Medicine and Health Sciences Commons^™

Rationale And Design Of A Trial Of Angiotensin-Converting Enzyme Inhibition In Infants With Single Ventricle., Daphne T. Hsu, Seema Mital, Chitra Ravishankar, Renee Margossian, Jennifer S. Li, Lynn A. Sleeper, Richard V. Williams, Jami C. Levine, Brian W. Mccrindle, Andrew M. Atz, Darlene Servedio, Lynn Mahony, Pediatric Heart Network Investigators, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Angiotensin converting enzyme (ACE) inhibitors are known to improve clinical outcome and ventricular function in adults with heart failure. Infants with single-ventricle physiology show abnormalities in ventricular function as well as poor growth. The ability of an ACE inhibitor to preserve ventricular function and improve growth in these infants is unknown.

METHODS: The Pediatric Heart Network designed a randomized, double-blind trial to compare outcomes in infants with single-ventricle physiology receiving enalapril or placebo. Neonates < or =45 days old were eligible. The primary outcome is weight-for-age Z-score at 14 months of age. Secondary outcomes include other measures of somatic growth, laboratory and functional measures of heart failure, developmental indices, measures of ventricular size and function, and the relationship of the renin-angiotensin-aldosterone system genotype to the response to enalapril. The incidence and spectrum of adverse events will also be compared between treatment groups.

RESULTS: A total of 1,245 neonates were screened and 533 (43%) were eligible. The consent rate was 43%; 230 subjects were enrolled. Parental reluctance to …

Review Of Cancer Among Indigenous Peoples, Sasha Stumpers, Neil Thomson

Research outputs pre 2011

This review provides a comprehensive synthesis of population-level cancer statistics and other key information for Aboriginal and Torres Strait Islander people alongside comparative figures for non-Indigenous Australians. It includes general information on the extent of cancer, including: incidence, hospitalisation and mortality. The review also provides information on the extent of cancer for specific cancers: lung, cervical, breast, prostate, liver, pancreatic and colorectal (bowel). Finally, the review discusses issues surrounding Aboriginal and Torres Strait Islander people’s use of cancer services.

Prolonged Monitoring After Decelerations On Outpatient Non-Stress Tests: How Long Is Enough?, P. Koduri, Md, M. Giraldo, Md, V. Berghella, Md, S. P. Chauhan, Md

Department of Obstetrics and Gynecology Faculty Papers

Objective: To determine the appropriate duration of prolonged monitoring following decelerations noted on outpatient non-stress test (NST).

Conclusion: Prolonged monitoring beyond 120 min is not associated with increased rate of delivery secondary to NRFS or worse neonatal outcome measured by the 5 minute Apgar score. Monitoring after a deceleration on outpatient NST may be limited to less than 120 minutes. Larger studies are needed to confirm this finding.

Does 17 Alpha-Hydroxyprogesterone Caproate Decrease The Rate Of Preterm Birth In Women With An Ultrasound-Indicated Cerclage?, T. J. Rafael, D. Mackeen, V. Berghella

Department of Obstetrics and Gynecology Faculty Papers

Objective: To estimate whether the use of 17 alpha-hydroxyprogesterone caproate (17P) in women with an ultrasound-indicated cerclage (UIC) reduces the rate of preterm birth (PTB).

Conclusions: Among women with a prior spontaneous PTB and current UIC for CL<25mm, 17P did not reduce the rate of PTB <35 weeks.

Effectiveness Of 17-Alpha-Hydroxyprogesterone Caproate On The Prevention Of Preterm Birth In Women With A History-Indicated Cerclage, D. Mackeen, Md, T. J. Rafael, Md, J. Zavodnick, Ba, V. Berghella, Md

Department of Obstetrics and Gynecology Faculty Papers

Objective: To determine whether 17-alpha-hydroxyprogesterone caproate (17P) reduces the incidence of preterm birth (PTB) in women with a history-indicated cerclage.

Conclusions: 17P does not appear to have an effect on preterm birth <35 weeks in women with a history-indicated cerclage.

Cervical Cancer Prevention In Pregnant Women: Is Biopsy Useful?, N. S. Seligman, Md, J. Zavodnick, Ba, K. Mccullen, Md

Department of Obstetrics and Gynecology Faculty Papers

Objective: To estimate if cervical biopsy at the time of colposcopy changes the management or outcome of abnormal cervical cytology during pregnancy.

Conclusion: Biopsy of suspected cervical lesions can be safely deferred until after pregnancy because there were no significant changes between antepartum and postpartum CC and no missed cases of cervical cancer were detected.

Quality Improvement In Small Office Settings: An Examination Of Successful Practices., Daniel Wolfson, Elizabeth Bernabeo, Brian Leas, Shoshanna Sofaer, Gregory Pawlson, Donna Pillittere

College of Population Health Faculty Papers

BACKGROUND: Physicians in small to moderate primary care practices in the United States (U.S.) (<25 >physicians) face unique challenges in implementing quality improvement (QI) initiatives, including limited resources, small staffs, and inadequate information technology systems 23,36. This qualitative study sought to identify and understand the characteristics and organizational cultures of physicians working in smaller practices who are actively engaged in measurement and quality improvement initiatives.

METHODS: We undertook a qualitative study, based on semi-structured, open-ended interviews conducted with practices (N = 39) that used performance data to drive quality improvement activities.

RESULTS: Physicians indicated that benefits to performing measurement and …

Behavioral Couple Therapy: Partner-Involved Treatment For Substance-Abusing Women, William Fals-Stewart, Wendy K.K. Lam, Michelle L. Kelley

Psychology Faculty Publications

Among the various psychosocial interventions presently available to treat alcohol and drug abuse, it could be argued that partner-involved treatments are the most broadly efficacious. There is not only substantial empirical support for the use of couple-based treatments in terms of improvements in primary targeted outcomes, such as substance use and relationship adjustment, but also in other areas that are of clear public health significance, including intimate partner violence (IPV), children's adjustment, and cost-benefit ratio and cost-effectiveness. During the last few decades, programmatic research on the application of partner-involved therapies for substance abuse has been among the most active and …

Alchoholism And Intimate Partner Violence: Effects On Children's Psychosocial Adjustment, Keith Klostermann, Michelle L. Kelley

Psychology Faculty Publications

It is widely recognized that alcoholism and relationship violence often have serious consequences for adults; however, children living with alcoholic parents are susceptible to the deleterious familial environments these caregivers frequently create. Given the prevalence of IPV among patients entering substance abuse treatment, coupled with the negative familial consequences associated with these types of behavior, this review explores what have been, to this point, two divergent lines of research: (a) the effects of parental alcoholism on children, and (b) the effects of children's exposure to intimate partner violence. In this article, the interrelationship between alcoholism and IPV is examined, with …

Mitochondrial Mislocalization Underlies Abeta42-Induced Neuronal Dysfunction In A Drosophila Model Of Alzheimer's Disease., Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, Koichi Iijima

Department of Biochemistry and Molecular Biology Faculty Papers

The amyloid-beta 42 (Abeta42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which Abeta42 induces neuronal dysfunction and degeneration remain elusive. Mitochondrial dysfunctions are implicated in AD brains. Whether mitochondrial dysfunctions are merely a consequence of AD pathology, or are early seminal events in AD pathogenesis remains to be determined. Here, we show that Abeta42 induces mitochondrial mislocalization, which contributes to Abeta42-induced neuronal dysfunction in a transgenic Drosophila model. In the Abeta42 fly brain, mitochondria were reduced in axons and dendrites, and accumulated in the somata without severe mitochondrial …

The Value Of Implantable Cardioverter-Defibrillators In Managing Atrial Fibrillation, Daniel Frisch

Division of Cardiology Faculty Papers

Atrial fibrillation (AF) is associated with an increased risk of mortality as well as significant morbidity including bothersome symptoms, exacerbation of heart failure, and thromboembolic events. Explanations for the mortality risk are variable, but the majority opinion favors AF as a marker of reduced health status, especially cardiovascular health.

Effects Of Dietary And Exercise Interventions On The Incidence Of Metabolic Syndrome, Ricky Mccoy Kirby

UNF Graduate Theses and Dissertations

Metabolic syndrome is a serious health problem in the United States. The presence of metabolic syndrome significantly increases the risk of developing type II diabetes and cardiovascular disease by producing a prothrombic state. The prothrombic state that results from the clustering of several independent cardiovascular risk factors within one individual increases the risk of micro and macro vascular changes and eventually to end organ damage.

There is considerable evidence to support the serious nature of this medical condition. Medications used to treat the hypertension, diabetic, and dyslipidemia components of metabolic syndrome can be a significant drain on the monthly budget …

The Relationship Between Preexisting Gastroesophageal Reflux Disease In Lung Transplant Recipients And The Development Of Post-Transplant Bronciolitis Obliterans, Heidy Abuan David-Robinson

UNF Graduate Theses and Dissertations

Lung transplant is a treatment modality for patients with end stage lung disease. Bronchiolitis obliterans syndrome (BOS) is the number one cause of morbidity and mortality in patients the first year after lung transplant. There are many risk factors which have been identified to increase the risk of BOS including acute rejection, lymphocytic bronchitis, medication non-compliance, bacterial or viral infections, older donor age, extended ischemic time, donor antigen-specific reactivity, human leukocyte antigen (HLA) mismatch, underlying disease and gastroesophageal reflux disease (GERD).

Advanced practice nurses can help in the primary prevention of BOS through the assessment and treatment of pre-transplant patients …

Dietary Interventions To Reduce Metabolic Syndrome In An Uninsured Population: An Evidence-Based Approach, Michele Smith Bednarzyk

UNF Graduate Theses and Dissertations

Recent studies show that more than one-third of U.S. adults (over 72 million people) were obese in 2005–2006. This includes 33.3% of men and 35.3% of women. Obesity is a primary factor in the development of metabolic syndrome, a condition that places individuals at high absolute risk of mortality and morbidity. The use of a nutritionally balanced diet aimed at weight reduction has the potential to decrease the prevalence of obesity, therefore reducing the incidence of metabolic syndrome and its consequences.

The purpose of this project was to investigate whether individual nutrition counseling would improve the outcomes of patients with …

New Nurse Residency - An Evidence Based Approach, Alice M. Nied

UNF Graduate Theses and Dissertations

Nurse educators believe that their graduates are well-prepared for entry level positions in nursing. In the acute healthcare setting, new graduates are placed on virtually every type of nursing unit, including critical care. Employers have developed formal orientations to familiarize new graduate nurses new with the institution and its policies and procedures and to teach the things employers believe new RNs need to know but do not, either because they were never taught the material or they have not retained it.

The purposes of this project were to (a) examine the evidence relative to a disconnect between nursing education and …

The Experiences Of Women Who Live With An Implantable Cardioverter-Defibrillator (Lcd), Jenea Mary Smith

UNF Graduate Theses and Dissertations

The implantable cardioverter defibrillator (lCD) is the most effective treatment available for terminating potentially life-threatening ventricular fibrillation and ventricular tachycardia. The lCD detects and attempts to correct these arrhythmias by pacing, cardioversion, and defibrillation thereby providing lifesaving therapy to patients at risk for sudden cardiac death. Currently, 150,000 Americans receive ICDs each year. Although most lCD recipients are men, more women are now qualifying for insertion (Stutts, Cross, Conti, & Sears, 2007).

Despite its established health benefits, lCD implantation is accompanied by psychological factors which merit research attention. This study investigated the experiences of women who live an lCD. The …

Effects Of Community Of Practice And Knowledge Translation Strategies On Nurse Practitioners' Knowledge And Practice Behavior, Helen M. Holman

UNF Graduate Theses and Dissertations

Background: Emerging evidence suggests that interactive CE activities will have the most effect in terms of knowledge and practice. Using technology to provide interactivity via computer-based applications is as effective an educational strategy as traditional education formats.

Methods: A randomized controlled trial was conducted to test the effectiveness and satisfaction of educational activities provided within an online community of practice(CoP) on nurse practitioner (NP) knowledge and practice behavior. The online interactive website combined certified continuing education, professional forum, Ask-the-Experts, national guideline links, patient education tools, and professional resources. A Two-Group Control Group design was used. Study participants were assessed on …

Obstetrical Screening Practices Of Nurse-Midwives And Nurse Practitioners, Laura Ann Abney

UNF Graduate Theses and Dissertations

With the continued growth in the numbers of nurse practitioners and certified nurse-midwives, more and more women will receive prenatal care from advanced practice nurses. The purpose of this research was to assess the routine screening practices of advance practice nurses providing prenatal care and to compare those practices with current guidelines. The study focused on five areas of prenatal screening: bacterial vaginosis, group B streptococcus, gestational diabetes, maternal serum markers, and fetal movement monitoring. The interaction model of client health behavior by Cheryl Cox, specifically professional-technical competencies, part of the client-professional element of the model, provided the theoretical framework …

Effects Of An Educational Intervention On Hospital Acquired Urinary Tract Infection Rates, Sharon Lanier Smith

UNF Graduate Theses and Dissertations

In today's hospital environment, good care has become synonymous with positive patient outcomes. Marring this landscape is the alarming rate of hospital acquired (nosocomial) infections. Urinary tract infection (UTI) is one of the most common hospital acquired infections. The major cause associated with these infections is the use of indwelling urinary catheters. Bacteria invade the lower urinary tract by ascending through or around the catheter. Morbidity associated with urinary catheter-associated UTI can be minimized by prudent decisions concerning catheter usage and good catheter care. The principle route of dispersal of nosocomial infections is likely from patient-to-patient via transiently contaminated hands …

Effects Of Provider Education On Documentation Compliance In The O.R., Brenda Kingdon

UNF Graduate Theses and Dissertations

Knowledge of The Joint Commission's National Patient Safety Goals and an effective provider cooperative practice involving communication and teamwork are essential for the delivery of safe and compliant patient care in the surgical setting. The purpose of this study was to assess the impact of an educational intervention for physicians and nurses designed to increase documentation of compliance with national patient safety standards. As events of noncompliance have impacted patient safety at the hospital where this project was conducted, measures were needed to assess barriers to compliance with standards of practice and to focus educational session plans on identified knowledge-base …

The Effect Of Moral Distress On Nursing Retention In The Acute Care Setting, Cynthia L. Cummings

UNF Graduate Theses and Dissertations

This descriptive study explored the relationship between moral distress, professional stress and intent to stay in the hospital setting. The study involved 234 nursing participants and was conducted via an online survey over a 90 day period. The survey tool consisted of 51 items taken from known moral distress, professional stress and intent to stay tools. The items were divided into frequency and intensity of occurrence. Various statistical measures were utilized to conclude that moral distress and professional stress factors were significant (p

Heritability And Variance Component Estimates Of Meat Quality In Japanese Quail (Coturnix Coturnix Japonica), Yakut Gevrekçi̇, İsmai̇l Oğuz, Mustafa Akşi̇t, Alper Önenç, Demi̇r Özdemi̇r, Özge Altan

Turkish Journal of Veterinary & Animal Sciences

A comparison of 3 methods for variance component estimation to compute the heritability of meat quality characteristics (body weight, breast meat weight, breast yield, l, a, b, c, h, and ph) was performed using the methods of maximum likelihood (ML), restricted maximum likelihood (REML), and minimum variance quadratic unbiased estimator (MIVQUE). The parent population was set up at random from a closed population of Japanese quail (Coturnix coturnix japonica). Selection was not applied for any productive characteristics and no special care was taken to avoid inbreeding. After 12-h feed withdrawal, the birds were weighed and slaughtered at 35 days of …

Effect Of Docking And Diet Energy On Carcass Fat Characteristics In Fat-Tailed Baluchian Sheep, Ali̇ Moharrery

Turkish Journal of Veterinary & Animal Sciences

Effects of docking on carcass fat characteristics were studied in fat-tailed sheep. Male lambs were randomly divided into 2 groups. One group was docked after birth using rubber rings, and the tails of the other group were left intact (control). After weaning, 20 lambs from each group were divided into 2 subgroups; one subgroup was fed with a normal energy diet (10.25 MJ/kg ME) and the other one with a high-energy diet (11.42 MJ/kg ME) for 84 days. At the end of the fattening period, 28 lambs were slaughtered for determination of warm carcass weight (WCW) and other carcass characteristics. …

Magnetic Resonance Imaging Findings Of Intracranial Tumors In Dogs: A Review Of 26 Cases, Ömer Beşalti, Y. Si̇nan Şi̇ri̇n, Zeynep Pekcan, Gonca Erbaş

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to report the magnetic resonance imaging (MRI) findings of intracranial tumors in 26 dogs. The medical records of dogs admitted to the Department of Surgery, Faculty of Veterinary Medicine, Ankara University for central nervous system disorders were reviewed, and dogs with intracranial tumors that were diagnosed with MRI between November 1997 and June 2006 were included in the study. MR images were obtained as T1 weighted (T1W), T2 weighted (T2W), and contrast enhanced T1 weighted (following Gd-DTPA administration) in the transverse, coronal (dorsal), and sagittal planes. The following features were evaluated in order to …

Industrial Copper Intoxication Of Iranian Fat-Tailed Sheep In Kerman Province, Iran, Ali Asghar Mozaffari, Amin Derakhshanfar, Jamileh Salar Amoli

Turkish Journal of Veterinary & Animal Sciences

An outbreak of industrial chronic copper poisoning in Iranian fat-tailed sheep in a region of southeast Iran is described. At least 10,000 out of 75,000 sheep (13.3%) originating from 50 flocks died over a period of 3 years in the Khatoon Abad region in Kerman province, Iran. The diagnosis was based on epidemiological, clinical, hematological, serum biochemical, urinalysis, necropsy and histopathological evaluations. Then findings were confirmed by toxicological analysis of liver and kidney samples. The details of epidemiological, clinical, laboratory and pathologic findings are described in the manuscript. These findings were indicative of chronic copper poisoning in affected sheep. Toxicological …

Immunohistochemical Studies On S100 Reactivity In Chicks Experimentally Infected With Eimeria Tenella I: The Localization Of S100 Protein And Its Subunits \Alpha And \Beta In Stages Of Eimeria Tenella, Lati̇fe Beyaz, Ayhan Atasever, Feyzullah Beyaz, Anil İça

Turkish Journal of Veterinary & Animal Sciences

The expression of the calcium-binding protein S100 and its subunits \alpha and \beta in the intracellular protozoon Eimeria tenella was investigated. For this purpose, anti-S100 whole molecule polyclonal antibody and anti-S100 \alpha and anti-S100 \beta monoclonal antibodies were used on paraffin sections collected from the cecum, ileum, colon, rectum, and bursa of Fabricius of chicks experimentally infected with E. tenella. One hundred seventy-five 2- to 3-day-old specific pathogen-free chicks were used. The chicks were divided into experiment and control groups, to include 94 and 81 chicks, respectively. All the chicks in the experimental group received 10,000 spored oocytes in 0.5 …

Concentration Of Products Of Nitric Oxide Oxidation And Some Vitamins In Sheep With Naturally Acquired Babesiosis, Handan Mert, İbrahi̇m Yörük, Yeter Değer, Ni̇hat Mert, Semi̇ha Dede, Fatmagül Yur

Turkish Journal of Veterinary & Animal Sciences

The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, \alpha- and \delta-tocopherol, and vitamin D_3) in sheep naturally infected with Babesia ovis. The investigation included 30 infected and 10 control sheep. Serum \alpha -tocopherol levels were significantly lower (P < 0.05), and nitrate and nitrite concentrations were significantly higher (P < 0.05) in infected animals than in controls. It is thought that the elevated nitrate and nitrite levels of the sheep infected with babesiosis were due to the result of damage caused by Babesia. On the other hand, a significant decrease was observed in \alpha -tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.

Serum Adenosine Deaminase Activity In Domestic Animals: Reference Values, Nuri̇ Altuğ, Nazmi̇ Yüksek, Zahi̇d Ağaoğlu, İhsan Keleş

Turkish Journal of Veterinary & Animal Sciences

This study was aimed to determine normal serum adenosine deaminase (ADA) activity in domestic animals in both sexes and that were considered healthy on the basis of clinical and laboratory examinations. In this study, 262 non-pregnant animals of both sexes, belonging to 5 species [cattle (n = 50), sheep (n = 65), goat (n = 52), dog (n = 55), and cat (n = 40)] were used. Serum total ADA and ADA1 isoenzyme activities were found to be 6.34 ± 0.31 IU/l and 6.34 ± 0.31 IU/l in cattle, 7.57 ± 0.30 IU/l and 7.31 ± 0.47 IU/l in sheep, …

Effect Of Leptin Gene Polymorphisms On Milk Production Traits Of Jersey Cows, Hanna Kulig, Marek Kmiec, Inga Kowalewska Luczak, Gabriela Andziak

Turkish Journal of Veterinary & Animal Sciences

A total of 181 Jersey cows were used to investigate how leptin gene polymorphisms affect milk production traits such as milk yield, fat and protein yield, and fat and protein content. Two single-nucleotide polymorphisms (SNPs) were genotyped, including the A59V in exon 3 and Sau3AI in intron 2. The genotype, allele, and haplotype frequencies were estimated. Statistical analysis revealed that the A59V polymorphism significantly affected the milk, protein, and fat yield (P Keywords: Leptin, SNP, Jersey cows, milk production traits

Detection Of Bordetella Avium By Polymerase Chain Reaction In The Lungs And Tracheas Of Turkeys With Pneumonia, Süheyla Türkyilmaz, Sevi̇n Kirdar, Fulya Ocak, Şebnur Hazimoğlu

Turkish Journal of Veterinary & Animal Sciences

Lung, trachea, and serum samples obtained from turkeys showing clinical signs of respiratory disease were examined for the presence of Bordetella avium infection (bordetellosis) using culture, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR). The material of this study consisted of 2 live turkeys at the age of 24 weeks with respiratory distress, nasal discharge, and cough that had been brought to the Microbiology Laboratory of the Faculty of Veterinary Medicine, Adnan Menderes University. The results of the study show that B. avium, the causative agent of bordetellosis, was not isolated from either the lung or trachea, while both …