Medicine and Health Sciences Commons^™

Claudins Interact With Lilrb Immune Inhibitory Receptors To Promote Myeloid Immunosuppression In Cancer, Xiaoye Liu, Ryan Huang, Zhiqiang Ku, Jingjing Xie, Heyu Chen, Yubo He, Qi Lou, Chengcheng Zhang, Xing Yang, Cheryl Lewis, Jade Homsi, Ankit Gupta, Lei Dong, Kenian Chen, Annabel Tu, Liming Du, Hailong Yu, Qing Hu, Meng Fang, Bufan Li, A E M Adan Khan, Caroline Simith, Samuel John, Lin Xu, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

The Brown Foundation: Institute of Molecular Medicine

The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific binding between tight junction claudins (CLDNs) and leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) and LILRB5. In multiple human cancer cohorts, the spatial proximity of LILRB2-positive macrophages to CLDN-expressing cancer cells correlated with clinical outcomes, highlighting this spatial relationship as a potential biomarker. In syngeneic LILRB2-transgenic and humanized mouse models, CLDN18.2-LILRB2 interactions triggered bidirectional signaling, enhanced the immunosuppressive activity of myeloid cells, and accelerated tumor progression. These effects were reversed by …

Translationally-Relevant Tumor Resection Model For Murine Preclinical Models Of Oral Squamous Cell Carcinoma, Gemalene M Sunga, Alejandra Cobos Perez, Andrea H Molina, Nourhan Hussein, Neeraja Dharmaraj, Andrew Sikora, Simon Young

Faculty, Staff and Student Publications

Currently, the first-line treatment for the most common form of head and neck squamous cell carcinoma (HNSCC), oral cavity squamous cell carcinoma (OSCC), is surgical resection, followed by risk-adapted treatments, such as chemoradiotherapy. However, with the current standard of care and even the emergence of new treatments, such as checkpoint blockade, the overall survival for advanced, recurrent disease remains high, and the prevalence of head and neck cancer is projected to continue to increase in the coming years. Thus, deeper investigation into current standard-of-care modalities, in addition to novel therapeutics, is necessary to translate potential and promising treatment options to …

Medicare Part D Formulary Coverage Of Disease-Modifying Therapies For Multiple Sclerosis, Pengxiang Li, Matthew J Klebanoff, John K Lin, Keya D Doshi, Salim Chahin, Jalpa A Doshi

2020-Current year OA Pubs

No abstract provided.

Opportunities And Barriers For Innovation At The Interface Of Engineering And Maternal-Fetal Medicine, Thomas S Howlett, Jacqueline G Parchem, Kelsey L Swingle

Faculty, Staff and Student Publications

The development of safe and effective maternal-fetal therapeutics is significantly hindered by chronic underfunding, inequitable access to specialized care, and persistent sociopolitical stigmas surrounding women’s health. Addressing these challenges will require interdisciplinary collaboration between clinicians, scientists, and engineers to design accessible therapeutics for maternal-fetal healthcare.

Implementing Measurement-Based Care In Virtual Mental Health Services For Rural Veterans: Provider Insights From A Pre-Implementation Evaluation, Amanda Heeren, Kimberly Mccoy, Lindsey Fuhrmeister, Natalie Suiter, Jan A Lindsay, Chloe Hoang, Laura Marsh, John Fortney, Carolyn Turvey

Faculty, Staff and Students Publications

Background

Measurement-Based Care (MBC) uses repeated standardized psychological assessments to monitor treatment progress and guide clinical decision-making. Although MBC improves outcomes when results are discussed collaboratively, adoption across the Veterans Health Administration (VHA) remains below 50%, particularly in virtual and rural settings. This pre-implementation evaluation explored provider perspectives to inform development of a digital MBC workflow for rural tele-mental health settings.

Methods

Using the Alacrity Center’s Discover, Design, Build, and Test model and User Centered Design, we conducted a pre-implementation survey of mental health providers at a VHA Medical Center providing care to rural and highly rural Veterans in South …

Mental Health Under Pressure: A Scoping Review Of Suicide In The Dental Workforce, Man Hung, Spencer John, Nicholas Beasley, Amir Mohajeri, Connor Schwartz, Martin S. Lipsky

Institute on Aging Publications

Aims:

Suicide among healthcare professionals is a growing concern. Despite evidence of high psychological distress in dental practice, suicide in dentists remains underexplored. This scoping review systematically examined the literature on suicide and suicidal ideation among dentists, including prevalence, risk factors, and temporal trends.

Methods:

Searches of PubMed, Scopus, Web of Science, and Dentistry and Oral Sciences Source identified English-language studies reporting suicide, suicidal ideation, or related mental-health risks in dental professionals. Duplicates were removed; titles/abstracts and full texts were screened against predefined criteria. Data were extracted and thematically analysed.Results Fourteen studies met the inclusion criteria and were mostly retrospective …

Single State Agency Licensure Requirements For Substance Use Disorder Treatment Programs In The United States: Results Of A National Survey, Brooks Yelton Ma, Lmsw, Melissa A. Westlake, Amanda J. Abraham, Colleen M. Grogan, Olivia Hinds, Christina M. Andrews

Faculty Publications

Background

Substance use disorder (SUD) remains a critical public health crisis in the United States, with high prevalence and overdose mortality rates. Despite the availability of effective treatments, including medications that significantly reduce overdose risk, fewer than 20% of Americans with active SUD receive treatment annually. Single State Agencies (SSAs), which oversee federal funding and regulate SUD treatment programs, hold significant authority to impose licensure and reporting requirements intended to promote treatment quality.

Methods

This study presents findings from a national survey of SSAs across 50 states and the District of Columbia (94% response rate) conducted between 2020 and 2021, …

The Effect Of Articulatory Cues On Phonemic Segmentation, Word Reading, Nonword Reading, And Nonword Spelling: A Clinical Trial, Robyn Becker, Grace T. Clark, Iyad Ghanim, Kaitlyn Verney, Alexis Gallagher

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose: Although some studies suggest articulatory cues may help enhance early literacy outcomes, research has yet to isolate their specific contribution to the gains. Framed by the motor theory of speech perception (Liberman & Mattingly, 1985), this study seeks to fill this gap by providing phonemic segmentation training using articulatory cues and comparing reading/spelling outcomes to two different comparison groups to attempt to control for the motivation and attention the articulatory cues may provide.

Method: Twenty-seven typically developing four and five year-olds were seen individually for seven weekly sessions during a typical day in a preschool classroom (NCT06504264). The participants …

The Effect Of Cerebral Somatosensory Network Priming On Language Function In Chronic L-Mca Ischemic Stroke: A Companion Case Study, Mandelin E. Wollesen

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Chronic aphasia following a left middle cerebral artery (L-MCA) stroke is often associated with limited recovery beyond the acute phase, necessitating interventions that target neuroplastic mechanisms. This study examined the effects of somatosensory pneumotactile stimulation paired with cognitive-linguistic tasks on functional language performance in an individual with chronic aphasia. Using a single-subject pre-post design, the participant completed a 10-week intervention protocol involving repeated pneumotactile stimulation via the GALILEO system combined with language and motor tasks. Outcomes were assessed using standardized measures, discourse-based language samples, oral reading, repetition, and phonemic verbal fluency. Discourse was analyzed using Correct Information Units (CIUs), words …

Organ Procurement Organization Utilization Of Portable Hypothermic Oxygenated Machine Perfusion In Liver Transplantation: The First Us Experience, Christine E. Haugen, Muhammad Bilal Moeen-Ud-Din, Abdalla M. Hadhoud, Achintya Kaw, James R. Butler, James V. Guarrera, Sherry Quire, Ralph C. Quillin

Department of Surgery Faculty Papers

BACKGROUND: Advanced machine perfusion techniques have increased the use of hard-to-place organs, effectively changing the liver transplantation landscape. Liver transplantation machine perfusion has been driven largely by industry or individual transplant centers. We describe the implementation of a portable, organ procurement organization-initiated hypothermic oxygenated machine perfusion strategy for liver transplantation as a proof of concept.

METHODS: Surgeons and staff at a regional organ procurement organization (Indiana Donor Network) were trained to use and cannulate liver allografts using a portable hypothermic oxygenated machine perfusion platform. We evaluated all liver transplantations recovered and placed on hypothermic oxygenated machine perfusion (N = 18) …

Eeg In Patients With Altered Mental Status In The Emergency Department, Mariama Runcie, Neal Nolan, Olivia Yoo, Robert Silbergleit, Fábio A Nascimento, Maura Kennedy, M Brandon Westover, Joshua N Goldstein

2020-Current year OA Pubs

BACKGROUND: Altered mental status is a common chief complaint in the emergency setting, and the initial evaluation often fails to find an etiology. Subclinical (electrographic) seizures and nonconvulsive status epilepticus (NCSE) are potential causes of delirium and altered mental status, but require electroencephalogram (EEG) for diagnosis. It is not clear how often subclinical seizure or NCSE is present in those with undifferentiated altered mental status, nor which patients are most likely to benefit from emergent EEG. METHODS: We performed a retrospective review of patients presenting to a single academic medical center emergency department (ED) over a one-year period with the …

Florence S.T.C. Building Starts, Birmingham News

Documents

Student health at Florence State Teachers College to be enhanced with new gymnasium for the school

Construction Projects Picking Up At Una Again, Jennifer Edwards

Documents

Demolition of Floyd Hall and other talk of new construction for The University of North Alabama

Media Center Gets New Studio, Name, Timesdaily

Documents

New Media Center and grand opening for the new Communications Building (former Gymnasium) in 1988

Health, Physical Education Program At College Will Be Aided By New Gym And Pool, The Florence Times

Documents

Construction of new Gymnasium and Pool at Florence State Teachers College

Goal-Directed Perfusion Strategies And Postoperative Acute Kidney Injury: A Scoping Review, Austin Davis

Student Works

Background: Acute kidney injury (AKI) remains a frequent and clinically important complication following cardiopulmonary bypass (CPB). Goal-directed perfusion (GDP) strategies—most commonly targeting indexed oxygen delivery (DO₂i) and/or other hemodynamic and metabolic parameters—have been proposed to reduce renal injury by improving renal oxygenation and perfusion during CPB.

Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Scoping Review (PRISMA-ScR) compliant scoping review identified 28 adult CPB studies evaluating GDP strategies and postoperative AKI outcomes.

Results: Maintenance of indexed oxygen delivery (DO2i) above critical thresholds and minimizing hemodilution were consistently associated with reduced AKI.

Conclusion: GDP strategies centered on maintaining …

Geographic Variation In Adrd Prevalence And Mortality And Their Association With Social Vulnerability Across Us Counties: A Spatial Epidemiological Analysis Using Norc And Cdc Svi Data, Dean Kyne

Sociology Faculty Publications

Introduction: Geographic disparities in Alzheimer’s disease and related dementias (ADRDs) remain insufficiently understood at the national scale, limiting efforts to address inequities in dementia burden across USA communities. This study examined county-level variation in ADRD prevalence and mortality and evaluates the association between social vulnerability and these outcomes.

Methods: This cross-sectional ecological study analyzes 2020 county-level ADRD prevalence and all-cause mortality among Medicare beneficiaries from the NORC Dementia DataHub. The analytic sample included 3,108 USA counties in the contiguous USA and the District of Columbia. ADRD outcomes included (1) prevalence of highly likely ADRD and (2) prevalence of all determinations, …

The History Of Women In Neuroradiology In North America From 1990 To The Present, Vijay M. Rao

Department of Radiology Faculty Papers

From 1990 to 2024, women neuroradiologists in North America have made tremendous progress in the areas of leadership, clinical innovation, research, education, diversity, equity and inclusion, and global outreach. This chapter begins with summaries of their key accomplishments in four broad domains, followed by short biographical sketches of numerous luminaries organized by leadership roles and areas of expertise, and ending with conclusions and future directions.

Gamified Simulation Training: An Opportunity For Improvement In Healthcare Education, Naya Hawkins-Grier, Ashley Martinez, Tara Subrahmanyan, Kelly Fan, Ryan Leudtke

Posters

Introduction: Improvements to education are currently being studied, as lectures alone have been shown to lack the ability to engage students effectively. Research has shown that simulation-based methods are promising new methods; however, they still leave room for improvement in the area of motivation. This program was introduced to introduce gamification to the WMed EIH2 program during the simulation section. The aim of this addition is to improve information retention and engagement among the kalamazoo high school student during the program. Methods: During each monthly session, the students were divided into two groups. Both groups completed individual pre-quizzes, …

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …

Icdpicr2 Calculates Abbreviated Injury Scale Scores From Diagnostic Codes: Limitations For Traumatic Brain Injury Epidemiology, Joseph Piatt

Department of Pediatrics Faculty Papers

BACKGROUND: Many large data sets are limited in their usefulness for trauma epidemiology by a paucity of clinical data reflecting injury severity. Software packages have been developed for extrapolation of diagnostic codes to Injury Severity Scores commonly used in trauma research. The aim of this project was to evaluate one recently upgraded package, ICDPICR2.

METHODS: Data were taken from the Trauma Quality Improvement Program (TQIP) for 2022. The inclusion criterion was an Abbreviated Injury Scale (AIS) head score of 1 or greater. The ICDPICR2 package in R was used to calculate AIS body region scores and Injury Severity Scores (ISS) …

Exploring The Ethical And Practical Considerations Of Artificial Intelligence In Real-World Health Care Settings: Stakeholder Focus Group Study, Carmen Wendy Ulizio, Devika Dua, Naya Meenkashi Mukul, Santosh Areti, Kristin Kostick-Quenet, Vasiliki Nataly Rahimzadeh

Center for Medical Ethics and Health Policy Staff Publications

Background: Artificial intelligence (AI) technologies continue to transform how we research human disease, diagnose and treat patients, and operate hospitals. However, emerging ethical dilemmas surrounding their design, use, and oversight demand both policy attention and empirical research.

Objective: This study aims to explore current AI development, integration, and use activities across the Texas Medical Center (TMC), the largest medical center in the world, and identify emerging ethical priorities.

Methods: We conducted a total of 3 qualitative focus groups via Zoom (Zoom Video Communications, Inc) between May and June 2025 to gauge the perspectives of 19 clinicians, developers, administrators, and patient …

Depolymerizing F-Actin Accelerates The Exit From Pluripotency To Enhance Stem Cell-Derived Islet Differentiation, Nathaniel J Hogrebe, Mason D Schmidt, Punn Augsornworawat, Sarah E Gale, Mira Shunkarova, Jeffrey R Millman

2020-Current year OA Pubs

In this study, we demonstrate that cytoskeletal state at the onset of directed differentiation impacts the exit of human pluripotent stem cells (hPSCs) from pluripotency and downstream lineage specification. In particular, depolymerizing F-actin with latrunculin A (latA) during the first 24 h of definitive endoderm formation facilitates efficient loss of pluripotency and alters Activin/Nodal, BMP, c-Jun, and WNT signaling dynamics. These signaling changes influence downstream patterning of the gut tube, leading to improved pancreatic progenitor identity and decreased expression of markers associated with other endodermal lineages. Continued differentiation generates islets containing a higher percentage of β cells that exhibit improved …

Dexmedetomidine (Precedex) Versus Propofol: In Patients Requiring Sedation While Mechanically Ventilated,, How Does The Use Of Dexmedetomidine (Precedex) Compared To Propofol, Affect Reintubation Within 48 Hours Post Extubation?, Kimberly Barbee, Markela Albright, Malak Amro, Evelyn Caty-Pletcher, Margaret Havey Phd, Aprn, Acnp-Bc, Chfn, Fhrs, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C

Doctor of Nursing Practice Projects

Keywords: dexmedetomidine, propofol, reintubation, sedation2

Abstract Assignment

Background

Sedation management in the ICU plays a key role in extubation readiness and post-extubation outcomes in mechanically ventilated patients. Although both propofol and dexmedetomidine are commonly used in critical care, there is limited evidence comparing their impact on early reintubation. This quality improvement (QI) project examined whether sedative choice was associated with reintubation within 48 hours of extubation.

Methods

A retrospective QI analysis was conducted in a cohort of 38 mechanically ventilated adult patients. Patients received either propofol (n = 31) or dexmedetomidine (n = 7) prior to extubation. Reintubation within …

Himmelfarb Library Liaison Letter - April 2026, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Shsp Dean's Newsletter, Spring 2026, Robert W. Amler

SHSP Dean’s Newsletter

No abstract provided.

Depressive And Anxiety Symptomatology Among Caregivers Of Children 0-3 Years In Nairobi City County: Community-Based Prevalence Study, Esther Chongwo, Japhet Adina, Kevinson Mwangi, Tabitha Shali, Edwin Dzoro, Cynthia Shitote, Vibian Angweny, Rachel Odhiambo, Margaret Kabue, Amina Abubakar

Institute for Human Development, East Africa

Caregivers of young children in low-resource urban settings face multiple stressors, which can affect their mental health. There is limited population-based evidence on the prevalence and correlates of depression and anxiety among caregivers of young children in these contexts. This study assessed the prevalence and associated factors of depressive and anxiety symptoms among caregivers of young children in Nairobi City County. We conducted a cross-sectional household survey with 2,903 primary caregivers of children 0–3 years. Depressive and anxiety symptoms were assessed using validated Swahili versions of the Patient Health Questionnaire-9 and the Generalised Anxiety Disorder-7, respectively, with a cut-off score …

Identification Of Bioactive Inhibitors In Dragon Fruit (Hylocereus Undatus) Targeting Top2a Protein In Human Breast Cancer, Md Iftehimul, Soharth Hasnat, Md Hasibur Rahman, Md Shohel Hossain, Md Arju Hossain, Abdul Barik, Md Faisal Amin, Dipta Dey, Tofazzal Islam, M. Nazmul Hoque

School of Integrative Biological & Chemical Sciences Faculty Publications

Breast cancer (BC) is the second most common cause of cancer-related mortality worldwide. Topoisomerase II alpha (TOP2A), a key enzyme involved in DNA replication and repair, represents an important biomarker and a promising therapeutic target in BC. This study investigated the therapeutic potential of bioactive compounds from dragon fruit (Hylocereus undatus) as inhibitors of TOP2A using computational biology approaches. A total of 72 phytochemicals were retrieved from the PubChem database and evaluated for binding affinity, toxicity, drug-likeness, and inhibitory potential against TOP2A. Among these, fifteen compounds satisfied Lipinski's rule of five and were predicted to be non-toxic and non-carcinogenic. Further …

The Role Of Outer Setting Health System Factors In The Use Of Hydroxyurea For Ugandan Children With Sickle Cell Anemia, Rollins Angela, Joseph Rujumba, Ruth Namazzi, Deogratius Munube, John Chandy, Russell Ware, Doreen Apolot, Andew Ssali, Henry Nancy, Robert Opoka

Paediatrics and Child Health, East Africa

Sickle cell anemia (SCA) causes childhood morbidity and mortality in Uganda and other countries in sub-Saharan Africa. Hydroxyurea is safe and effective, but not currently widely used in Uganda. We piloted a toolkit to support hydroxyurea use in two public health clinics: a regional referral hospital in a peri-urban area and a district hospital in a rural area. Implementation supports included a manual, expert training, and coaching over 2 years. We conducted key informant interviews and focus groups with national stakeholders, hospital leaders, healthcare workers, patient caregivers, and patients early in Year 1 and later in Year 2. Embedded research …

Paws And Practice: Overcoming Barriers To Mindfulness, Hazel Norris

2026 Awards for Excellence in Student Research and Creative Activity - Documents & Media

With the rise in chronic illnesses, healthcare professionals have sought to improve habits and behaviors to extend longevity and quality of life. However, for many people, unhealthy habits, such as smoking or binge eating, may develop as a way of coping with life stressors, which can make behavior changes harder to implement. Recently, there has been an increase in new research on whether improving mindfulness could be used to combat this problem. If mindfulness does encourage more engagement in health-promoting behaviors while protecting against risky behaviors, mindfulness-based behavior interventions could be very valuable for improving the health of college students …