Medicine and Health Sciences Commons^™

Calcifying Fibrous Pseudotumor In Association With Hyaline Vascular Type Castleman's Disease., Muhammad Azam, Yousuf A Husen, Shahid Pervez

Department of Pathology and Laboratory Medicine

Calcifying fibrous pseudotumor is a recently described rare entity. It is considered as sclerosing end stage of inflammatory myofibroblastic tumor. An association with hyaline vascular type Castleman's disease has also been described. We report a case of a 13-year-old boy who presented with pain in epigastrium. Computed tomography scan of abdomen revealed a circumscribed mass arising from the gastric wall along the greater curvature. Histology revealed a tumor composed of spindle cells present within the dense hyalinized collagenous tissue. Lymphoplasmacytic infiltrate was seen along with lymphoid follicles, dystrophic and ossifying calcification. Tumor cells were focally positive for alpha smooth muscle …

Frequency And Distribution Of Endodontically Treated Teeth, Hina Ahmed, Durr E. Sadaf, Munawar Rahman

Section of Dental-Oral Maxillofacial Surgery

Objective: To determine the distribution and pattern of carious teeth involvement in permanent teeth requiring endodontic treatment. Study Design: Cross-sectional study. Place and Duration of Study: Dental Section of The Aga Khan University Hospital, Karachi, from September 2004 to March 2005. Methodology: Data was collected from the dental records of patients. Tooth was the unit of evaluation. Variables studied were demographics, tooth type, etiology of endodontic treatment and pattern of caries involvement. Data was analyzed using chi-square test and Fischer’s exact test. Results: The total number of patients was 190; total number of teeth involved were 235. Females had more …

Does The Sensation Of Breathlessness Change Over Time In People With Chronic Obstructive Pulmonary Disease? A Systematic Review, Claire Mcevoy, Marie Williams

Internet Journal of Allied Health Sciences and Practice

The aim of this systematic review was to identify and appraise studies which tracked changes in the sensation of breathlessness, as described in terms of intensity, unpleasantness, its effect on impairment levels or quality of life, over two or more years in people with COPD. Four major databases were searched. Twelve studies were included for full analysis. These studies were a mix of observational and experimental in their design, and were found to have high methodological quality. Subjects in the studies were, overall, severely impaired at the start of the two year period, according to level of airflow restriction. Impairment …

Distress With Breathing In People With Lung Cancer: A Systematic Review, Elizabeth Quast, Marie Williams

Internet Journal of Allied Health Sciences and Practice

While the prevalence of shortness of breath has been reported to be as frequent as pain in people with lung cancer, less attention has been paid to the distress associated with this symptom (dyspnea). This systematic review of the literature was undertaken to investigate how this symptom has been assessed and whether breathlessness in people with lung cancer is distressing. Using a pre-determined search strategy and inclusion criteria, thirty-one primary studies were identified and included in this review. A variety of outcome measures have been used to assess the experience of dyspnea with domains including intensity, distress, quality of life, …

Review Of: Developing Cultural Competence In Physical Therapy Practice, Veronica Jackson

Internet Journal of Allied Health Sciences and Practice

No abstract provided.

The Early Development Of Gender Differences, Matthew H. Mcintyre, Carolyn P. Edwards

Department of Psychology: Faculty Publications

This article reviews findings from anthropology, psychology, and other disciplines about the role of biological factors in the development of sex differences in human behavior, including biological theories, the developmental course of sex differences, and the interaction of biological and cultural gendering processes at different ages. Current evidence suggests that major biological influences on individual differences in human gender, to the extent that they exist, operate primarily in early development, during and especially prior to puberty. Biological effects are likely to be mediated by relatively simple processes, like temperament, which are then elaborated through social interactions (as with mother and …

Airway Smooth Muscle As An Immunomodulatory Cell., Gautam Damera, Omar Tliba, Reynold A. Panettieri, Jr.

College of Pharmacy Faculty Papers

Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM) also modulates airway inflammation in asthma. ASM myocytes secrete or express a wide array of immunomodulatory mediators in response to extracellular stimuli, and in chronic severe asthma, increases in ASM mass may also render the airway irreversibly obstructed. Although the mechanisms by which ASM secretes cytokines and chemokines are shared with those regulating immune cells, there exist unique ASM signaling pathways that may provide novel therapeutic targets. This review provides an overview of our current understanding of the proliferative as well as synthetic properties of ASM.

Transcriptional Regulation Of Cytokine Function In Airway Smooth Muscle Cells., Deborah Clarke, Gautam Damera, Maria B. Sukkar, Omar Tliba

College of Pharmacy Faculty Papers

The immuno-modulatory properties of airway smooth muscle have become of increasing importance in our understanding of the mechanisms underlying chronic inflammation and structural remodeling of the airway wall in asthma and chronic obstructive pulmonary disease (COPD). ASM cells respond to many cytokines, growth factors and lipid mediators to produce a wide array of immuno-modulatory molecules which may in turn orchestrate and perpetuate the disease process in asthma and COPD. Despite numerous studies of the cellular effects of cytokines on cultured ASM, few have identified intracellular signaling pathways by which cytokines modulate or induce these cellular responses. In this review we …

Unlv Magazine, Matthew K. Jacobsen, Holly Ivy De Vore, Lisa Arth, Cate Weeks, Greg Lacour, Tony Allen, Afsha Bawany, Barbara Cloud, Gian Galassi, Phil Hagen, Karyn S. Hollingsworth, Michelle Mouton, Erin O'Donnell

UNLV Magazine

No abstract provided.

Lsuhsc Facilities Daily Update: October 2009, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2009

LSUHSC Dailly Facilities Updates from October 2009. These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Biweekly Update: October 2009, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2009

LSUHSC Facilities Biweekly Updates from October 9 and 23, 2009. Original document for October 23 is misdated as "October 9. 2009".

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Jefferson Alumni Bulletin – Volume 58, Number 3, Fall 2009

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 58, Number 3, Fall 2009 Dean’s Message, page 2 Findings--Researchers Counter Allergy to Plavix with Steroids and Antihistamines, page 4 Why in the World Would You Go into Medicine Today?, page 6 Philadelphia 1918: The Flu Pandemic Hits Home, page 14 New Movie Underscores Healthcare Conflicts, page 20 Faculty Profile: Vincenzo Berghella, MD ’90, page 22 On Campus, page 24 Class Notes, page 28 Looking at Scholarships from Both Sides, page 36 Alumni Giving, page 38 In Memoriam, page 50 By the Numbers, page 53

How Early Do Antibiotics Have To Be To Impact Mortality In Severe Sepsis? A Prospective, Observational Study From An Emergency Department, Shahla Siddiqui, Nawal Salahuddin, Adeel Raza, Junaid Razzak

Department of Anaesthesia

BACKGROUND: The objective of this study was to assess the promptness of antibiotic administration to patients presenting with sepsis and the effects on survival and length of hospitalization.

METHODS: Consecutive, adult patients presenting with Systemic Inflammatory Response Syndrome (SIRS) to the emergency department of the Aga Khan University hospital were enrolled in a prospective, observational study over a period of 4 months. Univariate, multivariate regression modeling and one-way ANOVA were used to examine the effects of various variables on survival and for significant differences between timing of antibiotic administration and survival, two-sided p values < 0.05 were considered significant.

RESULTS: One hundred and eleven patients …

Youtube And Other Web 2.0 Applications For Nursing Education, Margaret M. Hansen Edd, Msn, Rn, Scott Erdley

Nursing and Health Professions Faculty Research and Publications

Web 2.0 applications, such as the popular YouTube™ online video network, may enhance health care students' learning and retention while providing connections with peers and faculty. Today's students are consumers of popular social networking tools, such as "Facebook" and "MySpace," as well as the personal video sharing site, YouTube™. Furthermore, novel cellular 1 phones, such as Apple Computer's© iPhone and the innovative Palm phone, have the capacity to i show You Tube videos, which are now literally a "touch" away from viewing. The authors set out to I explain Web 2.0 applications and the impact on health care students' education, …

Determination Of Complication Rate Of Picc Lines In Oncological Patients, Ghulam Haider, Shiyam Kumar, Basit Salam, Nehal Masood, Asim Jamal, Yasmeen Abdul Rasheed

Department of Radiation Oncology

OBJECTIVE: To determine the complication rate of (PICCs) peripherally inserted central catheters in cancer patients with a 1 year prospective cohort study.

METHODS: All PICCs inserted in adult cancer patients in Radiology Department of The Aga Khan University Hospital were followed prospectively till removed or patient expired and pattern of complications noted.

RESULTS: One hundred and fourty six PICCs were inserted over a period of 1 year and followed for a total of 3329 catheter-days; median placement, 14 days: range 3-218 days. Of these 67 (32.8%) PICCs were complicated and removed earlier, for a rate of 14.4/1000 PICC-days. Patients with …

Foxp3-Expressing T Regulatory Cells (T-Regs) Increase With The Severity Of Active Disease In Chronic Hepatitis C, Adam D. Toll, Md, John L. Farber, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The hepatitis C virus (HCV) leads to chronic disease in 80% of those infected and is associated with a chronic inflammatory response that is mediated by both cytokine producing (CD4+) and cytotoxic T cells (CD8+). FoxP3-expressing, CD4+, CD25+T cells (T-regs) are a subset of T lymphocytes that inhibit immune responsiveness and thereby control immunological reactions. Whether FoxP3+ T regulatory cell-mediated suppression is a factor in HCV persistence and/or the course of chronic liver injury has not been defined. In order to assess the association between these T regulatory cells and the severity of chronic hepatitis C, we evaluated liver biopsies …

Establishing The Purity Of Mononuclear Cell Preparations Using Morphology And Flow Cytometry, Adam Holtz, Bs, Adam D. Toll, Md, Susan W. Burkholder, Md, Alicia M. Carlin, Ba, Linda F. Blumstein, Bs, Kathleen A. Schroeder, Bs, Eric M. Behling, Md, Tina B. Edmonston, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Context: Simple tandem repeat loci are used to track bone marrow engraftment using mononuclear buffy coat cells and T-cells. Poor isolation purity of these subpopulations can result in lower analytical sensitivity of the bone marrow engraftment assay by diluting the cell population in question with other nucleated cells. Validation of the mononuclear cell preparation can be performed by flow cytometry or by counting cell populations on the slide. Conclusions: Our results show that the purity of the Histopaque-1077 mononuclear cell preparation is excellent and that morphology may be sufficient to validate the mononuclear cell isolation method if flow cytometry is …

Labrad : Vol 34, Issue 3 - October 2009, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• Detection of Amoebic Meningitis by Wet Film of Cerebrospinal Fluid (CSF)
• Biochemical Tests in the Diagnosis of Anaemia
• Pathophysiology and Laboratory Investigation in Anaemia of Chronic Disease
• Haematogones: A pitfall in the Diagnosis of Leukemias/Lymphoma in Children
• Porphyria: The Mysterious Disease
• Imaging Features of Thalassaemia and Sickle Cell Anaemia
• N-Terminal Pro-BNP for Rapid Diagnosis of Heart Failure
• Frozen Section: A Rapid Diagnostic Tool
• Prenatal Diagnosis of ß-Thalassaemia
• Farewell to Administrative Director, Mr Sajid Khan

Voz De Los Internos: Atención De Salud En El Recinto Penal En Arica, Chile, Lily Hoffman

Independent Study Project (ISP) Collection

According to both international and Chilean laws, incarceration does not affect one’s right to healthcare. Despite this protection, the health of prisoners’ remains a controversial topic in many communities, which may contribute to the inconsistencies in the levels of access to, and quality of, healthcare services in jails/prisons. A voice that is commonly overlooked, despite its value, is that of the patients of healthcare systems in jails/prisons around the world. This project was conducted in the maximum security prison complex in Arica, Chile and includes interviews with twenty-two incarcerated individuals based on their experiences with healthcare services in prison. Sixty-eight …

Conocimientos, Percepciones, Y Prácticas De Mujeres Jóvenes Acerca Del Papiloma Virus Humano, Michelle Marie Picón Ruiz

Independent Study Project (ISP) Collection

Background: Efforts by the Chilean Ministry of Health to reduce the mortality rates due to cervical cancer by 40% during 2000 - 2010 have successfully impacted every age group except for young women between the ages of 20-24. Cervical cancer is caused by Human Papiloma Virus (HPV), the most common Sexually Transmitted Infection (STI). Both are detected by the Papanicolaou test, or Pap smear. Cervical cancer found in older women most likely developed from an HPV infection contracted in their youth. This study aims to understand the knowledge, practices, and perceptions that young women in Arica, Chile have about their …

El Rol De La Partera En La Provincia De Parinacota, Liana Langdon-Embry

Independent Study Project (ISP) Collection

For centuries, the Aymaran people of the Parinacota Province in Northern Chile have been deeply committed to ancestral practices, where a Cosmo vision rears a connection between human beings, the natural environment, and the spiritual world. The Aymaran medicinal practices replicate this relationship, with the indigenous medicine man and midwives historically holding a central role in the natural healing of community members. This study describes the present-day role of Señora Fausta Pairo Mollo, the midwife in the altiplano region of Parinacota. In particular, it examines how her practices has been integrated into the official medical system, while also investigating how …

“I Didn’T Feel Like Living”: The Prevalence, Perceptions, And Prevention Of Hiv/Aids Among Tibetan Refugees In Kathmandu, Caitlin Macleod-Bluver

Independent Study Project (ISP) Collection

The fight against HIV/AIDS is a global one, a concern that is addressed by both the Nepali government and the Tibetan government in exile. Both governments have taken measures to prevent the further spread of the epidemic among their populations, increase knowledge and awareness about the disease, and provide better treatment and care to those living with HIV/AIDS. However, there is a gap between these efforts, particularly within the Tibetan refugee community. As a result of Tibetan’s refugee status in Nepal, fewer resources have been allocated for dealing with and understanding the risk factors for Tibetans in exile in Nepal. …

From The Editor: State Journals Of Public Health, Mckinley Thomas

Journal of the Georgia Public Health Association

State Journals of Public Health

Impaired Regulation Of The Tnf-Alpha Converting Enzyme/Tissue Inhibitor Of Metalloproteinase 3 Proteolytic System In Skeletal Muscle Of Obese Type 2 Diabetic Patients: A New Mechanism Of Insulin Resistance In Humans, A Monroy, S Kamath, A O. Chavez, V E. Centonze, M Veerasamy, A Barrentine, J J. Wewer, D K. Coletta, C Jenkinson, Sara M. Reyna

School of Medicine Publications

Aims/hypothesis: TNF-alpha levels are increased in obesity and type 2 diabetes. The regulation of TNF-alpha converting enzyme (TACE) and its inhibitor, tissue inhibitor of metalloproteinase 3 (TIMP3), in human type 2 diabetes is unknown.

Methods: We examined TACE/TIMP3 regulation: (1) in lean and obese normal glucose tolerant (NGT) individuals and in type 2 diabetes patients; (2) following 6 h of lipid/saline infusion in NGT individuals; and (3) in cultured human myotubes from lean NGT individuals incubated with palmitate. Insulin sensitivity was assessed by a euglycaemic clamp and TACE/TIMP3 was evaluated by confocal microscopy, RT-PCR, western blotting and an in vitro …

Extra, Extra, Read All About It!, Irvin Sam Schonfeld

Publications and Research

No abstract provided.

Identifying Publication Outlets In Occupational Health Psychology: An Opinion Survey, Maria Karanika-Murray, Irvin Sam Schonfeld, Leigh Schmitt

Publications and Research

No abstract provided.

Ethnic Differences In Do-Not-Resuscitate Orders After Intracerebral Hemorrhage, Darin B Zahuranec, Devin L Brown, Lynda D Lisabeth, Nicole R Gonzales, Paxton J Longwell, Melinda A Smith, Nelda M Garcia, Lewis B Morgenstern

Faculty, Staff and Student Publications

OBJECTIVE: To explore ethnic differences in do-not-resuscitate orders after intracerebral hemorrhage.

DESIGN: Population-based surveillance.

SETTING: Corpus Christi, Texas.

PATIENTS: All cases of intracerebral hemorrhage in the community of Corpus Christi, TX were ascertained as part of the Brain Attack Surveillance in Corpus Christi (BASIC) project.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Medical records were reviewed for do-not-resuscitate orders. Unadjusted and multivariable logistic regression were used to test for associations between ethnicity and do-not-resuscitate orders, both overall ("any do-not-resuscitate") and within 24 hrs of presentation ("early do-not-resuscitate"), adjusted for age, gender, Glasgow Coma Scale, intracerebral hemorrhage volume, intraventricular hemorrhage, infratentorial hemorrhage, …

Venoarterial Pco2 Difference: A Marker Of Postoperative Cardiac Output In Children With Congenital Heart Disease, Muhammad Furqan, Fahad Hashmat, Munir Amanullah, Mansoor Khan, Hina K Durani, Anwarul Haque

Department of Paediatrics and Child Health

OBJECTIVE: To determine the relationship between venoarterial carbon dioxide gradient (DeltapCO2) and central venous oxygen saturation (ScvO2) in children after cardiac surgery.

STUDY DESIGN: A cohort study.

PLACE AND DURATION OF STUDY: The Paediatric cardiac intensive care unit of the Aga Khan University Hospital, Karachi, from June 2006 to May 2007.

METHODOLOGY: All children admitted in the paediatric cardiac intensive care after complete repair of congenital heart defect using cardiopulmonary bypass were included in the study. Simultaneous arterial and central venous blood gas samples were obtained from a catheter placed in the artery (either radial or femoral) and superior vena …

Primary Language Spoken At Home And Children's Dental Service Utilization In The United States, Matthew Noyce, Aniko Szabo, Nicholas M. Pajewski, Scott Jackson, T. Gerard Bradley, Christopher Okunseri

School of Dentistry Faculty Research and Publications

Objective: Language barriers have been well documented as a contributing factor to disparities in the receipt of medical services, especially for Hispanic children. However, there is a paucity of information on the effect of language barriers on children's dental service utilization. We examined the association of primary language spoken at home with the receipt of preventive and routine dental care for children in the United States. Methods: We analyzed data from the Medical Expenditure Panel Survey (2002-2004), which contains data on 21,049 children weighted to represent 75.8 million children nationally. Results: Among children aged 1-18 years, 13 percent spoke a …

Oncology Nurses' Perceptions Of Self-Compassion: A Pilot Study, Miriam R. Lindell

Theses and Graduate Projects

Oncology nurses face extraordinary stressors in their work. If this stress becomes prolonged, these nurses are at risk for burnout and compassion fatigue. One effective way for nurses to manage stress is to care for themselves, body, mind, and spirit. The concept of self-compassion reflects a meaningful approach to self-care. This pilot study explored the perception'of self-compassion by hospital based oncology nurses. A convenience sample of 37 oncology nurses was surveyed using four demographic questions and the Self-Compassion Scale by Kristin Neff. The results demonstrated positive correlation between years of nursing experience and years of oncology nursing experience with common …