Medicine and Health Sciences | Open Access Articles

The Impact Of Hesi Case Studies On The Hesi Exit Examination Scores For Nursing Students Preparing For The National Council Licensure Examination For Registered Nurses, Christine Cloutier Mihal

Seton Hall University Dissertations and Theses (ETDs)

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Is This A Mirror I See Before Me?: Adolescent Girls Use Imaginal Writing To Re-Vision Life Experience: A Dissertation, Cameron L. Marzelli

Expressive Therapies Dissertations

This participant observer collective case study was an investigation of the ways in which an imaginal writing process might facilitate resilience in adolescent girls who had previously used writing to respond to challenging life experience.

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A Sensory Processing Approach For Young Children With An Adversity To Eating, Zondra S. Thompson

Occupational Therapy Capstones

Eating and drinking are basic to our health and survival; it is also an integral part of our social life. For parents, feeding their children is a vital part of how they care for and nurture them. It is difficult for both the parents and the child when eating becomes a stressful experience. Children with sensory processing dysfunction often approach mealtimes with apprehension and discomfort. The willingness or inability to eat may be a sensory-processing based problem, which often exhibits as a behavioral problem such as, the child refusing to eat, to try new foods, or to touch different foods. …

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Staging, Prognosis, And Treatment Of Merkel Cell Carcinoma: A Population-Based Study, Douglas Michael Housman

Yale Medicine Thesis Digital Library

Merkel cell carcinoma (MCC) is a rare form of skin cancer, often described as the most aggressive cutaneous malignancy. Its high propensity for dermal-lymphatic invasion, local recurrence, and rapid lymphatic and distant metastasis poses a significant treatment challenge to clinicians. Combining its highly aggressive nature with its low incidence, merkel cell carcinoma is a particularly difficult cancer to study. Two major staging criteria exist for Merkel cell carcinoma. The purpose of this study is to validate and compare the Memorial Sloan Kettering Cancer Center (MSKCC) staging criteria with the American Joint Committee on Cancer (AJCC) Tumor, Node, Metastasis (TNM) staging …

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Infectious Diseases Of The Eye: Loa Loa, Onchocerciasis, & Trachoma, Lindsay N. Wise

Honors Program Theses

On December 16, 2006, I will graduate from the University of Northem Iowa with University Honors and a B.A. in both biology and psychology. I have always been interested in medicine and diseases, and this semester I wanted to explore some options for my future. At the start of the semester, I was considering applying to optometry schools after graduating from UNI. I am also highly interested in going on a mission trip, and perhaps a medical mission trip. ln light of these interests, I decided to design my senior honors thesis around infectious diseases of the eye. With the …

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Racial Disparities In Cardiovascular Risk Associated With Body Mass Index In Men And Women: A Subject-Level Meta-Analysis, Jill Abell

MUSC Theses and Dissertations

Introduction The prevalence of obesity is increasing in all segments of the population. While excess body mass is associated with increased disease risks, the magnitude of the risks are unclear from existing studies. In this dissertation we examine the association between BMI and cardiovascular outcomes, CHD, stroke and CVD mortality and blood pressure in four gender-race subgroups. Methods This study uses Black Pooling Project data which includes subject level data on 27,691 men and women and 450,962 person-years of follow-up. Analysis includes linear regression and Cox Proportional Hazard models and is gender-race specific. Subject-level meta-analysis is used to obtain overall …

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Hypoxic Preconditioning Of Embryonic Stem Cells: A Novel Transplantation Strategy To Improve Recovery After Stroke, Michelle Hedrick Theus

MUSC Theses and Dissertations

Embryonic stem (ES) cell transplantation therapy offers a novel therapeutic alternative for ameliorating the pathologic consequences of cerebral ischemia. The success of ES cell transplantation therapy relies not only on initial survival in the post-ischemic brain but also on whether or not these cells will reliably differentiate into the appropriate neuronal phenotypes required for cerebral repair. To address both issues, the present study investigates the neural differentiation of retinoic acid treated ES cells and how activating signaling pathways common in response to hypoxia can impact their usefulness as graft material intended to repair, replace and restore function after stroke. These …

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The Prevalence Of The Need For Esthetic Crown Lengthening In Post Orthodontically Treated Subjects, Bryan Marc Konikoff

Theses and Dissertations

Prevalence information on excessive gingival display in post-orthodontic patients is limited. By studying one aspect, namely the size relationship of the clinical crowns of teeth, in an orthodontic population, we can begin to quantify their need for periodontal plastic surgery. In this two part study, 200 plaster models were used as subjects, followed by a clinical exam of 31 of those subjects. These models represented patients before and directly after orthodontic therapy, and the Part 2 clinical exams were performed at least five years later. The lengths and widths of the six anterior teeth were measured and these values were …

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Characterizing Salmonella Fecal Shedding Among Racehorses In Louisiana, Anna Marie Chapman

LSU Master's Theses

Salmonella is an important intestinal pathogen in horses capable of infecting populations without demonstrating clinical illness. This study was performed to determine the prevalence of Salmonella fecal shedding among racehorses in Louisiana. Three serial fecal samples were collected from 429 Thoroughbred horses housed at four racetracks. Feces were tested for Salmonella by microbiologic culture with selective primary enrichment and delayed secondary enrichment (DSE). Samples were also evaluated for the presence of Salmonella by polymerase chain reaction (PCR) using genus-specific oligonucleotide primers. A total of 7 (1.6%) horses were positive for Salmonella by either primary bacterial culture or DSE and an …

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Female Genital Mutlation [Sic]: An Emerging Public Health Concern, Sarah Jan Brown

Senior Honors Theses and Projects

No abstract provided.

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Single Nucleotide Polymorphisms In The Folypoly-Gamma-Glutamate Synthetase Gene, Nadine Thompson

Theses and Dissertations

Folic acid is an essential vitamin utilized in the one-carbon metabolism pathway for the synthesis of purine and thymidine nucleotides, which are necessary for cell growth and proliferation. As a result, the enzymes that participate in the metabolism of folic acid have been good targets for cancer chemotherapy. Folylpoly-γ-glutamate synthetase (FPGS) is an enzyme in the folate metabolism pathway that catalyzes the addition of glutamic acid to the naturally occurring folates, thereby allowing the retention of folate cofactors in cells. Similarly, in the case of cancer chemotherapy, antifolates, such as Lometrexol and Tomudex are retained in cells through the activity …

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Lack Of Knowledge Of Mother-To-Child Transmission In Kenya Among Women Ages 15-49, Nisha Warrier

Theses and Dissertations

Purpose: The epidemic of mother-to-child transmission (MTCT) of HIV/AIDS in resource-poor countries is dramatic; it is responsible for nearly 90% of childhood infections. The primary purpose of analysis was to understand the distribution of factors and their association with lack of knowledge of MTCT in Kenya. In parallel, another aim was to identify the relationship between media, particularly frequency of radio exposure, and lack of knowledge.Methods: This study used the 2003 Kenya Demographic and Health Survey (DHS) collected for 8,195 women, ages 15-49. Descriptive analysis, univariate analysis, and logistic regression were completed on SPSS 14 software.Results: In the sample, 1151 …

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Relationship Between Cb1 And S1p Receptors In The Central Nervous System, Lauren Michele Collier

Theses and Dissertations

There is significant sequence homology and anatomical co-distribution between cannabinoid (CB1) and sphingosine-1-phosphate (S1P) receptors in the CNS, but potential functional relationships between these lysolipid receptors have not been examined. Therefore, to investigate possible relationships between these two systems at the level of G-protein activation, agonist-stimulated [35S]GTPγS binding and autoradiography were conducted. Autoradiographic studies were first performed to localize receptor-mediated G-protein activation in mouse brain. Coronal brain slices were processed for stimulation of [35S]GTPγS binding using the synthetic cannabinoid agonist WIN 55,212-2 (WIN) or SIP. High levels of WIN- and S1P-stimulated [35S]GTPγS binding were observed in the caudate putamen, hippocampus, …

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Factors Associated With The Provision Of Coronary Heart Disease Preventive Careservices, Patricia Carcaise-Edinboro

Theses and Dissertations

The Anderson and Aday access framework (1974) is utilized to investigate the association of individual and community level, predisposing, socio-demographic, and enabling factors, on potential and realized access to coronary heart disease (CHD) preventive care. The cross-sectional study is based on a sample of adults age 18-85 from the Medical Expenditure Panel Survey (MEPS) who were identified with CHD risk or who had a CHD diagnosis.Variables from the MEPS and the Area Resource File (ARF) are used to test logistic regression models for dependent variables measuring primary and secondary CHD preventive care services. The primary preventive care measures include blood …

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The Corbett Pain Scale: A Multidimensional Pain Scale For Adult Intensive Care Patients, Gina M. Corbett

Theses and Dissertations

There are no reliable tools that evaluate pain in adult critical care patients who cannot communicate as a result of sedation or illness. This was an observational study in which postoperative cardiothoracic intensive care patients were assessed for pain using both the newly devised Corbett Pain Scale (CPS) and the Numerical Pain Scale (NPS). The CPS was evaluated for content validity, criterion validity, construct validity, test re-test reliability and internal consistency. Thirteen male and seven female patients (n=20) were enrolled and underwent a maximum of five pain assessments each. The mean total scores of the CPS (.740, SD+1.03) and the …

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Factors Associated With Hospital Commitment To Provide Child/Adolescent Psychiatric Services, Lea Anne Gardner

Theses and Dissertations

General acute care hospitals play a particularly important role in the delivery of children's mental health given the extant lack of alternatives to long term hospitals for patients requiring a restrictive treatment environment (Glied and Cuellar, 2003). This cross-sectional study identifies environmental and organizational factors associated with general acute care and children's hospitals in the United States that provide hospital-based child/adolescent psychiatric services and the number of services. Two macro-level theories, Resource Dependence Theory and Institutional Theory were used to identify environmental and organizational factors. A nationwide sample of hospitals was drawn from the 2003 AHA annual survey. Data from …

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Assessing Epidermal Growth Factor Expression In The Rodent Hippocampus Following Traumatic Brain Injury, Janice Mabutas Daus

Theses and Dissertations

Hippocampal neurons are vulnerable to injury, as indicated by the prevalence of learning and memory deficits following traumatic brain injury. Research indicates that proliferation of neural precursor cells increases following brain injury, which implies that there is an endogenous response in the hippocampus to replenish neurons and restore cognitive function. Studies show that mitogenic growth factors may drive this proliferative response; one of which is epidermal growth factor. Because adults and the elderly manifest the most enduring deficits following TBI, it is critical to investigate how EGF expression following injury may relate to injury-induced cell proliferation and the degree of …

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The Effect Of Silencing The Wilms' Tumor 1 Gene On The Radiation Sensitivity Of Glioblastoma Cells, Dana C. Chan

Theses and Dissertations

Glioblastomas are among the most devastating of human cancers with a median survival of only 9-12 months. This type of brain tumor is incurable, largely due its remarkable proliferative capacity and resistance to current treatments. High levels of the Wilms' Tumor 1 (WTI) gene have been identified in glioblastomas, suggesting an oncogenic function. Moreover, known WT1 target genes have been implicated in resistance to radiation. To determine the role of WT1 in radiation resistance, two glioblastoma cell lines expressing WT1 were treated with siRNAs to silence this gene. Confirmation of WT1 knockdown was achieved through real-time PCR and Western blot. …

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Serum Anti-Phosphorylcholine And Anti-Cardiolipin Concentrations Following Periodontal Scaling And Root Planing, Reve W. Chaston

Theses and Dissertations

Atherosclerosis is an insidious disease with serious morbidity and mortality including ischemic heart disease, stroke, and myocardial infarction. This condition is progressive and can start early in life eventually leading to large plaques and arterial occlusion. Two key components of this process are the immune system and lipids; in particular, LDL which accumulates within the arterial walls and macrophages which recognize and engulf oxidized-LDL (oxLDL) to form foam cells. Knowing that certain antibodies directed against bacterial antigens such as phosphorylcholine (PC) and cardiolipin (CL) show opsonizing cross-reactivity with oxLDL it can be proposed that there is a link between immune …

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Health Promoting Lifestyle And Quality Of Life In Patients With Chronic Obstructive Pulmonary Disease, Saichol Janwijit

Theses and Dissertations

Chronic obstructive pulmonary disease (COPD) has a severe impact on quality of life (QOL). Using the Health Promotion Model as a guide, a cross-sectional, correlational design was used to describe relationships among individual characteristics and experiences (age, gender, race, severity of illness, resilience), behavior-specific cognitions and affect (self-efficacy, barriers, social support), behavioral outcomes (health promoting lifestyle), and QOL in this patient population. One hundred and twenty participants were recruited from three clinics at Virginia Commonwealth University Health System. In addition to a demographic survey, participants completed a 151-item questionnaire incorporating measures resilience, severity of illness, self-efficacy, and barriers to a …

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Factors Influencing Health Status In Community-Dwelling Older Adults, Janet Jestina Byam-Williams

Theses and Dissertations

This descriptive, correlational study was based on Pender's Health Promotion Model (Pender, Murdaugh, & Parsons, 2002). The purpose was to examine factors influencing health status in community-dwelling, older white and black adults. The following research question was addressed by the study: What are the relationships among the individual characteristics (age, gender, race, education, and income); the behavior-specific cognitions and affect (perceived self-efficacy, perceived barriers, and interpersonal influences); and the behavioral outcomes (health-promoting behaviors), and health status in community-dwelling whites and blacks 65 years of age and older? The convenience sample of 113 participants from four congregate meal sites in Central …

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Factors Associated With High Sexual Risk Behavior In Single Women, Thomas B. M. Leecost

Theses and Dissertations

Objective: This study was to identify factors associated with High Sexual Risk Behavior (HSRB) in single Afro American women seen in an Epidemiology/Sexual transmitted disease (EPID/STD) Clinic in Richmond, Virginia from January 2006 through April 2006.Method: Participants were 154 single women (no history of marriage) between the ages of 18-30 visiting the EPID/STD clinic for the first time.Demographic information was obtained from their records. A volunteer interview was given that contained 101 variables to evaluate for High Sexual Risk Behavior (HSRB). HSRB was defined to response 'yes' to the question, "During the past 3 months did you have sex with …

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Functional Redistribution Of Hippocampal Cannabinoid Cb1 Receptors In The Rat Pilocarpine Model Of Acquired Epilepsy, Katherine Winslow Falenski

Theses and Dissertations

Cannabinoids, such as the marijuana derivative Δ9-THC, are known to have CBl receptor-mediated anticonvulsant effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats has not been characterized. Therefore, this dissertation was initiated to evaluate the effect of epileptogenesis on the distribution and function of the endogenous CBI receptor system in the rat pilocarpine model, a well-established model of acquired temporal lobe epilepsy. Using immunohistochemistry, we demonstrated that chronically epileptic rats exhibit a unique, long-term, and specific redistribution of …

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The Life Pattern Of People With Spinal Cord Injury, Ronald R. Alligood Ii

Theses and Dissertations

This aim of this study was to answer the research question: "What is the Life Pattern of the Person with Spinal Cord Injury?" The unitary appreciative inquiry design, which has conceptualized through Rogers' (1986) science of unitary human beings, provided an approach for understanding the phenomenon in the context of human wholeness. The data, obtained through the methodology of unitary appreciative inquiry, led to the development of individual synopses for each of the participants. Once the synopses were completed, a composite pattern profile was constructed by the researcher that was indicative of the life pattern of people with spinal cord …

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The Anti-Plaque Efficacy Of Listerine® Used In Combination With Toothbrushing In Orthodontic Patients, Zachary A. Casagrande

Theses and Dissertations

The bactericidal efficacy of Listerine®, the essential oil-containing mouthrinse, has long been recognized. The purpose of this study was to determine whether Listerine® mouthrinse, when added to the standard oral hygiene regimen, had an added benefit in reducing plaque and gingivitis development in orthodontic patients over a six-month period. 50 orthodontic patients from the Virginia Commonwealth University Department of Orthodontics were assigned either to the brushing + flossing (N= 25) or brushing + flossing + Listerine® (N = 25) group. At baseline (TI), measurements for the Ramfjord teeth were recorded for the gingival index, plaque index and bleeding index. Subsequent …

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Southeast Asian Immigrant Women's Perspectives On Domestic Violence, Pataporn Saengkhiew

Theses and Dissertations

This study addresses the question, "What is the lived experience of Southeast Asian immigrant women who live in the United States related to domestic violence, including the relationships with their partners, their knowledge of domestic violence, and the existence of domestic violence in the Asian community?" Fourteen Thai women engaged in semistructured interviews during which they were asked to describe their experience. This study chose the phenomenological approach, using content analysis that identified six major themes representing essential aspects of the experience, as described by the participants: (a) Knowledge about Domestic Violence and Sources of Information, (b) The experience of …

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Use Of A Synthetic Substrate For Orthodontic Bond Strength Testing, Elijah B. Saikaly

Theses and Dissertations

In vitro bond strength studies are of great importance and interest since they allow the prediction of clinical success of orthodontic adhesives. There are many studies that have investigated bond strength values of bonding systems. However, due to the variation in the materials and methods employed, it is very difficult and often impossible to make comparisons among data. The use of a substrate as an alternate to enamel for mechanical tests would minimize these variables and reduce the challenges faced with in vitro bond strength tests. The purpose of this study was to investigate the suitability of Macor as a …

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Characterization Of Perphenazine And Scopolamine Aerosols Generated Using The Capillary Aerosol Generator, Xihao Li

Theses and Dissertations

The characterization of perphenazine and scopolamine aerosols generated using the capillary aerosol generator (CAG) was reported. Variables including steady state power, the formulation vehicle, the drug concentration and the formulation flow rate were studied for their effects on the chemical stability and particle size of these drug aerosols.Stability-indicating HPLC and LC-MS assays were developed and validated for perphenazine and scopolamine, respectively. The chemical stability of each compound was investigated under a variety of stress conditions and the structure of degradation products was proposed.Perphenazine aerosols were generated from propylene glycol (PG) formulations with concentrations of 9, 48 and 90mM at formulation …

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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, And Non-Specific Inflammatory Responses, Brian Joseph Kelley

Theses and Dissertations

A significant component of diffuse brain injury (DBI) is diffuse axonal injury (DAI) which is responsible for the morbidity and mortality associated with this condition. DAI and its experimental counterpart traumatic axonal injury (TAI) result in scattered microscopic pathology characterized by focal impairment of axonal transport leading to progressive swelling and delayed axotomy. DBI-mediated perisomatic axotomy does not result in acute neuronal death suggesting that delayed axotomy was responsible for this unanticipated response. To evaluate this hypothesis, we examined the spatiotemporal progression of DBI-mediated perisomatic TAI. LM / TEM identified impaired axonal transport within 15 - 30 min post-injury. Perisomatic …

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Ige Production Regulation Via Cd23 Stalk Engagement And Cell Cycle Stimulation, Timothy Hays Caven

Theses and Dissertations

CD23, the low affinity receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 (lz-ECCD23). The goal was to examine the role of the necessity of the CD23 stalk for binding IgE. Using PCR-based mutagenesis to delete the majority of the stalk, binding to IgE was lost. Further studies examined the effect of lz-ECCD23 in preventing IgE from binding FcεRI and therefore acting as a therapeutic agent. It …

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Full-Text Articles in Medicine and Health Sciences

The Impact Of Hesi Case Studies On The Hesi Exit Examination Scores For Nursing Students Preparing For The National Council Licensure Examination For Registered Nurses, Christine Cloutier Mihal

Seton Hall University Dissertations and Theses (ETDs)

Is This A Mirror I See Before Me?: Adolescent Girls Use Imaginal Writing To Re-Vision Life Experience: A Dissertation, Cameron L. Marzelli

Expressive Therapies Dissertations

A Sensory Processing Approach For Young Children With An Adversity To Eating, Zondra S. Thompson

Occupational Therapy Capstones

Staging, Prognosis, And Treatment Of Merkel Cell Carcinoma: A Population-Based Study, Douglas Michael Housman

Yale Medicine Thesis Digital Library

Infectious Diseases Of The Eye: Loa Loa, Onchocerciasis, & Trachoma, Lindsay N. Wise

Honors Program Theses

Racial Disparities In Cardiovascular Risk Associated With Body Mass Index In Men And Women: A Subject-Level Meta-Analysis, Jill Abell

MUSC Theses and Dissertations

Hypoxic Preconditioning Of Embryonic Stem Cells: A Novel Transplantation Strategy To Improve Recovery After Stroke, Michelle Hedrick Theus

MUSC Theses and Dissertations

The Prevalence Of The Need For Esthetic Crown Lengthening In Post Orthodontically Treated Subjects, Bryan Marc Konikoff

Theses and Dissertations

Characterizing Salmonella Fecal Shedding Among Racehorses In Louisiana, Anna Marie Chapman

LSU Master's Theses

Female Genital Mutlation [Sic]: An Emerging Public Health Concern, Sarah Jan Brown

Senior Honors Theses and Projects

Single Nucleotide Polymorphisms In The Folypoly-Gamma-Glutamate Synthetase Gene, Nadine Thompson

Theses and Dissertations

Lack Of Knowledge Of Mother-To-Child Transmission In Kenya Among Women Ages 15-49, Nisha Warrier

Theses and Dissertations

Relationship Between Cb1 And S1p Receptors In The Central Nervous System, Lauren Michele Collier

Theses and Dissertations

Factors Associated With The Provision Of Coronary Heart Disease Preventive Careservices, Patricia Carcaise-Edinboro

Theses and Dissertations

The Corbett Pain Scale: A Multidimensional Pain Scale For Adult Intensive Care Patients, Gina M. Corbett

Theses and Dissertations

Factors Associated With Hospital Commitment To Provide Child/Adolescent Psychiatric Services, Lea Anne Gardner

Theses and Dissertations

Assessing Epidermal Growth Factor Expression In The Rodent Hippocampus Following Traumatic Brain Injury, Janice Mabutas Daus

Theses and Dissertations

The Effect Of Silencing The Wilms' Tumor 1 Gene On The Radiation Sensitivity Of Glioblastoma Cells, Dana C. Chan

Theses and Dissertations

Serum Anti-Phosphorylcholine And Anti-Cardiolipin Concentrations Following Periodontal Scaling And Root Planing, Reve W. Chaston

Theses and Dissertations

Health Promoting Lifestyle And Quality Of Life In Patients With Chronic Obstructive Pulmonary Disease, Saichol Janwijit

Theses and Dissertations

Factors Influencing Health Status In Community-Dwelling Older Adults, Janet Jestina Byam-Williams

Theses and Dissertations

Factors Associated With High Sexual Risk Behavior In Single Women, Thomas B. M. Leecost

Theses and Dissertations

Functional Redistribution Of Hippocampal Cannabinoid Cb1 Receptors In The Rat Pilocarpine Model Of Acquired Epilepsy, Katherine Winslow Falenski

Theses and Dissertations

The Life Pattern Of People With Spinal Cord Injury, Ronald R. Alligood Ii

Theses and Dissertations

The Anti-Plaque Efficacy Of Listerine® Used In Combination With Toothbrushing In Orthodontic Patients, Zachary A. Casagrande

Theses and Dissertations

Southeast Asian Immigrant Women's Perspectives On Domestic Violence, Pataporn Saengkhiew

Theses and Dissertations

Use Of A Synthetic Substrate For Orthodontic Bond Strength Testing, Elijah B. Saikaly

Theses and Dissertations

Characterization Of Perphenazine And Scopolamine Aerosols Generated Using The Capillary Aerosol Generator, Xihao Li

Theses and Dissertations

Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, And Non-Specific Inflammatory Responses, Brian Joseph Kelley

Theses and Dissertations

Ige Production Regulation Via Cd23 Stalk Engagement And Cell Cycle Stimulation, Timothy Hays Caven

Theses and Dissertations