius M. Gadotti, Haitao You, Ravil R. Petrov, N. Daniel Berger, Philippe Diaz, Gerald W. Zamponi

Biomedical and Pharmaceutical Sciences Faculty Publications

Background: Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181. Results: NMP-181 action on CB1 and CB2 receptors was characterized in radioligand binding and in vitro GTP gamma[S-35] functional assays, and block of transiently expressed human Cav3.2 T-type channels by NMP-181 was analyzed by patch clamp. The analgesic effects and in vivo mechanism of action of NMP-181 delivered spinally or systemically were analyzed in formalin and CFA mouse models of pain. NMP-181 inhibited peak Ca(V)3.2 currents with IC50 values …

Chhs July E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Preventative Care And Culture, Anna Wagman

Independent Study Project (ISP) Collection

This paper explores the intersection between culture and health. The similarities and differences between methods for preventative medicine employed by traditional and allopathic systems are discussed. These ostensibly disparate systems, in reality, display many parallels in regards to their delivery. The effects of industrial progress, and therefore cultural change, on the health of the inhabitants of rapidly urbanizing African cities are examined. Historical information from studies of Great Britain, the first area to undergo a full industrial revolution is also drawn on. These analyses essentially predict the societal issues that come with urbanization, such as the amalgamation of preexisting pollutants …

Review Of Ourselves Unborn: A History Of The Fetus In Modern America, By Sara Dubow, Rose Holz

Women's and Gender Studies Program: Faculty Publications

With the publication of the Bancroft Prize-winning Ourselves Unborn, Sara Dubow offers a long overdue analysis and historicization of what has become a central feature in battles over reproductive rights: the fetus. Drawing upon legal and legislative records as well as educational tracts, museum exhibits, medical textbooks and journals, personal memoirs, and the popular press, Dubow traces what she calls “fetal stories” (4) in America from the late nineteenth century through the early twenty-first. In so doing, she persuasively reminds her readers the following: First, that our understanding of the fetus is not simply a product of biology or theology. …

Christian Villanueva - Trauma Exposure Reported By Women Recently Deported From The U.S. To Mexico, Christian Villanueva

Ronald E. McNair Scholars Program 2013

In 2012 the U.S. deported approximately 200,000 individuals to Mexico; a significant proportion of these individuals were women. The combined effect of previous traumatic experiences with that of being deported to Mexico is detrimental to women’s health. The trauma suffered through this process results in high levels of stress that lead to a variety of mental and physical health problems for Mexican women, disproportionally compared to men, who entered into and are deported from the U.S. The purpose of this study is to describe the life history of trauma exposure of women who have recently been deported from the U.S. …

Guadalupe Avalos - Filling Caskets More Quickly Than Cribs?: A Comparison Of Infant Mortality In Milwaukee And Costa Rica, Guadalupe Avalos

Ronald E. McNair Scholars Program 2013

Metropolitan Milwaukee had infant mortality rates at 9.5 deaths per 1,000 live births in 2010, according to the Milwaukee Health Department. This rate is a reversal of earlier decades. Between 2005 and 2008, Milwaukee experienced its highest infant mortality rate at 11 deaths per 1,000 live births. Disparities are most evident between African-Americans and Whites. Therefore, most explanations of infant mortality rates are compared between the two backgrounds. Since 2008, infant mortality rates have dwindled; however, the rates remain unacceptably high. A rate of 9.5 deaths per live births is detrimental and a public health issue.

By analyzing causes that …

A Randomized Clinical Trial Of Trans-Dermal Nicotine Replacement In Pregnant African-American Smokers, Ayman El-Mohandes, Richard Windsor, Sylvia Tan, David C. Perry, Marie G. Gantz, Michele Kiely

Publications and Research

We compared acceptability, adherence and efficacy of trans-dermal nicotine patches and cognitive behavioral therapy (Group 1) to cognitive behavioral therapy alone (Group 2) in minority pregnant smokers. This is a randomized controlled trial. 52 women were recruited during pregnancy with a mean gestational age 18.5 ± 5.0 weeks and followed through delivery. Randomization was by site and initial cotinine levels. Interventionists and interviewers were blinded to group assignment. Two different nicotine replacement therapy dosing regiments were administered according to the baseline salivary cotinine level. A process evaluation model summarized patient adherence. The main outcome measure was self-report of cessation since …

Physical, Behavioral, And Psychological Traits Of Gay Men Identifying As Bears, David A. Moskowitz, Jonathan Turrubiates, Hector Lozano, Christopher Hajek

NYMC Faculty Publications

The Bear community exists as a subculture in reaction to the larger gay community. It rejects the normative idealized male beauty revered by mainstream gay men. While qualitative data document such self-identifiers as masculine-acting gay men who weigh more and have more body hair, there has to date been no quantitative analysis of this group's characteristics. In response, we conducted two large-scale studies of gay men identifying as Bears (n = 469) to survey their self-reported physical, behavioral, and psychological traits. Our studies indicated that Bears were more likely to be hairier, heavier, and shorter than mainstream gay men. They …

Assessing The Efficacy Of A Modified Therapeutic Community On The Reduction Of Institutional Write-Ups In A Medium Security Prison, Lee Wayne Maglinger, Aaron W. Hughey, Monica Galloway Burke

Counseling & Student Affairs Faculty Publications

This study explored the impact a modified TC (Therapeutic Community) had on reducing institutional disorder as documented by institutional write-ups. The number of institutional write-ups exhibited by clients participating in a modified TC was compared with the number of write-ups exhibited by inmates in five non-treatment units over a four-year period. ANOVA (analysis of variance) revealed that the number of write-ups exhibited by clients in the TC was significantly lower than the number exhibited by inmates in the other five dorms (F_{(4, 24)} = 5.61, p < 0.002).Further, when examined by category of offense (major/minor), it was found that the write-ups of clients in the TC generally were not as severe as those exhibited by inmates in the general prison population. The implications of these findings for corrections administrators are discussed and specific recommendations are provided.

You Missed A Spot! Disinfecting Shared Mobile Phones, Roberta Basol, Jean Beckel, Judy Gildsdorf-Gracie, Amy Hilleren-Listerud, Terri Mccaffrey, Sherri Reischl, Pamela Rickbeil, Mary Schimnich, Kirsten Skillings, Mary A. Struffert

Articles

The use of portable mobile devices has facilitated timely communication among healthcare team members. It's now a common practice for hospital-owned mobile phones to be shared among healthcare employees from shift to shift. Despite the benefit of increased, timely communication between caregivers, sharing mobile devices can lead to the spread of healthcare-associated infections (HAIs). This article looks at the efficacy of two types of cleaning products on shared mobile phones carried by RNs at a 489-bed, Magnet-designated, Midwestern regional medical center. The cleaning methods evaluated were 70% isopropyl alcohol wipes and ethyl alcohol wipes.

Dimensions Of Suicidality: Analyzing The Domains Of The Sis-Map Suicide Risk Assessment Instrument And The Development Of A Brief Screener, Megan Johnston, Charles Nelson, Amresh Shrivastava

Data and Test Instruments

This study aimed at validating the domains of suicidality assessed by the Scale for Impact of Suicidality—Management, Assessment and Planning of Care (SISMAP) and creating a brief screener based on the full scale. A total of 50 individuals with suicidal ideation were given the SIS-MAP interview. Support was found for these domains of suicide risk; in particular, the subscales of ideation and protective factors for suicide risk were highly reliable. For each domain of suicidality, items most predictive of total risk index scores were selected to create a brief screener aimed at expediting the assessment process. The screener was reliable, …

Prevalence And Prognostic Significance Of Long Qt Interval Among Patients With Chest Pain: Selecting An Optimum Qt Rate Correction Formula, Amer A. Hasanien, Barbara J. Drew, Jill Howie-Esquivel, Gordon Fung, Patricia Harris

Collected Faculty Scholarship

Background: Little is known about the prevalence and prognostic significance of long QT interval among patients with chest pain during the acute phase of suspected cardiovascular injury.

Objectives: Our aim was to investigate the prevalence and prognostic significance of long QT interval among patients presenting to the emergency department (ED) with chest pain using an optimum QT rate correction formula.

Methods: We performed secondary analysis on data obtained from the IMMEDIATE AIM trial (N, 145). Data included 24-hour 12-lead Holter electrocardiographic recordings that were stored for offline computer analysis. The QT interval was measured automatically and rate corrected using seven …

Alcohol In The Life Narratives Of Women: Commonalities And Differences By Sexual Orientation, Laurie A. Drabble, K. Trocki

Faculty Publications

Aim: The aim of this study was to explore social representations of alcohol use among women, with a focus on possible differences between sexual minority and heterosexual women. Methods: This qualitative study was part of a larger study examining mediators of heavier drinking among sexual minority women (lesbian identified, bisexual identified, and heterosexual identified with same sex partners) compared to heterosexual women based on the National Alcohol Survey. Qualitative in-depth life history interviews were conducted over the telephone with 48 women who had participated in the 2009–2010 National Alcohol Survey, including respondents representing different sexual orientation groups. Questions explored the …

Alumni Newsletter July 2013, Communications Disorders & Sciences

Newsletters and Documents

No abstract provided.

Intouch Volume Nineteen Number Five, New York Medical College

Yearbooks and Newsletters

"A publication for the New York Medical College community"

An Hsi Report: The Public Health Implications Of Intensive Farm Animal Production In South Asia, Humane Society International

HSI REPORTS

Intensive farm animal production (IFAP) is being increasingly implemented to meet the rising demand for animal source foods in South Asia. The siting of IFAP facilities in urban or peri-urban areas leads to large proximate animal populations, increasing human exposure to pollutants and pathogens. Improperly managed wastes from IFAP facilities and abattoirs can contaminate water with excess nutrients, pathogens, veterinary pharmaceuticals, antibiotics, heavy metals, and hormones, and can release ammonia, hydrogen sulfide, volatile organic compounds, bioaerosols, and particulate matter into the air compartment. The unregulated nature of IFAP in South Asia creates a risk for zoonotic transmission, including anthrax, brucellosis, …

The College Of Pharmacy, South Dakota State University

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 2 Endowed professorship created A trust created by a pharmacist who never attended college is providing the funds for the college’s first endowed professorship.
[Page] 3 Berry power The inaugural speaker at the Francis Miller Lecture extols the value of blueberries in fighting cancer — and he’s got the research to prove it. [Page] 4 Medication safety Deidra Van Gilder and Tasha Rausch are part of a national effort to curb medication mistakes through the Patient and Clinical Pharmacy Service Collaborative.
[Page] 6 Ashley Potter The P3 student took a rather indirect route to leadership in a student pharmaceutical …

Resveratrol And Its Metabolites Modulate Cytokine-Mediated Induction Of Eotaxin-1 In Human Pulmonary Artery Endothelial Cells, Joseph M. Wu, Tze-Chen Hsieh, Ching-Jen Yang, Susan C. Olson

NYMC Faculty Publications

Coronary heart disease (CHD) is a leading cause of death in many developed countries. Evidence has long implicated endothelial injury and inflammation as apical events in the pathogenesis of atherosclerosis, the primary cause of CHD. Numerous risk factors contribute to a damaged, inflamed endothelium. Conversely, cardioprotective agents targeting the dysfunctional endothelium have also been identified, notably from dietary sources. We have used cultured human pulmonary artery endothelial cells (HPAECs) to test the diet-mediated cardioprotective hypothesis. In this review, we summarize our recent findings on control of transcription and expression of inflammation biomarker eotaxin-1 in HPAECs exposed to single or combined …

Β-Adrenergic Blockade In Cardiovascular Disease, William H. Frishman

NYMC Faculty Publications

The development and subsequent clinical application of the β-adrenergic receptor blocking drugs represent one of the major advances in human pharmacotherapeutics. No other class of synthetic drugs has demonstrated such widespread therapeutic utility for the treatment and prevention of so many cardiovascular diseases. In addition, these drugs have proven to be molecular probes that have contributed to our understanding of the disease, and on the molecular level, both the structure and function of the 7 transmembrane G protein receptors that mediate the actions of many different hormones, neurotransmitters, and drugs. The evolution of β-blocker drug development has led to refinements …

Transcriptome Profiling Of Hippocampal Ca1 After Early-Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies For Epilepsy, L K. Friedman, J Mancuso, A Patel, V Kudur, J R. Leheste, S Iacobas, J Botta, D A. Iacobas, D C. Spray

NYMC Faculty Publications

Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early-life conditioning seizures we profiled and compared the transcriptomes of CA1 subregions from control, 1 × KA- and 3 × KA-treated animals. More genes were regulated following 3 × KA (9.6%) than after 1 × KA (7.1%). Following 1 × KA, genes supporting oxidative stress, growth, development, inflammation and neurotransmission were upregulated (e.g. Cacng1, …

Teaching Residents To Teach: Preparing Faculty And Clinical Educators, Sarah Nisly, Tracy Sprunger, Alison Walton, Tracy Costello, Jane M. Gervasio, Mary H. Andritz

Scholarship and Professional Work – COPHS

Abstract from the 114th Annual Meeting of the American Association of Colleges of Pharmacy, Chicago, IL, July 13-17, 2013.

Concise Review: Endothelial Stem And Progenitor Cells And Their Habitats, Michael S. Goligorsky, Petri Salven

NYMC Faculty Publications

Recent studies on the stem cell origins of regenerating tissues have provided solid evidence in support of the role of the resident cells, rather than bone marrow-derived or transplanted stem cells, in restoring tissue architecture after an injury. This is also true for endothelial stem and progenitor cells: local pools exist in the vascular wall, and those cells are the primary drivers of vascular regeneration. This paradigm shift offers an opportunity to rethink and refine our understanding of the multiple therapeutic effects of transplanted endothelial progenitor cells, focusing on their secretome, sheddome, intercellular communicational routes, and other potential ways to …

School-Centered Approaches To Improve Community Health: Lessons From School-Based Health Centers, Olga Acosta Price

Center for Health and Health Care in Schools

No abstract provided.

Putting Regulatory Data To Work At The Service Of Public Health: Utilizing Data Collected Under The Clean Water Act, Jyotsna S. Jagai, Barbara J. Rosenbaum, Suzanne M. Pierson, Lynne C. Messer, Kristen M. Rappazzo, Elena N. Naumova, Danelle T. Lobdell

Community Health Faculty Publications and Presentations

Under the Clean Water Act, the US Environmental Protection Agency (EPA) collects information from states on intended use and impairment of each water body. We explore the feasibility of using these data, collected for regulatory purposes, for public health analyses. Combining EPA impairment data and stream hydrology information we estimated the percent of stream length impaired for any use, recreational use, or drinking water use per county in the US as exposure variables. For health outcomes we abstracted county-level hospitalization rates of gastrointestinal infections, GI (ICD-9CM 001-009 excluding 008.45) and gastrointestinal symptoms, GS (ICD-9CM 558.9, 787) among US adults aged …

Physical Education In West Virginia Schools: Are We Doing Enough To Generate Peak Bone Mass And Promote Skeletal Health?, Franklin D. Shuler Md, Phd, Dana Lycans, Thomas Gill Md, Ali Oliashirazi Md

Orthopaedics

Peak bone mass (PBM) is attained at 25-35 years of age, followed by a lifelong decline in bone strength. The most rapid increase in bone mass occurs between the ages of 12-17. Daily school physical education (PE) programs have been shown to produce measurable increases in PBM, but are not federally mandated. Increases in PBM can decrease the lifelong risk of osteoporosis and fractures; critical for West Virginia prevention programs. Nationally only 1 in 6 schools require PE three days per week, with 4% of elementary schools, 8% of middle schools and 2% of high schools providing daily PE. In …

Progression Of Carotid Plaque Volume Predicts Cardiovascular Events, Thapat Wannarong, Grace Parraga, Daniel Buchanan, Aaron Fenster, Andrew A House, Daniel G Hackam, J David Spence

Medical Biophysics Publications

BACKGROUND AND PURPOSE: Carotid ultrasound evaluation of intima-media thickness (IMT) and plaque burden has been used for risk stratification and for evaluation of antiatherosclerotic therapies. Increasing evidence indicates that measuring plaque burden is superior to measuring IMT for both purposes. We compared progression/regression of IMT, total plaque area (TPA), and total plaque volume (TPV) as predictors of cardiovascular outcomes.

METHODS: IMT, TPA, and TPV were measured at baseline in 349 patients attending vascular prevention clinics; they had TPA of 40 to 600 mm(2) at baseline to qualify for enrollment. Participants were followed up for ≤5 years (median, 3.17 years) to …

Erps Reveal The Temporal Dynamics Of Auditory Word Recognition In Specific Language Impairment., Jeffrey G Malins, Amy S Desroches, Erin K Robertson, Randy Lynn Newman, Lisa M D Archibald, Marc F Joanisse

Brain and Mind Institute Researchers' Publications

We used event-related potentials (ERPs) to compare auditory word recognition in children with specific language impairment (SLI group; N=14) to a group of typically developing children (TD group; N=14). Subjects were presented with pictures of items and heard auditory words that either matched or mismatched the pictures. Mismatches overlapped expected words in word-onset (cohort mismatches; see: DOLL, hear: dog), rhyme (CONE -bone), or were unrelated (SHELL -mug). In match trials, the SLI group showed a different pattern of N100 responses to auditory stimuli compared to the TD group, indicative of early auditory processing differences in SLI. However, the phonological mapping …

Interpreting Children's Dreams Through Humanistic Sandtray Therapy, Karrie L. Swan, April A. Schottelkorb

Counselor Education Faculty Publications and Presentations

Children’s dreams often depict waking-life events and experiences. Although dream work therapy for adults is fairly established, recommendations for processing children’s dreams appear fractional. Because of the distinct developmental needs of children, we postulated that sandtray therapy might assist children to express and discover enlarged meanings in dreams. In this article, we present the Sandtray for Interpreting Childhood Dreams (SICD) intervention for the purpose of potentially helping children gain insight into how their dreams may be related to past and present waking-life experiences. An explanation and application of the model is presented, and the developmental rationale for using the SICD …

A Multicenter Randomized Controlled Trial Of A Plant-Based Nutrition Program To Reduce Body Weight And Cardiovascular Risk In The Corporate Setting: The Geico Study, S. Mishra, J. Xu, U. Agarwal, J. Gonzales, S. Levin, Neal D. Barnard

Medicine Faculty Publications

Background/objectives:

To determine the effects of a low-fat plant-based diet program on anthropometric and biochemical measures in a multicenter corporate setting.

Subjects/methods:

Employees from 10 sites of a major US company with body mass index 25 kg/m² and/or previous diagnosis of type 2 diabetes were randomized to either follow a low-fat vegan diet, with weekly group support and work cafeteria options available, or make no diet changes for 18 weeks. Dietary intake, body weight, plasma lipid concentrations, blood pressure and glycated hemoglobin (HbA_1C) were determined at baseline and 18 weeks.

Results:

Mean body weight fell 2.9 kg …