Medicine and Health Sciences Commons^™

Zinc-Finger Protein Mcpip In Cell Death And Differentiation, Craig Younce

Electronic Theses and Dissertations

Monocyte chemotactic protein-1 (MCP-1) plays a critical role in the development of cardiovascular diseases. How MCP-1 contributes to the development of heart disease is not understood. We present evidence that MCP-1 causes death in cardiac myoblasts, H9c2 by inducing oxidative stress, ER stress and autophagy via a novel Znfinger protein, MCP-1 induced protein (MCPIP). MCPIP expression caused cell death and knockdown of MCPIP, attenuated MCP-1 induced cell death. Expression of MCPIP resulted in induction of iNOS and production of reactive oxygen (ROS). It caused induction of NADPH oxidase subunit phox47 and its translocation to the cytoplasmic membrane. Oxidative stress led …

Epigenetic Control Mechanisms In Somatic Cells Mediated By Dna Methyltransferase 1, Bongyong Lee

Electronic Theses and Dissertations

DNA methylation regulates gene expression through a complex network of protein/protein and protein/DNA interactions in chromatin. The maintenance methylase, DNA methyltransferase 1 (DNMT1), is a prominent enzyme in the process that is linked to DNA replication and drives the heritable nature of epigenetic modifications in somatic cells. The mechanistic details that explain how DNMT1 catalytic action is directed in a chromatin setting are not well understood. We hypothesize that post translational modifications and a variety of protein-protein interactions processes are key regulatory elements that set the methylation of CpG elements essential for normal growth behavior in somatic cells. These fundamental …

Reactive Oxygen And Nitrogen Species Induce Protein And Dna Modifications Driving Arthrofibrosis Following Total Knee Arthroplasty., Theresa A Freeman, Javad Parvizi, Craig J Della Valle, Marla J Steinbeck

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Arthrofibrosis, occurring in 3%-4% of patients following total knee arthroplasty (TKA), is a challenging condition for which there is no defined cause. The hypothesis for this study was that disregulated production of reactive oxygen species (ROS) and nitrogen species (RNS) mediates matrix protein and DNA modifications, which result in excessive fibroblastic proliferation. RESULTS: We found increased numbers of macrophages and lymphocytes, along with elevated amounts of myeloperoxidase (MPO) in arthrofibrotic tissues when compared to control tissues. MPO expression, an enzyme that generates ROS/RNS, is usually limited to neutrophils and some macrophages, but was found by immunohistochemistry to be expressed …

Isolated Polyethylene Exchange Versus Acetabular Revision For Polyethylene Wear, Camilo Restrepo, Elie Ghanem, Carrie Houssock, Mathew Austin, Javad Parvizi, William J. Hozack

Department of Orthopaedic Surgery Faculty Papers

Polyethylene wear and osteolysis are not uncommon in THA mid- and long-term. In asymptomatic patients the dilemma faced by the orthopaedic surgeon is whether to revise the cup and risk damage to the supporting columns and even pelvic discontinuity or to perform isolated polyethylene exchange and risk a high rate of postoperative recurrent instability and dislocation that will necessitate further surgery. We retrospectively reviewed 62 patients (67 hips) who underwent revision arthroplasty for polywear and osteolysis. Thirty-six hips had isolated polyethylene exchange, while 31 had full acetabular revision. The minimum followup was 2 years (mean, 2.8 years; range, 2-5 years). …

Well Leg Compartment Syndrome: The Debit Side Of Hemilithotomy Position, Shahryar Noordin, Salim Allana, Muhammad Abdul Wajid

Section of Orthopaedic Surgery

We describe a case of well leg compartment syndrome following unilateral lithotomy position in a patient undergoing contralateral antegrade intramedullary femoral nailing. Following two-incision four compartment fasciotomy, the patient recovered with no residual defects. We dissuade use of the hemilithotomy position for antegrade femoral nailing procedures in favour of another previously described position, because this predisposes patients to position-associated complications without offering any substantial advantage.

Haemodynamic Response To Induction, Laryngoscopy And Tracheal Intubation In Diabetic And Non-Diabetic Patients, Asif Ali Khan, Fauzia Anis Khan

Department of Anaesthesia

OBJECTIVE: Presence of autonomic neuropathy in diabetic patients can alter the haemodynamic response to induction and tracheal intubation. This trial was conducted to compare this response in 30 non-diabetic (control group) and 30 diabetic patients including both insulin and non-insulin dependent.

METHODS: A prospective, age matched case controlled study was conducted at the Aga Khan University Hospital, for one year. After pre-medication with tablet midazolam 7.5 mgs orally, patients received pethidine 0.8 mg kg(-1), thiopentone sodium 4 to 5 mg kg(-1) for induction and vecuronium 0.1 mg kg(-1) to facilitate tracheal intubation. Following manual ventilation with isoflurane 0.8% in oxygen …

Letter By Jeilan Et Al Regarding Article, "Longitudinal Strain Delay Index By Speckle Tracking Imaging: A New Marker Of Response To Cardiac Resynchronization Therapy"., Jeilan Mohamed, Jiun H. Tuan, G. Andre' Ng

Internal Medicine, East Africa

We read with interest the recent article by Lim et al.1 This article demonstrated a strong correlation between a novel longitudinal strain delay index and left ventricular end-systolic volume reduction in both ischemic and nonischemic patients.

The principle outlined by the authors is that an increased longitudinal strain delay index requires both dyssynchrony (defined in their article as a discrepancy between the time of end-systolic contraction and the time to peak strain) and residual contractility. Their concept elegantly considers the problem of cardiac resynchronization therapy (CRT) nonresponse in heart failure patients who have myocardial segments with delayed contraction due …

Natural Medicine: Personal Responsibility And Self-Empowerment, Kimber Lopez

Pomona Senior Theses

Although most “alternative” medical practices have existed far longer than conventional healthcare, modern allopathic continues to be the dominant system of medicine used in the United States. Herbal medicine is one of the oldest healing practices known to humankind and continues to be practiced today despite the numerous challenges modern society poses. As Julie Stone and Joan Mathews illuminate in Complimentary Medicine and the Law, “Plant-based remedies have been the principal source of medicines in healing traditions around the world and, as the World health Organization is at pains to remind us, 80 percent of the world’s population still depends …

Aadej Comm 40 1 2009

AADEJ - The Communicator

The Communicator is the official journal of the American Association of Dental Editors and Journalists (AADEJ). It is published quarterly, distributed digitally via email to members, and posted on the Association's website, AADEJ.org. Each issue includes regular updates from the editorial team and AADEJ board, as well as feature articles on current issues in the field.

Aadej Comm 40 3&4 2009

AADEJ - The Communicator

The Communicator is the official journal of the American Association of Dental Editors and Journalists (AADEJ). It is published quarterly, distributed digitally via email to members, and posted on the Association's website, AADEJ.org. Each issue includes regular updates from the editorial team and AADEJ board, as well as feature articles on current issues in the field.

This is a combined issue for 2009, issue 3 and 4.

Developing Evidenced Based Practice For Social Emotional Screenings In Schools, Kim Anderson

All Graduate Theses, Dissertations, and Other Capstone Projects

The social problem being addressed through this project includes several challenges faced by our nation's schools, namely increasing numbers of disciplinary referrals, suspensions, and expulsions (Marchant, Anderson, Caldarella, Fisher, Young,Young, 2009). Further research states that "more and more children entering school are unprepared to learn, unable to cope with the social tasks involved in making friends and getting along with others, and unaware of their negative social effect on others," (Marchant et al., 2009, p.131). Only about 20% of children and adolescents with a psychiatric disorder in the United States receive any kind of mental health services (Fritz, 2007). Yet …

School Improvement Programs, Kimberly Barry

All Graduate Theses, Dissertations, and Other Capstone Projects

Teachers face a growing number behavior challenges that effect the delivery of classroom instruction (Center for Effective Collaboration and Practice , n.d). This affects how the teacher teaches and how the other students learn. Disruptions in the classroom force teachers to direct their attention to that student resulting in less time teaching. School wide programs help school staff develop expectations for behavior and allows for a common language amongst all staff and students. There are many school wide programs that claim to make behaviors decrease. It can be very cumbersome and time consuming for schools to go through all of …

Acute Psychiatric Group Therapy For Hospitalized Individuals With Serious And Persistent Mental Illness, Lindsey Bednar

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this study was to identify group therapy interventions to be provided during a time limited acute psychiatric hospitalization for individuals with serious and persistent mental illness (SPMI) derived from evidenced-based research.

Research Question: What skills deficits and theory of practice are most efficacious with individuals with SPMI diagnosis served by ISJ Behavioral Health Unit?

Mental Health Relapse Prevention: What Does The Research Say?, Robin Bode

All Graduate Theses, Dissertations, and Other Capstone Projects

This Capstone Project researches evidenced-based literature in the area of mental health relapse prevention planning. The literature review explored best practices in providing mental health relapse prevention interventions and identified research study outcomes. The South Central Crisis Center of Mankato provides residential sub-acute care, crisis assessment, intervention, education and psychiatric urgent care to individuals that identify mental health issues as their primary concern (South Central Crisis Center, 2003). Within the 10 bed facility, clients participate in psycho-social educational groups and receive individual clinical services. Prior to discharge clients meet with the mental health professional to complete an In Home Treatment …

In Step With Our Parents: 3-Part Educational Series, Kate Boisen-Macdonald

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project is to educate adult children caring for their parents, so they can identify as caregivers so they can better cope with, identify with, and/or navigate the role of care giving, and be aware of the resources available to them.

Social Work Involvement In Supporting Survivors Of An Unexpected Death In An Emergency Department, Jennifer E. Buchanan

All Graduate Theses, Dissertations, and Other Capstone Projects

People occasionally present to a hospital’s emergency department (ED) after an event such as a heart attack or a motor vehicle accident that results in their sudden and unexpected death. Although members of the ED attempt to support the survivors as much as possible, due to the fast pace of the environment and responsibilities to other patients, the survivors may not always be provided with the necessary resources and support. This can leave survivors feeling isolated and confused about the appropriate course of action after this type of experience. A planned, organized approach delivered by educated and sensitive staff can …

Bring Mental Health Services Home: Meeting The Mental Health Needs Of Adolescents And Their Families In Rural Minnesota, Laura Filzen

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project was to develop a program that addressed housing and therapeutic support to adolescents experiencing mental health issues, allowed adolescents to remain in the community, and promoted reunification with their families. “An important indicator of success for children in out-of-home care is a timely transition to reunification” (Park and Ryan, 2009). Based on the literature and practice, it is believed that intensive family therapy is needed to promote reunification and reduce recidivism of placement.

Increasing Referrals For Services Through Collaboration With Community Agencies, Benjamin Mohr

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of the project is to investigate how a non-profit organization can collaborate better with other agencies to increase referrals for services. Research was conducted to determine the best avenue of increasing utilization of services in southeast Minnesota by strategic planning. A survey was conducted of 15 southeast Minnesota counties to conduct a SWOT analysis of 3 key services offered by Family Focus that are currently underutilized. Information was compiled in order to support a more comprehensive marketing plan to build relationships with county agencies and increase awareness and use of the services provided by the agency. Recommendations and …

Assessment Of Parenting Skills Of Mothers In Court Ordered Substance Abuse Treatment, Barb Pieske

All Graduate Theses, Dissertations, and Other Capstone Projects

Objective of this project was for me to search for an assessment tool that gives an understanding of mothers who are court ordered to substance abuse treatment. Methods: Search scholarly literature and consult with field supervisor. Results: Adoption of an assessment tool that identifies the strengths and weakness of parenting skills. Conclusion: A structured interview assessment allows the therapist to gather data on the parent with a person centered perspective with a holistic approach.

Implementation And Data Tracking Of School-Linked Mental Health Services At A Rural Mental Health Agency, Jim Redmond

All Graduate Theses, Dissertations, and Other Capstone Projects

In late December of 2007 Tom McNeely, the clinical director for the Sioux Trails Mental Health Center, received a Request for Proposals (RFP) from the Minnesota Department of Human Services soliciting grant applications for a new school-linked mental health program. The school-linked program would provide students (K-12) attending public schools full therapeutic services in an effort to reduce mental health issues as a barrier to learning. This approach mirrored Sioux Trails’ belief that a holistic philosophy incorporating prevention and early intervention is the most effective healthcare service. Since the RTF seemed a good fit for the agency, Mr. McNeely, along …

Social Work Ethics Computer-Based Training Minnesota State University, Mankato Department Of Social Work, Rebecca Robinson-Wargelin

All Graduate Theses, Dissertations, and Other Capstone Projects

At the Community Behavioral Health Hospital, St.Peter (CBHH),a discussion was held regarding Ethics Continuing Education Hours(CEUs). The Minnesota Board of Social Work(MNBSW)and Minnesota State Statute 148D.130 require that Licensed Social Workers receive two hours of ethics-specific CEUsper licensure renewal. Through this discussion,it appeared that it would be beneficial to create an ethics computer-based training(CBT), which would be of no expense to State Operated Services(SOS)Social Workers.This option would also provide convenience for social workers, who as a majority,reside within rural areas.The CBT created is in accordance to requirements of the MNBSW and has an emphasis to include the National Association of …

From A Consumer’S Perspective: What Is Helpful For Residents Of Four Bed Group Homes To Maintain Good Mental Health, Ronna R. Severson

All Graduate Theses, Dissertations, and Other Capstone Projects

The population with mental illness has faced many changes in the services provided to them throughout the years. And fortunately, in recent years there has been many progressions in the field that have made the services even better. This transformation all began with the gradual process of closing mental health hospitals and the opening of community based alternatives, otherwise known as deinstitutionalization (Brunt & Hansson, 2002, p. 611). The main objective of the deinstitutionalization movement was to create more humane services for the individuals with mental illness (Searight& Handal, 1987, p. 8). Through this process one of the community based …

Pervasive Developmental Disorder, Electric Training Modules, Jennifer Stuehrenberg

All Graduate Theses, Dissertations, and Other Capstone Projects

The South Central Crisis Center is a State Operated Services mental health facility in Mankato, Minnesota. The center is designed to offer people suffering an acute mental health episode, such as suicidal thoughts, or who need a medication adjustment or other psychiatric services, up to a few days in a safe, secure environment. The center accepts referrals from law enforcement, county or health care professionals in these participating counties: Blue Earth, Brown, Faribault, Freeborn, Le Sueur, Martin, Nicollet, Rice, Sibley and Watonwan. Recently, the program has been serving a larger amount of clients who have a diagnosis of Asperger’s Disorder …

Parent Training, Support And Psychoeducational Groups As Evidence Based Practice In Children's Mental Health, Dorothy Wagner

All Graduate Theses, Dissertations, and Other Capstone Projects

The evidence base for programs in children’s mental health has expanded significantly in the last decade (Burns, 2003), yet the implementation of these programs has lagged behind (Walrath, Sheehan, Holden, Hernandez & Blau, 2005). The purpose of this project is to research current evidence based practices and programs that could improve and/or update services that are provided to children and adolescents diagnosed with severe emotional disturbance (SED) in Steele County. Research and analysis of the feasibility of implementing a group intervention to provide support, psychoeducation and/or skills training to families was conducted.

Elevated Corticotropin-Releasing Hormone In Human Pregnancy Increases The Risk Of Postpartum Depressive Symptoms, Ilona S. Yim, Laura M. Glynn, Christine Dunkel Schetter, Calvin J. Hobel, Aleksandra Chicz-Demet, Curt A. Sandman

Psychology Faculty Articles and Research

Postpartum depression (PPD) is common and has serious implications for the mother and her newborn. A possible link between placental corticotropin-releasing hormone (pCRH) and PPD incidence has been discussed, but there is a lack of empirical evidence.

Maturation Of The Human Fetal Startle Response: Evidence For Sex-Specific Maturation Of The Human Fetus, Claudia Buss, Elyssia Poggi Davis, Quetzal A. Class, Matt Gierczak, Carol Pattillo, Laura M. Glynn, Curt A. Sandman

Psychology Faculty Articles and Research

Despite the evidence for early fetal experience exerting programming influences on later neurological development and health risk, very few prospective studies of human fetal behavior have been reported. In a prospective longitudinal study, fetal nervous system maturation was serially assessed by monitoring fetal heart rate (FHR) responses to vibroacoustic stimulation (VAS) in 191 maternal/fetal dyads. Responses were not detected at 26 weeks gestational age (GA). Sex-specific, age-characteristic changes in the FHR response to VAS were observed by 31 weeks' GA. Males showed larger responses and continued to exhibit maturational changes until 37 weeks'GA, females however, presented with a mature FHR …

The Lived Experience Of Hiv-Positive Tanzanian Orphans, Carol A. Parker

Walden Dissertations and Doctoral Studies

The purpose of this investigation was to generate a context- specific model of the lived experience of HIV positive Tanzanian orphans. With the advent of anti-retroviral drugs, Sub-Saharan African populations with high burdens of human immunodeficiency virus (HIV) face annually accumulating increases in the number of HIV positive children, and ultimately adults. Perinatally infected, these children often become orphans while still young. Extended interviews were performed with a purposive sample of 12 HIV infected orphaned children between 9 and 12 years of age. Half of the research participants lived in an orphanage and half were children living with guardians in …

Factors Affecting Retention Of Veteran Classroom Teachers: A Q -Method Study, Theresa Hollingsworth Hafen Corry

Walden Dissertations and Doctoral Studies

Teacher attrition compromises efforts to provide a quality teacher in every classroom, and attrition brings high financial and organizational costs to school districts. Yet, there are few studies on retention of veteran teachers. Within a framework of economic, organization, and attrition theories, the purpose of this study was to provide a clearer focus on factors that contribute to the retention of veteran teachers using Q-methodology. The independent variables were 49 participants from a large school district in the southwest United States. The dependent variable was the Q-sample of multiple factors. Using previous literature, a concourse was developed. The P-sample of …

Comparative Efficacy Of 2 Topical Anesthetics For The Placement Of Orthodontic Temporary Anchorage Devices, Derek S Reznik, Arthur H Jeske, Jung-Wei Chen, Jeryl English

Faculty, Staff and Student Publications

This study compared the effectiveness of topical benzocaine 20% versus a combination of lidocaine, tetracaine, and phenylephrine in providing sufficient analgesia for the placement of orthodontic temporary anchorage devices (TADs). The 2 topical anesthetics were tested against each other bilaterally using a randomized, double-blind, crossover design. The agents were left in place for the amount of time prescribed by the manufacturer. The TAD was then placed, and each subject rated the degree of pain on a Heft-Parker visual analogue scale. A pulse oximeter was used to record the preoperative and postoperative pulse rates. Statistically significant differences in perceived pain (P …

Incidental Detection Of An Occult Oral Malignancy With Autofluorescence Imaging: A Case Report, Nadarajah Vigneswaran, Sheila Koh, Ann Gillenwater

Faculty, Staff and Student Publications

BACKGROUND: Autofluorescence imaging is used widely for diagnostic evaluation of various epithelial malignancies. Cancerous lesions display loss of autofluorescence due to malignant changes in epithelium and subepithelial stroma. Carcinoma of unknown primary site presents with lymph node or distant metastasis, for which the site of primary tumour is not detectable. We describe here the use of autofluorescence imaging for detecting a clinically innocuous appearing occult malignancy of the palate which upon pathological examination was consistent with a metastatic squamous cell carcinoma.

CASE DESCRIPTION: A submucosal nodule was noted on the right posterior hard palate of a 59-year-old white female during …