Medicine and Health Sciences Commons^™

Studies On Drug Solubilization Mechanism In Simple Micelle Systems, Shaoxin Feng

University of Kentucky Doctoral Dissertations

Poor aqueous solubilities of drug candidates limit the biopharmaceutical usefulness in either oral or parenteral dosage forms. Lipid assemblies, such as micelles, may provide a means of enhancing solubility. Despite their usefulness, little is known about the means by which micelles accomplish this result. The goal of the current dissertation is to provide the molecular level understanding of the mechanism by which simple micelle systems solubilize drugs. Specifically, the location, orientation and amount of the drug molecules in micelle systems are the focuses of the work.

Three series of model drugs, steroids, benzodiazepines and parabens, in three surfactant systems with …

Experimental And Molecular Dynamics Simulation Studies Of Partitioning And Transport Across Lipid Bilayer Membranes, Ravindra Wadhumal Tejwani

University of Kentucky Doctoral Dissertations

Most drugs undergo passive transport during absorption and distribution in the body. It is desirable to predict passive permeation of future drug candidates in order to increase the productivity of the drug discovery process. Unlike drug-receptor interactions, there is no receptor map for passive permeability because the process of transport across the lipid bilayer involves multiple mechanisms. This work intends to increase the understanding of permeation of drug-like molecules through lipid bilayers.

Drug molecules in solution typically form various species due to ionization, complexation, etc. Therefore, species specific properties must be obtained to bridge the experiment and simulations. Due to …

Roles Of Emx2 In Odorant Receptor Gene Expression And Olfactory Sensory Neuron Axon Growth, Jeremy Colin Mcintyre

University of Kentucky Doctoral Dissertations

The sense of smell relies upon the detection of odorants by neurons located in the nasal cavity. These neurons, referred to as olfactory sensory neurons (OSNs), line the olfactory epithelium and extend axons that make synaptic connections with mitral/tufted cells in the olfactory bulb. The mechanisms by which these synaptic connections form remain largely unknown. The development of these synaptic connections relies on the axons of immature OSNs innervating the olfactory bulb. The primary goal of this dissertation was to identify components of the mechanisms used by immature OSN axons to innervate the olfactory bulb. To accomplish this goal, a …

Role Of Oxidative Stress And T Cell Homing In The Development Of Murine Syngeneic Graft-Versus-Host Disease, Jacqueline Perez-Rodriguez

University of Kentucky Doctoral Dissertations

Syngeneic graft-versus-host disease (SGVHD) is induced by reconstituting lethally irradiated mice with syngeneic BM cells followed by a 21 day treatment with the immunosuppressive agent cyclosporine A (CsA). Clinical symptoms of the disease appear 2-3 weeks following cessation of CsA therapy and disease-associated inflammation occurs primarily in the colon and liver.

The development of SGVHD is a complex process resulting from the cooperative interaction of multiple effector cell populations including NK cells, T cells and macrophages. T_H1 cytokines (IL-12, TNF-α, IFN- γ), produced by these effector cells, serve as inflammatory mediators contributing to the pathogenesis of SGVHD. The …

Pathogenesis Of Influenza A Virus: Inhibition Of Monocyte Differetiation Into Dendritic Cell, Saikat Boliar

University of Kentucky Doctoral Dissertations

Dendritic cells (DC) are a heterogeneous population of hematopoietic cells that play a versatile role in orchestrating immune responses against an array of invading pathogens, including influenza virus. These cells reside in lymphoid organs as well as in non-lymphoid tissues such as mucosal surfaces of respiratory and gastro-intestinal system. Recent investigations have suggested that in the steady state, dendritic cells are derived mainly from bone marrow precursor cells without a monocytic intermediate whereas during inflammation or infection, monocytes readily differentiate to generate monocyte derived dendritic cells (MoDC). The ability of virus infected monocytes to differentiate into MoDC was investigated and …

Consumer Perspectives Of Health During Prenatal Care In The Usa And Iceland: An Exploratory Study, Claudia Wiseman

Electronic Theses and Dissertations

Purpose: Prenatal care (PNC) is the healthcare service most often provided to women of childbearing age throughout the world. Poorly understood and defined, based on culture, and expensive for any healthcare system, PNC remains a target for change and improvement. The purpose of this cross-national qualitative research study using narrative inquiry methods was to explore consumer perspectives of individual health and routine PNC in the USA and Iceland. Methods: A purposive sampling technique was used to identify study participants (n = 32) from the United States (n = 16) and Iceland (n = 16). Data were collected via a semi …

Culture And The Social Context Of Health Inequalities, Carol Leler Mansyur, Benjamin C. Amick Iii, Luisa Franzini, Robert E. Roberts

Community & Environmental Health Faculty Publications

There is a great deal of recent interest and debate concerning the linkages between inequality and health cross-nationally. The U.S. National Institutes of Health recommended in 2001 that any new research on health disparities should include social and cultural systems as units of analysis. Nevertheless, many public health interventions and policies continue to decontextualize risk factors from the social environment. Exposures to social and health inequalities probably vary as a consequence of different cultural contexts. To identify the processes that cause social and health inequalities, it is important to understand culture's influence. Navarro's research on political institutions and inequality illustrates …

Probing The Urea Dependence Of Residual Structure In Denatured Human Α-Lactalbumin, Victoria A. Higman, Heike I. Rösner, Raffaella Ugolini, Lesley H. Greene, Christina Redfield, Lorna J. Smith

Chemistry & Biochemistry Faculty Publications

Backbone ¹⁵N relaxation parameters and ¹⁵N–¹H^N residual dipolar couplings (RDCs) have been measured for a variant of human α-lactalbumin (α-LA) in 4, 6, 8 and 10 M urea. In the α-LA variant, the eight cysteine residues in the protein have been replaced by alanines (all-Ala α-LA). This protein is a partially folded molten globule at pH 2 and has been shown previously to unfold in a stepwise non-cooperative manner on the addition of urea. ¹⁵N R₂ values in some regions of all-Ala α-LA show significant exchange broadening which is reduced as the urea …

Evaluation Of The Urinary Incontinence Scales© To Measure Change After Experiential Learning: A Pilot Study, Karen A. Karlowicz

Ellmer School of Nursing Faculty Publications

Evaluation of the effectiveness of the Urinary Incontinence Scales© to measure change after student participation in a disability-incontinence experiential learning activity was the focus of this pilot study. A comparison between pretest and posttest scores showed a significant increase in Belief and Practice subscale scores after participation in the experience. However, positive correlations between the variables measured could not be established.

Direct-To-Consumer Advertising For Erectile Dysfunction Drugs, Karen A. Karlowicz

Ellmer School of Nursing Faculty Publications

The author reflects on direct to consumer advertising which is concerned with erectile dysfunction drugs. She suggests that many people have problems with open discussions of sexual health problems. She argues that urologic nurses should have discussions with pharmaceutical representatives about ways to responsibly educate the public about erectile dysfunction drugs in a manner that is not offensive.

The Effects Of Visual Representations On Teacher Training Of Phonological Awareness Principles, Rachel Kennedy Powell

LSU Doctoral Dissertations

Teachers are now being held to high accountability standards in reading instruction, yet studies show that teachers lack adequate knowledge in reading and phonological awareness principles (Moats, 1994, 2009; Spencer, Schuele, Guillot, & Lee, 2008). The purpose of this study was to determine the effects of visual representations of letter/sound production (i.e., Phonic Faces, Norris, 2001) on improving teacher knowledge of phonological awareness principles, and to determine if there is a concomitant improvement in phonological awareness and reading acquisition for children in those classrooms. Seventeen kindergarten teachers from a Mississippi school were pretested on phonological awareness principles, then divided into …

Tumor Necrosis Factor Induced Oxidative Stress In The Central Nervous System Contributes To Sympathoexcitation In Heart Failure, Anuradha Guggilam

LSU Doctoral Dissertations

Despite advanced therapeutic strategies for post-myocardial infarction (MI) patients, many ultimately develop congestive heart failure (CHF), rendering the disease a major cause of death in the United States. MI is associated with an acute increase in sympathetic nervous system activity, becoming persistent in CHF patients. Increased pro-inflammatory cytokines (PICs) following MI are implicated in the pathogenesis of CHF. The increase in tumor necrosis factor (TNF), a primary PIC, correlates closely with heart disease severity. Moreover, central PIC production increases post-MI, and can affect the brain’s cardiovascular regulatory regions that control sympathoexcitation. Therefore, understanding how PICs modulate sympathoexcitation is important for …

Matrix Metalloproteinases In The Equine Systemic Inflammatory Response: Implications For Equine Laminitis, Lee Ann Fugler

LSU Doctoral Dissertations

Laminitis is a crippling and often life-threatening disease of the equine foot. Soft tissue damage characteristic of this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of equine MMPs and evaluation of the effectiveness of MMPIs in the horse are needed. Equine MMP-9 was harvested from neutrophils, purified by affinity chromatography, and evaluated using western blotting and gelatin zymography. The Biotrak MMP-9 Activity Assay was evaluated for use with equine samples using equine neutrophil MMP-9 as a standard, and was determined to have insufficient sensitivity …

Improving Follow-Up Of Abnormal Cancer Screens Using Electronic Health Records: Trust But Verify Test Result Communication, Hardeep Singh, Lindsey Wilson, Laura A Petersen, Mona K Sawhney, Brian Reis, Donna Espadas, Dean F Sittig

Faculty, Staff and Student Publications

BACKGROUND: Early detection of colorectal cancer through timely follow-up of positive Fecal Occult Blood Tests (FOBTs) remains a challenge. In our previous work, we found 40% of positive FOBT results eligible for colonoscopy had no documented response by a treating clinician at two weeks despite procedures for electronic result notification. We determined if technical and/or workflow-related aspects of automated communication in the electronic health record could lead to the lack of response.

METHODS: Using both qualitative and quantitative methods, we evaluated positive FOBT communication in the electronic health record of a large, urban facility between May 2008 and March 2009. …

An Introduction To Dezert-Smarandache Theory (Dsmt), Jean Dezert, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

The management and combination of uncertain, imprecise, fuzzy and even paradoxical or highly conflicting sources of information has always been, and still remains today, of primal importance for the development of reliable modern information systems involving artificial reasoning. In this introduction, we present a survey of our recent theory of plausible and paradoxical reasoning, known as Dezert-Smarandache Theory (DSmT), developed for dealing with imprecise, uncertain and conflicting sources of information. We focus our presentation on the foundations of DSmT and on its most important rules of combination, rather than on browsing specific applications of DSmT available in literature. Several simple …

Optimizing Computer-Aided Colonic Polyp Detection For Ct Colonography By Evolving The Pareto Front, Jiang Li, Adam Huang, Jack Tao, Jiamin Liu, Robert L. Van Uitert, Nicholas Petrick, Ronald Summers

Electrical & Computer Engineering Faculty Publications

A multiobjective genetic algorithm is designed to optimize a computer-aided detection (CAD) system for identifying colonic polyps. Colonic polyps appear as elliptical protrusions on the inner surface of the colon. Curvature-based features for colonic polyp detection have proved to be successful in several CT colonography (CTC) CAD systems. Our CTC CAD program uses a sequential classifier to form initial polyp detections on the colon surface. The classifier utilizes a set of thresholds on curvature-based features to cluster suspicious colon surface regions into polyp candidates. The thresholds were previously chosen experimentally by using feature histograms. The chosen thresholds were effective for …

Rapid Sensor Technology: A Risk And System Complexity Analyses Of Early Detection Of Influenza-Like-Illnesses, Cesar Ariel Pinto, Ipek Bozkurt

Engineering Management & Systems Engineering Faculty Publications

The development of effective and reliable methods to defend the nation against biological terrorism remains an urgent challenge to researchers in the areas of risk, bio-defense, public health, and emergency medicine. The emerging threat of the avian flu pandemic also highlights the unpreparedness of our nation's health care system to meet a highly contagious and infectious disease outbreak. The implementation of a rapid sensor technology for early detection of influenza-like-illness provides possible opportunities, as well as problems. Bounding and defining such a complex problem is one of the first challenges this research addresses. Approaching this problem from various perspectives such …

Effectiveness Of Transcutaneous Electrical Nerve Stimulation (Tens) On Post-Laminectomy And Dissectomy Pain : Preliminary Study, K. Sukonthamarn, N. Chaiprakit, A. Suputtiada, Tejapongvorachai T., S. Niruthisad

Chulalongkorn Medical Journal

No abstract provided.

Effects Of Elastic Chest Wall Restriction On Lung Function After Aerobic Exercise Training, M. Chottidao, O. Sinphurmsukskul, T. Chentanez

Chulalongkorn Medical Journal

No abstract provided.

Assessment Of Lower Extremity Peripheral Arterial Occlusive Disease (Paod): Comparison Of Contrast Enhanced-3d Magnetic Resonance Angiography And Digital Subtraction Angiographyl Digital Angiography, A. Tiraratchailert, S. Wangsuphachart

Chulalongkorn Medical Journal

No abstract provided.

Nonlinear Dynamics Of Infant Sitting Postural Control, Joan E. Deffeyes

Department of Psychology: Dissertations, Theses, and Student Research

Sitting is one of the first developmental milestones that an infant achieves. Thus measurements of sitting posture present an opportunity to assess sensorimotor development at a young age, in order to identify infants who might benefit from therapeutic intervention, and to monitor the efficacy of the intervention. Sitting postural sway data was collected using a force plate from infants with typical development, and from infants with delayed development, where the delay in development was due to cerebral palsy in most of the infants in the study. The center of pressure time series from the infant sitting was subjected to a …

The Relationship Between Frequency Of Physical Activity And Stereotypical Behaviors Among Adolescents With Autism, Justin M. Keyes

Master's Theses and Doctoral Dissertations

No abstract provided.

Hope (Health Of Prisoner Evaluation): Pilot Study Of Prisoner Physical Health And Psychological Wellbeing, Sharan Kraemer, Natalie Gately, Jenny Kessell

Research outputs pre 2011

Prisons offer a unique opportunity to make positive interventions not only in relation to health issues but also to address the social determinants of ill health. Even with the limited knowledge we have had in regard to the health of WA's prisoners it is apparent that prisons concentrate patients with significantly greater levels of morbidity than most other environments. It is also apparent that this concentration of morbidity parallels deficits in housing, nutrition, employment, education and family structure and is multiplied dramatically by the blight of mental illness and drug and alcohol abuse. Western Australia is unequalled in the Western …

Treating Burning Mouth Syndrome, Constance R. Sharuga, Debra Dotson, Tabitha Price

ETSU Faculty Works

Excerpt: Burning mouth syndrome (BMS) is a chronic, painful condition with no clear etiology or specific, proven treatment.

The Implementation Of The Kentucky Transitions: A Money Follows The Person Demonstration Grant Program, Amie Goodin

MPA/MPP/MPFM Capstone Projects

Kentucky Transitions is a Kentucky Medicaid program that is funded primarily by a grant from the Centers for Medicare and Medicaid Services. The purpose of this program is to transition individuals residing in long-term care facilities back into the community, where they will continue to receive health, social, and other benefits but do so in an approved residential setting. Individuals living in the community may experience higher quality of life and the increased ability to choose how and when they receive services, while Medicaid reaps the projected financial benefit of providing less-expensive community alternatives for care.

Though Kentucky Transitions operates …

Medication Therapy Management: Is It Worth Medicare’S Time?, Jennifer White

MPA/MPP/MPFM Capstone Projects

Problem:

Medication Therapy Management (MTM) is a service that a pharmacist can provide to any of their patients, but mostly to those who are either high risk patients for adverse events or those who are new to chronic medication therapy. As Medicare Part D has begun to cover MTM services, more and more pharmacists and other clinicians are becoming providers of MTM.

The intent of MTM is to decrease adverse events and healthcare costs to both the patient and the third party payer. In realizing the benefits of MTM, it is important to assess these outcomes to see if clinical, …

Physician Recruitment At Highlands Regional Medical Center: What Works?, Sarabeth Blankenship

MPA/MPP/MPFM Capstone Projects

There is a physician shortage in eastern Kentucky because older physicians are retiring, and younger physicians are choosing to practice in more urban, affluent areas. Eastern Kentucky is plagued with persistent poverty and lacks cultural amenities. These facts put together myths regarding rural practice create a shortage.

My research consisted of interviewing twenty physicians currently practicing at Highlands Regional Medical Center in Prestonsburg, Kentucky. I created a survey instrument that asked questions of physicians regarding demographics characteristics, medical school attended, and what motivated them to practice at Highlands. I chose Highlands because I was able to get interviews scheduled with …

Employability After Substance Abuse Treatment In Kentucky: An Analysis Of The Kentucky Treatment Outcome Study, Steven Scrivner

MPA/MPP/MPFM Capstone Projects

Public funding of substance abuse treatment (SAT) in Kentucky dates back to the 1950s when legislators sought to curb the problem of alcoholism through legislative acts. The definition of substance abuse expanded through the years to include other substances such as cocaine, marijuana and opiates.

Employment after SAT is a critically important outcome for policymakers to consider when allocating funds because it assists in social re-integration, helps to prevent relapse and promotes economic self-sufficiency. Because of this, employment is an important factor to consider when assessing the impact SAT has on its clients (participants).

The Kentucky Alcohol and Other Drug …

Policy Issues Affecting Maine’S Hospitals, John A. Gale Ms, Jennifer D. Lenardson Mhs

Rural Hospitals (Flex Program)

Legislators and other policymakers will be continually challenged to balance the needs of hospitals for appropriate reimbursement and oversight with supporting their provision of important services to local communities.

Best Practices For Increasing Pro-Social Behavior In Adolescents With Mental Health And Behavioral Disorders, Danielle Armbrust-Malone

All Graduate Theses, Dissertations, and Other Capstone Projects

Approximately 2 to 16 percent of the general population has a disruptive behavior disorder such as oppositional defiant disorder (ODD) or conduct disorder (CD) (Corcoran & Walsh, 2006). In a school setting, youth with these disorders may engage in acts such as disrespecting teachers, swearing at others, threatening others, assaulting staff or students, stealing, or vandalizing property and may benefit from a day treatment program which provides mental health services in a school setting. (Whitfield, 1999). Micro intervention strategies such as cognitive behavioral therapy and contingency management and mezzo interventions such as family therapy have been used to treat disruptive …