Medicine and Health Sciences Commons^™

The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming

Theses and Dissertations

Francisella tularensis was a facultative intracellular pathogen and a gram-negative coccobacillus which has been categorized by the CDC as a potential class A select agent due to its highly infectious properties and high mortality rates. Francisella tularensis was also responsible for the zoonotic disease tularemia, which was usually transmitted by arthropod vectors or via contact with infected animals. Francisella tularensis subspecies novicida has been used by many researchers in genetic pathogenesis experiments to try to elucidate genes responsible for virulence factors. One of these virulence factors was a capsular material which has been thought to be involved in either increasing …

The Influence Of Antiretroviral Therapy On Qtc Interval Amongst Hiv Patients At Aga Khan University Hospital, Nairobi, Jay Shavadia

Master of Medicine in Clinical Pathology

Aim: To determine the influence of antiretroviral (ARV) therapy on the QTC interval amongst HIV-infected patients. Design: Prospective Comparative survey of two population samples Patients and Setting: One hundred and thirty ARV naïve and one hundred and thirty treated HIV-positive patients selected from in and out patient departments of Aga Khan University Hospital underwent clinical evaluation and 12 lead resting ECG between August 2008 and March 2009. Methodology: Eligible HIV-positive patients were conveniently sampled and had a 12-lead electrocardiogram (ECG) performed to determine the QTinterval, corrected for the heart rate by the Bazzet formula. Analysis was then performed to determine …

Today - July 27, 2009, Loma Linda University

TODAY

Inside this issue:

-- Loma Linda University ranks in top third of top 100 colleges for Hispanics in United States
-- ‘Josh and Friends’ bring comfort to hundreds of children at Loma Linda University Children’s Hospital
-- School of Medicine anticipates 100th anniversary
-- LLU researchers discover source for 250 additional transplant hearts per year
-- New LLU bachelor’s graduates are top earners among colleges in survey
-- Loma Linda University student interns at San Bernardino mayor’s office
-- School of Public Health professor spreads health message in Fresno area
-- School of Public Health researchers may lead to change …

Content Validation Of Nutrition Diagnostic Term Involuntary Weight Loss By Board Certified Specialists In Gerontological Nutrition, Paula K. Ritter-Gooder

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to validate content of the Nutrition Diagnostic Term NC- 3.2 Involuntary Weight Loss using expert raters. This descriptive survey invited all Board Certified Specialists in Gerontological Nutrition (CSG) to participate by mail. An instrument was developed that included the definition, etiologies, and signs and symptoms of the diagnosis with items added from literature review. CSG rated how common or characteristic each item is to the diagnosis using a 5 point Likert scale. A weighted response for each item was used to calculate a Diagnostic Content Validity (DCV) score. DCV scores of 0.80 and above …

Omega-3 Fatty Acids Website Development For Registered Dietitian Education And Research, Martha M. Valverde

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The purpose of this project was to investigate interest of Midwestern dietitians in online omega-3 fatty acids information and education resources useful within their work setting. Qualitative in-depth interviews with ten registered dietitians, selected from the Nebraska Dietetic Association online membership map were used to identify themes useful in website development. Twelve overarching themes were identified. Valued online features include information that is easy to access, scan, save, print, and send. Findings highlight the need to reformat current online information to accommodate time sensitive search methods used by dietitians. Omega-3 fatty acids learning modules were developed and pilot tested for …

Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner

Theses and Dissertations

Therapeutic ultrasound (TUS) is a treatment modality that is used to accelerate tissue healing. TUS is thought to affect cellular processes of tissue healing, especially those that occur in the inflammatory and early proliferative phases. TUS can be applied using various parameter selections including intensity, wavelength, duty cycle and treatment duration and no clear consensus exists on optimal parameters for healing enhancement. Macrophages are important mediators of inflammation and their actions are critical to normal progression into the proliferative phase of healing. They complete many functions during these periods of tissue healing, among those being release of cytokines and growth …

Workload And Performance Factors Associated With Multimedia Job Aids For Community Health Workers, Jose F. Florez-Arango

Dissertations and Theses (Open Access)

This dissertation focuses on factors of multimedia job aids that modify workload, protocol adherence and clinical errors in community health workers. Literature shows that community health workers performance is not acceptable even with support of paper job aids. There are cognitive theories that try to explain reasons why the performance of community health workers is poor regardless of the access to paper based-job aid. Based on cognitive science and multimedia design theories an intervention was designed to compare alternative representations for the information contained on paper job aids and the capability of this new designed job aids to enhance community …

Effect Of Posture On Acromiohumeral Distance With Arm Elevation In Subjects With And Without Rotator Cuff Disease Using Ultrasonography, Nitin Kalra

Theses and Dissertations

Objectives: To examine the effects of posture on subacromial (SA) space with arm elevation in patients with rotator cuff disease (RCD) and healthy subjects. Background: Poor posture has been linked to altered scapular mechanics, theorized to lead to excessive SA space narrowing. However, no study has examined the direct effects of posture on SA space using ultrasonography. We hypothesize that when compared to a neutral posture, upright posture will increase SA space and slouched posture will decrease SA space. Methods: Subjects with painful RCD (n=31) and healthy (n=29) shoulders participated. SA space was measured on ultrasound generated images using the …

Novel Allosteric Inhibitors Of Thrombin, Bijoy Desai

Theses and Dissertations

Thrombin is a critical enzyme involved in blood coagulation and haemostasis. For this reason the study of its interactions with substrates, inhibitors and modulator is essential. It is also a unique enzyme in the serine protease family because unlike enzymes like trypsin and chymotrypsin its activity is modulated by various endogenous and exogenous ligands. This is due to the presence of “exosites” on the thrombin surface. Exosite II, unlike exosite-I, has not been characterized for its allosteric effect. In order to understand the structural basis of interaction and inhibition of inhibitor 4AS, which possibly interacts with exosite-II, native bovine thrombin …

Estimating The Effects Of Health Reform On Health Centers' Capacity To Expand To New Medically Underserved Communities And Populations, Leighton C. Ku, Peter Shin, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

Nearly 100 million persons reside in urban and rural communities that can be considered medically underserved as a result of inadequate supply of primary care physicians and elevated health risks. A report by the National Association of Community Health Centers and the Robert Graham Center estimated that 60 million people are "medically disenfranchised" and lack access to adequate primary health care because of where they live, even though many have health insurance. This brief assesses the potential effects of national health reform on health centers and on the number of patients they can serve. Because improving primary care access is …

A New Attitude About Huntington’S Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Behavioral And Molecular Analysis Of Individual Variation In Ethanol Drinking, Jennifer Wolstenholme

Theses and Dissertations

A majority of Americans regularly consume alcohol, but the risk factors leading to excessive drinking and alcohol abuse are unevenly distributed throughout the population. Genetic differences can account for only 40-60% of this variability. While variations in ethanol preference drinking in rodent models have been reported, the neurobiological factors underlying these behaviors are still not completely understood. Thus, these studies were designed to determine behavioral and molecular factors associated with the initiation of ethanol drinking preference in an inbred mouse model. We harnessed the power of inter-individual variation of ethanol drinking within an inbred mouse strain to essentially eliminate genetic …

Chaperone Association With Telomere Binding Proteins, Amy Depcrynski

Theses and Dissertations

The Hsp90 chaperone complex associates with the telomerase enzyme, facilitating the assembly of the ribonucleoprotein complex. While previous data from our laboratory indicate that Hsp90 and p23 remain stably associated with (functionally active) telomerase, more recent experiments suggest that these chaperones associate with telomeres independent of telomerase, presumably through a specific interaction with telomere binding proteins. The current study examines the novel interactions between TRF2, TRF1, TIN2 and TPP1 and molecular chaperones (Hsp90, Hsp70, p23). In vitro and in cell experiments have shown an interaction between TRF1 and TRF2 and the molecular chaperones Hsp90 and Hsp70. Inhibition of Hsp90 using …

Leadership Development Of Registered Dietitians, Anne Marie Bigley Hunter

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

This study investigated leadership development of Registered Dietitians in nationally elected or appointed leadership positions of the American Dietetic Association. An explanatory sequential mixed method design: participant selection model was used collecting qualitative data after a quantitative phase. Demographic data were collected via a mailed survey questionnaire followed by, with consent, a web based validated Sentence Completion Test International- Maturity Assessment Profile Research Version (2) (SCTi- MAP) to determine their stage of leadership development. Of the 97 participants, 86% (n=83) responded to the survey questionnaire with 92% (n=79) rating the importance of dietitians being leaders as very important; 100% (n=83) …

Does “Asymptomatic” Mean Without Symptoms For Those Living With Hiv Infection?, Suzanne Willard, William L. Holzemer, Dean J. Wantland, Yvette P. Cuca, Kenn M. Kirksey, Carmen J. Portillo, Inge B. Corless, Marta Rivero-Méndez, María E. Rosa, Patrice K. Nicholas, Mary Jane Hamilton, Elizabeth Sefcik, Jeanne Kemppainen, Gladys Canaval, Linda Robinson, Shahnaz Moezzi, Sarie Human, John Arudo, Lucille Sanzero Eller, Eli Bunch, Pamela J. Dole, Christopher Coleman, Kathleen Nokes, Nancy R. Reynolds, Yun-Fang Tsai, Mary Maryland, Joachim Voss, Teri Lindgren

School of Nursing & Midwifery, East Africa

Throughout the history of the HIV epidemic, HIV-positive patients with relatively high CD4 counts and no clinical features of opportunistic infections have been classified as ‘‘asymptomatic’’ by definition and treatment guidelines. This classification, however, does not take into consideration the array of symptoms that an HIV-positive person can experience long before progressing to AIDS. This short report describes two international multi-site studies conducted in 2003 - 2005 and 2005 - 2007. The results from the studies show that HIV-positive people may experience symptoms throughout the trajectory of their disease, regardless of CD4 count or classification. Providers should discuss symptoms and …

Relationship Among Stress Of Labor, Support, And Childbirth Experience In Postpartum Mothers, Sasamon Srisuthisak

Theses and Dissertations

Background: Due to the profound and life-changing aspects of giving birth and to each woman’s individualized birthing experience, it is important to understand the myriad of factors that contribute to a positive childbirth experience. The aims of this study were to: (1) identify factors related to a positive childbirth experience; (2) to examine relationships among women’s perceptions and personal evaluations of their childbirth experience, stress associated with labor pain, support from the nursing staff, initial contact with the baby following birth, support from partners, education, age, and obstetric history; and (3) to identify predictors of a positive childbirth experience. Method: …

Hp Newsletter June 2009 Download Full Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Book Review: Global Health And Global Aging, Safiya Abouzaid Pharmd

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Impact Of Serious Medication Errors For Health Care Providers

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Public-Private Balance In Healthcare: Political And Economic Tipping Points

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Follow-On Biologics, Patient Safety And Policy Focus Of Jsph Program In Dc

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Patient Navigator Outreach And Chronic Disease Prevention Act Of 2005: A Bipartisan Approach To Improving Access To Care And Addressing Health Disparities, Natalia M. Urrea

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Impact Of Education On Health Care Quality: The 18th Annual Dr. Raymond C. Grandon Lecture

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Master Of Science In Healthcare Quality And Safety (Ms-Hqs), Susan Desharnais Phd, Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The University Clinical Skills And Simulation Center: A Jefferson Gem Part Ii

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Jefferson Students' Improving Knowledge Of Issues In Health Policy, Daniel Z. Louis Ms

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

2009 Annual Quality/Risk Management Retreat

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Stimulus Money And Health Care Research And Investment, Eric Jutkowitz

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Losing My Dad, David B. Nash Md, Mba

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Exploring The Methylation Status Of Rai1 And The Rai1 Consensus Binding Sequence, Eri Kamura

Theses and Dissertations

Smith Magenis Syndrome (SMS) is a multiple congenital anomalies/ mental retardation disorder caused by deletion or mutation of the RAI1 gene on chromosome 17p11.2. The majority of patients with SMS phenotypes have a deletion or mutation of RAI1. However, some patients have been observed with SMS-like phenotypes and yet have no deletions or mutations in the RAI1 gene. One possible explanation could be aberrant methylation of RAI1 since RAI1 is present and yet may be silenced. In order to study this possibility, patient cell lines were treated with 5-Aza-2’-deoxycytidine. RNA was extracted and real-time PCR was used to check the …