Medicine and Health Sciences Commons^™

Primary Cardiac Tumors., Suraj Maraj, Md, Gregg S. Pressman, Md, Vincent M. Figueredo, Md

Division of Cardiology Faculty Papers

Primary cardiac tumors are a rare entity compared to tumors that metastasize to the heart. Patients with such tumors may be asymptomatic. Many cases are found incidentally during evaluation of an unrelated medical condition. It is important for the clinician to have a high index of suspicion when evaluating a patient presenting with signs and systemic symptoms concerning possible malignancy, plus cardiac specific symptoms or complications. These can include new onset dyspnea, congestive heart failure, arrhythmias or murmurs varying with body positions. Imaging, particularly the use of echocardiography, remains the cornerstone of diagnosis, and may be combined with new imaging …

All Hands On Deck, V.2, 2 April 2009

Articles - Patient Care

Actions Teams Launched.

Esat6-Induced Ifngamma And Cxcl9 Can Differentiate Severity Of Tuberculosis., Zahra Hasan, Bushra Jamil, Mussarat Ashraf, Muniba Islam, Muhammad S Yusuf, Javaid A Khan, Rabia Hussain

Department of Pathology and Laboratory Medicine

Background: Protective responses against Mycobacterium tuberculosis are dependent on appropriate T cell and macrophage activation. Mycobacterial antigen six kDa early secreted antigenic target (ESAT6) and culture filtrate protein 10 (CFP10) can detect M. tuberculosis specific IFNgamma responses. However, most studies have been performed in non-endemic regions and to study pulmonary tuberculosis (PTB). We have studied ESAT6 and CFP10 induced cytokine and chemokines responses in PTB and extrapulmonary (EPul) TB.
Methodology: IFNgamma, IL10, CXCL9 and CCL2 responses were determined using an ex vivo whole blood assay system in PTB (n = 30) and EPulTB Patients with limited (LNTB, n = …

Appropriate Practices In College/University Physical Activity Instructional Programs, Bridget F. Melton, Michele M. Sweeney, Jared A. Russel, Carrie L. Moore

Community Health: Faculty Presentations (1993-2018)

This session will introduce the audience to a new NASPE document that supports basic instructional programming at the college and university level. Based on NASPE’s former K-12 Appropriate Practice documents, this document will serve as an advocacy document for the importance of quality programming at the college/university level. Come and preview this new document!

Therapeutic Drugs In Cancer And Resistance., Aditi Pandya Martin

Theses and Dissertations

We investigated the mechanism of toxicity and resistance development of small molecule tyrosine kinase inhibitor lapatinib in HCT 116 colon cancer cells. Lapatinib mediated cell death in HCT 116 cells was caspase independent and involved cytosolic release of apoptosis inducing factor. Treatment of HCT 116 cells with 10µM Lapatinib lead to the outgrowth of lapatinib resistant HCT 116 cells. Our studies show that alterations in the expression and activation of Bcl-2 family proteins allow lapatinib resistant HCT 116 cells to resist cytotoxic effects of lapatinib as well as of other commonly used chemotherapeutic agents. In hepatoma and pancreatic cancer cells, …

Web Usability Testing With A Hispanic Medically Underserved Population, Mary Moore Phd, Randolph G. Bias, Katherine Prentice, Robin Fletcher, Terry Vaughn

Faculty Research, Publications, and Presentations

Skilled website developers value usability testing to assure user needs are met. When the target audience differs substantially from the developers, it becomes essential to tailor both design and evaluation methods. In this study, researchers carried out a multifaceted usability evaluation of a website (Healthy Texas) designed for Hispanic audiences with lower computer literacy and lower health literacy.

Clock-Cancer Connection In Non-Hodgkin’S Lymphoma: A Genetic Association Study And Pathway Analysis Of The Circadian Gene Cryptochrome 2, Richard G. Stevens

UCHC Articles - Research

Circadian genes have the potential to influence a variety of cancer-related biological pathways, including immune regulation, which may influence susceptibility to non-Hodgkin’s lymphoma (NHL). However, few studies have examined the role of circadian genes in lymphomagenesis. The current study examined Cryptochrome 2 (CRY2), a core circadian gene and transcriptional repressor, as a potential circadian biomarker for NHL. We first performed genetic association analyses of tagging SNPs in CRY2 and NHL risk using DNA samples from a population-based case-control study (N= 455 cases and 527 controls). Three SNPs were found to be significantly associated with risk of NHL when …

A Common Polymorphism In Serotonin Receptor 1b Mrna Moderates Regulation By Mir-96 And Associates With Aggressive Human Behaviors, Kevin P. Jensen, Jonathan Covault, Tamlin S. Conner, Henry R. Kranzler, Howard A. Tennen, Henry M. Furneaux

UCHC Articles - Research

Non-coding regulatory elements can transduce the human genome's response to environmental stimuli. Thus, there is a possibility that variation in non-coding regulatory elements may underlie some of the diversity in human behavior. However, this idea has remained largely untested due to the difficulty in accurately identifying regulatory elements in the 98% of the human genome that does not encode protein. The recent recognition that small trans-acting RNAs anneal to mRNA and regulate gene expression provides a means to identify and test such variants. Here we show that microRNA-directed silencing of mRNA can be attenuated by a common human polymorphism. We …

Mid-Atlantic Ethics Committee Newsletter, Spring 2009

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Com Outlook Spring 2009, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Lean And Obese Zucker Rats Exhibit Different Patterns Of P70s6 Kinase Regulation In The Tibialis Anterior Muscle In Response To High-Force Muscle Contraction, Anjaiah Katta, Sunil K. Karkala, Miaozong Wu, Sarath Meduru, Devashish H. Desai, Kevin M. Rice, Eric R. Blough

MIIR Faculty Research

Increased phosphorylation of the 70-kDa ribosomal S6 kinase (p70S6k) signaling is strongly correlated with the degree of muscle adaptation following exercise. Herein we compare the phosphorylation of p70S6k, Akt, and mammalian target of rapamycin (mTOR) in the tibialis anterior (TA) muscles of lean and obese Zucker rats following a bout of eccentric exercise. Exercise increased p70S6k (Thr389) phosphorylation immediately after (33.3 ± 7.2%) and during [1 h (24.0 ± 14.9%) and 3 h (24.6 ± 11.3%)] recovery in the lean TA and at 3 h (33.5 ± 8.0%) in the obese TA Zucker rats. mTOR (Ser2448) phosphorylation was elevated in …

Peer-Led Team Learning: A Prospective Method For Increasing Critical Thinking In Undergraduate Science Courses, Ian J. Quitadamo, C. Jayne Brahler, Gregory J. Crouch

Physical Therapy Faculty Publications

This study examined the impact of peer-led team learning (PLTL) on critical thinking gains in science and math courses at a research university in the Pacific Northwest.

College Of Health And Human Services International Service Learning Program: Gales Point, Belize, Jordan Norris, Carrierobin Menapace

Impact Belize

No abstract provided.

Overview Of Mapping Applications In Health Research, Helen Hemminger Mmhs

Disability & Aging

No abstract provided.

Chironian Spring/Summer 2009, New York Medical College

The Chironian

No abstract provided.

Jefferson Review - Spring 2009

Jefferson Review

Contents

Features

• 4 - University Restructures to Reflect Schools' Importance
• 8 - Extraordinary Growth at JCHP Marks Dean Erdmann's Tenure
• 12 - Pharmacy Students Learn Through Experience
• 16 - What's New in Interprofessional Education
• 18 - Jefferson Hospital Nursing Achieves MAGNET Status
• 20 - Groundbreaking Team Symposium Brings Disciplines Together
• 28 - Alumni Profile: Amanda Kingsland, MS '09

On Campus

• 22 - School of Health Professions
• 25 - School of Nursing
• 27 - School of Pharmacy
• 29 - Class Notes

An Experience In The Challenges Of Research: Prevention Of Age–Related Macular Degeneration, Hilary Snyder

Inquiry Journal 2009

No abstract provided.

Eligibility, Recruitment, And Retention Of African Americans With Severe Mental Illness In Community Research, Michelle Hampton, Mary White, Linda Chafetz

Faculty Publications

Data that addresses severely mentally ill (SMI) African Americans (AAs) likelihood to participate in clinical research is limited. This study’s purpose was to determine if differences exist between races regarding eligibility, recruitment, and retention in a community-based clinical trial. The sample included 293 participants. Data sources included clinical records and interviews. Logistic regression was used for analysis. AAs were as likely to participate and to complete followup interviews as Whites. In contrast to studies about non-mentally ill AAs, AAs with SMI appeared to be as willing to consent to and to remain in clinical research studies as Whites.

Getting The Most Out Of Conferences, Janet M. Brown, Nola A. Schmidt

Nursing and Health Professions Faculty Publications

No abstract provided.

Reflections (2009 Issue), College Of Health Professions

College of Health Professions Newsletters & Magazines

This issue highlights the achievements of the College of Education and Health Professions.

Una Manera De Vida Diferente: Embarazos En Adolescentes Y Planificación Familiar En La Zona De Intag, Ecuador, Jennifer Dabrow

Independent Study Project (ISP) Collection

Lack of family planning and high rates of adolescent pregnancy plague the poorest regions of the world. Not only does this deficiency result in the deaths of infants and mothers as well as significantly depressing quality of life, but, as the human population expands, we risk destroying much of the environment and natural resources upon which we depend. In Intag, a rural network of communities in the cloud forest of Ecuador, adolescent pregnancy is the norm and women commonly have upwards of 7 children. Working in the Subcentro health clinic of Apuela, I interviewed 50 mothers regarding their age during …

So You're Ready To Publish. Next Steps?, Anne Linton, Alexandra Gomes, Kathe Obrig

Himmelfarb Library Faculty Posters and Presentations

You've completed your research, analyzed the data, and written up your findings. Now you want to publish your results. What are the next steps? This poster is a "how to" guide to getting your article published in a scholarly journal.

Revisiting The Mind- Body Paradox: Can Brain Functioning Explain Moral Reasoning?, Brianna Mahan

Honors Projects in Science and Technology

With this paper, I attempt to explore possible neural correlates of morality. We define morality as the one part, structure, or process of the brain that could be linked to an innate ability to understand and determine right versus wrong. An understanding of right of right and wrong can provide us with a sense of guilt and empathy for an action or another person. Right and wrong will be defined through a primarily Judeo-Christian perspective, as it was the principle respondent among our questionnaire. There is a possibility for differences among other religions. For that reason, we expect the neural …

Over-Utilization Of Advanced Imaging In The Hospital Setting: An Educational Approach To Reduce Unnecessary Inpatient Studies, Guillermo Madero, J. Platnick, L. Voutsinas, R. Wetz, S. Buchbinder

Internal Medicine

By several measures, health care spending continues to rise, forcing businesses and families to cut back on operations and household expenses. In 2008, health care spending in the United States reached $2.4 trillion dollars, and is projected to reach $3.1 trillion in 2012.During the past decades, there has been a steady increase in the utilization of expensive inpatient imaging studies, with an overall increase in health care costs. In particular, advanced imaging includes CT, MRI and Nuclear Medicine, used for the diagnosis and management of hospitalized patients. The reasons for unnecessary imaging examinations include indirect financial benefit to physicians, medico-legal …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Spring, 2009 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's Column
• Alabama health libraries association - 2009 Executive committee
• News from around the state
• Executive Committee meeting minutes

Ua10/1 Cec: Clinical Exchange Corner, Mary Lloyd Moore, Laura Reynolds, Wku Suzanne Vitale Clinical Education Complex

CEC Publications

No abstract provided.

“But Who Can I Talk To?” Psychological Services For The Parents And Children Of Apdk, Jessica Steinke

Independent Study Project (ISP) Collection

This is a study examining the adequacy of the psychological services and support offered by the Association for the Physically Disabled of Kenya, APDK, to the children in its care and the families who utilize the centre. First and foremost this study examined the psychological effect physical disabilities have on children and their families to determine what services are necessary for these individuals. The availability of mental health services was then analyzed in the context of the need for them as expressed by children at APDK and parents of disabled children. It was discovered that very few services are available …

Constructions Of Disease In Mayo Village, Rachel Eades

Independent Study Project (ISP) Collection

Understanding how individuals and institutions negotiate illness and construct ideas about disease is important to public health efforts across the globe. Countries in sub-Saharan Africa suffer from a variety of health problems that many regions of the world have long since eradicated. Economic hardship, combined with high rates of communicable diseases, food poverty, lack of sanitation, and poor water quality make countries in sub-Saharan Africa some of the poorest and sickest in the world. Tanzania is a prime example. The purpose of this study was to explore how people in one rural, Tanzanian village construct ideas about disease – its …

The Effect Of Obesity On State Health Care Expenditures: An Empirical Analysis, Kristen Collins

Honors Projects in Economics

The purpose of this study is to examine the effects of obesity rates on per capita state health care expenditures. A two-stage least square regression model is used. In the first stage of the estimation, factors influencing obesity rates are determined. The determinants of obesity rates are outlined throughout the research process. In the second stage, the impact of obesity rates on per capita health expenditures across states is evaluated. The empirical results indicate that obesity rates do indeed have a direct effect on state health care expenditures. After reviewing the project’s results, various solutions are proposed as possible methods …

Inflammatory Biomarkers And Subclinical Atherosclerosis In African-American Women With Systemic Lupus Erythematosus (Sle), Edith M. Williams, Carlos J. Crespo, Joan Dorn

Community Health Faculty Publications and Presentations

Women with lupus are at increased risk for developing cardiovascular disease (CVD). Previous studies of atherosclerosis in SLE have not been representative of the minority groups most affected by lupus and its complications. Therefore, a study of 41 lupus cases and 83 controls was conducted to investigate the relationship between carotid atherosclerosis and inflammation in African-American women. Participation consisted of a questionnaire, physical examination, fasting blood draw, and ultrasound of the carotid arteries. There were observed differences between cases and controls with regard to carotid intima media thickness (IMT) and traditional cardiovascular risk factors, although few reached statistical significance. Tumor …