Medicine and Health Sciences Commons^™

Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: Fasl/Fas-Mediated Inhibition Of Cd4+ And Cd8+ Antiviral T Cells By Viral Antigen-Positive Veto Cells, Robert F. Rich, William R. Green

Dartmouth Scholarship

C57BL/6 (H-2^b ) mice generate type-specific cytolytic T-lymphocyte (CTL) responses to an immunodominant K^b-restricted epitope, KSPWFTTL located in the membrane-spanning domain of p15TM of AKR/Gross murine leukemia viruses (MuLV). AKR.H-2^b congenic mice, although carrying the responder H-2^b major histocompatibility complex (MHC) haplotype, are low responders or nonresponders for AKR/Gross MuLV-specific CTL, apparently due to the presence of inhibitory AKR.H-2^b cells. Despite their expression of viral antigens and K^b, untreated viable AKR.H-2^b spleen cells cause dramatic inhibition of the C57BL/6 (B6) antiviral CTL response to in vitro stimulation with AKR/Gross MuLV-induced …

Farmer Killed When Tractor Punctures Gas Line Causing An Explosion, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 62-year-old male was killed when the tractor he was operating punctured an aboveground gas line. He had recently moved to the area and was in the process of acquiring some land for farming. The land was overgrown with weeds and brush about 5 feet high. On a warm, clear afternoon he went out to clear the land with a tractor and rotary mower. Although the incident was unwitnessed, apparently he began mowing the field near a roadway and was likely on the third pass when the front of the tractor ran into an aboveground valve of a natural gas …

What's Happening: January 20, 1999, Maine Medical Center

What's Happening

No abstract provided.

In Sports Marketing, Only Constant Is Change, Rick Burton

Sport Management - All Scholarship

No abstract provided.

In The Affirmative, Vol.6, No.1 (Mid-January/Mid-February 1999), Mike Martin, The Aids Project

In the affirmative (1993-1999)

No abstract provided.

The Ecological Validity Of Jury Simulations: Is The Jury Still Out?, Brian H. Bornstein

Department of Psychology: Faculty Publications

Despite the need to assess the ecological validity of jury simulation research before generalizing from simulations to the behavior of real jurors, surprisingly little jury research has directly addressed issues of validity. The present paper reviews the extant research on two aspects of the validity question—specifically, research that has compared different samples of mock jurors, and research that has manipulated the medium of trial presentation. In addition, jury simulation research published in the first 20 years of Law and Human Behavior is analyzed with respect to these variables. The majority of simulations used student-jurors and presented the trial in written …

Locomotion And Conditioned Place Preference Produced By Acute Intravenous Amphetamine: Role Of Dopamine Receptors And Individual Differences In Amphetamine Self-Administration, M. T. Bardo, J. M. Valone, Rick A. Bevins

Department of Psychology: Faculty Publications

Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on single-trial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1–3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both …

Transgenic Mice Which Overexpress Neurotrophin-3 (Nt-3) And Method Of Use, Kathryn M. Albers, Brian M. Davis

Neuroscience Faculty Patents

Transgenic mice express increased levels of neurotrophin-3 (NT-3) in epithelium when their ancestors are microinjected with the NT-3 gene. The NT-3 growth factor expressing transgenic mice are useful in the study of neurodegenerative disorders of the brain such as Parkinson's syndrome and Alzheimer's disease, of the spinal cord motor neurons such as amyotrophic lateral sclerosis, and for testing drug candidates for the treatment of these diseases.

Canavanine Analogs And Their Use As Chemotherapeutic Agents, Peter A. Crooks, Gerald A. Rosenthal

Pharmaceutical Sciences Faculty Patents

This invention relates to canvanine analogs, their pharmaceutical compositions, and a method for treatment of cancer, particularly pancreatic cancer.

Ada News - 01/11/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Integrin-Dependent Control Of Translation: Engagement Of Integrin Alphaiibbeta3 Regulates Synthesis Of Proteins In Activated Human Platelets., Ravinder Pabla, Andrew S. Weyrich, Dan A. Dixon, Paul F. Bray, Thomas M. Mcintyre, Stephen M. Prescott, Guy A. Zimmerman

Cardeza Foundation for Hematologic Research

Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell-cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to influence gene expression by regulating transcription. In previous studies we found that platelets, which are naturally occurring anucleate cytoplasts, translate preformed mRNA transcripts when they are activated by outside-in signals. Using strategies that interrupt engagement of integrin alphaIIbbeta3 by fibrinogen and platelets deficient in this integrin, we found that alphaIIbbeta3 regulates the synthesis of B cell lymphoma 3 (Bcl-3) when platelet aggregation is induced …

Factors In Pediatrician Medication Administration, Kathleen Elaine Campbell

Masters Theses

King’s conceptual framework was used to examine the relationship between nurses’ stated beliefs of goals of pain management, their personal experience of pain, and their educational levels when choosing to intervene in the management of pain for pediatric patients. A descriptive correlational design was used with a convenience sample of 51 registered nurses in a West Michigan children’s hospital.

No significance was found between the goal of pain management and the level of stated intentions to intervene, the education level of the nurse and stated intentions to intervene, and nurses who have had a personal pain experience and their stated …

What's Happening: January 6, 1999, Maine Medical Center

What's Happening

No abstract provided.

Caduceus 1999, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.

Gender Differences In Mentoring In Australia: Mentor Functions And Outcomes, Terri A. Scandura Phd, Ethlyn A. Williams

Management Faculty Articles and Papers

The issue of gender differences in mentoring remains controversial since some studies find gender differences and many do not. Perhaps the context of the mentoring relationship provides an explanation of why gender affects mentoring in some studies. Since most studies of mentoring to date have employed U.S, samples, the question of whether gender differences may emerge in studies of menta ring in non-U.S. samples needs investigation. The present study will examine the role of gender, mentoring functions and the interactive effects of gender and mentoring in relation to career expectations, job satisfaction and organizational commitment in a sample of N=156 …

Modulation Of The Bursting Properties Of Single Mouse Pancreatic Β-Cells By Artificial Conductances, T.A. Kinard, G. De Vries, A. Sherman, L. S. Satin

Pharmacology and Toxicology Publications

Abstract

Glucose triggers bursting activity in pancreatic islets, which mediates the Ca²⁺ uptake that triggers insulin secretion. Aside from the channel mechanism responsible for bursting, which remains unsettled, it is not clear whether bursting is an endogenous property of individual β-cells or requires an electrically coupled islet. While many workers report stochastic firing or quasibursting in single cells, a few reports describe single-cell bursts much longer (minutes) than those of islets (15–60 s). We studied the behavior of single cells systematically to help resolve this issue. Perforated patch recordings were made from single mouseβ-cells or hamster …

Utilization Of Mental Health Services, Kevin M. Chun, P D. Akutsu

Psychology

No abstract provided.

The Continuing Decline In Medicaid Coverage, Leighton Ku, Brian K. Bruen

Health Policy and Management Faculty Publications

No abstract provided.

The Use Of Metaphor Graphics To Depict Sleep Research Results, Judith A. Floyd

Nursing Faculty Research Publications

Many nurses are not familiar with the highly technical language of research and the types of graphics that researchers use to communicate findings, creating a major barrier to research utilization in nursing. In an effort to find alternative approaches to displaying research results, W.G. Cole introduced "metaphor graphics" a decade ago as a way of graphically representing knowledge. He proposed that data be summarized using visual metaphors - i.e., abstract signs and symbols - to show patterns and convey meaning. Viewing human beings as imperfect processors of information who tend to reason using pattern recognition and mental models, Cole hypothesized …

Predictors Of Social Physique Anxiety In Adolescent Swimmers With Physical Disabilities, Jeffrey J. Martin

Kinesiology, Health and Sport Studies

The purpose was to examine predictors of social physique anxiety (SPA) in adolescent swimmers with physical disabilities. Participants were 57 swimmers (27 females, 30 males, ages 16-19, M = 16.2) with various physical disabilities. A three-way ANOVA revealed significant differences in SPA between countries and among disabilities but not gender. Stepwise multiple regression results indicated that self-esteem and the self-identity subscale of the Athletic Identity Measurement Scale (AIMS) were the best predictors of SPA but that gender, country, and type of disability were not significant.

Housing And Population Health: A Review Of The Literature, Stephen Hwang, Esme Fuller-Thomson, J. David Hurlchanski, Toba Bryant, Youssef Habib, Wendy C. Regoeczi

Sociology & Criminology Faculty Publications

Research into the relationship between housing and health has frequently been narrowly focused, fragmented, and of marginal practical relevance to either housing or health studies. Population health research, in its reference to the importance of the social and physical environment, rarely mentions housing. While it has been recognized for some time that there is a need for the development of a co-ordinated, integrated and cumulative body of housing and health research, there is still very little formal co-ordination between housing policy and population health policy. More attention needs to be paid to measuring the nature and extent to which better …

Low Vision In Older Adults, Jeffrey C. Michaels, Mary D. Bullock

Case Studies from Age in Action

Educational Objectives

1. Understand the epidemiology of visual impairments of older adults.

2. Understand the symptoms of functional loss secondary to visual impairments.

3. Understand the rehabilitative options available for those with vision loss.

4. Understand the multi-disciplinary approach in low vision rehabilitation.

5. Understand the impact of low vision rehabilitation services.

Ethical Concerns In The Care Of Individuals With Alzheimer’S Disease, Jeanne Sorrell

Case Studies from Age in Action

Educational Objectives

1. Identify important ethical concerns in the care of individuals with Alzheimer's Disease.

2. Describe the use of the Fairhill Guidelines as a frame-work for study of ethical issues related to the care of individuals with Alzheimer's Disease.

3. Discuss interventions to assist individuals with dementia and their family members in exploring ethical concerns.

Merging A Divided System: The Need To Integrate Care For Individuals Participating In Both The Medicare And Medicaid Programs, Regina L. Anderson-Cloud

Case Studies from Age in Action

Educational Objectives

1. Identify the underlying premises of the need to integrate care between the Medicare and Medicaid programs for individuals eligible for both insurances.

2. Discuss innovations aimed at assisting older adults with an improved Medicare/Medicaid system.

3. Describe relevant health care concerns related to the current fragmentation of the health care system for older adults who possess both Medicare and Medicaid.

Geriatric Interdisciplinary Team Training, Rita Jablonski, David A. Cifu, Peter A. Boling, Patricia Slattum, A. Leigh Peyton, F. Ellen Netting, Iris A. Parham, Joan B. Wood

Case Studies from Age in Action

Educational Objectives

1. To demonstrate the importance of training health care professionals in inter-disciplinary teamwork and geriatric health issues.

2. To increase one’s knowledge of the roles and responsibilities of the various disciplines involved in interdisciplinary teamwork.

Ovulatory And Metabolic Effects Of D-Chiro-Inositol In The Polycystic Ovary Syndrome, John E. Nestler, Daniela J. Jakubowicz , M.D., Paula Reamer , M.A., Ronald D. Gunn , M.S., Geoffrey Allan , Ph. D.

Obstetrics and Gynecology Publications

BACKGROUND

Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a d-chiro-inositol–containing phosphoglycan that mediates the action of insulin. We hypothesized that the administration of d-chiro-inositol would replenish stores of the mediator and improve insulin sensitivity.

METHODS

We measured steroids in serum and performed oral glucose-tolerance tests before and after the oral administration of 1200 mg of d-chiro-inositol or placebo once daily for six to eight weeks in 44 obese women with the polycystic ovary syndrome. The serum progesterone concentration was measured weekly to monitor for …

Alertness-Supporting Activities For Control Room Operators In Automated Industrial Plants, Roger C. Jensen

Safety Health & Industrial Hygiene

A survey of control room operators in a nuclear power plant identified practical activities for maintaining alertness during the early morning hours. Nine on-duty operators rated 16 activities they were allowed to do on shift. Activities most effective for alertness were splashing cool water on the face, drinking coffee, and doing things that used muscles. The least effective activities were passive monitoring and studying for exams. The large range of ratings indicates that activity has a major role in operator alertness during the early morning hours.

University Of South Alabama College Of Medicine Annual Report For 1999-2000, College Of Medicine

COM Annual Reports

The annual report of the University of South Alabama College of Medicine documents the achievements of the faculty in the areas of teaching, research, and service. These efforts and accomplishments are instrumental in enhancing the health and overall quality of life of people in the State of Alabama and throughout the nation. The University welcomes the opportunity to disseminate this information and invites comments and questions related to the contents of this report.

The Cardiovascular And Metabolic Adaptations To Iso-Caloric Moderate Intensity And High Intensity Exercise, Summerson Desmond

Theses, Dissertations and Capstones

Cardiovascular disease is the leading cause of death in the industrialized nations, and accounts for 1 million deaths in the United States each year (McArdle, Katch & Katch, 1991). One of the major risk factors for cardiovascular disease is physical inactivity, which is a behavioral modified risk factor. Physical inactivity plagues 59% of the people in the United States (ACSM Resource Manual, 1998). Physical inactivity often leads to obesity, diabetes, hypertension and hypercholemia, and places sedentary individuals at more risk for cardiovascular disease (CVD), or coronary heart disease (CHD). The question which remains unclear is the quantity and quality of …

Interaction Of Laminin Beta2 With Eps8 And Desmin In Muscle Cells, Luke Xueliang Cui

Theses, Dissertations and Capstones

Laminin β2 is localized to the synaptic basal lamina (BL) in muscle and glomerular BL in kidney. To find interacting proteins, a mouse kidney cDNA library was screened with domain I of rat laminin β2 using the yeast two-hybrid system. Fifteen positive clones were found. The DNA sequence of three each of these clones corresponded to the phosphoprotein Eps8 (epidermal growth factor receptor pathway substrate clone 8, which is tyrosine phosphorylated after EGF stimulation) and the intermediate filament (IF) protein keratin. To determine if this interaction occurred in muscle cells, C2 cells transfected with the rat …