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2003

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Articles 1861 - 1890 of 1922

Full-Text Articles in Medicine and Health Sciences

Some Microbiological And Chemical Properties Of Bologna-Type Sausage Samples From Different Brands, Güzi̇n Apaydin, Zi̇ya Gökalp Ceylan, Mükerrem Kaya Jan 2003

Some Microbiological And Chemical Properties Of Bologna-Type Sausage Samples From Different Brands, Güzi̇n Apaydin, Zi̇ya Gökalp Ceylan, Mükerrem Kaya

Turkish Journal of Veterinary & Animal Sciences

In this study, the microbiological and chemical quality of bologna-type sausage samples from 4 different brands (A,B,C,D) sold in Erzurum markets was determined. Microbiological analysis showed that while the total aerobic mesophilic bacteria numbers were


Effect Of Steam And Acid Treatment On The Feed Value Of Lentil Straw, Hati̇ce Kalkan, Ali̇ Karabulut Jan 2003

Effect Of Steam And Acid Treatment On The Feed Value Of Lentil Straw, Hati̇ce Kalkan, Ali̇ Karabulut

Turkish Journal of Veterinary & Animal Sciences

This research was carried out to determine the possibilities of improving the feed value of lentil straw with steam and acid treatment. Lentil straw (Lens culinaris M.) was used as feed material and three 3-year-old, Kıvırcık rams fitted with rumen cannula were used as the animal material. Lentil straw was impregnated with different concentrated H_2SO_4 solutions, and then autoclaved at different periods and temperatures. After these treatments, the nutrient contents and cell wall components of the lentil straw were determined, and rumen degradability characteristics were determined with the nylon bag technique and gas production technique. In conclusion, higher cell wall …


Studies On The In Vitro Maturation Of Cat Oocytes, Mi̇that Evecen, Hatem Atalla, Sema Bi̇rler, Alper Baran, Kemal Ak Jan 2003

Studies On The In Vitro Maturation Of Cat Oocytes, Mi̇that Evecen, Hatem Atalla, Sema Bi̇rler, Alper Baran, Kemal Ak

Turkish Journal of Veterinary & Animal Sciences

The aim of the present study was to investigate the effects of gonadotrophin and Bovine Serum Albumin (BSA) supplemented Synthetic Oviduct Fluid (SOF) and Ham's F-10 media on the in vitro maturation of cat oocytes. Oocytes collected from spayed stray queens served as the material of the study. The ovaries were brought to the laboratory within 2 h in PBS solution at 38 °C. Recovered oocytes were divided into two groups (Group 1: SOF + 0,4% BSA + 10 µg/ml FSH + 10 µg/ml LH, group 2: Ham's F-10 + 0,4% BSA + 10 µg/ml FSH + 10 µg/ml LH) …


Hepatorenal Syndrome And Efficiency Of Aldosterone Receptor Blockade On Hepatorenal System And Systemic Hemodynamics In Dogs With Experimentally Induced Hepatic Cirrhosis, Remzi̇ Gönül, Utku Bakirel, Abdullah Kayar, Yücel Meral, Mehmet Erman Or, Gülbi̇n Şennazli, Aydin Gürel, Emi̇ne Akdeni̇zli̇ Jan 2003

Hepatorenal Syndrome And Efficiency Of Aldosterone Receptor Blockade On Hepatorenal System And Systemic Hemodynamics In Dogs With Experimentally Induced Hepatic Cirrhosis, Remzi̇ Gönül, Utku Bakirel, Abdullah Kayar, Yücel Meral, Mehmet Erman Or, Gülbi̇n Şennazli, Aydin Gürel, Emi̇ne Akdeni̇zli̇

Turkish Journal of Veterinary & Animal Sciences

In this study, the clinical signs of hepatorenal syndrome that occurs during hepatic cirrhosis were investigated and a variety of diagnosis and therapy methods were investigated in the experimentally ligated bile ducts of dogs. The test group with ligated bile ducts (n = 14) and the sham operated control group (n = 14) were divided into 2 sub groups and administered a derivative of spironalactone (Aldoctan® tablet), an antagonist of the aldosteron receptor, at 1.5 mg/kg daily for 5 weeks. Hepatorenal changes and the systemic effects of the drug were determined by comparing the control and test groups during the …


The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar: A Toxicokinetic/Statistical Analysis With Clinical, Epidemiologic, And Mechanistic Implications, Manu Sebastian, Marie G. Gantz, Thomas Tobin, J. Daniel Harkins, Jeffrey M. Bosken, Charlie Hughes, Lenn R. Harrison, William V. Bernard, Dana L. Richter, Terrence D. Fitzgerald Jan 2003

The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar: A Toxicokinetic/Statistical Analysis With Clinical, Epidemiologic, And Mechanistic Implications, Manu Sebastian, Marie G. Gantz, Thomas Tobin, J. Daniel Harkins, Jeffrey M. Bosken, Charlie Hughes, Lenn R. Harrison, William V. Bernard, Dana L. Richter, Terrence D. Fitzgerald

Maxwell H. Gluck Equine Research Center Faculty Publications

During 2001, central Kentucky experienced acute transient epidemics of early and late fetal losses, pericarditis, and unilateral endophthalmitis, collectively referred to as mare reproductive loss syndrome (MRLS). A toxicokinetic/statistical analysis of experimental and field MRLS data was conducted using accelerated failure time (AFT) analysis of abortions following administration of Eastern tent caterpillars (ETCs; 100 or 50 g/day or 100 g of irradiated caterpillars/day) to late-term pregnant mares. In addition, 2001 late-term fetal loss field data were used in the analysis. Experimental data were fitted by AFT analysis at a high (P < .0001) significance. Times to first abortion (“lag time”) and abortion rates were dose dependent. Lag times decreased and abortion rates increased exponentially with dose. Calculated dose × response data curves allow interpretation of abortion data in terms of “intubated ETC equivalents.” Analysis suggested that field exposure to ETCs in 2001 in central Kentucky commenced on approximately April 27, was initially equivalent to approximately 5 g of intubated ETCs/day, and increased to approximately 30 g/day at the outbreak peak. This analysis accounts for many aspects of the epidemiology, clinical presentations, and manifestations of MRLS. It allows quantitative interpretation of experimental and field MRLS data and has implications for the basic mechanisms underlying MRLS. The results support suggestions that MRLS is caused by exposure to or ingestion of ETCs. The results also show that high levels of ETC exposure produce intense, focused outbreaks of MRLS, closely linked in time and place to dispersing ETCs, as occurred in central Kentucky in 2001. With less intense exposure, lag time is longer and abortions tend to spread out over time and may occur out of phase with ETC exposure, obscuring both diagnosis of this syndrome and the role of the caterpillars.


Alliances, The University Of New Mexico Health Sciences Center Jan 2003

Alliances, The University Of New Mexico Health Sciences Center

Alliances

The University of New Mexico Health Sciences Center magazine.


October - December 2002, January - March 2003 Nhrd Quarterly Report, Unm Health Sciences Library And Informatics Center Jan 2003

October - December 2002, January - March 2003 Nhrd Quarterly Report, Unm Health Sciences Library And Informatics Center

Native Health Database project records

Quarterly report to the IHS about the NHRD.


July - September 2003 Quarterly Report, Unm Health Sciences Library And Informatics Center Jan 2003

July - September 2003 Quarterly Report, Unm Health Sciences Library And Informatics Center

Native Health Database project records

NHDs quarterly report.


October - December 2003 Quarterly Report, Unm Health Sciences Library And Informatics Center Jan 2003

October - December 2003 Quarterly Report, Unm Health Sciences Library And Informatics Center

Native Health Database project records

NHDs quarterly report.


Embryo And Gamete Development Upon Exposure To Cca Components: Cro3, Cuo, And As2o5, Nerbana Talaat-Elsebaei Mahmoud Jan 2003

Embryo And Gamete Development Upon Exposure To Cca Components: Cro3, Cuo, And As2o5, Nerbana Talaat-Elsebaei Mahmoud

Theses and Dissertations in Biomedical Sciences

Production of functional gametes and healthy embryos is essential for proliferation of all vertebrates, especially humans. Many compounds have toxic effects on developing gametes and embryos among which are chromium trioxide (CrO3), cupric oxide (CuO) and arsenic pentaoxide (As2O5) as a mixture (CCA) or individually. Controversy surrounding the safety of CCA-treated wood centers primarily on the toxicity of its components and the potential for these metals to be released from the wood.

The aim of this research is to test the hypothesis that CCA components have deleterious effects on embryo development, oocyte maturation and …


Keberkesanan Latihan Bebanan Terhadap Peningkatan Kuasa Kaki Pelajar-Pelajar Perempuan Tingkatan 4, Ying Gay Tan Jan 2003

Keberkesanan Latihan Bebanan Terhadap Peningkatan Kuasa Kaki Pelajar-Pelajar Perempuan Tingkatan 4, Ying Gay Tan

Student Works (2000-2009)

Tujuan Kajian ini dijalankan adalah untuk mengkaji kesan latihan bebanan terhadap peningkatan Kuasa kaki pelajar-pelajar perempuan berumur 16 tahun (tingkatan 4) dalam sesuatu program latihan. Kajian latihan bebanan adalah berfokus pada kuasa kaki. Kajian ini melibatkan seramai 62 orang subjek perempuan (N=62) dari populasi 134 pelajar Tingkatan 4 yang sedang menuntut di sebuah sekolah di Kuala Kubu Bharu. Dari empat buah kelas Tingkatan 4, dua kelas dipilih secara rawak. Satu kelas dipilih secara rawak untuk dijadikan Kumpulan Kawalan iaitu 28 subjek (N=28) dan satu lagi kelas dijadikan Kumpulan Rawatan iaitu 34 subjek (N=34 ). Kaedah 'intact sampling' digunakan dimana semua …


Lip Profile Preferences In Varying Sagittal Mandibular Positions, Grant Gordon Coleman Jan 2003

Lip Profile Preferences In Varying Sagittal Mandibular Positions, Grant Gordon Coleman

Theses and Dissertations

The purpose of this study was to determine the influence of sagittal mandibular position on preferred lip position in profile. Five androgynous silhouette profiles differing only in the degree of mandibular retro- or prognathism (-25º, -18º, -11º, -4º, & +3º facial contour angles) were created. Using a computer animation program, evaluators moved the lips independently into the position deemed to be the most esthetic for each profile. Evaluators included adolescent orthodontic patients, parents of patients, and orthodontists. In general, no differences in preferred lip position were found between the –11º & -4º profiles or between the –18º & +3º profiles, …


An In-Vitro Comparison Of The Retention Of Prefabricated Parallel-Sided Vented Titanium Posts Cemented With Three Different Dual-Polymerizable Resin Cements, Maha Mamdouh Mostafa El-Sayed Jan 2003

An In-Vitro Comparison Of The Retention Of Prefabricated Parallel-Sided Vented Titanium Posts Cemented With Three Different Dual-Polymerizable Resin Cements, Maha Mamdouh Mostafa El-Sayed

Theses and Dissertations

AbstractAN IN-VITRO COMPARISON OF THE RETENTION OF PREFABRICATED PARALLEL-SIDED VENTED TITANIUM POSTS CEMENTED WITH THREE DIFFERENT DUAL-POLYMERIZABLE RESIN CEMENTSBy Maha M. El-Sayed, B.D.S., D.M.D.A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University.Virginia Commonwealth University, 2003Thesis Director: David R. Burns, D.M.D. Associate Professor and Program DirectorGraduate ProsthodonticsDepartment of ProsthodonticsPurpose: The purpose of this in-vitro study was to compare the retentive strength of an autopolymerizing resin cement to three dual-polymerizable resin cements when used to cement paraposts without light activation and to relate diametral tensile stress and hardness as a measure …


Orthodontic Faculty Recruitment And Retention: Goals And Perceptions, Sheldon L. Peck Jan 2003

Orthodontic Faculty Recruitment And Retention: Goals And Perceptions, Sheldon L. Peck

Theses and Dissertations

There is a shortage of faculty in academic dentistry and orthodontics in particular. The purpose of this study was to quantify real and perceived differences in income, workload, and satisfaction between full-time academic and private practice orthodontists. Surveys were returned by 119 (70%) faculty, 79 (36%) private practitioners, and 160 (59%) orthodontic residents. Average annual income for faculty was less than half that of private practitioners. Faculty also reported working significantly more hours per week and taking less vacation time. Though both faculty and practitioners perceived their own jobs to be more satisfying overall, faculty felt academics was more stressful, …


A Rural Vs. Urban Analysis Of Procedures Provided To Medicaid Recipients By Pediatric, General, And Public Health Dentists In The Commonwealth Of Virginia: Fiscal Years 1994-1995, Frank Carmen Pettinato Jan 2003

A Rural Vs. Urban Analysis Of Procedures Provided To Medicaid Recipients By Pediatric, General, And Public Health Dentists In The Commonwealth Of Virginia: Fiscal Years 1994-1995, Frank Carmen Pettinato

Theses and Dissertations

Purpose: The purpose of this study was to report the distribution of procedures provided to Virginia Medicaid children by three types of dental providers in rural and urban areas. Methods: Medicaid claims filed for dental patients younger than 21 were obtained and analyzed for fiscal years 1994 and 1995. Dental providers were categorized according to their practice type: general practice (GP), pediatric (PD) and public health (PH) dentists. Each type of practice was categorized as practicing in a Metropolitan, Urban, Rural or Completely Rural location and evaluated for percentages of preventive, diagnostic, and corrective services provided.Results: The number of procedures …


Measurement Of Forces And Moments In Three-Dimensional Archwires, Dwight Van Buelow Jan 2003

Measurement Of Forces And Moments In Three-Dimensional Archwires, Dwight Van Buelow

Theses and Dissertations

AbstractMEASUREMENT OF FORCES AND MOMENTS IN THREE-DIMENSIONAL ARCHWIRESBy Dwight V. Buelow, D.D.S.A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University.Virginia Commonwealth University, 2003Major Director: Steven J. Lindauer, D.M.D., M.D.Sc.Chairman and Professor, Department of OrthodonticsOrthodontic tooth movement occurs in response to the application of controlled mechanical force systems. The purpose of this study was to improve understanding of those force systems by evaluating differences between the resultants of two-dimensional and three-dimensional orthodontic appliance activations. An in-vitro model was constructed and three force-moment gauges were used to measure the forces and …


The Effect Of Endodontic Solutions On Resorcinol-Formalin Paste In Teeth, Madelyn Gay Gambrel Jan 2003

The Effect Of Endodontic Solutions On Resorcinol-Formalin Paste In Teeth, Madelyn Gay Gambrel

Theses and Dissertations

This study determined if any of six endodontic solutions would have a softening effect on resorcinol-formalin paste in extracted teeth, and if there were any differences in the solvent action between these solutions. Forty-nine single-rooted extracted teeth were decoronated two mm coronal to the CEJ, and the roots sectioned apically to a standard length of 15 mm. Canals were prepared to a 12mm WL and a uniform size with a #7 Parapost drill. Teeth were then mounted in a cylinder ring with acrylic. The resorcinol-formalin mixture was placed into the canals and was allowed to set for 60 days in …


K3 Endo, Pro Taper, And Pro File Systems: Breakage And Distortion In Severely Curved Roots Of Molars, Matthew Todd Ankrum Jan 2003

K3 Endo, Pro Taper, And Pro File Systems: Breakage And Distortion In Severely Curved Roots Of Molars, Matthew Todd Ankrum

Theses and Dissertations

K3 ENDO, PRO TAPER, AND PRO FILE SYSTEMS: BREAKAGE AND DISTORTION IN SEVERELY CURVED ROOTS OF MOLARS.By Matthew T. Ankrum, D.D.S.A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University.Virginia Commonwealth University, 2003Major Director: Gary R. Hartwell, D.D.S., M.S.Chairman and Professor, Department of EndodonticsIt was the aim of this study to investigate the incidence of file breakage and distortion when the Pro Taper, K3 Endo and ProFile systems were used to instrument canals in the severely curved roots of extracted molars.Forty-five roots of extracted mandibular and maxillary molars with curvatures …


The Bond Strength Of Adhesive Resin Cement: Time Differential Between Cementation And Finishing Of Cast Dowel-Cores, Purnima Joan Shahani Jan 2003

The Bond Strength Of Adhesive Resin Cement: Time Differential Between Cementation And Finishing Of Cast Dowel-Cores, Purnima Joan Shahani

Theses and Dissertations

THE BOND STREGTH OF ADHESIVE RESIN CEMENT: TIME DIFFERENTIAL BETWEEN CEMENTATION AND FINISHING OF CAST DOWEL-CORES By Purnima Joan Shahani, D.D.S., M.S.A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University.Virginia Commonwealth University, 2003Major Director: Peter C. Moon, M.S., PhDDirector of VCU Dental Biomaterials LaboratoryThis study compared the retention of cast dowel-cores cemented with Panavia® 21 subjected to immediate versus delayed high-speed finishing. Conventionally, finishing is delayed for 24 hours to one week to allow for optimal setting and ultimate strength of the cement. Forty-five recently extracted human …


Encouraging Adolescents Toward Mental Health Careers Via Website Biographies, Irmi U. Willcockson, Prabhu R. Shankar, Cynthia L. Phelps, Craig W. Johnson Jan 2003

Encouraging Adolescents Toward Mental Health Careers Via Website Biographies, Irmi U. Willcockson, Prabhu R. Shankar, Cynthia L. Phelps, Craig W. Johnson

Faculty, Staff and Student Publications

This project designed, developed, implemented and is currently evaluating the effectiveness of an interactive, multi-media website designed to encourage adolescents to consider careers in mental health. This Web-based learning environment features biographies of mental health scientists. Evaluation is conducted in a systematic, structured way using cognitive achievement, usability (ease of use), and affective scales (e.g., fun to use) as outcome measures


Rigorously Assessing Whether The Data Backs The Back School, David T. Vinh, Craig W. Johnson, Cynthia L. Phelps Jan 2003

Rigorously Assessing Whether The Data Backs The Back School, David T. Vinh, Craig W. Johnson, Cynthia L. Phelps

Faculty, Staff and Student Publications

A rigorous between-subjects methodology employing independent random samples and having broad clinical applicability was designed and implemented to evaluate the effectiveness of back safety and patient transfer training interventions for both hospital nurses and nursing assistants. Effects upon self-efficacy, cognitive, and affective measures are assessed for each of three back safety procedures. The design solves the problem of obtaining randomly assigned independent controls where all experimental subjects must participate in the training interventions.


Randomized Comparisons Among Health Informatics Students Identify Hypertutorial Features As Improving Web-Based Instruction, Craig W. Johnson, Yan Xing, Lan Yang Jan 2003

Randomized Comparisons Among Health Informatics Students Identify Hypertutorial Features As Improving Web-Based Instruction, Craig W. Johnson, Yan Xing, Lan Yang

Faculty, Staff and Student Publications

Hypertutorials optimize five features - presentation, learner control, practice, feedback, and elaborative learning resources. Previous research showed graduate students significantly and overwhelmingly preferred Web-based hypertutorials to conventional "Book-on-the-Web" statistics or research design lessons. The current report shows that the source of hypertutorials' superiority in student evaluations of instruction lies in their hypertutorial features. Randomized comparisons between the two methodologies were conducted in two successive iterations of a graduate level health informatics research design and evaluation course. The two versions contained the same text and graphics, but differed in the presence or absence of hypertutorial features: Elaborative learning resources, practice, feedback, …


The Physician's Perception Of Medical Error And Its Application To The Development Of An Educational Training Tool, Johnny E. Bates, Cynthia Phelps, Craig W. Johnson Jan 2003

The Physician's Perception Of Medical Error And Its Application To The Development Of An Educational Training Tool, Johnny E. Bates, Cynthia Phelps, Craig W. Johnson

Faculty, Staff and Student Publications

It is becoming clear that if we are to impact the rate of medical errors it will have to be done at the practicing physician level. The purpose of this project was to survey the attitude of physicians in Alabama concerning their perception of medical error, and to obtain their thoughts and desires for medical education in the area of medical errors. The information will be used in the development of a physician education program.


High Frequency Pure Tone Audiometry And High Frequency Distortion Product Otoacoustic Emissions: A Correlational Analysis, Kimberly J. Lavoie Jan 2003

High Frequency Pure Tone Audiometry And High Frequency Distortion Product Otoacoustic Emissions: A Correlational Analysis, Kimberly J. Lavoie

Dissertations and Theses

Previous studies show that pure tone thresholds are strongly correlated with distortion product otoacoustic emission amplitudes when evaluating the frequency range from 1 to 8 kHz (Avan & Bonfils, 1993). Little is known about correlations between these two measures at higher frequencies from 9-16 kHz. This study compared pure tone thresholds and distortion product otoacoustic emissions (DPOAEs) in this high frequency range for 29 normal hearing subjects ages 18-30. Pure tone thresholds were obtained at 250-16 kHz and distortion product otoacoustic emissions (DPOAE) 2,211-17,675 were measured in the same ears. DPOAE amplitudes were measured using a constant F1/F2 ratio of …


Immunological, Hematological, And Serum Biochemical Effects Of High Level Dietary Fish Oil And Vitamin E Supplementation In The Dog, Casey J. Leblanc Jan 2003

Immunological, Hematological, And Serum Biochemical Effects Of High Level Dietary Fish Oil And Vitamin E Supplementation In The Dog, Casey J. Leblanc

LSU Doctoral Dissertations

Inflammation is a component of the innate immune response. However, severe or prolonged inflammation can be detrimental. Dietary n-3 fatty acid supplementation has proven clinical benefits in chronic inflammatory diseases, most likely due to reduced synthesis of inflammatory mediators and inhibition of lymphocyte proliferation and function. The purposes of this study were to characterize alterations in inflammatory mediator production, and lymphocyte proliferation, in dogs fed a diet consisting of 0.65% n-3 fatty acids (DMB) with an n-6:n-3 fatty acid ratio of 3.4:1. Fifteen dogs were randomly assigned to one of three dietary groups for twelve weeks. Group Sunflower oil received …


Efecto De La Terapia Hormonal De Reemplazo Sobre La Funcion Cognitiva En La Menopausia, Belinda Hómez De Delgado, Gloria Pino, Gladys E. Maestre Jan 2003

Efecto De La Terapia Hormonal De Reemplazo Sobre La Funcion Cognitiva En La Menopausia, Belinda Hómez De Delgado, Gloria Pino, Gladys E. Maestre

School of Medicine Publications

Objetivo: Determinar el efecto de la terapia de reemplazo hormonal (TRH) sobre la función cognitiva en mujeres postmenopáusicas.

Métodos: Del registro de participantes en el “Estudio Maracaibo del Envejecimiento”, se seleccionaron 72 mujeres menopáusicas, entre 55 y 79 años. Treinta y seis mujeres fueron tratadas con TRH combinada continua con estrógenos equinos conjugados (EEC) y acetato de medroxiprogesterona (AMP) durante un año, y 36 mujeres no recibieron THR: controles, pareados. El grupo1: recibió EEC 0,625mg + AMP 2,5mg; el grupo2: EEC 1,25mg + AMP 5,0mg. A todas las mujeres se le aplicaron pruebas neuropsicológicas, antes y después del tratamiento.

Resultados: …


A Comparison Of Human Energy Fields Among Children, Youth, Adults, & Dahn Masters, Geoffrey K. Leigh, Karen A. Polonko, Catherine D. Leigh Jan 2003

A Comparison Of Human Energy Fields Among Children, Youth, Adults, & Dahn Masters, Geoffrey K. Leigh, Karen A. Polonko, Catherine D. Leigh

Sociology & Criminal Justice Faculty Publications

While concepts and investigations of human energy fields have been developed for centuries, there has been little systematic work comparing the fields of children, adolescents, and adults. In addition, general fields have had little comparison between average adults and those participating in an intense practice that may affect the field. Using the GDV machine, this research compared small groups of children, adolescents, average adults, and Dahn Hak Masters on measures of 20 basic aspects of the human energy fields, including the seven chakras. Differences were found in seven of the 13 field parameters as well as all seven measures of …


Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero Jan 2003

Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero

LSU Doctoral Dissertations

Complete sequencing and annotation of the M. leprae genome has provided new information related to proteins constituting its hypothetical proteome. Since M. leprae can not be grown in vitro, novel approaches are needed to determine which proteins are expressed during infection and whether these proteins are related to pathogenesis. Secreted proteins represent a distinct group of protein with respect to their structure and function, contribution to virulence and are of particular importance for vaccine development because they are often immunogenic and have the potential to be recognized early in infection. The objectives of this study were: 1) to identify putatively …


Role Of Endothelin In The Pathogenesis Of Acute Laminitis In Horses, Ashley Michelle Stokes Jan 2003

Role Of Endothelin In The Pathogenesis Of Acute Laminitis In Horses, Ashley Michelle Stokes

LSU Doctoral Dissertations

Acute laminitis is a severely debilitating disease of the laminae of the equine digit; however, the mechanism(s) of pathogenesis have yet to be fully elucidated. In physiologic states, the endothelium synthesizes substances, such as nitric oxide (NO; vasodilator) and endothelin-1 (ET-1; profound vasoconstrictor), which play a crucial role in vasomotor regulation. The overall hypothesis is that the initiating factor in the onset of acute laminitis is a disruption in the balance between NO and ET-1, which leads to digital vasoconstriction and subsequent laminar ischemic necrosis. In vitro studies with digital vessels from healthy horses and horses with naturally-acquired laminitis determined …


Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena Jan 2003

Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena

LSU Doctoral Dissertations

To study the protective responses of cyathostome-infected ponies, two challenges were performed employing animals with different histories of exposure to these parasites. The hypothesis developed and to be tested in these experiments was that ponies that had longer exposure to cyathostome contaminated pastures would express acquired resistance to infection. The assumption behind this hypothesis was that helminth-naïve ponies infected with cyathostomes would eliminate the infection using only innate immune responses. Whereas previously exposed ponies would eliminate the infection with acquired immune responses, and these would be more effective in ponies with longer exposure to cyathostomes. Thus, helminth-naïve animals would acquire …