Medicine and Health Sciences Commons^™

The Expression And Function Of Wilms' Tumor 1 In Malignant Glioma, Aaron J. Clark

Theses and Dissertations

The Wilms' tumor 1 gene is overexpressed in many types of cancer and is associated with poor prognosis and resistance to anti-cancer therapies. In vitro studies in non-glioma cells types have demonstrated that WTl plays a role in increased proliferation, resistance to apoptosis, and increased cellular invasion. We aimed to thoroughly characterize the expression pattern of Wilms' tumor 1 in human malignant glioma and discern its function in this complex disease process. We screened a large sample of established human malignant glioma cell lines and glioma tissue specimens of all grades for WT1 expression. The majority of cell lines and …

A Model For Studying Vasogenic Brain Edema, Anshu Shukla

Theses and Dissertations

Convection-enhanced delivery (CED) is a proven method for targeted drug delivery to the brain that circumvents the blood-brain barrier (BBB). Little study has been conducted in understanding CED in pathological brain states. This is of importance when dealing with chemotherapeutic agent delivery to brain tumors, where vasogenic edema (VE) exists. The current study aims to characterize a model of VE suitable for studying CED.VE was produced in the right hemisphere of the rat brain using multiple infusions of hyperosmotic mannitol (0.25mL/kg/s over 30 seconds) delivered through the right internal carotid artery. Magnetic resonance imaging (MRI) revealed consistent edema formation and …

Determinants Of Dating Violence Among Youth In The U.S., Candace Hamm

Theses and Dissertations

Background: Physical Dating Violence (PDV) victimization is a major public health concern among adolescents in the United States. Research has shown that determinants of PDV victimization are different for male and female adolescents. However, inconsistent findings entail that further research needs to be done using a representative sample of male and female adolescents.Objective: To identify gender-specific determinants of PDV victimization utilizing a nationally representative sample of high school adolescents.Methods: Data from the 2005 National Youth Risk Behavior Survey was used for this analysis. The study population included 6.951 male and 6,807 female students in grades 9 through 12. Bivariate and …

Pharmacological Studies Of Nicotine And Galantamine Effects On Age Associated Memory Impairment And The Neurotrophic System In Aged Female Rats, Kristen L. French

MUSC Theses and Dissertations

Nicotine and Galantamine were studied for their pharmacological effects on age associated memory impairment (AAMI) and the neurotrophin system in the aged female F344 rat. Nicotine was found to have dose dependent effects on cognition in the 24 month old rat. A low dose of nicotine improved both working and reference memory (WM, RM) performance on the water radial arm maze and also improved the ability of aged rats to handle an increasing WM load. A high dose did not improve WM and caused deficits in RM, and high cotinine levels in these subjects correlated with worse performance. Nicotine treatment …

Peripheral Arterial Disease Screening Of An Underserved High Risk Population, Laura Walter Triola

UNF Graduate Theses and Dissertations

Disparity in access to health care and preventive services places a heavier burden of morbidity on those with limited access and resources. Underserved populations with decreased access to appropriate health screening and therapeutic interventions often present with increased risks for peripheral arterial disease. Some patients with peripheral arterial disease are asymptomatic and may defer treatment while others present with occlusive disease requiring immediate therapy. Delaying diagnosis and treatment reduces quality of life and functional status. The prevalence of peripheral arterial disease has been extensively studied in the elderly population but the prevalence in the high-risk underserved population is unknown. The …

Women Who Continue Hormone Replacement Therapy Despite Findings From The Women's Health Initiative, Catherine Margaret Greenblum

UNF Graduate Theses and Dissertations

Since the results of the Women's Health Initiative (WHI) study were published in 2002, millions of women and their healthcare practitioners have had to re-examine decisions about the use of hormone replacement therapy. This level one descriptive study explored the characteristics of menopausal women who could not tolerate estrogen withdrawal and continued taking hormone replacement therapy despite findings of risk published in the Women's Health Initiative. The sample included the medical records of 1,195 patients in a single-physician OB-GYN practice in northeast Florida. All records of women with a birth date in 1954 or prior and a visit to the …

Adults With Low Vision: Continuing Education For Occupational Therapists And Occupational Therapy Students, Ashley Berglund, Kelli Hughes

Occupational Therapy Capstones

Low vision is a condition that occurs when an individual has "some amount of usable vision, but their visual functioning is impaired and interferes with their ability to carry out desired tasks" (Lampert & Lapolice, 1995, p. 885). Impairments in vision cause disruptions in areas of daily living including work and leisure, routines, habits, roles, and social participation. There is a great need for holistic and client-centered occupational therapy in low vision rehabilitation services to improve an individual's functional performance and overall quality of life.

A comprehensive literature review was conducted on low vision definitions and medical conditions, the variety …

Assistive Technology Guide For The Occupational Therapy Treatment Of Elementary School-Aged Children With Duchenne Muscular Dystropy, Kara Cook, Jessica Mcmahan

Occupational Therapy Capstones

No abstract provided.

Eating Disorders: A Guide For The Occupational Therapist, Randi Horner

Occupational Therapy Capstones

Eating disorders are serious illnesses that can impact physical and mental health. Increasingly, occupational therapists encounter this population in general psychiatric hospitals and treatment facilities, as well as specialized eating disorders treatment facilities. Yet, questions concerning the role of occupational therapy in the treatment of eating disorders remain. The purpose of this project is to increase the awareness of the role of occupational therapy in the treatment of eating disorders by providing a guide for effective treatment of these illnesses. A literature review includes information regarding eating disorders, the demographics and diagnostic criteria of eating disorders, multidisciplinary treatment settings and …

A Hippotherapy Protocol For Occupational Therapists, Callie Holt, Kirsten Sonderland

Occupational Therapy Capstones

Hippotherapy is an occupational, physical, and speech therapy treatment strategy that utilizes equine movement. Hippotherapy is utilized as part of an integrated treatment program to achieve functional outcomes. In hippo therapy, the client engages in activities that are enjoyable and challenging while the therapist modifies the horse's movement and grades sensory input to improve neurological function and sensory processing (American Hippotherapy Association, 2003).

The purpose of this scholarly project was to create a hippotherapy protocol for occupational therapists interested in developing a hippotherapy program. It was the intent that this hippotherapy protocol be utilized with individuals of all ages who …

A Wellness Program Module For Employees Of A Skilled Nursing Facility, Cindy Janssen

Occupational Therapy Capstones

No abstract provided.

Aquatic Therapy For Clients With Neurological Impairments: An Introductory Manual For Occupational Therapists, Jason C. Kjar

Occupational Therapy Capstones

No abstract provided.

A Model And Resource For Organizational Leadership For Occupational Therapists, April M. Kingsbury

Occupational Therapy Capstones

No abstract provided.

Training Assistance For Caregivers Working With Students With Traumatic Brain Injury, Randi L. Price

Occupational Therapy Capstones

Students who have suffered a traumatic brain injury (TBI) often require assistance from a variety of professionals and staff to complete their daily routines. Frequently it is a classroom assistant (paraprofessional), under the direction of a teacher, who attends to the student's basic and daily needs. Teachers and their assistants may receive some general training, but assistants, especially, are seldom offered an opportunity to attend trainings specific to managing the needs, difficulties, and behaviors that they are likely to encounter in their students. Unfortunately, according to J. Shuiz, Training Director and Special Education Services Coordinator for Natrona County School District …

A Family Guide To The Neonatal Intensive Care Unit, Merri M. Reese, Lori M. Thompson

Occupational Therapy Capstones

One of the many challenges facing health care professionals practicing in the neonatal intensive care unit (NICU) is providing appropriate care that is sensitive, individualized, and supportive to infant development and parental roles (Lawhon, 2002). Because the families are often the ultimate advocates and caregivers for infants in the NICU it is important that they understand and take part in their babies' care. Therefore, by providing clear and easy to understand explanations of equipment, technology, and procedures that are a part of the NICU environment, professionals can help alleviate parental stress and promote parental involvement.

An extensive review of literature …

Recreational Manual For Caregivers Of Individuals With Cerebral Palsy, Erica Bucher

Occupational Therapy Capstones

A brief literature review was conducted on cerebral palsy to gain general information and statistics. After reviewing the literature, it was noted that there is a significantly high number of children diagnosed with cerebral palsy each year. These individuals are at a high risk to experience the lack of opportunity for a wide choice of recreational activities. To understand the magnitude of the problem an extensive literature review was done on this topic. It was found that the lack of access and participation in independent recreational opportunities may lead to the development of dependent behavioral patterns, learned helplessness and depression. …

Resource Manual For Rural Occupational Therapy Practitioners, Janae Marie. Hughes

Occupational Therapy Capstones

Rural hospitals have been an integral part of the culture of rural America, where clients were once able to seek services needed in their hometowns. Now more than ever, rural facilities are facing increased challenges to remain viable and at the same time continue to deliver high quality care to their communities (American Hospital Association, 2005). With small towns becoming smaller, it is becoming increasingly difficult to recruit allied health professionals to these areas. The reasons for this vary from area to area yet there are some commonalities such as; the misperceptions of limited community activities and resources, lower pay …

A Treatment Protocol Utilizing Sensory Integrative Techniques For Treating Self-Mutilation, Nikki Stevens

Occupational Therapy Capstones

“It is estimated that one to two million people in the United States intentionally and repeatedly bruise, cut, burn, mark, scratch and mutilate different parts of their own bodies. This estimate represents only the adolescents and adults who actually seek help for the behavior” (Ferentz, 2002). The reasons for self-mutilation behaviors span across a considerable range from post-traumatic stress disorder to hypersensitivity. The research indicates parallels between children who have been sexually, physically, or emotionally abused and self-mulitlation. Basically, it is an unhealthy coping strategy to deal with overwhelming and intense feelings. The current treatment regime varies and includes: medication, …

Mental Illness And Barriers To Health Care Access, Charlene Powell

MPA/MPP/MPFM Capstone Projects

Statement of Problem

Access to health care in the United States is major concern, despite the fact that the country spends more per capita on health care than any other country. Individuals with mental illness may face greater access problems than the general population.

Research Question

• Does mental illness predict greater difficulties with access to health care?

Methodology

The 2004 National Health Interview Survey (NHIS) was used to examine the barriers to health care among individuals reporting a mental illness diagnosis. Nine questions relating to health access problems were drawn from the survey and combined into an access index. Multivariate …

Ky Pharmacists’ Perceptions On Medication Errors (Me): A Tool For Legitimate Discussions With The Kentucky Board Of Pharmacy?, J. D. Hammond

MPA/MPP/MPFM Capstone Projects

No executive summary.

The Effect Of Variability In Substance Abuse And Dependence Terminology On Physicians' Prescribing Decisions, Lisa Rochelle Burroughs Phipps

Theses and Dissertations

Prescription drug abuse is a continuing problem in the United States. Educating physicians on issues related to prescription drug abuse is a key factor in preventing and treating this problem. High variability has been found in substance abuse terminology in the literature, textbooks, and FDA-approved product labeling. This dissertation describes a survey study designed to address how the variability in substance abuse terminology, specifically package inserts, affects the prescribing decisions made by physicians.A random sample of 1008 physicians currently licensed and residing in the Commonwealth of Virginia received a letter of explanation, a self-administered questionnaire, and a follow-up reminder and …

Universal Design: An Educational Presentation For Occupational Therapy Students, Steve Fugere, Heather Grasser

Occupational Therapy Capstones

Purpose: Universal design is an emerging practice area within the profession of occupational therapy. Because universal design is an emerging area, educational resources on the topic are limited. If practitioners wish to work in this emerging area, more knowledge and skills need to be developed. The purpose of this scholarly project was to create a resource that could be used to educate occupational therapy students on universal design concepts. Information included in the presentation will help students understand the role of the occupational therapist in the design process.

Method: A literature review was conducted to examine the impact of the …

Body Mechanics Program For A Material Handling Environment, Jeremy Laine

Occupational Therapy Capstones

A series of improper body mechanics can lead to injury with in a manual material handling environment (Hagan, 2001). Improper body mechanics are a result of poor work habits that negatively reinforce a worker. When a worker in a manual material handling environment conducts his or her essential job functions, while ambulating to do their job, certain behaviors negatively reward a worker such as completing their tasks faster or what is perceived as more efficient. These behaviors specifically include, but are not limited to: increasing job pace or reckless speed, twisting repetitively, bending at the pelvis, back extension, forceful action, …

Giving All Children A Good Start To School: A Protocol In Defining Occupational Therapist's Role In School Readiness, Specifically In The Smart Program, Melissa Boll

Occupational Therapy Capstones

More children are entering school "not ready." Current research is showing that many "healthy" children are entering school not developmentally ready for formal learning. Based my own experiences working as a school occupational therapist for the past four years in rural area schools, this new trend is becoming more apparent. Teachers and other school professionals have increasing concerns over the numbers of children that seem "clumsy" or "awkward" compared to their peers. Children are expected to learn more than ever before upon entering school, the curriculum is no longer age-appropriate due to the pushing down of academics. Upon entrance to …

Exploring The Notion Of Emotional Attachment In Orford's Model Of Addiction : Review, And A Step Towards Operationalising Orford's Concept Of Strong Attachment In Addiction : A Qualitative Study, Kate E. Baily

Theses : Honours

Orford's (2001) notion that a strong emotional attachment to an object (drug) or activity (gambling) is a central component of addiction has received little empirical attention. The published research on attachment to inanimate objects was reviewed and led to the following conclusions. First, attachment theory has been validly applied to people's relationships with inanimate objects. Second, researchers have developed technologies (e.g., psychological measures, operational definitions) to enable empirical research in this area. Third, this research is in its early phases, but has produced reliable standardised measures of people's emotional attachment to brands. Further research is needed to operationalise Orford's (2001) …

Effect Of A Paediatric Incentive Spacer And Reinforcement Of Inhalation Technique Training In Preschool Children, Jasminka Murdzoska

Theses : Honours

Incorrect inhaled drug delivery technique is a common problem in paediatric asthma [1-4]. Previously, device technique training has been shown to significantly improve inhaler skills, using subjective methods, namely check-list analysis [5-8]. However, more objective measures are needed to examine more comprehensively the effect of training in preschool children and parents. Resistance to regular asthma therapy is also a frequent problem when attempting to treat young children. Reasoning with young children can be very difficult and parents often have to struggle with their child to achieve compliance [2]. The Funhaler spacer (FH) (Funhaler™; InfaMed, Australia) has been developed in an …

How Mothers Orchestrate Their Engagement In An Early Intervention Program, Patricia Eileen Brennan

Master's Theses and Doctoral Dissertations

A family-centered approach was espoused in IDEA Part C as the context for service to families with young children experiencing developmental delays. A phenomenological inquiry was conducted to explore how mothers of young children with disabilities orchestrate their engagement in an early intervention program, and to identify factors that support their participation. In-depth interviews were conducted with five mothers of children enrolled in a community-based program located in an urban area. An over-arching theme addressing the need for service providers to be “In my reality” emerged. Sub-themes highlighted needs of the mothers to understand their child’s condition, promote their child’s …

Retrospective Evaluation Of The Rockall Risk Scoring System In Patients With Nonvariceal Upper Gastrointestinal Hemorrhage At A Community Hospital, Mona D. Patel

Master's Theses and Doctoral Dissertations

Despite advances in diagnosis and treatment of patients with upper gastrointestinal hemorrhage (UGIH), the majority of hospitals do not risk-stratify patients with UGIH. One of the major challenges in triaging patients with nonvariceal UGIH is identifying patients’ who are at low risk. We retrospectively identified Rockall scores of 160 patients and the proportion of low-risk patients seen in the Emergency Department at Saint Joseph Mercy Hospital (SJMH) over a one-year period. Additionally, we determined adverse outcomes and healthcare resources utilized and evaluated whether certain antiplatelet agents, anticoagulants, and NSAIDS affected the Rockall scores. The Rockall scoring system identified 21% of …

A Comparison Of Three Phonological Awareness Tools Used To Identify Phonemic Awareness Deficits In Kindergarten-Age Children., Edgard Robelo

Electronic Theses and Dissertations

The purpose of this study was to determine if three different tests of phonological awareness: the Comprehensive Test of Phonological Processes (CTOPP) (Wagner, Torgesen, & Rashotte, 1999), The Phonological Awareness Test (PAT) (Robertson & Salter, 1997), and the Pre-Literacy Skills Screening (PLSS) (Crumrine & Lonegan, 1999) measure the same phonological awareness skills (content) in the same manner (procedures) and, whether typically-developing kindergarten-age students perform similarly on each of the tests. Twenty-five kindergarten students consisting of 14 males and 11 females (mean CA of 72.24 months) participated in this study. All participants were attending the second half of kindergarten in a …

Molecular Epidemiology Of Antibiotic Resistant Salmonella Enterica Strains From Different Animal And Human Sources In Ireland, David George Lee

Theses

In this study, 176 isolates of Salmonella were collected from different laboratories in Ireland. All isolates were confirmed to be of the genus Salmonella by performing bacteriological and biochemical tests. Briefly, all isolates were cultured onto XLD agar after which pure cultures were verified and stocked at this institute. Definitive identification was carried out using the API 20-E system and a separate urease test was also performed on all isolates. After confirmation of the genus, all isolates were prepared for antibiotic susceptibility testing and r-types were determined using sixteen antibiotics. Depending on the antibiotic resistance profiles, isolates were selected for …