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Articles 3091 - 3120 of 4384
Full-Text Articles in Medicine and Health Sciences
Convergence In Human Dialogues Time Series Analysis Of Acoustic Feature, Spyros Kousidis, David Dorran, Ciaran Mcdonnell, Eugene Coyle
Convergence In Human Dialogues Time Series Analysis Of Acoustic Feature, Spyros Kousidis, David Dorran, Ciaran Mcdonnell, Eugene Coyle
Conference papers
Convergence of acoustic/prosodic (a/p) features between two speakers is a well-known property of human dialogue. It has been suggested that this particular aspect of human interaction should be implemented in spoken dialogue systems, so that they can be perceived as more “humanlike”. This paper presents a quantitative analysis method that can provide information required for modeling the phenomenon of convergence. The analysis is a combination of TAMA, a previously introduced data extraction method, and bivariate time series analysis. Results show significant correlation of a/p features between speaker dyads in the recorded dialogues analyzed, and indicate a significant,amount of feedback, which …
Monitoring Convergence Of Temporal Features In Spontaneous Dialogue Speech, Spyros Kousidis, David Dorran
Monitoring Convergence Of Temporal Features In Spontaneous Dialogue Speech, Spyros Kousidis, David Dorran
Conference papers
This paper presents ongoing research on convergence of speech features in human dialogues, in view of simulating this behaviour in spoken dialogue systems. The TAMA method (time-aligned moving average), previously used on monitoring convergence of acoustic prosodic (a/p) features, is applied to temporal properties of speech (between-turn pauses and overlaps). The results are compared to those of an older study on the same features.
Factors Associated With Breastfeeding Among A Sample Of Chinese Mothers Who Gave Birth In Ireland, Qianling Zhou, Katherine Younger, John Kearney
Factors Associated With Breastfeeding Among A Sample Of Chinese Mothers Who Gave Birth In Ireland, Qianling Zhou, Katherine Younger, John Kearney
Conference Papers
Rationale & Objectives: The factors influencing breastfeeding rates are complex, and the socio-cultural environment has an important influence on how women choose to feed their infants. The present study sought to determine factors affecting breastfeeding practices of Chinese mothers who gave birth in Ireland. Materials & Methods: A cross-sectional survey (written in Chinese). Questionnaires were distributed to Chinese mothers in Chinese markets and language schools in Ireland. Results & Findings: Analyses was conducted on 236 completed questionnaires from Chinese mothers who had given birth in Ireland. Breastfeeding prevalence among the participants was 71%. Univariate analyses indicated that mothers who lived …
Perception Of Dietary Change And Attitudes Towards The Irish Diet Among Non-Nationals In Ireland., Qianling Zhou, Phensiri Asawasirisap, John Kearney
Perception Of Dietary Change And Attitudes Towards The Irish Diet Among Non-Nationals In Ireland., Qianling Zhou, Phensiri Asawasirisap, John Kearney
Conference Papers
Rationale & Objectives: Cross-cultural attitudes to diet differ significantly. This study examined attitudes towards the Irish diet and their perceived dietary change among a random sample of non-nationals living in Ireland. Materials & Methods: A self-administered cross-sectional survey was distributed to a randomly selected sample of English language students in Dublin. Results & Findings: 473 students from four geographical regions (Asia, Africa, South & Central American, and Europe) (response rate: 84%) completed the survey. Marked cultural differences between geographical regions were found with South & Central Americans being the most likely to indicate a decrease in fruit and vegetable intakes …
Breastfeeding Practices In China And Ireland: The Chinese Mothers In Ireland Survey., Qianling Zhou, Katherine Younger, John Kearney
Breastfeeding Practices In China And Ireland: The Chinese Mothers In Ireland Survey., Qianling Zhou, Katherine Younger, John Kearney
Conference Papers
Rationale & Objectives: Migration to another country may contribute to some changes in breastfeeding practices. This study explored the breastfeeding practices of immigrant Chinese mothers in China and following migration to Ireland, where breastfeeding is far less prevalent (43% initiation).
Materials & Methods: A cross-sectional survey involving Chinese mothers who had given birth in Ireland (CMI) or in China (CMC).
Results & Findings: Analyses was conducted on 285 completed questionnaires. 72 % of the sample breastfed their infants with no differences between CMI (71%) and CMC (78%) (P>0.05). However, breastfeeding rates at three months (62%) and six months (32%) …
Tril, A Functional Component Of The Tlr4 Signaling Complex, Highly Expressed In Brain, Susan Carpenter, Thaddeus Carlson, Jerome Dellacasagrande, Amaya Garcia, Sharon Gibbons, Paul J. Hertzog, Anthony Lyons, Lih-Ling Lin, Marina A Lynch, Tom P. Monie, Caroline Murphy, Katherine Seidl, Christine Anne Wells, Aisling Dunne, Luke O'Neill
Tril, A Functional Component Of The Tlr4 Signaling Complex, Highly Expressed In Brain, Susan Carpenter, Thaddeus Carlson, Jerome Dellacasagrande, Amaya Garcia, Sharon Gibbons, Paul J. Hertzog, Anthony Lyons, Lih-Ling Lin, Marina A Lynch, Tom P. Monie, Caroline Murphy, Katherine Seidl, Christine Anne Wells, Aisling Dunne, Luke O'Neill
Articles
TLR4 is the primary sensor of LPS. In this study, we describe for the first time TLR4 interactor with leucine-rich repeats (TRIL), which is a novel component of the TLR4 complex. TRIL is expressed in a number of tissues, most prominently in the brain but also in the spinal cord, lung, kidney, and ovary. TRIL is composed of a signal sequence, 13 leucine-rich repeats, a fibronectin domain, and a single transmembrane spanning region. TRIL is induced by LPS in the human astrocytoma cell line U373, in murine brain following i.p. injection, and in human PBMC. Endogenous TRIL interacts with TLR4 …
A Success Story In Shifting The Paradigm Together : Partnership Between Service And Education In Building An Onsite Clinical Nurse Leader Program, Enna Edouard Trevathan
A Success Story In Shifting The Paradigm Together : Partnership Between Service And Education In Building An Onsite Clinical Nurse Leader Program, Enna Edouard Trevathan
Doctor of Nursing Practice (DNP) Projects
Access to advanced academic preparation has been an important consideration in the design of educational programs for the working professional nurse. Nursing education has a history of developing and implementing strategies to respond to their needs beyond the traditional, on campus classroom setting. Nursing programs were early adopters of distance learning technologies, from the first two-way audio, one-way video classes, to satellite, two-way video classes to the recent proliferation of web-based programs. However, an innovative alternative is proposed - bringing the course work to the employment setting and designing the program to be responsive to the learning needs of the …
Improving Medication Safety By Implementing A Just Culture, Karen S. Lounsbury
Improving Medication Safety By Implementing A Just Culture, Karen S. Lounsbury
Doctor of Nursing Practice (DNP) Projects
No Abstract Available
Child Neurology Curriculum, Ruth K. Rosenblum
Child Neurology Curriculum, Ruth K. Rosenblum
Doctor of Nursing Practice (DNP) Projects
Provision of comprehensive health services to children and adolescents is a central role for school nurses. Children with chronic health conditions are at the intersection of the health and education systems. Recently, educators, neurology care providers (MD/NP/PA) have initiated discussions about the impact of a child’s health on their ability to learn. The purpose of this project was to develop a child neurology curriculum for school nurses. A needs assessment survey was distributed. The survey results revealed a need for further education and training in child neurology diagnoses. Four areas were chosen for curriculum development:seizures/ epilepsy, headaches/migraines, tics, and post-concussion …
Pesticide Policy And Farmworker Health, Joan D. Flocks
Pesticide Policy And Farmworker Health, Joan D. Flocks
UF Law Faculty Publications
Although data on the carcinogenicity of agricultural pesticides are still being generated and are thus incomplete, research such as the Agricultural Health Study indicates that populations with increased, regular exposure to pesticides have high rates of a variety of cancers (National Institutes of Health & Environmental Protection Agency 2008). Policies that regulate toxins such as pesticides are envisioned by the public to be empirical and objective, but toxins are socially produced and their regulation is just as often based on political and economic factors as it is on science (Luke 2000). This does not bode well for farm- workers who …
A Field-Based Testing Protocol For Assessing Gross Motor Skills In Preschool Children: The Children's Activity And Movement In Preschool Study Motor Skills Protocol, Harriet G. Williams, Karin A. Pfeiffer, Marsha Dowda, Chevy Jeter, Shaverra Jones, Russell R. Pate
A Field-Based Testing Protocol For Assessing Gross Motor Skills In Preschool Children: The Children's Activity And Movement In Preschool Study Motor Skills Protocol, Harriet G. Williams, Karin A. Pfeiffer, Marsha Dowda, Chevy Jeter, Shaverra Jones, Russell R. Pate
Faculty Publications
The purpose of this study was to develop a valid and reliable tool for use in assessing motor skills in preschool children in field-based settings. The development of the Children’s Activity and Movement in Preschool Study Motor Skills Protocol included evidence of its reliability and validity for use in field-based environments as part of large epidemiological studies. Following pilot work, 297 children (3–5 years old) from 22 preschools were tested using the final version of the Children’s Activity and Movement in Preschool Study Motor Skills Protocol and the Test of Gross Motor Development (2nd Edition). Reliability of the Children’s Activity …
Guidelines For Environmental Considerations In Occupational Therapy Home Programs For Arthritis, Lori Pachl
Guidelines For Environmental Considerations In Occupational Therapy Home Programs For Arthritis, Lori Pachl
Occupational Therapy Capstones
Problem: Occupational therapists frequently provide service to patients with arthritis within a variety of settings. The symptoms of arthritis can be detrimental to a patient's ability to participate in their daily functional activities. Pain, limitation in motion and decreased strength frequently disrupt the individual's ability to complete daily activities which can have a depressing affect. Historically through today, patients report that these symptoms increase with changes in weather conditions.
Changes in barometric pressure, humidity, cold temperatures and levels of precipitation have been reported by patients to affect their arthritic symptoms and pain levels (Aikman, 1996; Guedj, 1990; McAlindon, 2007; & …
A Team Approach To Cortical Visual Impairment (Cvi) In Schools, Donna Shaman
A Team Approach To Cortical Visual Impairment (Cvi) In Schools, Donna Shaman
Occupational Therapy Capstones
Cortical visual impairment (CVI) is presently the fastest growing cause of visual impairment in children. The influx of children with CVI entering school districts requires Individualized Education Program (IEP) teams to gain expertise about CVI and learn best practices to work with these children. CVI experts agree that a collaborative transdisciplinary team can best serve the complex needs of the children. Written by an occupational therapist, this project designs a CVI manual, A Team Approach to CVI in Schools, which reviews current literature and provides support for client centered, occupational based education for children with CVI. The literature review points …
Carpal Tunnel Syndrome: An In-Service And Guide On Education And Prevention, Derek Foss
Carpal Tunnel Syndrome: An In-Service And Guide On Education And Prevention, Derek Foss
Occupational Therapy Capstones
Carpal tunnel syndrome (CTS) is common among supermarket employees with a high prevalence among supermarket cashiers. In a study by Davis et. aI., (2001) it was found that supermarkets had the highest number of workman's compensation claims regarding CTS in Massachusetts. Of 247 reported cases of CTS in supermarkets 80 involved cashiers. Supermarket cashiers show a 19-60% CTS prevalence rate (Bonfiglioli et aI. , 2007). No prevention guide designed for supermarket employees was found in the literature; this scholarly project addresses the need for prevention of CTS among supermarket employees.
An extensive literature review was conducted to understand the need …
A Handwriting Manual For Early Elementary School Teachers, Jennifer Frueh, Nicole Kieffer
A Handwriting Manual For Early Elementary School Teachers, Jennifer Frueh, Nicole Kieffer
Occupational Therapy Capstones
Children in elementary school classrooms are expected to participate in fine motor activities up to 60% of the day. These fine motor activities include writing, cutting, gluing, coloring, and self care tasks such as buttoning and tying shoes (McHale & Cermak, 1992). In a literature review conducted by Feder and Majnemer (2007) it was found that poor handwriting has a negative impact on academic and social performance into adolescence. Consequences of poor handwriting may be avoidance of fine motor activities (Jackman & Stagnitti, 2007) and decreased academic performance which may lead to poor self esteem (McHale & Cermak, 1992).
Jackman …
Quad Strengthening And Hamstring Stretching As A Treatment Of Pes Anserine Bursitis, Jennifer Bernardy
Quad Strengthening And Hamstring Stretching As A Treatment Of Pes Anserine Bursitis, Jennifer Bernardy
Physical Therapy Scholarly Projects
Background/Purpose: This case study describes a 28-year-old woman’s six physical therapy visits over a period of four weeks for treatment of right pes anserine bursitis. The purpose of this case study is to describe the treatment of an individual with pes anserine bursitis using hamstring stretching, quadriceps strengthening, and iontophoresis and to describe the outcomes.
Case Description: Following a fall down eight steps in her home with her right knee underneath her. The patient presented with increased pain, swelling, loss of range of motion, and tenderness at the pes anserine. Treatment consisted of iontophoresis, hamstring stretches, and quadriceps strengthening.
Outcomes: …
Acute Physical Therapy Management Of Pediatric Patient With Traumatic Brain Injury, Michelle Holt
Acute Physical Therapy Management Of Pediatric Patient With Traumatic Brain Injury, Michelle Holt
Physical Therapy Scholarly Projects
Background and Purpose: Traumatic brain injury can cause many deficits including decreased balance and coordination. The purpose of this case report is to describe the interventions used and subsequent outcomes for a pediatric patient following traumatic brain injury in the acute care setting. Also, this case report serves to describe the methods and tools used in a hospital that is not equipped with pediatric-specific equipment or utilities.
Case Description: This paper describes the four-day inpatient physical therapy management of a six-year-old female who fell from a horse and sustained a left open depressed frontal skull fracture with an underlying subdural …
Status Post Rotator Cuff Repair With Interrupted Therapy And Comorbidities: A Case Report, Whitney Lesnau
Status Post Rotator Cuff Repair With Interrupted Therapy And Comorbidities: A Case Report, Whitney Lesnau
Physical Therapy Scholarly Projects
Background & Purpose: The purpose of this case study is to describe the plan of care that was completed despite interruption from multiple complications. Interrupted therapy has not been explored in research even though it is something physical therapists encounter often.
Case Description: This 45-year-old patient went through a right rotator cuff repair surgery followed by physical therapy to regain functional use of her shoulder. Her therapy was interrupted twice; first by her mother’s heart condition and then by her own neurological condition.
Intervention: The main component of treatment with this patient was range of motion exercises including passive, active-assistive, …
Outpatient Physical Therapy Management Of A Patient With Chronic Iliotibial Band Friction Syndrome, Kaley Schultz
Outpatient Physical Therapy Management Of A Patient With Chronic Iliotibial Band Friction Syndrome, Kaley Schultz
Physical Therapy Scholarly Projects
Background and Purpose. Iliotibial band friction syndrome (ITBFS) is one of the most common repetitive injuries treated in outpatient physical therapy and if left untreated, can lead to debilitating consequences for an individual. The purpose of this report is to describe the progression of conservative interventions that were used during outpatient physical therapy for a patient with the diagnosis of ITBFS in order for the patient to return to pain free activities of daily living.
Case Description. The patient was a 29 year old male who experienced pain over his c right greater trochanter and pain and snapping over …
Actividades De La Vida Diaria- Manual De Enseñanza Para El Paciente Y La Familia Sobre Lesiones De La Médula Espinal, Thomas Jefferson University Hospital And Magee Rehabilitation
Actividades De La Vida Diaria- Manual De Enseñanza Para El Paciente Y La Familia Sobre Lesiones De La Médula Espinal, Thomas Jefferson University Hospital And Magee Rehabilitation
Manual de Lesión de la Médula Espinal (Español)
Introducción
Las actividades de la vida diaria (ADL, por sus siglas en inglés) incluyen comer, beber, bañarse, asearse, vestirse e ir al baño. También incluyen los traslados funcionales, la ayuda electrónica para la vida diaria (EADL, por sus siglas en inglés) y el manejo en el hogar.
En cuanto sea adecuado, se le recomendará que realice por sí mismo tantas ADL como pueda. Es posible que necesite aprender nuevas técnicas, utilizar dispositivos de asistencia para compensar la disminución en la fuerza muscular y la amplitud de movimiento, o para compensar la disminución en la resistencia.
El entrenamiento para las ADL …
Sexualidad- Manual De Enseñanza Para El Paciente Y La Familia Sobre Lesiones De La Médula Espinal, Thomas Jefferson University Hospital And Magee Rehabilitation
Sexualidad- Manual De Enseñanza Para El Paciente Y La Familia Sobre Lesiones De La Médula Espinal, Thomas Jefferson University Hospital And Magee Rehabilitation
Manual de Lesión de la Médula Espinal (Español)
Introducción
En esta sección, aprenderá cómo las disfunciones de la médula espinal pueden afectar la forma en que se siente respecto de usted mismo, como hombre o como mujer, y la forma en que las disfunciones de la médula espinal pueden afectar su funcionamiento en el aspecto sexual. Es posible que, en este momento, recibir información sobre la sexualidad, el funcionamiento sexual, el control de la natalidad, la disfunción eréctil y la posibilidad de tener un bebé sea importante para usted, o es posible que prefiera dejar de lado estas cuestiones y pensar al respecto en otro momento. En cualquier …
Movilidad- Manual De Enseñanza Para El Paciente Y La Familia Sobre Lesiones De La Médula Espinal, Thomas Jefferson University Hospital And Magee Rehabilitation
Movilidad- Manual De Enseñanza Para El Paciente Y La Familia Sobre Lesiones De La Médula Espinal, Thomas Jefferson University Hospital And Magee Rehabilitation
Manual de Lesión de la Médula Espinal (Español)
Introducción
La movilidad se define como las actividades que se requieren para pasar desde la cama hasta la silla de ruedas, moverse en la silla de ruedas, pararse y caminar. Esto se logra, en primer lugar, estabilizando la columna vertebral a través de la cirugía, la inmovilización externa (mediante ortesis, tracción o yesos) o ambas, de manera que pueda moverse en forma segura sin causar mayores daños a la médula espinal. Una vez producida la disfunción de la médula espinal, su capacidad para moverse se verá limitada debido a debilidad muscular, dispositivos para inmovilización, reposo en cama o una combinación …
Substance P Increases Cell-Surface Expression Of Cd74 (Receptor For Macrophage Migration Inhibitory Factor): In Vivo Biotinylation Of Urothelial Cell-Surface Proteins, Katherine L. Meyer-Siegler, Shen-Ling Xia, Pedro L. Vera
Substance P Increases Cell-Surface Expression Of Cd74 (Receptor For Macrophage Migration Inhibitory Factor): In Vivo Biotinylation Of Urothelial Cell-Surface Proteins, Katherine L. Meyer-Siegler, Shen-Ling Xia, Pedro L. Vera
Molecular Medicine Faculty Publications
Macrophage migration inhibitory factor (MIF), an inflammatory cytokine, and its receptor CD74 are upregulated by bladder inflammation. MIF-mediated signal transduction involves binding to cell-surface CD74, this study documents, in vivo, MIF-CD74 interactions at the urothelial cell surface. N-hydroxysulfosuccinimide biotin ester-labeled surface urothelial proteins in rats treated either with saline or substance P (SP, 40 μg/kg). The bladder was examined by histology and confocal microscopy. Biotinylated proteins were purified by avidin agarose, immunoprecipitated with anti-MIF or anti-CD74 antibodies, and detected with strepavidin-HRP. Only superficial urothelial cells were biotinylated. These cells contained a biotinylated MIF/CD74 cell-surface complex that was increased in …
Unfoldomics Of Human Diseases: Linking Protein Intrinsic Disorder With Diseases, Vladimir N. Uversky, Christopher J. Oldfield, Uros Midic, Hongbo Xie, Bin Xue, Slobodan Vucetic, Lilia M. Iakoucheva, Zoran Obradovic, A. Keith Dunker
Unfoldomics Of Human Diseases: Linking Protein Intrinsic Disorder With Diseases, Vladimir N. Uversky, Christopher J. Oldfield, Uros Midic, Hongbo Xie, Bin Xue, Slobodan Vucetic, Lilia M. Iakoucheva, Zoran Obradovic, A. Keith Dunker
Molecular Medicine Faculty Publications
Background: Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack stable tertiary and/or secondary structure yet fulfills key biological functions. The recent recognition of IDPs and IDRs is leading to an entire field aimed at their systematic structural characterization and at determination of their mechanisms of action. Bioinformatics studies showed that IDPs and IDRs are highly abundant in different proteomes and carry out mostly regulatory functions related to molecular recognition and signal transduction. These activities complement the functions of structured proteins. IDPs and IDRs were shown to participate in both one-to-many and many-to-one signaling. Alternative splicing and posttranslational modifications …
Fgi-104: A Broad-Spectrum Small Molecule Inhibitor Of Viral Infection, Michael S. Kinch, Abdul S. Yunus, Calli Lear, Hanwen Mao, Hansen Chen, Zena Fesseha, Guangxiang Luo, Eric A. Nelson, Limin Li, Zhuhui Huang, Michael Murray, William Y. Ellis, Lisa Hensley, Jane Christopher-Hennings, Gene G. Olinger, Michael Goldblatt
Fgi-104: A Broad-Spectrum Small Molecule Inhibitor Of Viral Infection, Michael S. Kinch, Abdul S. Yunus, Calli Lear, Hanwen Mao, Hansen Chen, Zena Fesseha, Guangxiang Luo, Eric A. Nelson, Limin Li, Zhuhui Huang, Michael Murray, William Y. Ellis, Lisa Hensley, Jane Christopher-Hennings, Gene G. Olinger, Michael Goldblatt
Veterinary and Biomedical Sciences Faculty Publications
The treatment of viral diseases remains an intractable problem facing the medical community. Conventional antivirals focus upon selective targeting of virus-encoded targets. However, the plasticity of viral nucleic acid mutation, coupled with the large number of progeny that can emerge from a single infected cells, often conspire to render conventional antivirals ineffective as resistant variants emerge. Compounding this, new viral pathogens are increasingly recognized and it is highly improbable that conventional approaches could address emerging pathogens in a timely manner. Our laboratories have adopted an orthogonal approach to combat viral disease: Target the host to deny the pathogen the ability …
Regulation Of Alpha- And Beta-Actin Isoforms In The Contracting A7r5 Smooth Muscle Cell, Dawn Leah Brown-Turner
Regulation Of Alpha- And Beta-Actin Isoforms In The Contracting A7r5 Smooth Muscle Cell, Dawn Leah Brown-Turner
Theses, Dissertations and Capstones
Two isoforms of actin have been found to be present in A7r5 smooth muscle cells, α- and β-actin. This body of work sets out to examine the different regulatory factors of the two actin isoforms during smooth muscle contraction. The response of the actin isoforms to phorbol 12, 13-dibutyrate (PDBu) is markedly different. α-Actin remodels to podosomes around the periphery of the cell, while β-actin merely shortens. One protein involved in smooth muscle contraction induced by PDBu is protein kinase C (PKC). Two inhibitors of PKC, staurosporine and bisindolymaleimide, were used prior to PDBu stimulation and after PDBu stimulation to …
2009 Supplement Vol. 1, American Dental Association
2009 Supplement Vol. 1, American Dental Association
ADA Transactions
This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …
Professional Product Review Vol. 4 No. 1, American Dental Association, Council On Scientific Affairs
Professional Product Review Vol. 4 No. 1, American Dental Association, Council On Scientific Affairs
Professional Product Review
A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.
Kawasaki Syndrome In Texas, Alberto Coustasse, Julius J. Larry, Witold Migala, Cody Arvidson, Karan P. Singh
Kawasaki Syndrome In Texas, Alberto Coustasse, Julius J. Larry, Witold Migala, Cody Arvidson, Karan P. Singh
Management Faculty Research
The authors examined hospitalization rates of Kawasaki Syndrome (KS) among Texas children to isolate clusters, identify demographic disparities, and suggest possible causative factors. Using a retrospective cross-sectional study design, they studied 330 KS cases from 2,818,460 hospital discharges. The majority of the cases (61.5%) occurred within the 1-4-years-old category, representing the highest hospitalization rate (14.3 per 100,000 children). Almost 75% of the KS population was less than 5 years old, with hospitalization rates approximately 8 times higher than that of all other children (p < .05). KS diagnosis occurred for only 49.4% of all KS cases upon admission. Along with high-density clusters identified in major metropolitan areas, the authors found the highest rates of KS among Asian and Pacific Islander and non-Hispanic black children. Genetic predispositions and access to healthcare issues may explain the results. The authors recommend improving educational initiatives with healthcare providers and establishing KS as a reportable condition.
Rhoa/Rho-Kinase Signaling: A Therapeutic Target In Pulmonary Hypertension, Scott A. Barman, Shu Zhu, Richard E. White
Rhoa/Rho-Kinase Signaling: A Therapeutic Target In Pulmonary Hypertension, Scott A. Barman, Shu Zhu, Richard E. White
PCOM Scholarly Works
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive elevation of pulmonary arterial pressure and vascular resistance due to pulmonary vasoconstriction and vessel remodeling as well as inflammation. Rho-kinases (ROCKs) are one of the best-described effectors of the small G-protein RhoA, and ROCKs are involved in a variety of cellular functions including muscle cell contraction, proliferation and vascular inflammation through inhibition of myosin light chain phosphatase and activation of downstream mediators. A plethora of evidence in animal models suggests that heightened RhoA/ROCK signaling is important in the pathogenesis of pulmonary hypertension by causing enhanced constriction and remodeling of …