Medicine and Health Sciences Commons^™

Exploring Current Practices In Pediatric Arv Rollout And Integration With Early Childhood Programs In South Africa: A Rapid Situation Analysis, Desiree Michaels, Brian Eley, Lewis Ndhlovu, Naomi Rutenberg

HIV and AIDS

This Horizons program report describes the status of pediatric HIV treatment in selected sites in South Africa, identifies gaps in service delivery, and proposes recommendations for strengthening services and expanding children’s access to treatment. The study provides much needed information on critical issues of pediatric HIV care, especially regarding health service and contextual issues surrounding the expansion of access to treatment for HIV-infected children, and key factors that facilitate sustainability of treatment by young children. The aims of the study were to identify successful program strategies in pediatric HIV treatment in South Africa and to determine priority knowledge gaps to …

Abcs For Hiv Prevention In Kenya: Messages, Beliefs, And Barriers, Julie Pulerwitz, Tiffany Lillie, Louis Apicella, Ann P. Mccauley, Tobey C. Nelson, Simon Ochieng, Peter Mwarogo, Karusa Kiragu, Edward Kunyanga

HIV and AIDS

A great deal of attention has been focused recently on promoting the “ABCs” of HIV prevention— abstinence or delaying sex, being faithful to one sexual partner or reducing the number of sexual partners, and consistently using condoms during sex. Yet even as programs that focus on the ABCs to prevent sexual HIV transmission are rolled out, questions remain about how well different groups in varied cultural contexts understand the terms, as well as how best to address challenges to adopting the ABC behaviors. The Horizons Program and FHI/IMPACT developed a collaborative research study in 2004 to explore how adults and …

Informed Consent In Hiv Prevention Trials: Report Of An International Workshop, C. Elizabeth Mcgrory, Barbara Friedland, Cynthia Woodsong, Kathleen M. Macqueen

HIV and AIDS

This report summarizes key themes and issues on informed consent in HIV prevention trials as part of an international workshop co-hosted by Population Council and Family Health International in May 2005.

A Group M Consensus Envelope Glycoprotein Induces Antibodies That Neutralize Subsets Of Subtype B And C Hiv-1 Primary Viruses, Hua-Xin Lin, Laura L. Sutherland, Shi-Mao Xia, Mary E. Brock, Richard M. Scearce, Stacie Vanleeuwen, S. Munir Alam, Mildred Mcadams, Eric A. Weaver, Zenaido T. Camacho, Ben-Jiang Ma, Yingying Li, Julie M. Decker, Gary J. Nabel, David C. Montefiori, Beatrice H. Hahn, Bette T. Korber, Feng Gao, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity, and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wildtype (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the …

Simultaneous Measurement Of Water Volume And Ph In Single Cells Using Bcecf And Fluorescence Imaging Microscopy, Francisco J. Alvarez-Leefmans, José J. Herrera-Pérez, Martín S. Márquez, Victor M. Blanco

Pharmacology and Toxicology Faculty Publications

Regulation and maintenance of cell water volume and intracellular pH (pH_i) are vital functions that are interdependent; cell volume regulation affects, and is in turn affected by, changes in pH_i. Disruption of either function underlies various pathologies. To study the interaction and kinetics of these two mechanisms, we developed and validated a quantitative fluorescence imaging microscopy method to measure simultaneous changes in pH_i and volume in single cells loaded with the fluorescent probe BCECF. CWV is measured at the excitation isosbestic wavelength, whereas pH_iis determined ratiometrically. The method has a time resolution of …

'Science Of Trivalency', Kwaku L. Carlisle Woods Rn Md Metd1, Dr. Kwaku L Carlisle Woods Rn Md Metd1

Walden Faculty and Staff Publications

Due to mine cross cultural living, (I was born in the U.S. but grew in Southeast Asia), I became very interested in the Anthological, Social and Scientific difference between cultures. This led to a historical meta evaluation of humanity in general. Using the principals of Noetic Science, this evaluation reviled the ignorance and down right absence of any educational opportunities to learn the true functional abilities of mankind.

Nutritional Quality Of Lunches At A Seventh-Day Adventist School, M. Justine Markert

Master's Theses and Doctoral Dissertations

The purpose of this study was to determine if what the 3rd, 4th, and 5th grade children (n=36) at Central Valley Christian Academy (CVCA) were eating for lunch followed the beliefs of the Seventh-day Adventist (SDA) church and if lunches brought from home (LFH) provided more nutritional quality than combination lunches.

This study showed that LFH (n=26) provided more overall nutrients for the students when compared with school-provided entrée lunches (n=1) and combination lunches (n=9). When comparing LFH with combination lunches, LFH met more of the nutritional requirements based on the Recommended Dietary Intake (RDI) and the Dietary Guidelines for …

The Accuracy Of Ultrasound In The Diagnosis Of Congenital Abnormalities, Shama Munim, Salva Nadeem, Nadya Ali Khuwaja

Department of Obstetrics & Gynaecology

Objective: To determine the accuracy of ultrasound in the diagnosis of congenital abnormalities at the Aga Khan University Hospital, Karachi.
Methods: The data of congenital abnormalities was obtained from the obstetrical database and medical records of all cases complicated by congenital abnormalities, delivering from January 2001 to December 2003 and was reviewed. Antenatal ultrasounds had been performed by operators with different level of experience. In addition this data was retrieved from the termination and Congenital anomaly register. A structured data collection form was used to collect information of different variables of interest.
Results: Congenital abnormalities, complicated 2.8% (n=170), of all …

Phloroglucinol In Irritable Bowel Syndrome, Wasim Jafri, Javed Yakoob, Sajjad Hussain, Nadim Jafri, Muhammad Islam

Section of Gastroenterology

Objective: To determine the efficacy and tolerability of phloroglucinol, an antispasmodic agent in the treatment of Irritable Bowel Syndrome (IBS). Methods: It was an open label (quasi interventional) study. One hundred patients coming to the gastroenterology clinics of Aga Khan University Hospital with IBS as defined by the Rome II criteria were enrolled between February 2004 and September 2004 to participate in the trial and were treated as outpatients. Phloroglucinol (Himont) 50mg orally three times daily was given for two months. Symptoms were assessed before and during treatment using a questionnaire. Results: One hundred patients were enrolled in the study. …

Multiple Pregnancies: Determining Chorionicity And Amnionicity, Traci B. Fox

Department of Radiologic Sciences Faculty Papers

The determination of chorionicity and amnionicity in multiple gestations is one that confounds many in the medical field. The importance of diagnosing the type of multiple gestation cannot be overstated. This is intended to be an introductory primer and refresher to chorionicity and amnionicity. We will first examine what determines mono- versus dichorionic twinning including zygosity and cleavage of the zygote.

Baseline Household Survey: Jhelum District, Pakistan Initiative For Mothers And Newborns (Paiman)

Reproductive Health

The Pakistan Initiative for Mothers and Newborns (PAIMAN) is a five-year project funded by the United States Agency for International Development (USAID). PAIMAN is committed to assisting the Government of Pakistan in implementing the full spectrum of interventions necessary to address maternal and neonatal health issues. USAID has provided a grant to implement PAIMAN in ten districts of Pakistan’s four provinces. The goal of the project is to reduce maternal, newborn, and child mortality. The project calls for a multipronged and integrated strategic approach combining individual health care with public health and community-based interventions. To ensure that success is properly …

Baseline Survey: Summary Report Of District Sukkur, Pakistan Initiative For Mothers And Newborns (Paiman)

Reproductive Health

This summary report presents some of the key findings of a 2005 baseline household survey in Sukkur district, one of the ten districts in Pakistan that are the focus of the PAIMAN project. The Pakistan Initiative for Mothers and Newborns (PAIMAN) is a five-year project funded by the United States Agency for International Development. The project is committed to assisting the Government of Pakistan in implementing the full spectrum of interventions necessary to address maternal and neonatal health (MNH) issues. PAIMAN district survey results are presented individually for each of the ten districts. PAIMAN developed a monitoring and evaluation plan …

Baseline Household Survey: Jaffarabad District, Pakistan Initiative For Mothers And Newborns (Paiman)

Reproductive Health

The Pakistan Initiative for Mothers and Newborns (PAIMAN) is a five-year project funded by the United States Agency for International Development (USAID). PAIMAN is committed to assisting the Government of Pakistan in implementing the full spectrum of interventions necessary to address maternal and neonatal health issues. USAID has provided a grant to implement PAIMAN in ten districts of Pakistan’s four provinces. The goal of the project is to reduce maternal, newborn, and child mortality. The project calls for a multipronged and integrated strategic approach combining individual health care with public health and community-based interventions. To ensure that success is properly …

Sulcular Sulfide Monitoring: An Indicator Of Early Dental Plaque-Induced Gingival Disease, Aleksandra Pavolotskaya, Gayle Mccombs, Michele Darby, Kenneth Marinak, Naik N. Dayanand

Dental Hygiene Faculty Publications

Purpose. The purpose of this study was to evaluate the relationship between volatile sulfur compounds (VSC) and gingival health status and to determine if volatile sulfur compounds can detect early dental plaque-induced gingival disease. Methods. A split-mouth design with randomly selected quadrants of the mandibular arch enabled 39 participants to serve as their own controls. At baseline and at three subsequent appointments (days 7, 14, and 21) gingival inflammation (GI), bleeding on probing (BOP), and sulfide levels (SUL) were measured using the Gingival Index and the Diamond Probe/Perio 2000 System. For three weeks, participants refrained from brushing and flossing one …

The Psychological Effects Of Exposure To Wartime Trauma In Bosnian Residents And Refugees: Implications For Treatment And Service Provision, Sandina Begic, Theodore Mcdonald

Public and Population Health Faculty Publications and Presentations

It has been widely reported that exposure to war-related trauma leads to psychological distress in human beings, and it has been hypothesized that this psychological distress may be compounded when people leave their war-torn countries and begin their lives as refugees in a new country. In this study, we explored whether a systematic relationship existed between the level of traumatic wartime events experienced by Bosnian residents and refugees living in the western United States and their levels of post-traumatic stress disorder (PTSD), anxiety, and depression. We also explored whether differences in levels of these mental health problems existed between Bosnian …

Pioglitazone Induces Apoptosis Of Macrophages In Human Adipose Tissue, Angela M. Bodles, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Bounleut Phanavanh, Charlotte A. Peterson, Robert E. Mcgehee Jr., Neda Rasouli, Martin Wabitsch, Philip A. Kern

Clinical and Translational Science Faculty Publications

Metabolic syndrome and type 2 diabetes mellitus are associated with an increased number of macrophage cells that infiltrate white adipose tissue (WAT). Previously, we demonstrated that the treatment of subjects with impaired glucose tolerance (IGT) with the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone resulted in a decrease in macrophage number in adipose tissue. Here, adipose tissue samples from IGT subjects treated with pioglitazone were examined for apoptosis with terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining. TUNEL-positive cells were identified, and there was a significant 42% increase in TUNEL-positive cells following pioglitazone treatment. Overlay experiments with anti-CD68 antibody …

Top-10 Positional-Release Therapy Techniques To Break The Chain Of Pain: Part 2, Timothy E. Speicher, David O. Draper

All PTHMS Faculty Publications

Positional-Release Therapy (PRT) is advocated as an effective indirect therapeutic treatment for acute, subacute, and chronic somatic dysfunction. Initial investigations have shown PRT to significantly reduce low back and hip pain and improve hip strength. The effects of PRT are thought to occur from placing a patient’s tissues in a position of comfort for an extended period of time.

Clinically, the practice of PRT and its therapeutic benefits have an established history. What is lacking is research into the neural and physiologic mechanisms of the process by which PRT alleviates somatic dysfunction. It can be tempting to view the technique …

Master Of Health Science, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Cutaneous And Presumed Visceral Leishmaniasis In A Soldier Deployed To Afghanistan, James P. Woodrow, Joshua D. Hartzell, Jim Czarnik, David Brett-Major, Glenn Wortmann

Journal Articles: Epidemiology

Leishmaniasis has been frequently diagnosed in US military personnel returning from duty in Southwest Asia. The majority of cases have demonstrated cutaneous disease, although a few cases of visceral disease have been documented. We present the case of an immunocompetent, HIV-negative, US Army soldier who suffered both visceral and cutaneous manifestations of leishmaniasis after returning from deployment in Afghanistan. Overlap of cutaneous and visceral involvement is rare and has not been reported in our cohort. Latent Plasmodium vivax infection may have been an exacerbating cofactor. We discuss this case and present a review of the literature.

Laboratory Diagnosis Of Tuberculosis In Primary Care, David Brett-Major, Thomas E. Walsh

Journal Articles: Epidemiology

No abstract provided.

The Science Of Prevention Strategies, Rachel Abrishami, Jeffery A. Goad

Pharmacy Faculty Articles and Research

"From newborn screening for Phenylkentonurea (PKU) and the birth dose of Hepatitis B vaccine to prostate and breast cancer screening and pneumococcal immunization for older adults, the science of health maintenance is multi-tiered and spans the lifetime of an individual. Primary, secondary, and tertiary prevention strategies are used in concert with each other to enable healthcare professionals and their patients to sustain and improve the quality of life."

Methods For The Study Of Signaling Molecules In Membrane Lipid Rafts And Caveolae, Rennolds S. Ostrom, Paul A. Insel

Pharmacy Faculty Articles and Research

Lipid rafts and caveolae are cholesterol- and sphingolipid-rich microdomains of the plasma membrane that concentrate components of certain signal transduction pathways. Interest in and exploration of these microdomains has grown in recent years, especially after the discovery of the biochemical marker of caveolae, caveolin, and the recognition that caveolin interacts with many different signaling molecules via its scaffolding domain. There are three major types of caveolins (1, 2, and 3), with some selectivity in their expression in different tissues. Results assessing lipid raft/caveolae co-localization of molecules in signal transduction pathways have provided support for the idea that signaling components are …

Quality Of Life Measurement In Persons With Schizophrenia: Are We Measuring What’S Important?, Marion Becker, Ronald J. Diamond

Mental Health Law & Policy Faculty Publications

No abstract provided.

Safety Of A Red Diode Laser Source For Fetal Retinal Stimulation Studies, Alois (Al) J. Adams, James D. Wilson

Journal of the Arkansas Academy of Science

No abstract provided.

Com Outlook Winter 2006, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Contagious Discourse: Germs, Mass Media, And The Shaping Of Reality, Amy Richardson Ballagh

College of Graduate Studies: Theses & Dissertations

Over the past two decades, mass media coverage of certain infectious diseases has become more abundant. News reports of many of these contagious illnesses invoke fear in many people, such as Ebola and pandemic influenza; multidrug-resistant strains of infectious diseases, such as tuberculosis; and agents of biological warfare, a concern that is now at the forefront with many Americans due to the most recent act of bioterrorism on American soil following the events of September 11th. This dissertation focuses on the American public's perception of infectious diseases, particularly as portrayed in the cultural science curriculum. I examine the cyclic nature …

Utility Of Health Belief Model Constructs In Predicting Dietary Behaviors Among Female University Students: A Pilot Investigation, Vanessa Emily Anderson

College of Graduate Studies: Theses & Dissertations

This study examined the relationship between Health Belief Model constructs as they related to dietary behaviors in a sample of university women 18-to-25 years of age (n=182). A cross-sectional, non-experimental design was utilized. Independent sample t-tests compared the mean of body mass indices (BMI) to dietary risk and race. Odds ratios amassed relationships between race and healthy food choices. Nearly one-third (32.4%) of participants were either overweight or obese. Black females had significantly higher BMI than white females; however, dietary risk from less-than-adequate fruit and vegetable consumption and consumption of high-fat foods were not related to race. Focus group participants …

Spectrum And Outcome Of Infections In Systemic Lupus Erythematosus Patients, Bushra Jamil, Sobia Rafi, Hammad Hussain, Khizar Hameed

Department of Medicine

No abstract provided.

Process Evaluation Of A School- And Home-Based Sun Safety Education Intervention, Robyn S. Johnston

Theses: Doctorates and Masters

Effective interventions that reduce children's sun exposure are likely to reduce melanoma incidence in the longer term. However, for such interventions to have an impact they must be adequately implemented. School-based sun protection programs have been evaluated to determine their effectiveness in changing behaviours, however, few studies have assessed the implementation of such programs, or the effect of their implementation on outcomes. Kidskin was a five-year intervention trial designed to assess the effectiveness of a multicomponent intervention in reducing sun exposure in children in Perth, Western Australia. This thesis describes the process evaluation of the school- and home-based educational components …

Hemoptysis, A Developing World Perspective, Omer Ashraf

Medical College Documents

Background: Hemoptysis is a significant clinical presentation in respiratory medicine. Often a life threatening emergency, it mandates prompt assessment and intervention. Various investigations and management protocols are proposed globally, to advocate a standardized approach towards patients presenting with hemoptysis. It is the etiology, however, that has been known to influence clinical outcome and prognosis. With marked contrast in geographical patterns of pulmonary pathologies, etiological agents for hemoptysis vary over the world. Studies in West, usually demonstrate neoplastic and non-granulomatous causes to be the leading agents for hemoptysis. The diagnostic accuracy of various investigations and efficacy of management alternatives has been …