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Medical School Watercooler Newsletter - October 18, 2009, Lindsey Lyle

Watercooler Newsletter

This is the October 18, 2009 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler

Contents Include

• This Week's DSS - "Pharmacogenomics and Individualized Drug Therapy"
• Dr. David Laycock Joins USA Physicians Group

Helping Counselors Develop Relational Competencies When Working With Religious & Spiritual Clients, Dr. Jill D. Duba, Craig Cashwell, Harriet Glosoff

Counseling & Student Affairs Faculty Publications

The professional counselor can describe the similarities and differences between spirituality and religion, including the basic beliefs of various spiritual systems, major world religions, agnosticism and atheism. The professional counselor recognizes that the client's beliefs (or absence of beliefs) about spirituality and/or religion are central to his or her worldview and can influence psychosocial functioning.

Polysorbate 80 Inhibition Of Pseudomonas Aeruginosa Biofilm Formation And Its Cleavage By The Secreted Lipase Lipa, C M. Toutain-Kidd, S C. Kadivar, C T. Bramante, S A. Bobin, Michael E. Zegans

Dartmouth Scholarship

Surface-associated bacterial communities known as biofilms are an important source of nosocomial infections. Microorganisms such as Pseudomonas aeruginosa can colonize the abiotic surfaces of medical implants, leading to chronic infections that are difficult to eradicate. Our study demonstrates that polysorbate 80 (PS80), a surfactant commonly added to food and medicines, is able to inhibit biofilm formation by P. aeruginosa on a variety of surfaces, including contact lenses.

News In Brief

Jefferson Surgical Solutions

No abstract provided.

Those Who Give-Family Member Helps Philly Get Its “Rear In Gear” To Prevent Colon Cancer

Jefferson Surgical Solutions

No abstract provided.

Sharon Molotsky, Rn, Bsn, Ccrc Clinical Research Nurse Project Manager

Jefferson Surgical Solutions

No abstract provided.

New Cancer Research Angle From A Surprising Source

Jefferson Surgical Solutions

No abstract provided.

Meet Our Surgical Interns

Jefferson Surgical Solutions

No abstract provided.

Ventricular Assist Device Program Gains Prestigious Accreditation

Jefferson Surgical Solutions

No abstract provided.

Overview-Charles J Yeo, Md

Jefferson Surgical Solutions

No abstract provided.

Bariatric And Metabolic Surgery Program Turns A Life Around

Jefferson Surgical Solutions

No abstract provided.

The Surgeon Speaks

Jefferson Surgical Solutions

No abstract provided.

Download The Full Pdf Of Jefferson Surgical Solutions Fall 2009, Volume 4, Number 2.

Jefferson Surgical Solutions

No abstract provided.

Threshold And Memory: A New Theoretical Model For Athlete Cam Use, Ben Koh

Medical Conference Papers

Introduction: The role of theory in research cannot be over emphasised. Present literature on athlete complementary and alternative medicine (CAM) use poses two problems: in the few studies on CAM use that have utilised theory, the use of theory has been inconsistent or lack validation; in athlete motivational studies, theoretical models focused on the athlete and the sport and not on health-seeking. Many theories exist in the literature to help explain health-seeking behaviour, but the bulk of studies that employ theory focused on the general nonathlete population and mainly applied in the setting of conventional medicine use. Difficulties in using …

Using Primary Care To Bend The Cost Curve: The Potential Impact Of Health Center Expansion In Senate Reforms, Leighton C. Ku, Sara J. Rosenbaum, Peter Shin

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

This analysis of reforms being considered in the United States Senate reaches conclusions similar to those of our prior analyses of reforms being considered in the House of Representatives. The combination of expanded health insurance coverage and investments in the expansion of community health centers can produce substantial long-term savings both for the overall health care system and for the federal government. Our analysis of the Senate provisions from the HELP and Finance Committees estimates $369 billion in total medical savings, including $105 billion in federal Medicaid savings. The Senate provisions produce larger savings because they authorize larger funding increases …

Biomarker Changes Associated With Tuberculin Skin Test (Tst) Conversion: A Two-Year Longitudinal Follow-Up Study In Exposed Household Contacts, Rabia Hussain, Najeeha Talat, Firdaus Shahid, Ghaffar Dawood

Department of Pathology and Laboratory Medicine

Background:A high prevalence (50-80%) of Tuberculin Skin Test Positivity (TST+ >or=10 mm indurations) has been reported in TB endemic countries. This pool forms a huge reservoir for new incident TB cases. However, immune biomarkers associated with TST conversion are largely unknown. The objective of this study was to identify immune biomarkers associated with TST conversion after acute Mycobacterium tuberculosis (MTB)
Methodology/Principal Findings:A 24 month longitudinal study was carried out in a recently MTB exposed cohort of household contacts (HC = 93, 75% TST+). Control group consisted of unexposed community controls (EC = 59, 46%TST+). Cytokine secretion was assessed …

The Brain In Its Body: Motor Control And Sensing In A Biomechanical Context, Hillel J. Chiel

Faculty Scholarship

Although it is widely recognized that adaptive behavior emerges from the ongoing interactions among the nervous system, the body, and the environment, it has only become possible in recent years to experimentally study and to simulate these interacting systems. We briefly review work on molluscan feeding, maintenance of postural control in cats and humans, simulations of locomotion in lamprey, insect, cat and salamander, and active vibrissal sensing in rats to illustrate the insights that can be derived from studies of neural control and sensing within a biomechanical context. These studies illustrate that control may be shared between the nervous system …

My New Profession: Hd Activist, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Pathways To Care: Duration Of Untreated Psychosis From Karachi, Pakistan., Haider A. Naqvi, Sajjad Hussain, Muhammad Zaman, Mohammad Islam

Department of Psychiatry

Background: Substantial amount of time is lost before initiation of treatment in Schizophrenia. The delay in treatment is labelled as Duration of Untreated Psychosis (DUP). Most of these estimates come from western countries, where health systems are relatively better developed. There is dearth of information on pathway to care from developing countries. Methods And Results: Patients with ICD-10 based diagnosis of Schizophrenia were enrolled by convenient method of sampling. The pathway to care was explored through a semi-structured questionnaire. Onset, course and symptoms of psychosis were assessed using Interview for the Retrospective Assessment of the Onset of Schizophrenia (IRAOS). Ethical …

Post Partum Anxiety And Depression In Peri-Urban Communities Of Karachi, Pakistan: A Quasi-Experimental Study, Niloufer Sultan Ali, Badar S. Ali, Iqbal Azam Syed

Department of Family Medicine

Background: Postpartum anxiety and depression is a major public health concern because of its adverse effects on the cognitive and social development of the infant. Globally postpartum depression has been widely investigated but as anxiety is a more prominent feature of postpartum depression we assessed the prevalence of anxiety and depression and their associated factors in post partum women.
Methods: A quasi-experimental study investigating the impact of postpartum anxiety and depression on child growth and development was conducted in two peri-urban, multiethnic, communities of Karachi, a mega city of Pakistan. A house to house questionnaire based survey was done by …

Medical School Watercooler Newsletter - October 11, 2009, Lindsey Lyle

Watercooler Newsletter

This is the October 11, 2009 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler

Contents Include

• Distinguished Scientist Seminar - "How Does Nitric Oxide Kill Beta Cells"

Protection Against Mucosal Shiv Challenge By Peptide And Helper-Dependent Adenovirus Vaccines, Eric A. Weaver, Pramod N. Nehete, Bharti P. Nehete, Stephanie J. Buchl, Donna Palmer, David C. Montefiori, Philip Ng, K. Jagannadha Sastry, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Groups of rhesus macaques that had previously been immunized with HIV-1 envelope (env) peptides and first generation adenovirus serotype 5 (FG-Ad5) vaccines expressing the same peptides were immunized intramuscularly three times with helperdependent adenovirus (HD-Ad) vaccines expressing only the HIV-1 envelope from JRFL. No gag, pol, or other SHIV genes were used for vaccination. One group of the FG-Ad5- immune animals was immunized three times with HD-Ad5 expressing env. One group was immunized by serotype-switching with HD-Ad6, HD-Ad1, and HD-Ad2 expressing env. Previous work demonstrated that serum antibody levels against env were significantly higher in the serotype-switched group than in …

The Calling Of Nursing, Christoffer H. Grundmann

Theology Faculty Presentations

(excerpt) "Baffled by the broad variety and diversity of nursing and unable to discover one single common thread of thought and discussion in the literature, I got desperate and finally turned to Dean Brown for help, hoping to get some viable direction. And, indeed, I did, yet of course not the way I expected. When I asked her if she would be so kind as to name me the standard instruction textbook used for nursing education and practice, she unhesitatingly replied: 'There isn’t one. Because there are so many content areas in nursing, there is no one text that is …

Keap1 E3 Ligase-Mediated Downregulation Of Nf-Kappab Signaling By Targeting Ikkbeta, Dung-Fang Lee, Hsu-Ping Kuo, Mo Liu, Chao-Kai Chou, Weiya Xia, Yi Du, Jia Shen, Chun-Te Chen, Longfei Huo, Ming-Chuan Hsu, Chia-Wei Li, Qingqing Ding, Tsai-Lien Liao, Chien-Chen Lai, Ann-Chi Lin, Ya-Hui Chang, Shih-Feng Tsai, Long-Yuan Li, Mien-Chie Hung

Faculty, Staff and Student Publications

IkappaB kinase beta (IKKbeta) is involved in tumor development and progression through activation of the nuclear factor (NF)-kappaB pathway. However, the molecular mechanism that regulates IKKbeta degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)-based ubiquitin ligase, Kelch-like ECH-associated protein 1 (KEAP1), is responsible for IKKbeta ubiquitination. Depletion of KEAP1 led to the accumulation and stabilization of IKKbeta and to upregulation of NF-kappaB-derived tumor angiogenic factors. A systematic analysis of the CUL3, KEAP1, and RBX1 genomic loci revealed a high percentage of genome loss and missense mutations in human cancers that failed to facilitate IKKbeta degradation. Our …

Temporal Order Processing Of Syllables In The Left Parietal Lobe, Dana C. Moser, Julie M. Baker, Carmen E. Sanchez, Chris Rorden, Julius Fridriksson

Communication Sciences & Disorders

Speech processing requires the temporal parsing of syllable order. Individuals suffering from posterior left hemisphere brain injury often exhibit temporal processing deficits as well as language deficits. Although the right posterior inferior parietal lobe has been implicated in temporal order judgments (TOJs) of visual information, there is limited evidence to support the role of the left inferior parietal lobe (IPL) in processing syllable order. The purpose of this study was to examine whether the left inferior parietal lobe is recruited during temporal order judgments of speech stimuli. Functional magnetic resonance imaging data were collected on 14 normal participants while they …

Community-Based Suicide Prevention Research In Remote On-Reserve First Nations Communities, Corinne A. Isaak, Mike Campeau, Laurence Y. Katz, Murray W. Enns, Brenda Elias, Jitender Sareen

Aboriginal Policy Research Consortium International (APRCi)

Suicide is a complex problem linked to genetic, environmental, psychological and community factors. For the Aboriginal population more specifically, loss of culture, history of traumatic events, individual, family and community factors may also play a role in suicidal behaviour. Of particular concern is the high rate of suicide among Canadian Aboriginal youth. While the need to develop interventions to reduce suicidal behaviour for First Nations on-reserve populations is evident, there may be an element of distrust of researchers by Aboriginal communities. Furthermore, research in mental health and specifically suicide is much more sensitive than studying medical illnesses like diabetes. Clearly, …

Estimating The Economic Gains For States As A Result Of Medicaid Coverage Expansions For Adults, Peter Shin, Leighton C. Ku, D. Richard Mauery, Brad Finnegan, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

This policy research brief examines the Medicaid eligibility expansions under the pending legislative proposals, including the House Tri-Committee bill, the Senate Health, Education, Labor and Pensions Committee bill and the Senate Finance Committee bill. Using new Census Bureau data, the researchers find that under both the House and Senate Finance Committee proposals, about 9.6 million nonelderly adults would gain Medicaid eligibility by 2014. Furthermore, the federal and state expenditures are less than Medicaid's positive impact on the economy amounting in a return of three dollars in new business activities for every dollar of state Medicaid investment. Because Medicaid is designed …

Intracranial Eeg Reveals A Time- And Frequency-Specific Role For The Right Inferior Frontal Gyrus And Primary Motor Cortex In Stopping Initiated Responses, Nicole Swann, Nitin Tandon, Ryan Canolty, Timothy M Ellmore, Linda K Mcevoy, Stephen Dreyer, Michael Disano, Adam R Aron

Faculty, Staff and Student Publications

Inappropriate response tendencies may be stopped via a specific fronto/basal ganglia/primary motor cortical network. We sought to characterize the functional role of two regions in this putative stopping network, the right inferior frontal gyrus (IFG) and the primary motor cortex (M1), using electocorticography from subdural electrodes in four patients while they performed a stop-signal task. On each trial, a motor response was initiated, and on a minority of trials a stop signal instructed the patient to try to stop the response. For each patient, there was a greater right IFG response in the beta frequency band ( approximately 16 Hz) …

Ua12/2/1 College Heights Herald, Vol. 85, No. 10, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. Articles:

• Ulber, Emily. Wood Selig Up for Raise – Athletics
• Kenney, Erin. Leaps & Bounds – Parkour, Felix Perrone, Evan Goad
• Hicks, Billy. City Could Move Parking Garage Near Western – Downtown Redevelopment
• Fox, Emily. A Thousand Words – Roger Reed, Shake Rag Reed’s
• Ulber, Emily. Colleges Prepare for End of Stimulus Money – Budget
• Bilby, Tara. Kentucky Gets H1N1 Vaccine – Swine Flu, Influenza
• Erskine, Anne. Editorial Cartoon: Get Off My Lawn – Gary Ransdell, Tailgating
• Keep Tailgating Tradition
• Vote on Parking Garage Move
• Hicks, Billy Tough Economy …

The Emergent Generation Gap In Attitudes Toward Khat Use In Urban Ethiopia, Nikki Lynn Rogers, Jared A. Embree, Yigzaw Kebede, Josephine Wilson, Mary J. Huber, Dennis Moore

Population and Public Health Sciences Faculty Publications

No abstract provided.