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Articles 3961 - 3990 of 4384
Full-Text Articles in Medicine and Health Sciences
Evaluation Of The Knowledge Of Hospital Cleaning Staff About Prevention Of Nosocomial Infections, Tansu Yamazhan, Meltem Işikgöz Taşbakan, Şebnem Çalik, Hüsnü Pullukçu, Oğuz Reşat Si̇pahi̇, Sercan Ulusoy
Evaluation Of The Knowledge Of Hospital Cleaning Staff About Prevention Of Nosocomial Infections, Tansu Yamazhan, Meltem Işikgöz Taşbakan, Şebnem Çalik, Hüsnü Pullukçu, Oğuz Reşat Si̇pahi̇, Sercan Ulusoy
Turkish Journal of Medical Sciences
Aims: Detection of risk groups and infection sources and awareness of the routes of transmission of infections are important for prevention of hospital infections. In this study, we aimed to evaluate the knowledge level and the behavior models of hospital cleaning staff about nosocomial infections. Materials and Methods: A 21-item questionnaire about nosocomial infections was administered to the hospital cleaning staff. Results: Out of 290 hospital cleaning staff, 240 (82.7%, 122 male, 118 female, aged 36.2±8.7) were included in the study. When evaluated according to their educational status, 55.4% had graduated from primary school. Fifty-four percent of the staff had …
Relation Between Objectively Measured Growth Determinants And Ambulation In Children With Cerebral Palsy, Ni̇lüfer Kutay Ordu Gökkaya, Asli Çalişkan, Di̇lek Karakuş, Hali̇l Uçan
Relation Between Objectively Measured Growth Determinants And Ambulation In Children With Cerebral Palsy, Ni̇lüfer Kutay Ordu Gökkaya, Asli Çalişkan, Di̇lek Karakuş, Hali̇l Uçan
Turkish Journal of Medical Sciences
Aims: Cerebral palsy (CP) is a well-known neurodevelopmental condition beginning in early childhood and persisting throughout one´s life span. Feeding problems and eating impairments in CP children are well documented in the literature. The aims of our study were to determine the prevalence of linear growth retardation and the other growth determinants in this patient group and to identify the contributing factors and their relationship with ambulation. Materials and Methods: A cross-sectional and prospective study was carried out between March 2007 and July 2007 in our pediatric inpatient rehabilitation service, and a total of 34 CP patients (22 male, 12 …
Seroprevalence Of Hepatitis A Infection In The Turkish Republic Of Northern Cyprus, Zafer Kurugöl, Güldane Koturoğlu, Sadik Akşi̇t, Ti̇jen Özacar
Seroprevalence Of Hepatitis A Infection In The Turkish Republic Of Northern Cyprus, Zafer Kurugöl, Güldane Koturoğlu, Sadik Akşi̇t, Ti̇jen Özacar
Turkish Journal of Medical Sciences
Aims: This study was conducted to determine the seroprevalence of hepatitis A virus (HAV) infection in the Turkish Republic of Northern Cyprus. Materials and Methods: A total of 660 unvaccinated persons 1 to 30 years old were selected for the study with cluster sampling. Information on sociodemographic characteristics was gathered for each participant and, in 641 of them, anti-HAV antibodies were assayed using an enzyme immune assay. Results: Anti-HAV prevalence in the Turkish population under the age of 30 in Northern Cyprus was 23.9%. For the age groups 1-5, 6-10 and 11-15 years, seroprevalence rates were relatively low (11.4, 9.4 …
The Prevalence Of Consanguineous Marriages In The City Of Malatya, Turkey, Şengül Yüksel, Ayşegül Kutlubay, Leyla Karaoğlu, Sai̇m Yoloğlu
The Prevalence Of Consanguineous Marriages In The City Of Malatya, Turkey, Şengül Yüksel, Ayşegül Kutlubay, Leyla Karaoğlu, Sai̇m Yoloğlu
Turkish Journal of Medical Sciences
Aims: The aim of this study was to determine the prevalence of consanguineous marriages and the associated factors in the city of Malatya. Materials and Methods: Thirty cluster survey methodology was used to select the study population. Selecting 13 married women per cluster, a total of 409 women were interviewed at their home. Information on the sociodemographic and fertility characteristics of the women and genetic disorders among children was gathered using a face-to-face questionnaire. Data analysis was done by SPSSWIN 13.0. Results: The overall prevalence of consanguinity was 28.4%, with a mean inbreeding coefficient of 0.01081. The principal type of …
Orbital Emphysema Due To Nose Blowing, Mustafa Sever, Tunç Büyükyilmaz
Orbital Emphysema Due To Nose Blowing, Mustafa Sever, Tunç Büyükyilmaz
Turkish Journal of Medical Sciences
Orbital emphysema is a rare ocular emergency in the absence of trauma, sinusitis and/or surgical intervention. We report a case of orbital emphysema in a 29-year-old male caused by forceful blowing of the nose. The patient presented with sudden and painful onset of right periorbital swelling and nose-bleed following forceful blowing of the nose. There was no history of sinusitis, facial trauma or previous surgery. Examination of the patient disclosed crepitant eyelid swelling, ptosis, and mild unilateral exophthalmos and inferomedial strabismus in the neutral position. Otorhinolaryngologic and ophthalmic examinations were accompanied by computerized tomography, which demonstrated areas of emphysema in …
Papillary Carcinoma On The Thyroglossal Cyst Wall, Ş. Si̇nan Kürkçüoğlu, Selahatti̇n Genç, Ümi̇t Tunçel, Funda Demi̇rağ
Papillary Carcinoma On The Thyroglossal Cyst Wall, Ş. Si̇nan Kürkçüoğlu, Selahatti̇n Genç, Ümi̇t Tunçel, Funda Demi̇rağ
Turkish Journal of Medical Sciences
Thyroglossal duct cysts are usually located at the midline of the neck. While the coexistence of a carcinoma in a thyroglossal duct cyst is extremely rare, papillary carcinoma represents almost 80% of the cases. Its treatment is usually decided based on postoperative histopathological examinations. Although the Sistrunk procedure is often seen as adequate, the treatment of thyroglossal duct cysts remains controversial. In the present study, the Sistrunk procedure was used to excise a thyroglossal duct cyst in a 24-year-old female. Papillary carcinoma was confirmed with the histopathological examination following the surgery. We did not perform thyroidectomy, neck dissection or radioactive …
The Relationship Between Plasma Homocysteine And Early Coronary Collateral Vessel Development After Acute Myocardial Infarction, Telat Keleş, Tahi̇r Durmaz, Ni̇hal Akar Bayram, Murat Akçay, Ekrem Yeter, Hüseyi̇n Ayhan, Engi̇n Bozkurt
The Relationship Between Plasma Homocysteine And Early Coronary Collateral Vessel Development After Acute Myocardial Infarction, Telat Keleş, Tahi̇r Durmaz, Ni̇hal Akar Bayram, Murat Akçay, Ekrem Yeter, Hüseyi̇n Ayhan, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Aim: Homocysteine is known to inhibit endothelial cell proliferation, which is a key event in angiogenesis. Factors responsible for the presence or absence of coronary collateral circulation are poorly understood. Therefore, in this study we investigated the effect of plasma homocysteine level on the early formation of angiographically visible collaterals after acute myocardial infarction. Materials and Methods: The study included 60 patients that had ST-segment elevation myocardial infarction (STEMI). All the patients underwent coronary angiography 1-4 days after admission (mean: 2.3 ± 1.2 days). Patients were graded according to Rentrop classification. Patients with grade 0 or 1 collateral vessels were …
Mutational Analysis Of The Mefv Gene In Egyptian Patients With Familial Mediterranean Fever, Ayşenur Öztürk, Ezzat Elsobky, Solaf M. Elsayed, Mostafa Alhodhod, Nejat Akar
Mutational Analysis Of The Mefv Gene In Egyptian Patients With Familial Mediterranean Fever, Ayşenur Öztürk, Ezzat Elsobky, Solaf M. Elsayed, Mostafa Alhodhod, Nejat Akar
Turkish Journal of Medical Sciences
Aim: Familial Mediterranean fever is an autosomal recessive disease affecting primarily populations surrounding the Mediterranean basin. The aim of this study was to find the distribution of MEFV gene mutations in a group of Egyptian patients with FMF and to evaluate any predictive genotype-phenotype correlation in this group of patients. Materials and Methods: The study included 112 patients (59 males and 53 females). Sequencing of the exon 10, exon 3, and exon 5 and PCR/RFLP analysis of E148Q and R202Q mutations of exon 2 of the MEFV gene were performed for all the patients according to a previously described technique. …
Evaluation Of Ribavirin Genotoxicity With Sister Chromatid Exchange And Micronuclei Assays In Humans, Abdulgani̇ Tatar, Zülal Özkurt, Ahmet Hacimüftüoğlu, Ahmet Yeşi̇lyurt, Serhat Vançeli̇k
Evaluation Of Ribavirin Genotoxicity With Sister Chromatid Exchange And Micronuclei Assays In Humans, Abdulgani̇ Tatar, Zülal Özkurt, Ahmet Hacimüftüoğlu, Ahmet Yeşi̇lyurt, Serhat Vançeli̇k
Turkish Journal of Medical Sciences
Aim: The main objective of this study was to assess the genotoxicity of ribavirin in 15 patients who were suffering from Crimean-Congo haemorrhagic fever and treated with the therapy dose of the antiviral agent. Materials and Methods: Genotoxicity was evaluated using the cytokinesis-blocked micronucleus (MN) and sister chromatid exchange (SCE) assays in lymphocyte cultures that were prepared from blood samples collected from the 15 patients. The blood samples were taken on day 9 of a 10-day therapeutic regimen of ribavirin and 1 month after the cessation of therapy. Results: In all patients, the frequency of sister chromatid exchanges and the …
Comparison Of Trauma Scores For Adults Who Fell From Height As Survival Predictivity, Mehmet Eryilmaz, Murat Durusu, Öner Menteş, Tahi̇r Özer, Seli̇m Kiliç, Gürkan Ersoy, Özcan Altinel, Murat Kalemoğlu, Nurkan Törer
Comparison Of Trauma Scores For Adults Who Fell From Height As Survival Predictivity, Mehmet Eryilmaz, Murat Durusu, Öner Menteş, Tahi̇r Özer, Seli̇m Kiliç, Gürkan Ersoy, Özcan Altinel, Murat Kalemoğlu, Nurkan Törer
Turkish Journal of Medical Sciences
Aim: Falls from a height and their subsequent injuries and traumas can cause morbidity and death. In the present study, ISS, NISS, RTS, and TRISS values were analyzed to assess mortality probabilities of patients who fell from a height. Materials and Methods: Patients' age, gender, height of falls (0-2 m, 3-5 m, and 6 m and above), organ pathologies, and ISS, NISS, RTS, and TRISS scores were evaluated in terms of mortality. Results: Regarding the survival rate, no statistically significant difference was found between age and gender (P > 0.05). We determined that all trauma scores were correlated with mortality, and …
Prevalence Of Hepatitis B Infection Among Schoolchildren In Southeast Turkey, Bünyami̇n Di̇ki̇ci̇, Hakan Uzun, Ayfer Gözü, Mücahi̇t Fi̇dan
Prevalence Of Hepatitis B Infection Among Schoolchildren In Southeast Turkey, Bünyami̇n Di̇ki̇ci̇, Hakan Uzun, Ayfer Gözü, Mücahi̇t Fi̇dan
Turkish Journal of Medical Sciences
Aim: Hepatitis B virus (HBV) infection is a worldwide health problem. The objectives of this study were to determine the impact of the Expanded Programme on Immunization (EPI) on the prevalence of HBsAg carrier rate and immunity developed against HBV infection among schoolchildren in southeast Turkey. Materials and Methods: The study population consisted of 147,200 healthy schoolchildren between 6 to 17 years of age living in the Mardin area. A total of 802 children were randomly selected by systematic sampling method. Hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), and antibody to hepatitis B core antigen (anti-HBc) were analyzed …
Subcutaneous Mucormycosis In An Immunocompetent Nigerian Child, Edirin Omorigho Yusuf, Alphonsus Ndidi Onyiriuka
Subcutaneous Mucormycosis In An Immunocompetent Nigerian Child, Edirin Omorigho Yusuf, Alphonsus Ndidi Onyiriuka
Turkish Journal of Medical Sciences
A 13-year-old girl presented with a three-month history of generalized blisters on her body following a traumatic injury to her leg with a piece of wood while farming. The lesions were hemorrhagic, itchy and tender on pressure. The patient was non-diabetic, non-leukemic, non-neutropenic, and not previously on immunosuppressive drugs, nor was there any evidence of immunosuppression. Culture and microscopic examination of scrapings from the skin lesions revealed growth of a Mucor spp. She was initially placed on potassium iodide and responded well for about a month, then relapsed. The patient was successfully treated with itraconazole monotherapy.
A Simple Surgical Technique For Repair Of Iridodialysis, Şengül Özdek, Mehmet Cüneyt Özmen
A Simple Surgical Technique For Repair Of Iridodialysis, Şengül Özdek, Mehmet Cüneyt Özmen
Turkish Journal of Medical Sciences
A simple surgical technique is described for repair of iridodialysis and a traumatic iridodialysis case is presented. In this technique, a 10-0 polypropylene suture is used for repair. The knot is left in the anterior chamber to avoid suture related complications such as erosion, patient discomfort, and infection. This technique can be a safe and easy way to repair large iridodialysis.
Linear And Whorled Nevoid Hypermelanosis In Trisomy 13, Şengül Yüksel, Serap Savaci, Uğur Biçak, Cengi̇z Yakinci, Bülent Mizrak
Linear And Whorled Nevoid Hypermelanosis In Trisomy 13, Şengül Yüksel, Serap Savaci, Uğur Biçak, Cengi̇z Yakinci, Bülent Mizrak
Turkish Journal of Medical Sciences
Linear and whorled nevoid hypermelanosis (LWNH) is a reticulate pigmentary disorder with a sporadic occurrence, generally representing a genetic mosaicism. In this case, we describe a two-month-old girl with trisomy 13, who presented with various systemic anomalies such as congenital ventricular septal defect, microcephaly, auricular deformities, flatness of nasal root, overlapping fingers, umbilical hernia, and LWNH. G-banding chromosomal analyses were performed on cultured peripheral blood lymphocytes of the patient and the parents. The karyotype of the patient was 47, XX,+13[100], with no mosaicism. The karyotypes of the parents were normal. To our knowledge, we present the first patient with LWNH …
A Rare Case Of Pilomatricoma With Bullous Appearance, Ayşe Serap Karadağ, Meral Ekşi̇oğlu, Eki̇n Özlük, Gülfer Akbay, Alev Eken, Savaş Serel, Hesna Müzeyyen Astarci
A Rare Case Of Pilomatricoma With Bullous Appearance, Ayşe Serap Karadağ, Meral Ekşi̇oğlu, Eki̇n Özlük, Gülfer Akbay, Alev Eken, Savaş Serel, Hesna Müzeyyen Astarci
Turkish Journal of Medical Sciences
Background: Pilomatricoma is a rare, benign adnexal tumor differentiating toward elements of the hair matrix and shaft. It typically presents as a solitary, deep, dermal nodule. In addition, bullous changes can be rarely seen. Methods: A 16-year-old girl with firm, mobile, multilobule and non-tender mass that has a soft, hemorrhagic blister-like formation on the left infraclavicular region is described. Results: The histopathologic findings were consistent with pilomatricoma. In the dermis above the tumor, there were numerous dilated lymphatic and blood vessels. No pathologic elastic fibrils were identified with elastin stains. Collagen fibrils were normal with Mason trichrome stain. Conclusions: The …
Sexual Functioning In Hemodialysis Patients And Their Spouses: Results Of A Prospective Study From Turkey, Ayşegül Yilmaz, Ceren Göker, Orhan Murat Koçak, Bahi̇re Aygör, Vesi̇le Şentürk, Gökhan Nergi̇zoğlu, Ati̇lla Soykan, Hakan Kumbasar
Sexual Functioning In Hemodialysis Patients And Their Spouses: Results Of A Prospective Study From Turkey, Ayşegül Yilmaz, Ceren Göker, Orhan Murat Koçak, Bahi̇re Aygör, Vesi̇le Şentürk, Gökhan Nergi̇zoğlu, Ati̇lla Soykan, Hakan Kumbasar
Turkish Journal of Medical Sciences
Aims: This study aimed to evaluate sexual functioning among hemodialysis patients and their spouses. Materials and Methods: The study was conducted by the Consultation Liaison Psychiatry Division at the Hemodialysis Unit of the Department of Nephrology, Ankara University, School of Medicine as well as 3 private dialysis centers in Ankara. The study group consisted of 45 hemodialysis patients and their spouses. All couples filled out a socio-demographic and occupational data form and a validated Turkish version of the Arizona Sexual Experiences Scale. The couples were also evaluated by a psychiatrist using the Hamilton Depression Scale, Hamilton Anxiety Scale, and Mini …
Survival In Esophageal Cancer Patients With Hematogenous Distant Organ Metastases, Ati̇la Türkyilmaz, Ati̇lla Eroğlu, Yener Aydin, Ömer Yilmaz, Nuretti̇n Karaoğlanoğlu
Survival In Esophageal Cancer Patients With Hematogenous Distant Organ Metastases, Ati̇la Türkyilmaz, Ati̇lla Eroğlu, Yener Aydin, Ömer Yilmaz, Nuretti̇n Karaoğlanoğlu
Turkish Journal of Medical Sciences
Objective: Esophageal cancer is a rapidly progressive cancer. In the majority of patients local invasion or distant metastasis may be present at the time of diagnosis. The present study reviewed the records of esophageal cancer patients with hematogenous distant organ metastases with the aim of reporting primary tumor location, histological type, location of metastases, and survival rates, according to treatment administered. Method: Distant organ metastasis was detected in 50 of 316 consecutive patients that presented to the Thoracic Surgery Department of Atatürk University between 2002 and 2007. Patient age and gender, tumor location, history of esophagectomy, metastasis organ, treatment type, …
Lack Of Association Between Tlr4 Polymorphism And Severe Gram-Negative Bacterial Infection In Neonates, Tuba Turul Özgür, Leman Yel, Şule Yi̇ği̇t, Lütfi̇ye Mesci̇, Özden Sanal, İlhan Tezcan, Gülsevi̇n Teki̇nalp, Fügen Ersoy
Lack Of Association Between Tlr4 Polymorphism And Severe Gram-Negative Bacterial Infection In Neonates, Tuba Turul Özgür, Leman Yel, Şule Yi̇ği̇t, Lütfi̇ye Mesci̇, Özden Sanal, İlhan Tezcan, Gülsevi̇n Teki̇nalp, Fügen Ersoy
Turkish Journal of Medical Sciences
Aim: Gram-negative microorganisms are responsible for a significant percentage of systemic bacterial infections in neonates, which tend to progress to sepsis. Toll-like receptor 4 (TLR4), one of the receptors in the innate immune system, binds to the lipopolysaccharide (LPS) present on gram-negative bacteria. Following ligation, a cascade of cellular signals leads to activation of NF\kappaB, resulting in the generation of such proinflammatory cytokines as TNF\alpha, IL-1, IL-2, and IL-6. These are the mediators of inflammation, which is the cellular response to activation of the innate immune system. As such, TLR4 appears to be a very likely candidate involved in the …
A Comparison Of Different Doses Of Remifentanil And Tracheal Lidocaine On Attenuation Of Cardiovascular Responses To Laryngoscopy And Tracheal Intubation, Mohammadreza Safavi, Azim Honarmand
A Comparison Of Different Doses Of Remifentanil And Tracheal Lidocaine On Attenuation Of Cardiovascular Responses To Laryngoscopy And Tracheal Intubation, Mohammadreza Safavi, Azim Honarmand
Turkish Journal of Medical Sciences
Background: The efficacy of remifentanil infusion versus tracheal lidocaine for attenuation of the cardiovascular responses to tracheal intubation has been previously reported. This study compared hemodynamic stability during anesthesia induction and intubation using tracheal lidocaine and remifentanil. Materials and Methods: The study included 90 patients that were scheduled for elective surgery under general anesthesia and randomly allocated to 3 treatment groups: remifentanil 1 µg kg-1 min-1 bolus over 30 s, followed by an infusion of 0.5 µg kg-1 min-1 (R1); remifentanil 0.5 µg kg-1 min-1 over 30 s and an infusion of 0.25 µg kg-1 min-1 (R2); tracheal lidocaine (TL) …
Evaluation Of The Performance Of A Carotid Subclavian By-Pass As A Source For Internal Thoracic Artery, İbrahi̇m Duvan, Alper Gürbüz, Meti̇n Demi̇rci̇n
Evaluation Of The Performance Of A Carotid Subclavian By-Pass As A Source For Internal Thoracic Artery, İbrahi̇m Duvan, Alper Gürbüz, Meti̇n Demi̇rci̇n
Turkish Journal of Medical Sciences
The concomitance of atherosclerotic subclavian occlusive lesion with coronary artery disease has an extraordinary importance in coronary artery bypass surgery. The development of a lesion in the subclavian artery proximal to the internal thoracic artery (ITA) before or after coronary artery bypass graft (CABG) by ITA can result with the coronary-subclavian steal syndrome and myocardial ischemia may occur. It is pretty vital to be aware of the presence of the subclavian occlusive lesion in patients undergoing CABG. We present in this paper an atherosclerotic case that had a concomitant brachiocephalic and coronary artery disease. He had both carotid and subclavian …
Comparison Of Zeocin And G418 Resistance Markers In Pichia Pastoris, Allison Moy
Comparison Of Zeocin And G418 Resistance Markers In Pichia Pastoris, Allison Moy
University of the Pacific Theses and Dissertations
The methylotrophic yeast, Pichia pastoris, has been used to successfully produce and express over 700 heterologous proteins. Currently, the only two dominant selectable markers available are the Zeocin and blasticidin resistance genes. This study focused on characterizing and developing the modified G418 selectable marker so it could be used for primary selection of single copy and multicopy strains. To demonstrate its use as a selectable marker the SLPI reporter gene was inserted into the Zeocin resistance vector, pPICZB, and the new G418 resistance vector, pKANa B. The resulting constructs were then transformed into P. pastoris yJC100 cells. Piggyback strains containing …
Editorial, Greg Cline
Michigan’S Families Deserve Access To Timely, Affordable And The Most Up-To-Date Health Care, Fred Upton
Michigan’S Families Deserve Access To Timely, Affordable And The Most Up-To-Date Health Care, Fred Upton
Michigan Journal of Public Health
No abstract provided.
The Beginning Of Public Health In Michigan Michigan State Board Of Health Reports, 1873-1900, G. Elaine Beane, Robert E. Mosher
The Beginning Of Public Health In Michigan Michigan State Board Of Health Reports, 1873-1900, G. Elaine Beane, Robert E. Mosher
Michigan Journal of Public Health
No abstract provided.
Evidence-Based Nursing Practice In Local Public Health, Naomi E. Ervin, Sue Ellen Bell, Joan T. Bickes
Evidence-Based Nursing Practice In Local Public Health, Naomi E. Ervin, Sue Ellen Bell, Joan T. Bickes
Michigan Journal of Public Health
Purpose: The purpose of this study was to identify the extent to which public health nursing in Michigan local health departments (LHDs) has based services and programs on research and other evidence. Method: The study was conducted using a descriptive survey design. The sample was composed of the 45 chief administrators of public health nursing services in each of the 45 Michigan LHDs. Data were analyzed using descriptive statistics. Narrative answers to open-ended items were examined to determine patterns. Findings: Thirty-six (80%) of the chief nursing administrators of the LHDs responded to the survey. Of these nursing administrators, 28 (77.8%) …
Editorial, Greg Cline
Keep Your Rear In The Clear: Colorectal Cancer Prevention Education Through Collaboration, Andrea Layman, Megan Holt, Julie Williams
Keep Your Rear In The Clear: Colorectal Cancer Prevention Education Through Collaboration, Andrea Layman, Megan Holt, Julie Williams
Michigan Journal of Public Health
No abstract provided.
Using Card Matching Games To Reinforce Health Concepts At A Public Health Event, George W. Dombi
Using Card Matching Games To Reinforce Health Concepts At A Public Health Event, George W. Dombi
Michigan Journal of Public Health
Colorectal cancer is the second most common cancer for males and females combined, after lung cancer. A diet rich in fruits and vegetables may play a role in colorectal cancer prevention. During March 13-18, 2009, the Colorectal Cancer Awareness Network (CRAN) of Southeastern Michigan, in partnership with Get Your Guts in Gear presented CoCo the Colossal Colon®, a 40-foot long, human colon model at the Detroit Science Center. Healthyfood card matching games were played to reinforced the message of fruit and vegetable consumption for good colon health. The goal of this report is to show how to make and use …