Medicine and Health Sciences Commons^™

Dual Regulation Of Telomerase Activity By Hsf1 And Its Role In Prostate Cancer Progression, Keith Douglas Ostergaard Jensen

Theses and Dissertations

It has been shown that the key components of the hsp90 chaperone complex, including hsp90, p23, hsp70, hsp40, and HOP (p60), associate with telomerase; however, their specific roles in telomerase function and tumor progression have not yet been defined. HSF1, the primary mammalian heat shock protein transcription factor, may affect telomerase activity and transformation by regulating the expression of several hsp90 chaperone complex proteins in response to stress as well as regulating the transcription of hTERT, the protein subunit of telomerase.In our in vitro model of prostate cancer progression, as cells progress from immortal but non-tumorigenic (P69) to tumorigenic (M2182) …

Interspecies Pharmacokinetic Scaling And Metabolism Of Alcohols And Glycols, Pankaj Gupta

Theses and Dissertations

Background: Despite the numerous pharmaceutical applications of alcohols andglycols, the interspecies differences with respect to their pharmacokinetics (PK) arepoorly understood. The aim of this research was to use in-vivo and in-vitro approaches to compare and model the PK characteristics across various species.Methods: Appropriate published in-vivo studies (in different species) foralcohols and glycols were carefully selected. PK analysis was performed using (a) noncompartmental analysis and (b) compartmental modeling to estimate relevant dose-independent PK parameters. Next, six alcohols (methanol, ethanol, 1 -propanol, 1 -butanol, 1-hexanol, and 1-octanol), two glycols (ethylene glycol and propylene glycol)and one secondary alcohol (2-propanol) were examined as in-vitro …

The Ethics Of Genetic Testing And The Role Of The Professional Nurse In Practice, Brad J. Phillips

Senior Honors Theses and Projects

No abstract provided.

Nutritional Quality Of Lunches At A Seventh-Day Adventist School, M. Justine Markert

Master's Theses and Doctoral Dissertations

The purpose of this study was to determine if what the 3rd, 4th, and 5th grade children (n=36) at Central Valley Christian Academy (CVCA) were eating for lunch followed the beliefs of the Seventh-day Adventist (SDA) church and if lunches brought from home (LFH) provided more nutritional quality than combination lunches.

This study showed that LFH (n=26) provided more overall nutrients for the students when compared with school-provided entrée lunches (n=1) and combination lunches (n=9). When comparing LFH with combination lunches, LFH met more of the nutritional requirements based on the Recommended Dietary Intake (RDI) and the Dietary Guidelines for …

The Validity Of The S/Z Ratio As A Voice Screening Tool, Larry L. Panozzo Jr.

Masters Theses

This study investigated the validity of the s/z ratio as a voice screening tool. Twenty female subjects, ten with vocal fold pathology and ten normal control subjects, participated in the current research project. Results indicated that although the s/z ratio was higher for the disordered group than the normal group, the difference was not significant (p=.18). Sensitivity equaled 90% while specificity equaled 50% when 1.1 was used as the cutoff value. When 1.4 was used as the cutoff value, sensitivity was 30% while specificity was 80%. In addition, there was a weak relationship between the clinician's perception of the size …

Role Modeling Attitudes And Physical Activity Behavior Of Cardiopulmonary Rehabilitation Professionals, Emily Dufrene

Masters Theses

Role models are individuals whose behavior, example or success can be observed and learned from. Health professionals are responsible for the motivation and production of goal directed behavior (Wilson & Petruska, 1984). Modeling behaviors that encourage physical performance, fitness, health, and quality of life should be the foundation for all individuals certified by the American College of Sports Medicine (ACSM Credentialed Professionals, 2005) as exercise specialists, fitness instructors, or program directors. Physicians, exercise physiologists and nurses working in cardiopulmonary rehabilitation programs are expected to model healthy behaviors for their own health benefit and to encourage their patients.

Does The Message Matter? Enhancing Patient Adherence Through Persuasive Messages, Muhammad F. Walji

Dissertations and Theses (Open Access)

To improve health and reduce costs, we need to encourage patients to make better healthcare decisions. Many informatics interventions are aimed at improving health outcomes by influencing patient behavior. However, we know little about how the content of a message in these interventions can influence a health-related decision. In this research we formulate a conceptual model to help explain and guide the design of “persuasive messages”, those which can change and influence patient behavior. We apply the conceptual model to design persuasive appointment reminder messages using humancentered design principles. Finally, we empirically test our hypotheses in a randomized controlled trial …

T Cell Integrin Dependent, Mkk3/P38 Mapk-Mediated Stabilization Of Labile Cytokine Mrnas, Scott David Degregorio

Yale Medicine Thesis Digital Library

The goal of this project is to elucidate the signaling pathway involved in the T cell integrin lymphocyte function-associated antigen 1 (LFA-1) engagement-mediated, HuR nuclear-to-cytoplasmic translocation and subsequent mRNA stabilization. To examine the pathway transducing LFA-1 engagement-mediated mRNA stabilization, we employed quantitative, real time RT-PCR in the presence of a transcriptional inhibitor to examine the half-life of interferon gamma (IFN-γ) mRNA, a labile cytokine transcript. We used immunofluorescence to observe the nuclear-to-cytoplasmic tranlocation of HuR, an mRNA-binding and stabilizing protein. We also used Western blot analysis to analyze the activity levels of specific mitogen activated protein kinases (MAPKs) upon LFA-1 …

Onset And Exacerbation Of Obsessive-Compulsive Disorder In Pregnancy And The Postpartum Period, Mariel Aida Focseneanu

Yale Medicine Thesis Digital Library

The overarching goal of this study was two-fold; to determine the prevalence of perinatal onset or worsening of OCD symptoms in women attending a university-based research program, and to determine whether there is a continuity between perinatal onset or worsening of OCD and premenstrual exacerbation of such symptoms. Women ages 18 to 69 years old that were enrolled in the Yale OCD Research Program between 1990 and 1995 were interviewed by phone or in person regarding demographics, onset and course of OCD, types of primary OCD symptoms, treatment history, comorbid diagnoses including substance use/abuse, and the impact of pregnancy and …

A Quantitative Analysis Of Computed Tomography Scanner Utilization In An Academic Medical Center, Amichai J. Erdfarb

Yale Medicine Thesis Digital Library

The purpose of this study is to quantify computed tomography (CT) scanner utilization and productivity in an academic hospital setting and determine the primary causes of idle time. Two CT scanners were observed for a total of 202 scanner-hours. Scanner time was divided into two primary components: "active" and "idle." Active time was further divided into preparation, scan, and take-down times. Independent variables recorded include in- vs. outpatient, IV contrast (IVC) vs. non-IVC, and scanner type. Primary contributors to idle time were identified in six main categories: preventative maintenance (PM), technical failure, upgrades, calibration, understaffing, and poor flow management. 275 …

Treating The Children Of Bolivia Infected With Chagas Disease: A Cost-Benefit Analysis, Gregory A. Magee

Yale Medicine Thesis Digital Library

The purpose of this study was to perform a cost-benefit analysis of an intervention to treat all the children in Bolivia (under 15 years of age) who are infected with Chagas disease. This research was carried out in La Paz, Bolivia where the author lived for a year collecting data in collaboration with the National Chagas Control Program, Bolivian Ministry of Health. Operational costs were based on current prices for laboratory testing and pharmaceuticals, average hourly wages for health care workers, and the number of children who would be treated. The benefit of the program was estimated as the sum …

The Process Of Implementing Health-Promoting Schools In Zhejiang Province, China: A Dissertation, Carmen E. Aldinger

Educational Studies Dissertations

This study describes in detail the processes, interventions, challenges, and self-reported changes associated with implementing the Health-Promoting Schools (HPS) project in Zhejiang Province, China. It is a descriptive study, based on a case study model, using illustrative examples from nine schools. Grounded theory analysis revealed detailed pre-implementation, implementation, and monitoring and evaluation processes; classroom-based, school-wide and outreach activities; and modifications to the physical and psycho-social school environment. Schools faced a number of challenges related to understanding and integrating the HPS concept and a lack of professional development and support. Yet. participants reported many health-conducive changes in their attitudes, conceptual knowledge, …

Observations On Healthcare And The Cultural Perceptions Of Pain And Pain Management At Bebalem Hospital, Tchad Africa, Nealey Mccall Hearns

Senior Honors Theses and Projects

No abstract provided.

Metacarpal-Phalangeal Arthroplasty: A Post-Operative Approach, Lance Norman

Occupational Therapy Capstones

No abstract provided.

Traumatic Brain Injury (Tbi): Caregiver And Family Education Handbook, Heather Yekel, Breana Medlock

Occupational Therapy Capstones

Life can be very confusing for the friends, family member(s), and caretaker(s) of those individuals who are diagnosed with a Traumatic Brain Injury (TBI). The people who live with and care for the individual with a TBI want to know how they can help and what they can do to speed up the recovery. They also want to know what they can expect from their loved one, how much time the recovery will take, and what is causing the changes in their behavior?

A review of the literature was conducted and professionals, who are currently providing services to individuals diagnosed …

Nurture Your Infant And Yourself: A Breastfeeding Program, Kathryn J. Conrad

Occupational Therapy Capstones

No abstract provided.

Livin' Right! Morning, Noon, And Night: A Multi-Disciplinary Wellness Camp [For] Children With Obesity Issues, Lynne R. Bradbury

Occupational Therapy Capstones

The prevalence of childhood obesity is rapidly increasing in the United States and the percentage of overweight or obese children in South Dakota exceeds the objective set by the U.S. Department of Health and Human Services (2000). An extensive review of literature was completed on the prevalence and characteristics of obesity in children as well as interventions such as a multi-disciplinary team approach and family involvement. A review of the use of measurement tools both for screening and outcome measures was also conducted. There are significant health and societal impacts that accompany the increasing prevalence of obesity in our communities. …

Children With Limb Deficiency: The Impacts Of Using A Prosthetic For Functional Independence, Kirsten Brandt, Michelle Grimes

Occupational Therapy Capstones

Many emotions, questions, and concerns may arise for parents and caregivers upon learning that their child has a limb deficiency. Educational resources for parents of children with limb deficiencies may be lengthy, time consuming to find and read, and full of medical jargon. The purpose of this scholarly project was to develop an educational booklet that is concise and easy to read for parents and caregivers of children with limb deficiencies.

An extensive literature review was conducted addressing the physical and psychological impacts children with limb deficiencies experience during daily activities. Parents with children who have limb deficiencies, individuals with …

School-Based Practice: Integrating The Occupational Therapy Practice Framework, Nancy M. Daly

Occupational Therapy Capstones

Occupational therapists in school-based practice frequently experience change due to the evolution of the profession and education reform. This project examines the impact of these changes relative to the integration of client-centered and occupation-based services in contemporary educational practice. Occupational therapists have identified significant barriers that impact the efficiency and effectiveness of service delivery. This paper, through the review of current occupational therapy and special education literature, explores the integration of collaboration, client-centered occupation-based care, and service delivery. The increasing requirements for accountability and professional standards define documentation needs. Findings indicate a need for school-based occupational therapists to have processes …

Eating Disorder Programming In Four-Year College Recreation Wellness Centers, Tiffany Jean Anderson, Amanda Lynn Gulka

Physical Therapy Scholarly Projects

Eating disorders are more prevalent in the college-age group when compared to the lifetime prevalence. Because of this increased prevalence, college recreation/wellness center staff should be aware of their clients in terms of the increased risk for eating disorders. College wellness/recreation centers, while serving the campus community, also serve the individuals within this community diagnosed with or at-risk for an eating disorder. Through survey research, we show who is employed at wellness/recreation centers, what type of training they receive regarding eating disorder, how this training is provided along with its content, and what method of public awareness on eating disorders …

Muscle Activation In Individuals Who Are Status-Post A Stroke During Over Ground, Treadmill, And Body Weight Supported Gait: A Comparative Study, Rhonda L. Breitbach, Kelly L. Malmin, Beth M. Nordmark, Jennifer A. Pederson

Physical Therapy Scholarly Projects

Purpose: The purpose of this study was to evaluate individuals who are status post stroke during ambulation over ground, on a treadmill without support, and on a treadmill with partial body weight support (PBWS) to determine if there are any differences in muscle activation of major muscle groups in the lower extremity.

Subjects: Two subjects were recruited for this study. Subjects were included if they were over the age of 50 years, could fulfill a two-hour time commitment, and walk independently with or without the use of an assistive device. Subjects were excluded if they have had surgery or an …

An Electromyographic Study Of Upper Trapezius, Lower Trapezius, And Serratus Anterior Muscle Activity During Traditional And Modified Muscle Testing Positions, Jace Everett, Mike Fowler, Jason Haak, Robby Luck

Physical Therapy Scholarly Projects

Purpose: The purpose of this study is to assess the muscle activity of the shoulder joint force couple induced by the upper trapezius, lower trapezius, and serratus anterior to determine if they are more effectively recruited during the traditional exercise position of forward shoulder elevation in 145° of shoulder abduction versus a modified position of shoulder external rotation while in 80° of shoulder abduction and 90° of elbow flexion

Methods: Nine participants took part in this randomized study in which EMG data was collected during 4 exercise trials of 10 repetitions each on the right shoulder. EMG activity was monitored …

Balance Comparison Of Open- And Closed-Back Shoes, Tiffany Hemberger, Sara Henderson, Eric Loiland

Physical Therapy Scholarly Projects

A growing number of healthcare professionals have been choosing to wear an open-back shoe rather than a traditional closed-back shoe in the workplace. Healthcare professionals incorporate dynamic balance and quick reactions during direct patient interaction. The purpose of the study was to determine if dynamic balance would be affected in healthcare professionals when wearing open-back shoes versus closed-back shoes.

Thirty-two healthcare professionals or students of healthcare professions (28 females and 4 males) were recruited for this study. Subjects ranged in age from 20 to 62 years (mean age 28.2 years), with the majority being physical therapists or physical therapy students. …

Role Of Z-Coilª Shoes On Plantar Pressure Forces During Short Distance Walking, Tyler Volle, Michael Rider, Brett Jenks, Benjamin Deubner

Physical Therapy Scholarly Projects

Purpose: The Z-CoiL ® company has marketed a shoe that is advertised to decrease pressure and attenuation of forces on the foot, ankle, and other lower extremity joints. Evidence based studies, however, are lacking in support of this claim. The purpose of this study was to compare the peak pressure distributed onto the bottom of the foot from heel strike to midstance when walking bare foot, using a personal athletic shoe, and using a Z-CoiL ® shoe.

Subjects: Thirty subjects without any current history of orthopedic pathologies were examined in this study. Fourteen subjects were excluded from final data analysis, …

Use Of Quantitative Admissions Data To Predict Academic And Licensure Examination Performance Among Physical Therapist Students, Ralph Russell Utzman

Theses and Dissertations

Professional physical therapist education programs use a variety of measures of academic performance, aptitude, and interpersonal skills when selecting students for admission. Grade point averages (GPA) and scores on standardized tests, such as the Graduate Record Examination (GRE), are commonly used quantitative measures. The purpose of this study was to investigate the utility of these measures in predicting which physical therapist students will encounter difficulty in the academic program or in passing the National Physical Therapist Examination (NPTE). This study used a retrospective longitudinal design. A nationally representative sample of 20 programs was drawn from the population of physical therapist …

Examining The Progression Of Disability Benefits Among Employees In The United States, Carolyn E. Danczyk-Hawley

Theses and Dissertations

The following project is a compilation of three separate articles all utilizing a database extracted from the UNUM/Provident Life Insurance Company, including all consecutive short-term disability (STD) claims filed with UNUM from January 1, 1994 to December 31, 1996 from claimants who were also insured for long-term disability (LTD) by UNUM. The resulting sample includes 77,297 claims.The results of these studies are part of a larger investigation that documented the Progression of Disability Benefits (PODB) phenomenon. PODB refers to the migration of workers with work-limiting disabilities through a system of economic benefits resulting in their placement onto Social Security Disability …

There Is More To Vision Than Seeing Clearly, Dawn Cardinal, Genea Nannemann

Occupational Therapy Capstones

"Vision is not simply the ability to read a certain size letter at a distance of 20 feet. Vision is a complex and adaptable information gathering and processing system which collects, groups, analyzes, accumulates, equates, and remembers information" (American Optometric Association, 2005, p.1). The purpose of this project is to develop a parent/caregiver handbook that will educate parent/caregivers with children who have visual deficits and to benefit the Vision Therapy Project, which is located in Casper, Wyoming. This project is a non-profit organization dedicated to provide assistance and education to parents/caregivers with children in need of vision therapy. Information for …

Factors For Hiv /Aids Risk In Yunnan Province, China Near The Myanmar Border., Yan Xiao

All ETDs from UAB

No abstract provided.

Contribution Of Non-Occupational Exposure Factors And Non-Noise Occupational Exposure To Loss Of Hearing Sensitivity Among Anniston Army Depot Worker., Katrina L. Wright

All ETDs from UAB

No abstract provided.

A National Estimate Of The Cost Of Illness In Parkinson's Disease Using Retrospective Data Analysis, Katherine Anderson

Theses and Dissertations (ETD)

No abstract provided.