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Full-Text Articles in Medicine and Health Sciences

A Qualitative Analysis Of Pediatricians' Perspectives Regarding Barriers, Facilitators, And Strategies For Providing Timely Autism Spectrum Disorder Screening And Diagnosis, Mallika Mathur, Jinni Tang, Christine Markham, Sandra Mckay, Ruosha Li, Deepali Ernest, Allison Marshall, Shreela Sharma Apr 2026

A Qualitative Analysis Of Pediatricians' Perspectives Regarding Barriers, Facilitators, And Strategies For Providing Timely Autism Spectrum Disorder Screening And Diagnosis, Mallika Mathur, Jinni Tang, Christine Markham, Sandra Mckay, Ruosha Li, Deepali Ernest, Allison Marshall, Shreela Sharma

Faculty, Staff and Student Publications

Background: Autism spectrum disorder (ASD) is a developmental disorder that has increased in prevalence over the years. Diagnosis and subsequent intervention by the age of 3 is essential for development. However, recent estimates indicate that less than 50% of children receive an evaluation by age 3. Underserved populations are more likely to receive an evaluation at an older age. Several barriers in the diagnostic process have been identified; however, limited studies have aimed at understanding the specifics of these barriers among underserved populations and whether current strategies are beneficial for all children.

Objectives: The aim of this study was to …


The Ki-67 Proliferation Index And Recurrence Risk Of Intracranial Meningioma: A Multicenter, Retrospective Cohort Study Of 5,050 Patients, Christian Mirian, Lasse Rehné Jensen, Tareq A Juratli, Andrea Daniela Maier, Anders Broechner, Sverre H Torp, Helen A Shih, Ramin A Morshed, Jacob S Young, Stephen T Magill, Luca Bertero, Walter Stummer, Dorothee Cäcilia Spille, Benjamin Brokinkel, Soichi Oya, Satoru Miyawaki, Nobuhito Saito, Martin Proescholdt, Yasuhiro Kuroi, Konstantinos Gousias, Matthias Simon, Jennifer Moliterno, Ricardo Prat-Acin, Stéphane Goutagny, Vikram C Prabhu, John T Tsiang, Johannes Wach, Erdem Güresir, Junkoh Yamamoto, Young Zoon Kim, Joo Ho Lee, Daniel W Kim, Matthew Koshy, Karthikeyan Perumal, Mustafa K Baskaya, Donald M Cannon, Dennis C Shrieve, Chang-Ok Suh, Jong Hee Chang, Maria Kamenova, Sven Straumann, Jehuda Soleman, Ilker Y Eyüpoglu, Tony Catalan, Austin Lui, Philip V Theodosopoulos, Michael W Mcdermott, Fang Wang, Pedro Góes, Aria Jamshidi, Ricardo Komotar, Michael Ivan, Evan Luther, Luis Souhami, Marie-Christine Guiot, Tamás Csonka, Toshiki Endo, Olivia Claire Barrett, Randy Jensen, Tejpal Gupta, Akash J Patel, Tiemo J Klisch, Jun Won Kim, Francesco Maiuri, Valeria Barresi, María Dolores Tabernero, Simon Skyrman, Ian Law, David Scheie, Bjarne Winther Kristensen, Tina Nørgaard Munch, Torstein Meling, Kåre Fugleholm, Paul Blanche, Tiit Mathiesen Apr 2026

The Ki-67 Proliferation Index And Recurrence Risk Of Intracranial Meningioma: A Multicenter, Retrospective Cohort Study Of 5,050 Patients, Christian Mirian, Lasse Rehné Jensen, Tareq A Juratli, Andrea Daniela Maier, Anders Broechner, Sverre H Torp, Helen A Shih, Ramin A Morshed, Jacob S Young, Stephen T Magill, Luca Bertero, Walter Stummer, Dorothee Cäcilia Spille, Benjamin Brokinkel, Soichi Oya, Satoru Miyawaki, Nobuhito Saito, Martin Proescholdt, Yasuhiro Kuroi, Konstantinos Gousias, Matthias Simon, Jennifer Moliterno, Ricardo Prat-Acin, Stéphane Goutagny, Vikram C Prabhu, John T Tsiang, Johannes Wach, Erdem Güresir, Junkoh Yamamoto, Young Zoon Kim, Joo Ho Lee, Daniel W Kim, Matthew Koshy, Karthikeyan Perumal, Mustafa K Baskaya, Donald M Cannon, Dennis C Shrieve, Chang-Ok Suh, Jong Hee Chang, Maria Kamenova, Sven Straumann, Jehuda Soleman, Ilker Y Eyüpoglu, Tony Catalan, Austin Lui, Philip V Theodosopoulos, Michael W Mcdermott, Fang Wang, Pedro Góes, Aria Jamshidi, Ricardo Komotar, Michael Ivan, Evan Luther, Luis Souhami, Marie-Christine Guiot, Tamás Csonka, Toshiki Endo, Olivia Claire Barrett, Randy Jensen, Tejpal Gupta, Akash J Patel, Tiemo J Klisch, Jun Won Kim, Francesco Maiuri, Valeria Barresi, María Dolores Tabernero, Simon Skyrman, Ian Law, David Scheie, Bjarne Winther Kristensen, Tina Nørgaard Munch, Torstein Meling, Kåre Fugleholm, Paul Blanche, Tiit Mathiesen

Faculty, Staff and Students Publications

Purpose: The Ki-67 proliferation index (Ki-67 PI) has been associated with meningioma recurrence, yet its clinical utility remains debated. Whether Ki-67 PI provides prognostic information across subgroups defined by both WHO grade and extent of resection remains to be investigated.

Methods: We analyzed 5,050 patients with intracranial meningiomas from the international PERNS cohort (42 centers, diagnosed between 1989-2019) who underwent surgical resection without postoperative radiotherapy. Ki-67 PI prognostic accuracy was assessed up to 10 years postoperatively by using ROC analyses and estimating its association with the risk of recurrence.

Results: Results demonstrated that the prognostic value of Ki-67 PI differed …


Mitochondrial Presequences Harbor Variable Strengths To Maintain Organellar Function, Youmian Yan, Baigalmaa Erdenepurev, Thiago N Menezes, Ian Collinson, Natalie M Niemi Apr 2026

Mitochondrial Presequences Harbor Variable Strengths To Maintain Organellar Function, Youmian Yan, Baigalmaa Erdenepurev, Thiago N Menezes, Ian Collinson, Natalie M Niemi

2020-Current year OA Pubs

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of what dictates strong versus weak presequences is lacking. Furthermore, the extent to which presequence strength affects mitochondrial function and cellular fitness remains unclear. Here, we capitalize on the MitoLuc protein import assay to define multiple aspects of presequence strength. We find that select presequences, including …


A Regional Scoping Review Of School-Based Nutrition Interventions Conducted Across Nordic Countries, Basil H. Aboul-Enein, Stephen Gambescia, Nada Benajiba, Norah Eid Aljohani, Teresa Keller, Patricia J. Kelly Apr 2026

A Regional Scoping Review Of School-Based Nutrition Interventions Conducted Across Nordic Countries, Basil H. Aboul-Enein, Stephen Gambescia, Nada Benajiba, Norah Eid Aljohani, Teresa Keller, Patricia J. Kelly

College of Nursing Faculty Papers & Presentations

BACKGROUND AND AIMS: While Nordic countries have a relatively high socioeconomic status population, they are challenged by the health deficit of rising obesity and overweight among young people. The aim of this regional scoping review is to identify best practices for designing and implementing effective school nutrition programs in Nordic countries and identify gaps for further research.

METHODS: Using the PRISMA-ScR guidelines, a scoping review was conducted across nine academic databases between 1980 and May 2025.

RESULTS: Fifty-three studies met the inclusion criteria, from small pilot interventions to large national or international cohorts involving thousands of students across the five …


Intravascular Position-Sensitive Positron-Counting Catheter For Atherosclerotic Plaques, Takehiro Nakahara, Shinichiro Fujimoto, Jagat Narula, H William Strauss, Navneet Narula, Tohru Minamino, Hiroyuki Daida, Masahiro Jinzaki Apr 2026

Intravascular Position-Sensitive Positron-Counting Catheter For Atherosclerotic Plaques, Takehiro Nakahara, Shinichiro Fujimoto, Jagat Narula, H William Strauss, Navneet Narula, Tohru Minamino, Hiroyuki Daida, Masahiro Jinzaki

Faculty, Staff and Student Publications

Purpose: Rupture prone high-risk atheromatous plaques are characterized by large necrotic core volumes covered by thin fibrous caps which are positively remodeled; these plaques are significantly inflamed by the cells of monocyte-macrophage origin. We propose that the development of a position-sensitive positron-counting catheter, adding directionality with lead shields (sCath), would help record quantitative location-specific uptake of specifically targeted radiotracers against inflammation.

Methods: For in-vitro study, the catheter was placed on 18F point sources to measure the radioactivity counts. For ex-vivo study, the 9 aortas dissected from the rabbit model of atherosclerosis were exposed, and catheters were pulled back every 1 …


Untangling Impacts Of Socioeconomic Position, Chronic Disease, And Low-Level Pm2.5 Exposure On Mortality Among Native American Medicare Beneficiaries, Judy Wendt Hess, Wenyaw Chan Apr 2026

Untangling Impacts Of Socioeconomic Position, Chronic Disease, And Low-Level Pm2.5 Exposure On Mortality Among Native American Medicare Beneficiaries, Judy Wendt Hess, Wenyaw Chan

Faculty, Staff and Student Publications

Ambient fine particulate matter (PM2.5) is associated with increased mortality at concentrations below current regulatory standards. Studies of low-level exposure often rely on large administrative cohorts whose geographic and demographic composition may influence observed associations. In a prior analysis, we observed an association between long-term PM2.5 and all-cause mortality among Native American Medicare beneficiaries living in zip codes within the lowest decile of PM2.5 exposure. The present study, a case-control analysis of 1,713,399 low-PM2.5-exposed beneficiaries enrolled in traditional Medicare during 2015-2016, evaluated whether this association could be explained by geographic context, socioeconomic position (SEP), or baseline health status. We used …


Comparison Of Same-Day Discharge Robotic-Assisted Radical Prostatectomy In An Ambulatory Surgery Center Versus Hospital Setting, Nishant S. Kumar Bs, Ranko Miocinovic Md, Tom D. Beris Md, Maya Goyal Bs, Vineet Kumar Bs, Amit R. Patel Md Apr 2026

Comparison Of Same-Day Discharge Robotic-Assisted Radical Prostatectomy In An Ambulatory Surgery Center Versus Hospital Setting, Nishant S. Kumar Bs, Ranko Miocinovic Md, Tom D. Beris Md, Maya Goyal Bs, Vineet Kumar Bs, Amit R. Patel Md

Medical Student Research Symposium

Introduction

Robotic-Assisted Radical Prostatectomy (RARP) is the predominant surgical approach for localized prostate cancer in the United States and over 50% of RARP are performed as ambulatory or same-day discharge encounters. Current literature supports that RARP performed in the outpatient setting are as effective and have no increase in complications compared to those performed inpatient and cost nearly 20% less than those performed inpatient.

Methods

Between May 2021 and December 2021, two-high volume robotic surgeons at an independent multi-specialty physician group performed RARP in both a freestanding ambulatory surgery center (ASC) and in an affiliated hospital. Data on demographics, clinical …


Barriers And Facilitators To Lung Cancer Screening In Arab/Middle Eastern And North African (Mena) Communities, Sara Komaiha, Mustafa Sharba, Ahmad Dulli, Faten Abda, Rawan Antar, Dana Sunbulli, Jad Fawaz, Ragad Almsaddi, Jawad Saad, Yasmin Snounu, Morhaf Al Achkar Apr 2026

Barriers And Facilitators To Lung Cancer Screening In Arab/Middle Eastern And North African (Mena) Communities, Sara Komaiha, Mustafa Sharba, Ahmad Dulli, Faten Abda, Rawan Antar, Dana Sunbulli, Jad Fawaz, Ragad Almsaddi, Jawad Saad, Yasmin Snounu, Morhaf Al Achkar

Medical Student Research Symposium

Background: Lung cancer remains the second most prevalent cancer worldwide, with an estimated 2.21 million new cases in 2025. Screening rates for colorectal and cervical cancers are consistently lower among Middle Eastern and North African (MENA) populations compared to White populations, suggesting similarly low participation in lung cancer screening (LCS). This study explores multilevel determinants of LCS engagement.

Methods: Using the Socio-Ecological Model and the Health Belief Model frameworks, this qualitative study examines how individual, interpersonal, and community factors shape screening behaviors. Screening-eligible adults and key LCS stakeholders, including clinicians, administrators, and community leaders, are recruited for focus groups and …


Patient Reported Outcome Participation And Completion In Total Joint Arthropathy: A Socioeconomic Analysis, Diana Kernen Ba, Michelle Yi Mse, Kathleen Jahnke Bs, Nevil Khurana Ms, Ezra Goodrich Md, Charles Day Md, Mba Apr 2026

Patient Reported Outcome Participation And Completion In Total Joint Arthropathy: A Socioeconomic Analysis, Diana Kernen Ba, Michelle Yi Mse, Kathleen Jahnke Bs, Nevil Khurana Ms, Ezra Goodrich Md, Charles Day Md, Mba

Medical Student Research Symposium

Background
Patient-reported outcome measures (PROMs) assess symptoms, function, and overall health from a patient perspective. Although PROM engagement has been studied across orthopaedics, limited work has examined both participation and completion specifically in joint replacement. This study evaluated associations between sociodemographic factors and PROM participation and completion among total joint arthroplasty patients.

Methods
We performed a retrospective review of all primary arthroplasties completed by a single surgeon in 2023 at a Midwestern tertiary health system. PROMs included PROMIS PF, PROMIS PI, and either HOOS JR or KOOS JR. Demographic data and Area Deprivation Index (ADI) were collected. Participation was defined …


Clinical Insights Into Early-Onset Pancreatic Cancer, Ken Huynh, Ling Huang, Kyra Langley, Julie Clark, David Kwon Apr 2026

Clinical Insights Into Early-Onset Pancreatic Cancer, Ken Huynh, Ling Huang, Kyra Langley, Julie Clark, David Kwon

Medical Student Research Symposium

Background: Pancreatic cancer is the third leading cause of cancer-related death in the U.S., with a 5-year survival of 12.8%. Black patients experience higher incidence, later-stage diagnosis, and worse survival than other groups. Early-onset pancreatic cancer (EOPC, age < 50 years) represents 5–12% of cases and shows distinct features including male predominance, later presentation, and associations with smoking, obesity, and diabetes. Data on EOPC among Black patients remain limited. Given Detroit’s large Black population, this study characterizes clinical and demographic factors associated with EOPC to identify potential risk patterns.

Methods: A retrospective cohort study of pancreatic adenocarcinoma cases (October 2005– February 2025) was conducted using the Henry Ford Health REDCap database. Demographic, clinical, and biomarker data were extracted from electronic records. Statistical comparisons between groups were performed using chi-square, Fisher’s exact, or t-tests.

Results: Of 2,436 patients, 243 met inclusion criteria: 86 EOPC, 81 average-onset (AOPC), and 76 late-onset (LOPC). EOPC …


Exploring The Role Of Patient Feedback In Medical Education, Hovhannes John Hayrapetyan, Stella Hayrapetyan, Diane L. Levine Md Apr 2026

Exploring The Role Of Patient Feedback In Medical Education, Hovhannes John Hayrapetyan, Stella Hayrapetyan, Diane L. Levine Md

Medical Student Research Symposium

Background: Patient feedback is increasingly recognized as a valuable yet underutilized component of medical student assessment. When collected reliably, delivered with specificity, and embedded in a supportive learning environment, feedback can improve communication, professionalism, and patient-centered behaviors while promoting reflective, self-directed learning. However, studies highlight limitations including inadequate longitudinal evidence for sustained improvement, inconsistent use of structured tools, and insufficient faculty guidance. Instruments such as the Patient Feedback in Clinical Practice (PFCP) questionnaire show promise but require broader testing, and links between learner feedback and patient outcomes remain weak.

Methods: A comprehensive literature review was conducted using PubMed, Google Scholar, …


Survivin And Caspases Coordinate Proteolytic Cleavage Of The Saga Chromatin Modifying Complex, Elinor Harrison, Alejandro Damian, Cj Talton Apr 2026

Survivin And Caspases Coordinate Proteolytic Cleavage Of The Saga Chromatin Modifying Complex, Elinor Harrison, Alejandro Damian, Cj Talton

Medical Student Research Symposium

Title: Survivin and Caspases Coordinate Proteolytic Cleavage of the SAGA Chromatin Modifying Complex

Elinor Harrison1, Alejandro Damian1, CJ Talton1, Jelly H Soffers1, Abudu I Bello1, Kara M Costanzo1, Joe Bean1, Ryan D Mohan1

1Wayne State University School of Medicine

Background: The Spt Ada Gcn5 Acetyltransferase (SAGA) chromatin modifying complex is a critical regulator of gene expression. Mutation or stoichiometric imbalance of SAGA subunits leads to a spectrum of diseases in model organisms and in humans, including neurodegeneration. SAGA contributes to gene activation through coordinated …


A Systemic Review Of Functional Outcomes And Patient Satisfaction Across Lower-Limb Prosthetic Types In Military Personnel And Veterans, Emma Ho Harris, Amir Ghafarian, Sen Gao, Khaled Saleh, Jason Pasley Apr 2026

A Systemic Review Of Functional Outcomes And Patient Satisfaction Across Lower-Limb Prosthetic Types In Military Personnel And Veterans, Emma Ho Harris, Amir Ghafarian, Sen Gao, Khaled Saleh, Jason Pasley

Medical Student Research Symposium

Background: Military personnel and veterans are at increased risk of lower-limb amputation, often due to combat-related trauma such as improvised explosive devices (IEDs), as well as secondary factors including tobacco use, peripheral artery disease, and diabetes. This study systematically reviews and compares lower-limb prosthetic technologies in military personnel and veterans, focusing on functional outcomes, mobility, and patient satisfaction.

Methods: A comprehensive literature search was conducted using PubMed MeSH terms to identify studies examining lower-limb prosthetic use and outcomes among military personnel and veterans. The final MeSH-based search yielded 27 results.

Results: The review included 27 studies on lower-limb prosthetic use …


Data Science In Medicine: Bridging The Statistics & Research Skills Education Gap Through Multi-Platform Bootcamps, Marta Haireek, Muhammad Idrees, Yiannos Demetriou, Laura Benjamins, Alan Dombkowski Apr 2026

Data Science In Medicine: Bridging The Statistics & Research Skills Education Gap Through Multi-Platform Bootcamps, Marta Haireek, Muhammad Idrees, Yiannos Demetriou, Laura Benjamins, Alan Dombkowski

Medical Student Research Symposium

Background

Presently, there is great emphasis on medical students' research output and demand for healthcare practitioners with skills in data appraisal, research methodologies, and evidence interpretation; however, medical students do not receive formal training in research and data science. This presents a major gap in medical education as curriculums focus on USMLE preparation without exposure to statistical software or analytical thinking required for productive research outcomes or evidence appraisal. Accordingly, the “Data Science Research Bootcamp” addressed this gap through workshops focused on Python, R, and SPSS.

Methods

WSUSOM students attended Python (n=22), R (n=9), and SPSS (upcoming) workshops to learn …


Fatty Acid Metabolism And Retinal Endothelial Barrier Functionality, Mason J. Gardiner, Mohamed Shawky, Shaimma El Tanani, Ahmed S. Ibrahim Apr 2026

Fatty Acid Metabolism And Retinal Endothelial Barrier Functionality, Mason J. Gardiner, Mohamed Shawky, Shaimma El Tanani, Ahmed S. Ibrahim

Medical Student Research Symposium

Background: This study examines how fatty acid synthesis and β-oxidation pathways support the integrity of the human retinal endothelial barrier under normal conditions and identifies key enzymes required for maintaining barrier stability. Understanding these pathways helps address gaps in knowledge about retinal changes in disease and highlights potential pharmacologic targets.

Methods: Human retinal endothelial cells (HRECs) were cultured on electrode arrays and monitored by Electric Cell-Substrate Impedance Sensing (ECIS) until stable membrane resistance was achieved. Media were then replaced with solutions containing published inhibitors of fatty acid synthesis or β-oxidation. Barrier effects were tracked for 80 h. Cytotoxicity (LDH assays) …


Kelim Score Predicts Recurrence And Survival In Bevacizumab-Treated Advanced Ovarian Cancer: A Real-World Pilot Study, Mohammed Elshafey, Pontia Doroudian, Madeline Ruth Evans, Ira Winer Apr 2026

Kelim Score Predicts Recurrence And Survival In Bevacizumab-Treated Advanced Ovarian Cancer: A Real-World Pilot Study, Mohammed Elshafey, Pontia Doroudian, Madeline Ruth Evans, Ira Winer

Medical Student Research Symposium

Background:
The KELIM score, derived from CA-125 kinetics, reflects intrinsic tumor chemosensitivity in ovarian cancer. This retrospective study evaluated whether KELIM predicts clinical outcomes in patients receiving bevacizumab in a real-world setting.

Methods:
Twenty-four patients with advanced ovarian cancer treated with platinum-based chemotherapy and bevacizumab at a tertiary center in Detroit, MI, were included. KELIM scores were calculated from CA-125 values during the first 100 treatment days (www.biomarker-kinetics.org) and classified as favorable (≥1.0) or unfavorable (< 1.0). Progression-free survival (PFS) was measured from diagnosis to recurrence, and overall survival (OS) from diagnosis to last contact or death. Surgical outcomes, debulking approach, PARP inhibitor use, and survival status were analyzed descriptively.

Results:
Nineteen patients (79%) had favorable KELIM, and five (21%) had unfavorable KELIM. Compared to the favorable group, the unfavorable group had …


Glucose Metabolic Abnormalities Of Thalamic Nuclei In Patients With Drug-Resistant Focal Epilepsy: A High-Resolution Pet Study, Halle N. Escher, Maysaa Basha, Otto Muzik, Csaba N. Juhasz Apr 2026

Glucose Metabolic Abnormalities Of Thalamic Nuclei In Patients With Drug-Resistant Focal Epilepsy: A High-Resolution Pet Study, Halle N. Escher, Maysaa Basha, Otto Muzik, Csaba N. Juhasz

Medical Student Research Symposium

Background

Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is often used during presurgical evaluation of drug-resistant epilepsies. Interictal glucose hypometabolism can involve the thalamus ipsilateral to the epileptic focus. As targeted stimulation of specific thalamic nuclei is increasingly utilized to control seizures, analysis of intrathalamic variations of metabolic abnormalities may help identify the optimal target and monitor treatment effects.

Methods

FDG-PET scans performed on a high-resolution PET scanner were used to measure glucose uptake in 12 patients (median age: 27.5 years) ipsi- and contralateral to the epileptic focus in the whole thalamus and five thalamic regions (dorsomedial, lateral, anterior, superior nuclei, and …


Evaluating Relative Value Units For Hypertension And Diabetes Care In A Student-Run Free Clinic: A Retrospective Chart Review, Gabriel Doree, Isabella Imirowicz, Anthony Kavanagh, Emily Yao, Robert Sherwin Md Apr 2026

Evaluating Relative Value Units For Hypertension And Diabetes Care In A Student-Run Free Clinic: A Retrospective Chart Review, Gabriel Doree, Isabella Imirowicz, Anthony Kavanagh, Emily Yao, Robert Sherwin Md

Medical Student Research Symposium

Evaluating Relative Value Units for Hypertension and Diabetes Care in a Student-Run Free Clinic: A Retrospective Chart Review

Gabriel Doree, Isabella Imirowicz, Anthony Kavanagh, Emily Yao, Robert Sherwin, MD

Background: Hypertension and diabetes impose major financial and health burdens in the United States, disproportionately affecting uninsured and unhoused populations. Student-run free clinics (SRFCs) provide critical chronic disease management yet are rarely evaluated using standardized economic metrics such as Relative Value Units (RVUs).

Methods: This retrospective chart review quantified RVUs generated by hypertension and diabetes visits at the Cass-Costea SRFC in Detroit over six months. CPT codes were retrospectively assigned to …


The Use Of Large Language Models In Enhancing Patient Education Materials For Pancreatic Neuroendocrine Tumors, Brendan Dolan, Aniela Crayton, Emerson Woodbury, Miguel Tzita, Eliza Beal Md, Gregory Dyson Phd Apr 2026

The Use Of Large Language Models In Enhancing Patient Education Materials For Pancreatic Neuroendocrine Tumors, Brendan Dolan, Aniela Crayton, Emerson Woodbury, Miguel Tzita, Eliza Beal Md, Gregory Dyson Phd

Medical Student Research Symposium

Background:

Incidence and prevalence of Pancreatic Neuroendocrine Tumors (PNETs) has increased in recent years. More than half of American adults endorse utilizing the internet within the past year to search for medical information. This study aims to investigate the use of Large Language Models (LLMs), a popular type of artificial intelligence, to improve the efficacy of online patient education materials (oPEMs) in providing accurate and digestible information to patients with a PNET diagnosis.

Methods: Content from 36 web pages related to PNET was transferred to two popular LLMs, Chat GPT and Google Gemini, with the prompt “rewrite the following text …


Evaluating Kwensante's Dual-Channel Health Education: A Pilot Assessment Of Online And Radio Interventions For Metabolic Syndrome Literacy, William M. Davie, Nikuze Poshi, Carline Dugue, Jean-Alix Simeon, Anil Aranha, Marie-Louise Jean-Baptiste Apr 2026

Evaluating Kwensante's Dual-Channel Health Education: A Pilot Assessment Of Online And Radio Interventions For Metabolic Syndrome Literacy, William M. Davie, Nikuze Poshi, Carline Dugue, Jean-Alix Simeon, Anil Aranha, Marie-Louise Jean-Baptiste

Medical Student Research Symposium

Background

Metabolic syndrome (MetS) is a cluster of conditions, including insulin resistance, dyslipidemia, central obesity, and hypertension,that raises the risk of cardiovascular disease and type 2 diabetes. Its prevalence is rising, especially among Haitian immigrants (HI), who face added risks from dietary acculturation and low health literacy. The KwenSante Radio Program (KSRP), launched in Haitian Creole in 2012, provides culturally tailored health education. This study evaluates whether KSRP improves MetS knowledge among HI in Greater Boston.

Methods

A parallel, convergent mixed-methods design was used. Data were collected and analyzed independently before integration. An online survey and interview, developed with Tufts …


A Ubiquitin Code Written In Circadian Time: Evaluating Protein Linkages In A Drosophila Model, Alejandro Damian, Elinor Harrison, Cj Dalton Apr 2026

A Ubiquitin Code Written In Circadian Time: Evaluating Protein Linkages In A Drosophila Model, Alejandro Damian, Elinor Harrison, Cj Dalton

Medical Student Research Symposium

Background: Ubiquitin is a small polypeptide that serves many functions within a cell, including modifying proteins, marking them for degradation through the ubiquitin-proteasome system (UPS). Circadian rhythms regulate many cellular processes, but its role on the individual linkages of ubiquitin is poorly understood. This project aims to determine whether there is a circadian pattern for the conjugation of ubiquitin. Methods: Wild-type (Oregon R) Drosophila were entrained to a circadian cycle with standard light and dark environments. The whole heads were then frozen and removed at different times and used to quantify protein linkages using western blotting and antibodies to each …


A Retrospective Study On The Associations Of Clinical Measures To Mortality In Pediatric Extracorporeal Membrane Oxygenation (Ecmo) Patients, Ammar F. Chauhdri, Ryan Davis Md, Christina Shanti Md, Michelle Veenstra Md, Megan Zacarias, Samantha Carranza, Laura Sansoterra, Nimr Assaf, Christian Hudson-Bradford Md, Elika Ridelman Phd Apr 2026

A Retrospective Study On The Associations Of Clinical Measures To Mortality In Pediatric Extracorporeal Membrane Oxygenation (Ecmo) Patients, Ammar F. Chauhdri, Ryan Davis Md, Christina Shanti Md, Michelle Veenstra Md, Megan Zacarias, Samantha Carranza, Laura Sansoterra, Nimr Assaf, Christian Hudson-Bradford Md, Elika Ridelman Phd

Medical Student Research Symposium

A Retrospective Study on the Associations of Clinical Measures to Mortality in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Patients

Ammar Chauhdri; Ryan Davis, MD; Christina Shanti, MD; Michelle Veenstra, MD; Megan Zacarias; Samantha Carranza; Laura Sansoterra; Nimr Assaf; Christian Hudson-Bradford, MD; Elika Ridelman, PhD

Background: Extracorporeal membrane oxygenation (ECMO) is a form of temporary cardiopulmonary support used in critically ill pediatric patients when conventional therapies fail, yet survival to discharge remains only ~50% nationwide. Prior studies have identified candidate mortality predictors and developed basic risk scores, but these models have limited accuracy and are often derived from registry-level or narrowly defined …


Effect Of Pre-Training Patients Using A Self-Directed Slideshow Presentation On Visual Field Reliability In First-Time Test Takers, Lillian M. Centlivre B.S., Derek Zahnleuter B.S., Rahul Babu B.S., Chaesik Kim, Kaitlin Ziadeh Md, Hanna Simmons Md, Vivian Rajeswaren Md, Aleskey Parker Williams Do, Jacob Im Md, Aleksey Mishulin Md, Faisal Ridha Al-Timimi Md, Hassan Tokko Apr 2026

Effect Of Pre-Training Patients Using A Self-Directed Slideshow Presentation On Visual Field Reliability In First-Time Test Takers, Lillian M. Centlivre B.S., Derek Zahnleuter B.S., Rahul Babu B.S., Chaesik Kim, Kaitlin Ziadeh Md, Hanna Simmons Md, Vivian Rajeswaren Md, Aleskey Parker Williams Do, Jacob Im Md, Aleksey Mishulin Md, Faisal Ridha Al-Timimi Md, Hassan Tokko

Medical Student Research Symposium

Title: Effect of Pre-Training Patients Using a Self-Directed Slideshow Presentation on Visual Field Reliability in First-Time Test Takers

Authors: Lillian Centlivre BS, Derek Zahnleuter BS, Rahul Babu BS, Chaesik Kim BSEE, Kaitlin Ziadeh MD, Hanna Simmons MD, Vivian Rajeswaren MD, Aleksey Parker Williams DO, Jacob Im MD, Aleksey Mishulin MD, Faisal Ridha Al-Timimi MD, Hassan Tokko MD

Background: Visual field (VF) testing is essential for detecting glaucoma, but reliability is limited by patient inexperience and poor fixation. Prior studies report VF test reliability around 59%, primarily attributed to increased fixation loss (FL). Other studies note 75.9% reliability using training videos …


Hormonal Birth Control Misinformation On Tiktok: A Content Analysis Of Influencer Narratives, Sarah Bdeir, Jana Hatahet, Liselle Tungol, Khush Hussain, Rumyah Rafique, Raneem Sabbaq, Ragad Almsaddi Apr 2026

Hormonal Birth Control Misinformation On Tiktok: A Content Analysis Of Influencer Narratives, Sarah Bdeir, Jana Hatahet, Liselle Tungol, Khush Hussain, Rumyah Rafique, Raneem Sabbaq, Ragad Almsaddi

Medical Student Research Symposium

Background:

Hormonal birth control is the most common form of reversible contraception. In the U.S., pharmacy data show oral contraceptive pill prescriptions declined 25.6% from March 2021 to October 2023. Meanwhile, patients increasingly seek health information on social media. On TikTok, “hormone hacking” content has surged, often portraying birth control as artificial, harmful, or even carcinogenic, despite a lack of supporting evidence. While accessible information on social media can be valuable, such narratives risk spreading misinformation, fueling mistrust in women’s health.

Methods:

We conducted a qualitative content analysis of 50 TikTok videos (March and September 2025) under #birthcontrol, #hormonehealth, #birthcontroltoxicity, …


Mechanisms Of Ventricular Catheter Obstruction, Mohamed Khalil Attie Ms, Christopher Roberts Ms, Carolyn Harris Phd Apr 2026

Mechanisms Of Ventricular Catheter Obstruction, Mohamed Khalil Attie Ms, Christopher Roberts Ms, Carolyn Harris Phd

Medical Student Research Symposium

Background: Hydrocephalus is treated primarily with ventriculoperitoneal shunts, which fail over time mainly due to proximal ventricular catheter (VC) obstruction of the drainage holes. Prior computational fluid dynamics (CFD) studies based on idealized geometries have suggested that cerebrospinal fluid (CSF) preferentially enters distal holes due to lower resistance, thereby increasing the risk of obstruction at those locations. However, these models do not incorporate explanted VC data, patient-specific anatomy, or differences in catheter architecture.

Methods: To evaluate whether flow distribution matches failure sites, we compared obstruction patterns from 30 explanted catheters with CFD simulations of four commercial VC designs. For every …


Outreach Challenges And Strategies For Educating Arab/Mena Community On Colorectal Cancer Screening, Rawan Antar, Faten Abda, Dana Sunbulli, Ahmad Dulli, Mustafa Sharba, Sara Komaiha, Jad M. Fawaz, Ragad Almsaddi, Jawad Saad, Yasmin Snounu, Morhaf Al Achkar Apr 2026

Outreach Challenges And Strategies For Educating Arab/Mena Community On Colorectal Cancer Screening, Rawan Antar, Faten Abda, Dana Sunbulli, Ahmad Dulli, Mustafa Sharba, Sara Komaiha, Jad M. Fawaz, Ragad Almsaddi, Jawad Saad, Yasmin Snounu, Morhaf Al Achkar

Medical Student Research Symposium

Background: Arab/MENA communities in Michigan face unique cultural, linguistic, and structural barriers that contribute to lower colorectal cancer (CRC) screening awareness and uptake. “Trimming the Risks” was a community-engaged educational project designed to reach Arabic-speaking men through trusted social spaces, particularly barbershops, and through community-based Lunch and Learn sessions. This project assesses engagement patterns from this initiative to identify effective strategies and challenges to improve future MENA engagement.

Methods: Our educational initiative implemented two main interventions. Pilot A trained barbers on CRC screening information through a structured 2-hour session, provided iPads with bilingual educational videos, and equipped barbers to guide …


Assessing Functional Visual Recovery After Retinal Regeneration In Zebrafish Using The Optokinetic Response (Okr), Yeganeh Tabatabaei Alavi, Yeganeh Tabatabaei Alavi Apr 2026

Assessing Functional Visual Recovery After Retinal Regeneration In Zebrafish Using The Optokinetic Response (Okr), Yeganeh Tabatabaei Alavi, Yeganeh Tabatabaei Alavi

Medical Student Research Symposium

Zebrafish have a unique ability to regenerate retinal neurons through Müller glia-mediated reprogramming, a process not found in mammals. While structural regeneration has been extensively documented, the degree to which regenerated photoreceptors restore functional vision remains unclear. The optokinetic response (OKR), a reflexive eye-tracking behavior triggered by moving visual stimuli, provides a quantitative, non-invasive method to assess visual performance. This study aims to determine whether photoreceptor regeneration following acute and chronic light-induced injury results in functional restoration of vision. Adult zebrafish will be divided into three groups: uninjured control, acute injury (short-term high-intensity light), and chronic injury (long-term low-intensity light). …


Parkinsonism Induced By Carbon Monoxide Intoxication: A “Hidden Gem” In The Neurological Literature, Omer Abdullah, Peter A. Lewitt Apr 2026

Parkinsonism Induced By Carbon Monoxide Intoxication: A “Hidden Gem” In The Neurological Literature, Omer Abdullah, Peter A. Lewitt

Medical Student Research Symposium

Title

Parkinsonism Induced by Carbon Monoxide Intoxication: A Hidden Gem in the Neurological Literature

Authors

Omer Abdullah [1], B.S.; Peter A. LeWitt, M.D., M.Med.Sc. [1,2] Departments of Neurology and Pharmacology, Wayne State University School of Medicine [1]; Sastry Foundation Endowed Chair in Parkinson Disease Research, Detroit, Michigan, USA [2]

Background

Carbon monoxide (CO) exposure is a well-established cause of central nervous system injury, yet its role in precipitating Parkinsonism remains under-recognized. Early case reports from the 1970s first suggested CO intoxication as a potential cause of secondary Parkinsonism, often linked to bilateral globus pallidus injury. Despite this, the topic has …


Leveling The Playing Field: Ensuring Hydration Equity For Detroit’S Student-Athletes, David Abdelnour, Noah Kos, Alqasim Elnaggar, Jack Mao, Rumyah Rafique, Julian D Johnson, Marley Sternberg, Audrey Millar, Faith Scott, Susan Lagrand, Ammar Chaudhri, Magd Boutany, Rahul Vaidya Apr 2026

Leveling The Playing Field: Ensuring Hydration Equity For Detroit’S Student-Athletes, David Abdelnour, Noah Kos, Alqasim Elnaggar, Jack Mao, Rumyah Rafique, Julian D Johnson, Marley Sternberg, Audrey Millar, Faith Scott, Susan Lagrand, Ammar Chaudhri, Magd Boutany, Rahul Vaidya

Medical Student Research Symposium

Background:

The Detroit Public Schools Health Corps (DPSHC) provides free sideline medical coverage to Detroit Public Schools Community District (DPSCD) athletic events to address healthcare disparities in underserved communities. During 408 hours of coverage across 214 games, DPSHC volunteers observed frequent shortages of water and electrolyte drinks among teams. Given the importance of hydration in preventing heat-related illness and optimizing athletic performance, a systematic needs assessment was conducted.

Methods:

A survey was distributed to athletic coaches and administrators across DPSCD schools. Survey questions evaluated the availability of hydration resources, frequency of shortages, responsible providers, and priority needs for additional funding …


Retracted: Idea Density And Grammatical Complexity As Neurocognitive Markers, Diego Iacono, Gloria C. Feltis Apr 2026

Retracted: Idea Density And Grammatical Complexity As Neurocognitive Markers, Diego Iacono, Gloria C. Feltis

Department of Neurology Faculty Papers

The journal retracts the article titled “Idea Density and Grammatical Complexity as Neurocognitive Markers” [1], cited above. Following publication, concerns were brought to the attention of the Editorial Office regarding the presence of misnamed phrases and the accuracy of several references cited in this paper [1]. In accordance with the journal’s standard procedures, the Editorial Office and Editorial Board conducted an investigation that confirmed the presence of a misnamed phrase for ROSE model and significant number of non-existent references, which were determined to undermine the overall reliability of this study. In addition, the investigation identified indications of generative AI use …