Medicine and Health Sciences Commons^™

A Functional Difficulty And Functional Pain Instrument For Hip And Knee Osteoarthritis, Alan M. Jette, Christine M. Mcdonough, Pengsheng Ni, Stephen M. Haley

Dartmouth Scholarship

The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods and to assess its psychometric performance compared to the current standard in the field.

Relationships Among Perceived Burden, Depressive Cognitions, Resourcefulness, And Quality Of Life In Female Relatives Of Seriously Mentally Ill Adults, Jaclene A. Zauszniewski, Abir K. Bekhet, M. Jane Suresky

College of Nursing Faculty Research and Publications

Providing care and support to a seriously mentally ill (SMI) family member can have deleterious effects on one's health and quality of life. This study explored relationships among perceived burden, depressive cognitions, resourcefulness, and quality of life in 60 African-American and Caucasian women family members of SMI adults. Caucasians reported greater burden than African-Americans; the groups were similar in depressive cognitions, resourcefulness, and quality of life. In Caucasians and African-Americans, burden correlated with depressive cognitions and both correlated with poorer mental health. In African-Americans, burden also correlated with lower personal resourcefulness and both correlated with poorer mental health. The findings …

Nanofiber Scaffolds With Gradations In Mineral Content For Mimicking The Tendon-To-Bone Insertion Site, Xiaoran Li, Jingwei Xie, Justin Lipner, Xiaoyan Yuan, Stavros Thomopoulos, Younan Xia

MIIR Faculty Research

We have demonstrated a simple and versatile method for generating a continuously graded, bonelike calcium phosphate coating on a nonwoven mat of electrospun nanofibers. A linear gradient in calcium phosphate content could be achieved across the surface of the nanofiber mat. The gradient had functional consequences with regard to stiffness and biological activity. Specifically, the gradient in mineral content resulted in a gradient in the stiffness of the scaffold and further influenced the activity of mouse preosteoblast MC3T3 cells. This new class of nanofiberbased scaffolds can potentially be employed for repairing the tendon-to-bone insertion site via a tissue engineering approach.

The Play And Learn Classroom, Therese Mcgurkin Rn, Msn, Janet Paul Rn, Msn, Terri Schwartz Rn, Msn

Jefferson Hospital Staff Papers and Presentations

Providing a consistent curriculum to educate and train more than 2,000 members of a nursing department and over 1000 nursing students in a tertiary care hospital on a complex clinical documentation system can be a challenge to the educator. Training new employees on an ongoing basis and an entire department when periodic system upgrades occur requires that the curriculum and methodology be consistent and made available at any time – day or night. In order to maintain consistency of the curriculum and provide the learner with ample opportunity to “play and learn” we use computer – based training video tutorials …

Graduate Nurse Residency Programs: Bridging The Knowledge – Practice Gap, Elissa Harmon Rn, Msn, Ccrn

Jefferson Hospital Staff Papers and Presentations

Nurse residency programs provide the foundation needed to address the unique needs of the graduate nurse by providing a means to bridge the knowledge practice gap. The evidence based program curriculum developed by University HealthSystem Consortium (UHC) is utilized at Thomas Jefferson University Hospital. The program blends the collaborative atmosphere of peer networking opportunities with the promotion of critical thinking skills and hands on activities. The additional support eases the transition period as the graduate nurse is nurtured from advanced beginner to competent professional nurse. The Nurse Residency program promotes autonomy and effective decision making skills through application based learning …

Lifeline Of New Products- Destination: The Patient's Bedside, Mary Bent Mangano, Msn, Rn New Products Coordinator, Department Of Nursing Education

Jefferson Hospital Staff Papers and Presentations

The lifeline of a new product begins with an innovative process driven by an on-line request through our academic medical center’s intranet system. The individual championing the new product completes the request. Staff nurses have a voice in the decision making process of the acceptance or the rejection of new product(s) being used in a hospital setting. All requested products are thoroughly investigated as the item relates to new technology, cost, reimbursement, medical evidence and evidence-based practice. These critical factors assist in the decision making process to improve the quality of patient care while ensuring cost-containment and standardization, thereby, translating …

Boosting Health Information Technology In Medicaid: The Potential Effect Of The American Recovery And Reinvestment Act, Brad Finnegan, Leighton C. Ku, Peter Shin, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

The American Recovery and Reinvestment Act of 2009 (ARRA) will invest approximately $49 billion to expedite health information technology (HIT) adoption through Medicare and Medicaid. Our analysis of 2006 NAMCS data found that approximately 15 percent of the practicing office-based physicians in the country would qualify for up to $63,750 over six years in Medicaid financial incentives for HIT adoption. Included within the 45,000 eligible physicians are about 99 percent of all community health center physicians. If all qualifying physicians apply for the Medicaid incentives and receive the maximum level of payments, the federal government would invest more than $2.8 …

Method And System For In Situ Spectroscopic Evaulation Of An Object, Robert A. Lodder

Pharmaceutical Sciences Faculty Patents

A method and system for spectroscopically determining surface and product characteristics is employed for rapid detection of product characteristics and/or the presence or absence of suspected analytes, and the concentration of the analyte. The method and system uses a signal wide band detector that does not require focusing optics in many environments. It can be used for cleaning validation of pharmaceutical products and process equipment.

A Life-Or-Death Walk Into The Future, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Suppression Of Rhog Activity Is Mediated By A Syndecan 4–Synectin–Rhogdi1 Complex And Is Reversed By Pkcα In A Rac1 Activation Pathway, Arye Elfenbein, John M. Rhodes, Julia Meller, Martin A. Schwartz, Michiyuki Matsuda, Michael Simons

Dartmouth Scholarship

Fibroblast growth factor 2 (FGF2) is a major regulator of developmental, pathological, and therapeutic angiogenesis. Its activity is partially mediated by binding to syndecan 4 (S4), a proteoglycan receptor. Angiogenesis requires polarized activation of the small guanosine triphosphatase Rac1, which involves localized dissociation from RhoGDI1 and association with the plasma membrane. Previous work has shown that genetic deletion of S4 or its adapter, synectin, leads to depolarized Rac activation, decreased endothelial migration, and other physiological defects. In this study, we show that Rac1 activation downstream of S4 is mediated by the RhoG activation pathway. RhoG is maintained in an inactive …

Middle Aged Male With Pulmonary Tuberculosis And Refractory Hypercalcemia At A Tertiary Care Centre In South East Asia: A Case Report., Azra Rizwan, Najmul Islam

Department of Medicine

55-year male of Asian descent presented with weight loss, lethargy, drowsiness and low grade fever without cough. Examination revealed crackles in the chest but no focal neurological deficit. Chest X ray revealed an infiltrate consistent with tuberculosis. Biopsy of infiltrate was negative for malignancy. Corrected calcium level revealed parathyroid independent hypercalcemia. Further diagnostic work up for drowsiness and hypercalcemia was normal. Despite receiving hydration and pharmacotherapy for his hypercalcemia, his condition failed to improve. When steroids were started, the Patient's calcium levels and symptomatology resolved. Tuberculosis causing hypercalcemia is uncommon. Steroids are useful agents, particularly in refractory cases.

Addressing The Unforgettable Killer In A Forgetful Mind: A Look Into The Advances Of Treating Alzheimer's Disease, Heather Tews

Honors Theses

The world's population is getting older. Modern science has ensured that people are living longer and healthier lives. However, as the world ages, there is a looming epidemic of Alzheimer's disease promising to surface at any time. Currently, there are almost 30 million cases of Alzheimer's disease worldwide, and that number is only increasing. It is predicted that by 2050, that number will quadruple, and that 1 out of every 85 people will be living with Alzheimer's (Brookmeyer, Johnson, Ziegler-Graham & Arrighi, 2007). This disease kills about 100,000 people each year, which makes it the fourth leading cause of adult …

Integrative Health Studies Newsletter, Ciis

Integrative Health Studies Newsletter

This is the Summer 2009 issue of the Integrative Health Studies Newsletter at CIIS.

Number Of Aberrant Crypt Foci Associated With Adiposity And Igf1 Bioavailability, Helen Swede, Joseph C. Anderson, Richard G. Stevens, Joel Levine, Bruce M. Brenner, Carl D. Malchoff, Valerie B. Duffy, Devon C. Pleau, Daniel W. Rosenberg

Articles - Patient Care

Background Dysregulation of the insulin-like growth factor (IGF) system, a common consequence of adiposity-induced insulin resistance, may be a key underlying mechanism linking excess body weight with colon cancer. Evidence has been derived from studies of cancer and polyps. Supporting data about aberrant crypt foci (ACF), putative pre-polyp changes, have been generated only from animal studies to date. Methods We randomly selected 26 patients with sex-specific elevated waist-hip-ratio (WHR) and 26 with normal values from a series of 150 patients seeking routine colonoscopy at the University of Connecticut Health Center. Cross-sectional analyses were performed of ACF number (<5, ≥5) in relation to total IGF1, IGF-binding protein-3 (IGFBP3), insulin, body mass index (BMI), WHR and waist circumference (WC). Visualized ACF in the 20 cm of the distal colon were counted using advanced endoscopic imaging. Results Patients …

Com Outlook Summer 2009, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Medical Education Digest, Vol. 11 No. 4 (July/August 2009), Nova Southeastern University

Medical Education Digest

No abstract provided.

Use Of Phage Display To Isolate Specifi C Human Monoclonal Antibody Fragments Against A Potential Target For Multiple Myeloma, Pei Xiong Liew, Feng Ge, Charles A. Gullo, Gerrard Kh Teoh, William Yk Hwang

Biochemistry and Microbiology

Introduction: Multiple myeloma (MM), a malignancy of plasma cells, accounts for 10% of all haematological malignancies and is currently incurable. Although it can be treated, the disease tends to relapse after several years and becomes increasingly resistant to conventional therapy. Investigations into using humoral therapy for MM are now underway with a view that novel therapeutic agents may provide a more targeted therapy for MM.

Materials and Methods: Here, phage display, a faster and more efficient method compared to classical hybridoma fusion technology, was used as a proof-of-concept to isolate several single-chain Fragment variables (scFv) against Ku86.

Results …

Aging-Associated Dysfunction Of Akt/Protein Kinase B: S-Nitrosylation And Acetaminophen Intervention, Miaozong Wu, Anjaiah Katta, Murali K. Gadde, Hua Liu, Sunil K. Kakarla, Jacqueline Fannin, Satyanarayana Paturi, Ravi K. Arvapalli, Kevin M. Rice, Yeling Wang, Eric R. Blough

MIIR Faculty Research

Background: Aged skeletal muscle is characterized by an increased incidence of metabolic and functional disorders, which if allowed to proceed unchecked can lead to increased morbidity and mortality. The mechanism(s) underlying the development of these disorders in aging skeletal muscle are not well understood. Protein kinase B (Akt/PKB) is an important regulator of cellular metabolism and survival, but it is unclear if aged muscle exhibits alterations in Akt function. Here we report a novel dysfunction of Akt in aging muscle, which may relate to S-nitrosylation and can be prevented by acetaminophen intervention.

Principal Findings: Compared to 6- and 27-month rats, …

Santa Clara Magazine, Volume 51 Number 1, Summer 2009, Santa Clara University

Santa Clara Magazine

14 - INAUGURATING PRESIDENT ENGH By Steven Boyd Saum. On the occasion, a ringing challenge from President Engh: Make SCU a champion for environmental justice. Read the speech and see the photos.

22 - SAVING BOUNTY By Elizabeth Svoboda. Our food-safety system is in shambles, but there are ways to make it work again. For one answer, look to your leafy greens.

28 - CAN WE SOLVE HUNGER IN OUR LIFETIME? BY Dashka Slater. Here are six ideas that, practiced together, will make a difference.

34 - ALTERNATIVE REALITY: "WORLD WITHOUT OIL" By Paul Totah '79. Alternate reality games can …

Public Health Genomics: The Essentials. By Claudia N. Mikail, Rosemary M. Caron

Health Management & Policy

The sequencing of the human genome in 2001 provided researchers, clinicians, policymakers, ethicists, and public health practitioners with a myriad of information to potentially improve disease outcomes on an individual and population basis. Genomics is a burgeoning field of study that examines the interactions among the genetic material in the human body, including interactions with environmental and behavioral factors. The role of public health in this new field of study is complementary, since population trends, health disparities, and the social determinants of health contribute to our understanding of the underlying causes of disease provided by genomic research. Thus, the new …

An Interview With Alan J. Hovestadt: Aamft Past President And Long-Time Marriage And Family Counselor Educator, Gerald A. Juhnke, Michael F. Sunich, Kenneth Coll, Maritza Lebron-Striker

Counselor Education Faculty Publications and Presentations

Alan J. Hovestadt, EdD, is the immediate past president of the 24,000 member American Association for Marriage and Family Therapy (AAMFT) and a long-time IAMFC member who served as an IAMFC founding board member when ACA first granted IAMFC divisional status. Recently, Dr. Hovestadt was one of seven recipients of the prestigious American Counseling Association’s Presidential Award and was honored at the 2008 ACA Conference in Honolulu, Hawaii. Given Dr. Hovestadt’s prominence within both AAMFT and IAMFC and his long-time marriage and family counselor educator identity, the authors’ believed that an interview with Dr. Hovestadt would be of significant interest …

Genetic Enhancements And Expectations, Kelly Sorensen

Philosophy and Religious Studies Faculty Publications

Some argue that genetic enhancements and environmental enhancements are not importantly different: environmental enhancements such as private schools and chess lessons are simply the old-school way to have a designer baby. I argue that there is an important distinction between the two practices—a distinction that makes state restrictions on genetic enhancements more justifiable than state restrictions on environmental enhancements. The difference is that parents have no settled expectations about genetic enhancements.

Maine Barriers To Integration Study: The View From Maine On The Barriers To Integrated Care And Recommendations For Moving Forward, John A. Gale Ms, David Lambert Phd

Mental Health / Substance Use Disorders

Following up on the Environmental Scan report (http://muskie.usm.maine.edu/Publications/rural/Barriers-to-Integration-Environmental-Scan.pdf), the authors interviewed representatives from Maine’s business community, payers, purchasers, professional associations, state legislators, advocacy organizations, state government, and provider organizations. The interviews provided a context to understand the barriers to integration in Maine and develop recommendations to overcome them. Our Final Report presents key findings from the study, recommendations for addressing barriers, and next steps for moving forward. This study recognizes the need for integration of behavioral and physical health services in all settings. Although most discussions of integration focus on the development of behavioral health services in primary care settings, …

Health Insurance Profile Indicates Need To Expand Coverage In Rural Areas, Jennifer D. Lenardson Mhs, Erika C. Ziller Phd, Andrew F. Coburn Phd, Nathaniel J. Anderson Ms, Mph

Access / Insurance

Key Findings: A greater percentage of rural residents than urban residents are uninsured, especially those living in remote areas Among adults over age 50, uninsured rates are highest in the most remote rural places Compared to urban adults, rural adults are less likely to be in employment situations where private coverage is offered.

Classification And Developmental Biology Of Congenital Anomalies Of The Hand And Upper Extremity, Paul R. Manske, Kerby C. Oberg

Open Access Publications

No abstract provided.

The Effect Of Endothelin-1 On The Expression Of Cdk Inhibitors P21 & P27 In Bovine Corneal Endothelial Cells, Lakshmi Reddy Bollu

Masters Theses & Specialist Projects

Mammalian corneal endothelial cells are considered to be non-proliferative due to the arrest of cells at the G1 phase of the cell cycle. The purpose of this study was to determine whether the down regulation of cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated from bovine corneas and cultured in DMEM supplemented with 10% serum. 5-Bromo 2-deoxy Uridine (BrdU) incorporation was determined in serum starved cultures in 24-well plates as a measure of cell …

Fallow Bucks Get Hoarse: Vocal Fatigue As A Possible Signal To Conspecifics, Elisabetta Vannoni, Alan G. Mcelligott

Veterinary Science and Medicine Collection

Many studies of sexually selected vocal communication assume that calls remain stable throughout the breeding season. However, during this period, physiological and social factors change and these can have strong effects on the structure of calls and calling rates. During the rut, fallow bucks, Dama dama, reduce their feeding and increase the time and energy spent on vocalizing and fighting to gain matings, and consequently their body condition declines greatly. The availability of matings and intensity of competition between males also change. Therefore, we predicted that male vocal signalling would vary over time in response to the changing intersexual and …

Flight Physician - July, 2009, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Enhanced Student Learning And Public Health Awareness Through Capstone Projects, Jane M. Gervasio, Carriann E. Richey, Bruce G. Hancock, Iftekhar Kalsekar, Julie M. Koehler, Mary H. Andritz

Scholarship and Professional Work – COPHS

Abstract from the 110th Annual Meeting of the American Association of Colleges of Pharmacy, Boston, MA, July 18-22, 2009.

Intrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic Capacity And Reduces Messenger Ribonucleic Acid Translation Initiation And Nutrient Sensing In Fetal Liver And Skeletal Muscle., Stephanie R Thorn, Timothy Regnault, Laura D Brown, Paul J Rozance, Jane Keng, Michael Roper, Randall B Wilkening, William W Hay, Jacob E Friedman

Paediatrics Publications

Expression of key metabolic genes and proteins involved in mRNA translation, energy sensing, and glucose metabolism in liver and skeletal muscle were investigated in a late-gestation fetal sheep model of placental insufficiency intrauterine growth restriction (PI-IUGR). PI-IUGR fetuses weighed 55% less; had reduced oxygen, glucose, isoleucine, insulin, and IGF-I levels; and had 40% reduction in net branched chain amino acid uptake. In PI-IUGR skeletal muscle, levels of insulin receptor were increased 80%, whereas phosphoinositide-3 kinase (p85) and protein kinase B (AKT2) were reduced by 40%. Expression of eukaryotic initiation factor-4e was reduced 45% in liver, suggesting a unique mechanism limiting …