Medicine and Health Sciences Commons^™

Dietary Composition Modulates Brain Mass And Solubilizable Abeta Levels In A Mouse Model Of Aggressive Alzheimer's Amyloid Pathology, Steve Pedrini, Carlos Thomas, Hannah Brautigam, James Schmeidler, Lap Ho, Paul Fraser, David Westaway, Peter St George Hyslop, Ralph Martins, Joseph Buxbaum, Giulio Pasinetti, Dara Dickstein, Patrick Hof, Michelle Ehrlich, Sam Gandy

Research outputs pre 2011

Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease of the central nervous system (CNS). Recently, an increased interest in the role diet plays in the pathology of AD has resulted in a focus on the detrimental effects of diets high in cholesterol and fat and the beneficial effects of caloric restriction. The current study examines how dietary composition modulates cerebral amyloidosis and neuronal integrity in the TgCRND8 mouse model of AD. Methods: From 4 wks until 18 wks of age, male and female TgCRND8 mice were maintained on one of four diets: (1) reference (regular) commercial chow; (2) high …

Functional Interleukin-17 Receptor A Is Expressed In Central Nervous System Glia And Upregulated In Experimental Autoimmune Encephalomyelitis., Jayasri Das Sarma, Bogoljub Ciric, Ryan Marek, Sanjoy Sadhukhan, Michael L. Caruso, Jasmine Shafagh, Denise C. Fitzgerald, Kenneth S. Shindler, Am Rostami

Department of Neurology Faculty Papers

BACKGROUND: Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor, IL-17RA, which is expressed in many peripheral tissues; however, expression of IL-17RA in the central nervous system (CNS) and its role in CNS inflammation are not well understood.

METHODS: EAE was induced in C57Bl/6 mice by immunization with myelin oligodendroglial glycoprotein. IL-17RA expression in the CNS was compared between control and EAE mice using RT-PCR, in situ …

Transfusion Related Acute Lung Injury--Trali: An Under Diagnosed Entity, Bushra Moiz, Hasanat Sharif, Fauzia Ahmad Bawany

Department of Pathology and Laboratory Medicine

Transfusion related acute lung injury (TRALI) is a life-threatening complication of transfusion of blood and its components resembling acute respiratory distress syndrome (ARDS) or acute lung injury (ALI). TRALI is a particular form of ARDS that follows blood transfusion and is caused by donor-derived antibodies present in the transfused products, reacting with the recipients' blood cells, inducing release of inflammatory mediators thus compromising lung functions. Anti-HLA antibodies are the most frequently indicted inducers in this category. Literature search has not revealed any documented case of TRALI from Pakistan. This in no way implies that TRALI is non existent in this …

Presentation Of A Patient With Palpable Purpuric Rash, Safoorah Khalid, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Henoch Shonlein purpura (HSP) is a form of systemic vasculitis characterized by deposition of IgA dominant immune complexes in the small vessels. The triad of palpable purpuric rash on lower extremities, abdominal or renal involvement and arthritis is the typical presentation in this condition. The disease primarily affects children and is less common in adults. We report a case of a young female who presented with palpable purpura on legs, classical symptoms of HSP i.e. arthritis and off and on abdominal pain.

Fibromatous Periorchitis, Khurram Minhas, Abrar Barakzai, Asim Qureshi

Department of Pathology and Laboratory Medicine

We report a case of diffuse fibrous pseudotumour/fibromatous periorchitis, in a 43 year old male, that completely encased the right testis and was adjacent to a hydrocoele cavity. Although fibrous pseudotumours of this region are uncommon, they are reported to be the second most common benign paratesticular lesion after adenomatoid tumours. These comprise approximately 6 percent of paratesticular lesions, and are accepted as reactive lesions secondary to trauma, hydrocoele, infections or inflammation. Fibrous pseudotumours have a peak incidence in the third decade of life but can occur at any age. Clinically these lesions mimic malignancy resulting in the treatment by …

Cd20 Positivity In Classical Hodgkin's Lymphoma: Diagnostic Challenge Or Targeting Opportunity., Muhammad Abrar Barakzai, Shahid Ahmed

Department of Pathology and Laboratory Medicine

BACKGROUND:It is now well established that Hodgkin cells are clonal B cells with a CD30 and CD15 phenotype. However, on immunohistochemistry, in our experience and the experience of others, CD20 positivity in an otherwise typical classical Hodgkin's Lymphoma is not uncommon and if associated with CD15 negativity poses a potential diagnostic trap and is likely to be called B-NHL.
OBJECTIVE:To assess the frequency of B-cell related antigens CD20 and CD79a in classical Hodgkin's Lymphoma.
MATERIALS AND METHODS:A total of 91 consecutive cases of classical Hodgkin's Lymphoma were analyzed for co-expression of CD20 and CD79a. Both males and …

Psychometric Properties Of The Self-Assessment Of The Interpersonal Relationship Scale, Karen S. Dearing, Sheryl Steadman

Faculty Publications

The nurse-patient relationship is the basis of psychiatric nursing. The use of self defines nursing as an interactive, exploratory, caring, and health promoting process. No tool has been developed to determine specific areas for competency building using the principles of developing an interpersonal relationship. The specific aims of the study were two-fold: establish the reliability and validity of the Self-Assessment of the Interpersonal Relationship Scale (SAIRS) and determine the ability of SAIRS to measure student nurses development of interpersonal competencies with patients.

Engaging Students In The Fundamental Skill Lab: Scenario Based Simulations, Deborah O. Himes, Patricia K. Ravert, Colleen R. Tingey

Faculty Publications

Aims of this study: Students will be actively engaged in the basic nursing skills lab and develop critical nursing behaviors including:

- Assessment/ Intervention/ Evaluation

- Critical Thinking/ Clinical Decision Making

- Direct Patient Care

- Communication/ Collaboration

- Professional Behaviors.

Students will also remember more of what they learn through story-telling (patient cases) and role-playing. They will come prepared to perform as a nurse in lab.

Estimating Dysphonia Severity In Continuous Speech: Application Of A Multi-Parameter Spectral/Cepstral Model, Christopher Dromey, Shaheen N. Awan, Nelson Roy

Faculty Publications

The purpose of the study was to identify a sub-set of spectral/cepstral-based analysis methods that would most effectively predict dysphonia severity (as estimated via auditory-perceptual analysis) in samples of continuous speech. Acoustic estimates of dysphonia severity were used as an objective treatment outcomes measure in a set of pre- vs post-treatment speech samples. Pre- and post-treatment continuous speech samples from 104 females with primary muscle tension dysphonia (MTD) were rated by listeners using a 100 point visual analogue scale (VAS) and analysed acoustically with spectral/cepstral-based measures. Stepwise linear regression produced a three-factor model consisting of the cepstral peak prominence (CPP); …

Acoustic And Spectral Patterns In Young Children’S Stop Consonant Productions, Shawn L. Nissen, Robert Allen Fox

Faculty Publications

The aim of this study was to examine the acoustic and spectral patterns of stop articulation in the speech of pre-pubescent children. A set of voiceless stop consonants, /ptk/, produced by a group of adults and typically developing children 3–5 years of age were examined in terms of multiple acoustic and spectral parameters. Findings indicated that, with the exception of spectral kurtosis, the acoustic and spectral characteristics of the stop productions varied significantly as a function of place of articulation and vowel context. Sex-specific differences in spectral slope, mean, and skewness were found for the 5-year-old and adult speakers. Such …

Antimicrobial Activity Of Tigecycline Against Nosocomial Pathogens In Pakistan: A Multicenter Study, Altaf Ahmed, Afia Zafar, Sajjad Mirza

Department of Pathology and Laboratory Medicine

OBJECTIVE: To measure the in-vitro activity of various antibiotics including tigecycline against Gram negative and positive nosocomial aerobic isolates. METHODS: A total of 430 clinical isolates of both Gram positive (143) and negative (287) aerobic bacteria were used from 3 centres during the year 2006 and 2007. Minimum inhibitory concentration (MIC) was determined using broth micro dilution panels. Antibiotic resistance was interpreted using CLSI guidelines.
RESULTS: Most of the isolates were resistant to more than one drug. Resistance to tigecycline was not found. Tigecycline (1 microg/ml) had low MIC against organisms tested.
CONCLUSION: This data indicates that tigecycline, …

Traumatic Stress As A Predictor Of Suicidality, Sherry Malana Todd

Counseling & Human Services Theses & Dissertations

Suicide is a deliberate act of annihilation against one's self due to a crisis of problem solving. Far too many youth are dying by their own hands resulting in suicide being the third leading cause of death for 10-19 year olds (CDC, 2005). Suicide is particularly problematic for adolescents due to the impulsivity inherent in adolescent development. Since 1980, the national suicide rate of African American youth has increased by 114 percent (CDC). Suicidality has been positively correlated with depression and posttraumatic stress disorder (PTSD; Kessler et al., 1999). Suicidality is more prevalent when a person experiences a tragic or …

Incomplete Kawaski Disease: Are We Missing It, Abdul Gaffar Billoo, Saira Waqar Lone, Salman Siddiqui, Huba Atiq

Department of Paediatrics and Child Health

Kawasaki disease, also known as mucocutaneous lymph node syndrome or infantile polyarteritis nodosa is an acute febrile vasculitis of unknown etiology with a predilection for coronary arteries and potential for aneurysm formation. In Incomplete Kawasaki disease, children with fever lack the sufficient number of criteria to fulfill the epidemiologic case definition and are diagnosed when coronary artery disease is detected. We present a case report of a one and a half years old girl who came with features of incomplete Kawasaki disease, high grade fever, irritability, history of conjunctivitis and cracking of lips. She was investigated and had a platelet …

Controlled Evaluation Of Bactec Peds Plus/F And Bactec Lytic/10 Anaerobic/F Media For Isolation Of Salmonella Enterica Serovars Typhi And Paratyphi A From Blood, Megan E. Reller, Anita K. M. Zaidi, Shazia Sultana, Shazia Azeem, Beenish Hanif, Shahida Qureshi, Rumina Hasan, Zulfiqar Ahmed Bhutta, Rehana Akhter, Donald A. Goldmann

Department of Paediatrics and Child Health

We compared anaerobic lytic (AL) and pediatric aerobic resin-containing (Peds Plus/F) blood culture media for the isolation of Salmonella enterica serotype Typhi or Paratyphi A from children. The yields from AL and Peds Plus/F media were the same with equal volumes of blood, but recovery was faster from AL medium than Peds Plus/F medium (10.7 and 16.4 h, respectively) (P < 0.001).

Combined Effects Of Hyperglycemic Conditions And Hiv-1 Nef: A Potential Model For Induced Hiv Neuropathogenesis., Edward A Acheampong, Cassandra Roschel, Muhammad Mukhtar, Alagarsamy Srinivasan, Mohammad Rafi, Roger J Pomerantz, Zahida Parveen

Department of Neurology Faculty Papers

Hyperglycemic conditions associated with diabetes mellitus (DM) or with the use of antiretroviral therapy may increase the risk of central nervous system (CNS) disorders in HIV-1 infected patients. In support of this hypothesis, we investigated the combined effects of hyperglycemic conditions and HIV-1 accessory protein Nef on the CNS using both in vitro and in vivo models. Astrocytes, the most abundant glial cell type required for normal synaptic transmission and other functions were selected for our in vitro study. The results show that in vitro hyperglycemic conditions enhance the expression of proinflammatory cytokines including caspase-3, complement factor 3 (C3), and …

The Role Of Information And Communication Technologies In Managing Transition And Sustaining Women's Health During Their Midlife Years, Julie Dare

Theses: Doctorates and Masters

This research has been motivated primarily by a desire to extend and enrich existing research on women’s uses of information and communication technologies (ICTs) to manage relationships, and access and construct social support during their transitional midlife years. In doing so, this research addresses a gap in the literature on women’s consumption of such technologies. Since the late 1980s, when several landmark studies investigated women’s use of the telephone, there has been little systematic evaluation of the degree to which newer communication technologies have become integrated into women’s communication practices.

Another key feature of this research is an examination of …

Organisational Effectiveness In Selected Grass Roots Sport Clubs In Western Australia, Elissa J. Burton

Theses: Doctorates and Masters

Grass roots sport clubs are the foundation for sport in Australia, they cater for mass participation across all ages and are predominantly managed by volunteers. The benefits of being involved in sport and in particular a sport club, both from a health and social capital perspective are well documented (Houlihan & Green, 2006; Hoye & Nicholson, 2008; Stewart, Nicholson, Smith, & Westerbeek, 2004). Australian governments at every level, provide funding for sport to support these benefits and often directly to sport clubs. Yet there is little published research on what makes a grass roots sport club effective (Koski, 1995), particularly …

Self-Determination Theory In Motivation To Adopt Physical Activity In Older Adults: A Community Based Approach, Alastair Stewart

Theses: Doctorates and Masters

Australia has an increasingly aging population with increasing levels of physical inactivity. The potential detrimental effects of these two factors on the health of the community highlight the need to investigate methods to increase physical activity in older Australian adults. The study reported in this thesis formed part of the PATH (Physical Activity Time for Health) Project, a community-based research trial that compared two strategies to increase physical activity in underactive, 60-80 year old men (n = 66) and women (n = 188). Twelve recreation centres were randomised to either a supervised group based walking intervention with behavioural change components, …

Follow-Up Compliance Of Adolescents With Cervical Dysplasia In An Inner-City Population., Faunda N. Campbell Md, Eduardo Lara-Torre Md

Department of Pediatrics

No abstract provided.

Evaluation Of Dentoalveolar Compensation In Skeletal Class Ii Malocclusion In A Pakistani University Hospital Setting, Nabila Anwar, Mubassar Fida

Section of Dental-Oral Maxillofacial Surgery

OBJECTIVE: To quantitatively evaluate the pattern of dentoalveolar compensation in skeletal class II patients and to find which dentoalveolar parameter compensates the most for this sagittal jaw discrepancy.

STUDY DESIGN: Cross-sectional study. Place and Duration of Study: Dental Section, the Aga Khan University Hospital, Karachi, from January 2005 to March 2006.

METHODOLOGY: Cephalometric analyses were performed on pretreatment lateral cephalographs of 87 orthodontic patients who met the selection criteria. Various linear and angular measurements were taken. For a quantitative evaluation of dentoalveolar compensation, association was found between various dental and skeletal parameters by correlation analyses. To evaluate which parameter compensates …

Cognitive-Linguistic Abilities In Young And Middle-Aged Adults, Jamie Leigh Flatness

Dissertations and Theses @ UNI

The current study investigated the differences on cognition tests and whether or not an age effect existed between young versus middle-aged adults. Twenty young adults (ages 20-39) and twenty middle-aged adults (40-59) were given four cognitive tests to determine if differences in performance existed across the age groups. Tests included the Ross Information Processing Assessment-2nd revision (RIPA-2; Ross-Swain, 1996), the Rey Auditory Verbal Learning Test (RA VLT; Rey, 1964 ), the Wechsler Working Memory (WWM) subtests of the Wechsler Memory Scale, 3rd edition (WMS-Ill; Wechsler, 1997), and the Cognitive Linguistic Quick Test (CLQT,· Helm-Estabrooks, 2001 ). A series of one-factor …

The Relationship Between Cardiovascular Fitness And Risk Factors Of Type 2 Diabetes In Adults, La Toshia Burrell

Dissertations and Theses @ UNI

Obesity and overweight populations have increased dramatically in the last two decades in the United States causing a significant increase in the number of adults with type 2 diabetes. This alarming increase has become an important public health problem due to the associated diseases and health risks. As a result, there have been several programs developed specifically to help prevent or decrease the complications of type 2 diabetes. Physical fitness is an important component of many behavior modification programs. Research studies have conclusively shown beneficial effects of regular activity for disease risk reduction. However, many studies have examined associations between …

A Motor Speech Programming Investigation Using Inhibition: Part I, Jeffrey Thomas Backlin

Dissertations and Theses @ UNI

The current study investigated stop/go boundaries for speech acts (i.e. saying "uh, annul, annulment") in a speech inhibition task modeled on Slater-Hammel's (1959) experiment. Specifically, the project sought to answer the following research questions: (1) Can human speakers learn to stop a sweep hand using their voice? (2) What is the absolute (100%) inhibition threshold for "uh?" (3) What is the threshold at which one half of the spoken response for "uh," can be inhibited? Two additional studies were conducted for the additional stop targets "annul" (Williams, 2009) and "annulment" (Corbett, 2009). Self-report and informal speech-language screening assessed ten adult …

Examining The Intrinsic Motivational Level Of Task And Ego Goal Oriented Athletes In The Xl Sports Acceleration Program, Kira Melisa Werstein

Dissertations and Theses @ UNI

Acceleration programs are a new and popular tool used by youth athletes to prepare for upcoming sports seasons. Acceleration programs train athletes in the areas of speed, agility, power, coordination, and strength. Each of these aspects is important in the development of an athlete and effects athletic performance. It is important that acceleration programs also consider intrinsic motivation, because it will help advance the performance of each athlete. The purpose of this study is to examine motivational levels in task and ego goal oriented athletes over the length of a session at the XL Sports Acceleration Program. The Task and …

A Speech Motor Programming Investigation Using Inhibition, Alison Michele Corbett

Dissertations and Theses @ UNI

Motor learning and its applications have been extensively studied, particularly in the area of sports physiology and kinesiology. From these fields, many theories of movement and its control mechanisms have evolved. Previous research has drawn upon these theatrical principles to investigate the specific parameters of skilled movements, specifically the time required to complete an action. In particular, a finger-lift task has been used to study the refractory period during which a motor program can not be inhibited when trained to occur at a particular temporal target (Slater-Hammel, 1959). The current study applies key methodological concepts from Slater-Hammel's work to examine …