Medicine and Health Sciences Commons^™

Pondering An Exit From The Hd Closet, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Intellectual Property And Access To Medicines: An Analysis Of Legislation In Central America, Alejandro Cerón, Angelina Snodgrass Godoy

Anthropology: Faculty Scholarship

Globalization of intellectual property (IP) protection for medicines has been advancing during the past decade. Countries are obliged to adapt their legislation as a requirement of their membership to the World Trade Organization or as a condition of being part of international trade agreements. There is a growing recognition that, in low-income countries, stronger IP protection is a barrier to access to medicines. At the same time, the number of low-income countries writing national legislation to protect IP for pharmaceutical products is growing worldwide, but little research has been done on the ways in which this process is happening at …

The Development And Evaluation Of Low-Load Resistance Exercise With Blood Flow Restriction As A Countermeasure To Muscular Unloading, Summer B. Cook

Dissertations - ALL

Future space exploration must overcome both scientific and non-scientific obstacles. In accordance with the mission statement of the National Aeronautics Space Administration (NASA) (described in Chapter I), there were four major aims of these experiments. The first was to develop an exercise countermeasure to prevent muscle atrophy and weakness during simulated microgravity. The second and third aims were to determine the physiological adaptations in the knee extensor muscles and plantar flexor muscles following prolonged unloading in human subjects and to assess the effectiveness of the exercise countermeasure at preventing disuse atrophy. The final aim was to assess the relationship between …

Mechanisms Of Primary Axonal Damage In A Viral Model Of Multiple Sclerosis., Jayasri Das Sarma, Lawrence C. Kenyon, Susan T. Hingley, Kenneth S. Shindler

Department of Neurology Faculty Papers

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Recent studies have demonstrated that significant axonal injury also occurs in MS patients and correlates with neurological dysfunction, but it is not known whether this neuronal damage is a primary disease process, or occurs only secondary to demyelination. In the current studies, neurotropic strains of mouse hepatitis virus (MHV) that induce meningitis, encephalitis, and demyelination in the CNS, an animal model of MS, were used to evaluate mechanisms of axonal injury. The pathogenic properties of genetically engineered isogenic spike protein recombinant demyelinating and nondemyelinating strains of MHV were compared. …

Effect Of Eicosapentaenoic And Docosahexaenoic Acid On Resting And Exercise Induced Inflammatory And Oxidative Stress Biomarkers: A Randomized, Placebo Controlled, Cross­Over Study, Richard Bloomer, Douglas Larson, Kelsey Fisher-Wellman, Andrew Galpin, Brian Schilling

Kinesiology and Nutrition Sciences Faculty Research

No abstract provided.

Long Lasting Recruitment Of Immune Cells And Altered Epiperineurial Thickness In Focal Nerve Inflammation Induced By Complete Freund's Adjuvant, Geoffrey M. Bove

Biomedical Sciences Faculty Publications

Immune-mediated nerve inflammation is involved in many painful states in humans, and causes axonal and behavioral changes in rats. While models of nerve inflammation have been characterized using electrophysiological and behavioral methods, the presence of immune cells has not been fully assessed. We inflamed rat sciatic nerves using complete Freund's adjuvant and quantified the presence of ED-1 macrophages and TCR-αβ T-cells for up to 12 weeks. We report that these immune cells are prominent extraneurally up to 12 weeks following the induction of inflammation. This observation does not easily correlate with inflammation-induced axonal mechanical sensitivity, which peaks within 1 week …

Beyond Recovery: Colonization, Health And Healing For Indigenous People In Canada, Lynn F. Lavallee, Jennifer M. Poole

Aboriginal Policy Research Consortium International (APRCi)

How do we limit our focus to mental health when Indigenous teaching demands a much wider lens? How do we respond to mental health recovery when Indigenous experience speaks to a very different approach to healing, and how can we take up the health of Indigenous people in Canada without a discussion of identity and colonization? We cannot, for the mental health and recovery of Indigenous people in Canada have always been tied to history, identity, politics, language and dislocation. Thus, in this paper, our aim is to make clear that history, highlight the impacts of colonization and expound on …

Dronedarone., Chinmay Patel, Gan-Xin Yan, Peter R Kowey

Department of Medical Genetics Faculty Papers

Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been developed for the treatment of atrial fibrillation and atrial flutter. Similar to amiodarone, dronedarone is a potent blocker of multiple ion currents, including the rapidly activating delayed-rectifier potassium current, the slowly activating delayed-rectifier potassium current, the inward rectifier potassium current, the acetylcholine activated potassium current, peak sodium current, and L-type calcium current, and exhibits antiadrenergic effects. …

Urogenital Abnormalities In Men Exposed To Diethylstilbestrol In Utero: A Cohort Study, Julie R. Palmer, Arthur L. Herbst, Kenneth L. Noller, Deborah A. Boggs, Rebecca Troisi, Linda Titus-Ernstoff, Elizabeth E. Hatch, Lauren A. Wise, William C. Strohsnitter, Robert N. Hoover

Dartmouth Scholarship

Background: Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the 1940s70s, has been shown to cause reproductive problems in the daughters. Studies of prenatally-exposed males have yielded conflicting results.

Methods: In data from a collaborative follow-up of three U.S. cohorts of DES-exposed sons, we examined the relation of prenatal DES exposure to occurrence of male urogenital abnormalities. Exposure status was determined through review of prenatal records. Mailed questionnaires (1994, 1997, 2001) asked about specified abnormalities of the urogenital tract. Risk ratios (RR) were estimated by Cox regression with constant time at risk and control for year of …

Ada News - 08/17/2009, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Jnk1 Activation Predicts The Prognostic Outcome Of The Human Hepatocellular Carcinoma, Qingshan Chang, Jianguo Chen, Kevin J. Beezhold, Vince Castranova, Xianglin Shi, Fei Chen

Toxicology and Cancer Biology Faculty Publications

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with an extremely poor prognosis. The classification of HCC based on the molecular signature is not well-established.

RESULTS: In the present study, we reported HCC signature genes based on the JNK1 activation status in 31 HCC specimens relative to the matched distal noncancerous liver tissue from 31 patients. The HCCs with high JNK1 (H-JNK1) and low JNK1 (L-JNK1) were sub-grouped. Two different signature gene sets for both H-JNK1 and L-JNK1 HCC were identified through gene expression profiling. A striking overlap of signature genes was observed between the H-JNK1 …

Application Of Ict Iii: Survey Of Challenges In Hybrid Optical Wireless Broadband Network (How-B) For E-Health Systems, Noman Khan, Adnan Ashraf, B.S. Chowdhry, Manzoor Hashmani

International Conference on Information and Communication Technologies

The hybrid optical-wireless broadband network (HOW-B) is shows potential future for healthcare communication systems and networks. The marvel innovations in free space optics (FSO) based wireless communication, medical sensors and mobile network technologies have associated with emerging biological fields of telemedicine and bioinformatics. On the other hand, the progressive developments in optical based wireless technology have opened up a window for life-saving network services. The wireless network along with advance modeling technique of patient-care facilitates in monitoring of the physiological data, the treatment optimization, and continuous patient-care. This provides an improvement of care and quality of patient's life without interrupt …

Application Of Ict Iii: Use Of Information And Mobile Computing Technologies In Healthcare Facilities Of Saudi Arabia, Abdul Ahad Siddiqi, Munir Ahmed, Yasser M. Alginahi, Abdulrahman Alharby

International Conference on Information and Communication Technologies

Information technology forms an important part of the healthcare solution. Accurate and up-to-date information is essential to continuous quality improvement in any organization, and particularly so in an area as complex as healthcare. Therefore, diverse information systems must be integrated across the healthcare enterprise. The knowledge base in the medical field is large, complex, and growing rapidly. It includes scientific knowledge, as well as familiarity with the day-to-day business of providing healthcare. It is crucial to identify the processes in the healthcare sector that would most benefit from the support of information technology. This study is focused on the analysis …

Medical School Watercooler Newsletter - August 16, 2009, Lindsey Lyle

Watercooler Newsletter

This is the August 16, 2009 edition of the Frederick P. Whiddon College of Medicine - Watercooler.

Contents Include

• From Pigs to people: What You Need to Know About Swine Flu
• Dr. Dan Beals Returns to USA
• Advice For Moms-To-Be: Get Your Flu Shot Now
• New Pediatric Development - Behavioral Specialist
• Med School Cafe Lectures - Streaming Video

Artificial Intelligence – I: A New Hybrid Agent-Based Modeling & Simulation Decision Support System For Breast Cancer Data Analysis, Amnah Siddiqa, Muaz Niazi, Farah Mustafa, Habib Bokhari, Amir Hussain, Noreen Akram, Shabnum Shaheen, Fouzia Ahmed, Sarah Iqbal

International Conference on Information and Communication Technologies

In this paper, we present a novel technique of building hybrid decision support systems which integrates traditional decision support systems with agent based models for use in breast cancer analysis for better prediction and recommendation. Our system is based on using queries from data (converted to a standardized electronic template) to provide for simulation variables in an agent-based model. The goal is to develop an ICT tool to assist non-specialist biologist researcher users in performing analysis of large amounts of data by applying simple simulation techniques. To demonstrate the effectiveness of this novel decision support system, an extensive breast cancer …

Aging And Environmental Exposures Alter Tissue-Specific Dna Methylation Dependent Upon Cpg Island Context, Brock C. Christensen, E Andres Houseman, Carmen J. Marsit, Shichun Zheng, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas

Dartmouth Scholarship

Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variations in normal tissues due to aging, environmental factors, or innate susceptibility are poorly characterized. The plasticity, tissue-specific nature, and variability of gene expression are related to epigenomic states that vary across individuals. Thus, population-based investigations are needed to further our understanding of the fundamental dynamics of normal individual epigenomes. We analyzed 217 non-pathologic human tissues from 10 anatomic sites at 1,413 autosomal CpG loci …

Effects Of Non-Equilibrium Plasma On Eukaryotic Cells (Final Report: Grant Fa9550-06-1-0004), Mounir Laroussi, Fred C. Dobbs, Old Dominion University

Electrical & Computer Engineering Faculty Publications

This document is our final report describing the research activities carried out under AFOSR Grant FA9550-06-1-0004. First, descriptions of our cold plasma generation systems are presented. Two systems, developed with past and present AFOSR support, are available in our laboratory. The first is a pulsed device capable of emitting a cold plasma plume in room air. The second is an air plasma generator the core of which is a dielectric barrier discharge excited by a high AC voltage. Following these brief descriptions we first present the effects of an atmospheric pressure air plasma on four different types of eukaryotic microalgae. …

Diversity And Strain Specificity Of Plant Cell Wall Degrading Enzymes Revealed By The Draft Genome Of Ruminococcus Flavefaciens Fd-1, Margret E. Berg Miller, Dionysios A. Antonopoulos, Mark Brand, Albert Bari, Alvaro Hernandez, Jyothi Thimmapuram, Bryan A. White, Marco Rincon, Harry J. Flint, Bernard Henrissat, Pedro M. Coutinho

Cyber Center Publications

Ruminococcus flavefaciens is a predominant cellulolytic rumen bacterium, which forms a multi-enzyme cellulosome complex that could play an integral role in the ability of this bacterium to degrade plant cell wall polysaccharides. Identifying the major enzyme types involved in plant cell wall degradation is essential for gaining a better understanding of the cellulolytic capabilities of this organism as well as highlighting potential enzymes for application in improvement of livestock nutrition and for conversion of cellulosic biomass to liquid fuels.

The Effects Of Interx Therapy And Tens On Pain Relief In Patients Suffering From Medial Tibial Stress Syndrome, John Robert Erwin

Student Theses and Dissertations

One common injury throughout athletics involving running, is medial tibial stress syndrome (MTSS). In athletic training, electrical stimulation is used for control of pain associated with orthopedic injury. The purpose of this study is to compare the effect of InterX electrotherapy and Transcutaneous Electrical Nerve Stimulation's (TENS) ability to aid in the relief of pain from MTSS during running. Fourteen athletes with a current history of MTSS participated. A 2 minute warm up to reach an RPE score of 12 occurred first. Upon completion, the electrical stimulation was applied while the subject exercised at an RPE of 12 for 10 …

Rash, Otway Watkins, Jr., 1876-1966 (Sc 1970), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only for Manuscripts Small Collection 1970. Medical diplomas and business papers of Otway Watkins Rash, Jr., an Owensboro physician, including deed, U.S. Internal Revenue inventory form for opium and other narcotics, U.S. Treasury Department still registry form, stock certificate, and letters to Mrs. Grace Rash containing family information, especially on her Welsh relatives.

Modulations Of Cell Cycle Checkpoints During Hcv Associated Disease, Anwar Ali Siddiqui, Saira Sarfraz, Wasim Jafri, Saeed Hamid, Syed Ali

Department of Biological & Biomedical Sciences

Background

Impaired proliferation of hepatocytes has been reported in chronic Hepatitis C virus infection. Considering the fundamental role played by cell cycle proteins in controlling cell proliferation, altered regulation of these proteins could significantly contribute to HCV disease progression and subsequent hepatocellular carcinoma (HCC). This study aimed to identify the alterations in cell cycle genes expression with respect to early and advanced disease of chronic HCV infection.

Methods

Using freshly frozen liver biopsies, mRNA levels of 84 cell cycle genes in pooled RNA samples from patients with early or advanced fibrosis of chronic HCV infection were studied. To associate mRNA …

Identification Of Clinical, Laboratory And Genetic Covariates For Pharmacokinetics, Efficacy And Toxicity Of Sorafenib In Patients With Solid Tumors, Lokesh Jain

Theses and Dissertations

The goal of this research work was to understand the clinical-pharmacology based treatment approaches for sorafenib. Treatment with sorafenib is associated with high inter-patient variability in pharmacokinetic exposures, efficacy and toxicity. We explored the demographic, laboratory, clinical and pharmacogenetic factors to elucidate the sources of variability. In addition, we examined the impact of pharmacogenetic variation in VEGFR2, an important mediator of the VEGF pathway, on risk of prostate cancer. To support these investigations, (mainly single-dose) pharmacokinetic, pharmacogenetic, efficacy and toxicity information were collected from patients with solid tumors, enrolled in five phase I / II clinical trials at National Cancer …

Real Time Pcr Detection Of The Pi*Z And Pi*S Mutations Associated With Alpha-1 Antitrypsin Deficiency, Claudine L. Bartels, Angela L. Marchetti, W. Edward Highsmith, Gregory J. Tsongalis

Dartmouth Scholarship

Alpha-1 antitrypsin (A1AT or AAT) is a serine protease inhibitor (PI) which, when present at low levels, can cause chronic obstructive pulmonary disease (COPD) and liver disease in both children and adults. Several mutations within the SERPINA1 gene have been found to cause this deficiency. The most common variants are PI*Z and PI*S, each caused by a single nucleotide polymorphism (SNP). We describe a real time polymerase chain reaction (PCR) assay for the rapid genotyping of these polymorphisms. DNA was extracted from fourteen EDTA-anticoagulated whole blood samples using the Qiagen EZ1 blood extraction kit. SNP genotyping was performed using primer/probe …

Uncoupling Scavenger Receptor A-Mediated Phagocytosis Of Bacteria From Endotoxic Shock Resistance, Eyal Amiel, Julie L. Acker, Ryan M. Collins, Brent Berwin

Dartmouth Scholarship

Unresolved infection by gram-negative bacteria can result in the potentially lethal condition known as endotoxic shock, whereby uncontrolled inflammation can lead to multiple organ failure and death of the infected host. Previous results have demonstrated that animals deficient in class A scavenger receptor (SRA), a trafficking receptor for bacteria and bacterium-derived molecules, are more susceptible to endotoxic shock. This has been proposed to be a result of impaired SRA-dependent phagocytic clearance of bacteria resulting in stronger proinflammatory stimuli. In this report, we test the hypothesis that there is an obligate reciprocal relationship between SRA-mediated phagocytosis of bacteria and susceptibility to …

Primary Iga And Igg Subclass Deficiency In A 17-Year-Old Pakistani Girl: A Case Report., Taimur Saleem, Madiha Rabbani, Bushra Jamil

Department of Medicine

Primary immunodeficiency disorders pose a diagnostic dilemma for physicians in the developing countries such as Pakistan because of lack of adequate diagnostic facilities. We present here the case of a 17-year-old girl who had a history of recurrent respiratory tract infections since childhood and had been treated with anti-tuberculous medications thrice, for a total of 24 months. She had also received multiple courses of antibiotics. Her initial presentation to our hospital was with acute bronchopneumonia. Her past medical history of recurrent infections also alerted the treating physician to the possibility of bronchiectasis secondary to a variety of underlying potential pathologies …

Medical School Watercooler Newsletter - August 9, 2009, Lindsey Lyle

Watercooler Newsletter

This is the August 9, 2009 version of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• Adult/Peds Allergist Joins USA Physician Group
• USA COM Grads Reunite to Honor Mentor
• Dr. Jackson Leaves Legacy of Excellence
• August Med School Cafe
• Dr. William Richards

Medical School Watercooler Newsletter - August 9, 2009, Lindsey Lyle

Watercooler Newsletter

This is the August 9, 2009 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include

• Adult/Peds Allergist Joins USA Physicians Group
• USA COM Grads Reunite to Honor Mentor
• Dr. Jackson leaves Legacy of Excellence
• August Med School Cafe'
• Dr. William Richards

Automated Identification Of Noun Clauses In Clinical Language Samples, Britney Richey Manning

Theses and Dissertations

The identification of complex grammatical structures including noun clauses is of clinical importance because differences in the use of these structures have been found between individuals with and without language impairment. In recent years, computer software has been used to assist in analyzing clinical language samples. However, this software has been unable to accurately identify complex syntactic structures such as noun clauses. The present study investigated the accuracy of new software, called Cx, in identifying finite wh- and that-noun clauses. Two sets of language samples were used. One set included 10 children with language impairment, 10 age-matched peers, …

Health Center Data Warehouses: Opportunities And Challenges For Quality Improvement, A. Seiji Hayashi, Emily Jones, David M. Stevens, Peter Shin, Brad Finnegan, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

This Policy Research Brief reports on a pilot effort to leverage the growing presence of health center data warehouses to advance health care quality improvement through data sharing and exchange. This project builds on a partnership between the Michigan Primary Care Association and The George Washington University's Geiger Gibson/RCHN Community Health Foundation Research Collaborative that centers on developing approaches to using existing health center data for quality improvement.

Student Satisfaction With Simulation Experiences, Angeline Abdo, Patricia K. Ravert

Faculty Publications

Background: Some nursing schools use patient simulators to simulate patient scenarios.

Methods: Nursing students participated in five sessions using a patient simulator and then completed a questionnaire related to their experiences.

Results: Participants felt the experiences recreated real-life situations, tested their clinical decision-making, prepared them for the “real-life” clinical setting, and increased their confidence when in the clinical setting.

Conclusions: Patient simulator experiences enhance learning. Further research regarding student perceptions and instrument validation would contribute to an increased understanding of the use of patient simulators in nursing education.