Medicine and Health Sciences Commons^™

Fine-Structure Analysis Of The Processing And Polyadenylation Region Of The Herpes Simplex Virus Type 1 Thymidine Kinase Gene By Using Linker Scanning, Internal Deletion, And Insertion Mutations., Fang Zhang, Roger M. Denome, Charles N. Cole

Dartmouth Scholarship

Most eucaryotic mRNAs are polyadenylated. In higher eucaryotes, the sequence AATAAA is located 7 to 30 base pairs (bp) upstream from the site of processing and polyadenylation and is a critical part of the signal for processing and polyadenylation. Efficient cleavage and polyadenylation also require sequences downstream of polyadenylation sites. The herpes simplex virus type 1 thymidine kinase (tk) gene contains two copies of the AATAAA hexanucleotide and a GT box (18 of 19 consecutive residues are G or T) previously shown to be required for efficient processing and polyadenylation of tk mRNA (C. N. Cole and T. P. Stacy, …

Regulation By Adrenal Corticosteroids Of Sodium And Potassium Transport In Loop Of Henle And Distal Tubule Of Rat Kidney., Bruce A. Stanton

Dartmouth Scholarship

Studies were conducted to examine the effects of adrenalectomy (ADX) and selective, physiological adrenal corticosteroid replacement on sodium and potassium transport by the superficial loop of Henle and distal tubule of rat kidney in vivo. In the loop of Henle, ADX inhibited sodium reabsorption by 33%. Whereas dexamethasone had no effect on reabsorption, aldosterone increased sodium transport to control levels. Thus, physiological levels of mineralocorticoids, but not glucocorticoids, control a fraction of sodium reabsorption in the loop of Henle. ADX also inhibited potassium reabsorption in the loop of Henle. Both dexamethasone and aldosterone reversed the inhibition, although only aldosterone increased …

Tyrosyl Kinase Activity Is Inversely Related To Prostatic Acid Phosphatase Activity In Two Human Prostate Carcinoma Cell Lines., Ming-Fong Lin, Ching-Li Lee, Gail M. Clinton

Journal Articles: Biochemistry & Molecular Biology

Alterations in prostatic acid phosphatase (PAcP), a phosphotyrosyl phosphatase, corresponded to changes in overall tyrosyl kinase activity. PAcP added to extracts of prostate carcinoma cells with a low endogenous level of PAcP activity and elevated tyrosyl kinase activity decreased the tyrosyl kinase activity. On the other hand, when PAcP activity was decreased by the addition of androgens to cells, there was a corresponding increase in tyrosyl kinase activity.

Diel Patterns Of Active Vertical Migration In Seagrass Meiofauna, Keith Walters, Susan S. Bell

Integrative Biology Faculty and Staff Publications

Patterns of active vertical migration exhibited by sediment-associated meiofauna were examlned in a subtropical seagrass meadow. Total numbers, species composition and percentage of sediment meiofauna found to migrate were examined during two 24 h studies. Large numbers (>20,000 h^-1 m^-2) of harpacticoid copepods representing a substantial proportion (>50 %) of the total benthic harpacticoid community migrated from the sediment into the water column. Nineteen of 36 harpacticoid species identified migrated actively. Migration was greatest during nighttime. Results indicate the importance of vertical migration to benthic-pelagic interactions in shallow seagrass environments.

David Baltimore Oral History, David Baltimore

Oral History Collection

Susan Mehrtens' Note:

We met in Dr. Baltimore's office at the Whitehead Institute, and our meeting was short (less than 45 minutes) but direct and to the point: Baltimore credits The Jackson Laboratory for setting him on his course as a biologist, but beyond that, he sees Jax as a dated, low-key place. One speaking engagement at Jax that left him astonished to see an empty parking lot at 5PM made an indelible impression on him and he echoes the attitudes of others outside Jax--like Law and Sprott--that Jax is not a dynamic, hotshot institution on the cutting edge of …

Ua1b1/1/2 An Evening With A Scientist & A News Man, Harry Gray, James Ausenbaugh, Wku Rodes-Helm Lecture Series

WKU Administration Documents

Rodes-Helm lecture by Harry Gray and James Ausenbaugh entitled An Evening with A Scientist and a News Man moderated by Lowell Harrison. The lecture format allows each speaker 20 minutes to present his/her topic, response time to each other and ends with a question / answer session from the audience.

Dr. Harry Gray, a leading authority in the field of solar energy, fears that science is advancing so fast on so many fronts that the public can't keep up. More specifically, he worries that the news media's ability - or commitment - to help keep the public informed is limited. …

Barbara Sanford Oral History, Barbara Sanford

Oral History Collection

Susan Mehrtens' Note:

Barbara Sanford's interview echoes most of what I have heard from many of the staff regarding the Lab's mission and goals. The Lab's ideal size, geographical location--with its pluses and minuses--and the environment in which to do science in the current period--all find echoes on other tapes. There is little of candor, consequence or calculation here. Sanford clearly recognizes the stressful nature of scientific life in these times of federal cutbacks, and, as well, the frustrations of directing a laboratory whose size, complexity and needs preclude personal scientific work by the Director. In the face of such …

Donald Bailey Oral History, Donald Bailey

Oral History Collection

Susan Metrhens' Note:

Regarded by many of his peers at Jax as one of the most intuitive, prescient and creative scientists at the Lab, Bailey was a very reflective narrator. While he provides one anecdote of c.c. Little1s sartorial habits, this tape is largely devoid of anecdotal material, and is more a reminiscence by a scientist who was at Jax in the early '50's, who left and returned in 1967. I tried, through a variety of questions, to probe the synergy between Bailey and the Lab, the degree to which his prescience and creativity might be due to the freedom …

Priscilla "Skippy" Lane Oral History, Skippy Lane

Oral History Collection

Susan Mehrtens' Note:

We have in this tape the recollections of one of the most prolific authors in the field of mouse mutants, an indefatigable co-worker of Margaret Dickey, Margaret Green and currently, Muriel Davison. Full of scientific terms, this tape reveals clearly Lane's thorough absorption in the field to which she has devoted nearly the last forty years of her life. Toward the end of this tape, Lane alludes to Earl Green's sexist attitude, which other women have also mentioned to me on and off tape. Lane also waxes eloquently here about her efforts to establish a hiera'rchy within …

Information Interface - Volume 10, Issue 6 - November/December 1986, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Prevalence Of Sensitivity To Sulfiting Agents In Asthmatic Patients, Robert K. Bush, Steve L. Taylor, Karen Holden, Julie A. Nordlee, William S. Busse

Department of Food Science and Technology: Faculty Publications

Ingestion of sulfiting agents can induce wheezing in some asthmatic patients. However, neither the prevalence of sulfite sensitivity nor the clinical characteristics of the affected asthmatic population are known. In a prospective single-blind screening study, 120 non-steroid-dependent and 83 steroid-dependent asthmatic patients underwent challenge with oral capsules of potassium metabisulfite. Five non-steroid-dependent and 16 steroid-dependent asthmatic patients experienced a greater than 20 percent reduction in their one-second forced expiratory volume within 30 minutes following the oral challenge. Twelve of these sulfite reactors were rechallenged with metabisulfite capsules in a double-blind protocol. Under these conditions, only three of seven steroid-dependent patients …

Aryl Substituted 1h-4,5-Dihydro-1,2,3-Triazoles As Anticonvulsants, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

The Case For The Use Of Animals In Biomedical Research, Carl Cohen

Morality and Ethics of Animal Experimentation Collection

No abstract provided.

Information Interface - Volume 10, Issue 5 - October 1986, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Nurses Alumni Association Bulletin, Fall 1986, Flossie Roche, Patricia Dunn, Alice C. Boehret, Margaret Summers, Frederick B. Wagner Jr, Margaret M. Cossman, Vivian I. Moyer, Betty Piersol, Cathleen Keating, Doris E. Bowman, Lisa A. Ryan

Nursing Alumni Bulletins

Alumni Calendar

Officers and Committee Chairmen

The President's Message

Treasurer's Report

Nurses' Relief Fund

Scholarship Fund

Surgery for the Unborn- A Nurse's Own Story

Further Remembrances

Martha

From the Tju Historian "Old Main"

Congratulations to Our Graduates

Advanced Placement Program and Masters in Rehabilitation

Jefferson Surgical Center Opens

Profile in Courage- Update

Fiftieth Anniversary

Happy Birthday

Resume of Minutes of Alumni Association Meetings

Alumni Office News

Committee Reports

Bulletin

Social

Scholarship

Finance

In Memoriam, Names of Deceased Graduates

Luncheon Pictures

Class Notes

Caps, Pins, Transcripts, Class Address Lists

Change of Address Form

1986CAHS Alumni Directory

Bequests

Relief Fund Application

Scholarship …

Evaluating Hospice Care: The Family's Perspective, Linda Clark, M. Susan Jones, Doris Thayer, Beverly Cook

Nursing Faculty Publications

After the death of the hospice patient, the family can provide valuable information for the evaluation of hospice care and services. A family evaluation form facilitates this evaluation.

Ua68/13/4 Bowling Green, Vol. 7, No. 1, Kelly Thompson Chapter, Public Relations Student Society Of America

Student Organizations

Magazine produced by senior seminar class in public relations with the Kelly Thompson Chapter of the Public Relations Student Society of America and students in the WKU Department of Journalism.

Regular features include:

• Reflections
• Business
• Art
• Community Service
• Reminiscing
• Curiosities
• Entertainment

This issue includes articles:

• Gray, Beth. Caring Comes Home - Hospice
• Hornback, Todd. Alcoholics Anonymous: Finding a Better Way of Life
• McCoy, Steve. Area Underground Shared by Few - Cave & Karst
• McCormick, Rebecca. Architecture: History Lines the Streets
• McCormick, Rebecca. Landmark: Preservation & More
• Quinn, Paula. Madame Kennedy: Working with the Problem at Hand

Ua61/1 Wku Nursing Class 1986, Wku Nursing

WKU Administration Documents

Members of the 1986 nursing class: Jana Alvey, Phyllis Barber, Jane Bickett, Sharon Booth, Carolyn Bow, Dedra Briggs, Gina Brunetti, Kathy Bumm, Dotti Bush, Jewell Byers, Peggy Casdorph, Diana Childers, Deneace Clemons, Shirley Flatt, Damita Fletcher, Linda Glass, Greg Holzknecht, Theresa Houchens, Jenny Jones, Tammy Kronemeyer, Kate Lederer, Sandra McClendon, Becky McConnell, Janice Miller, Ronda Miller, Merrie Morrison, Pamela Morrison, Cynthia Offutt, Sharon Owens, Donna Pickett, Ruby Rhodes, Mitzi Rodgers, Rita Sandefur, Steven Scott, Jacqueline Smith, Kathy Smith, Allison Strader, Tina Strange, Heidi VanDyck, Elaine Warren and Margaret Whitehouse.

A Spray Programme For Table Grape Production In Western Australia, I. J. Cameron, P. Wood, A. Sproul

Viticulture published reports

This bulletin details the main sprays that can be used in table grape vineyards in Western Australia. Growers are advised to refer to the manufacturer's label for detailed recommendations since rates vary according to formulation. New chemicals are continually being marketed and any omissions are regretted and no preferences for any material or supplier is implied.

Genetic Characterization Of Human C-Rel Sequences, Elise Brownell, Stephen J. O'Brien, William Nash, Nancy Rice

Biology Faculty Articles

We isolated and sequenced a human genomic-DNA segment that is homologous to a portion of v-rel, the transforming gene of reticuloendotheliosis virus (strain T). We also localized the human rel sequences to human chromosome 2 by screening a panel of rodent x human somatic-cell hybrids with the newly described human rel segment.

Water-Cover Influences On Diatom Ingestion Rates By Meiobenthic Copepods, Alan W. Decho

Faculty Publications

Laboratory experiments on meiobenthic copepods using ¹⁴C-diatoms were conducted to investigate whether: (1) feeding rates or (2) food sources (planktonically-suspended foods or benthic sediment-associated foods) vary in response to the presence or absence of water-cover (i.e. simulated Higher-water vs Low-water conditions). Three diatom-feeding harpacticoids were examined. Scottolana canadensis feeds at significantly higher rates (2x) during Higher-water (HW) conditions (P<0.001), at which time it consumes planktonic foods; during Low-water (LW), feeding is greatly reduced. These feeding patterns are related to its burrow-dwelling and to its subtidal habitat. Cletocamptus deitersi remains virtually unaffected by changes in ambient water-cover, feeding at nearly equal rates during HW and LW conditions but always tending to consume more benthic diatoms. Microarthridion littorale consumes food at nearly equal rates during HW and LW …

Jefferson Alumni Bulletin – Volume Xxxvi, Number 1, Fall 1986

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVI, Number 1, Fall 1986

Diagnostic ultrasound: an expanded division, Page 2

Campus expansion, Page 7

Pine street and the Jefferson spirit, Page 13

Jefferson scene, Page 17

Class notes, Page 25

Multiple Function Intubation Apparatus And Method, Jane A. Norton, Diana L. Twyman, A. Byron Young, Robert Rapp

Surgery Faculty Patents

An apparatus and its method of use are provided allowing lavage, sump and enteral feeding operations with only one intubation. The apparatus includes a first tube having two distinct passageways. One of these passageways completely contains a second, feeding tube during intubation. Once the first tube is in place in the patient, the second tube is extended from the first tube so as to enter the stomach. The extension of the second tube opens ports in the first passageway of the first tube, thereby allowing sump or lavage treatment with the second passageway of the first tube serving as an …

Thomas Roderick Oral History, Thomas Roderick

Oral History Collection

Susan Metrhens' Note:

Roderick has been a scientist at Jax for thirty years, working in no other place. He was hired just as Earl Green replaced C.C. Little and Roderick worked with and for Green for some dozen years before moving into his own lab, on his own grants. Roderick is both perceptive and analytical and this tape is valuable for his willingness to reflect on trends and personalities. He also has a philosopher's willingness to consider the values that drive the lab. Roderick was forthcoming with anecdotes, including a most telling one of Rich Prehn showing the courage of …

1,2,3,-Triazole Anticonvulsant Drugs, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the September, 1986 edition of the ALHeLa newsletter - Synapse.

Contents include:

• Presidents column by Joyce Sims (AlHeLA President)
• Calendar of events
• Nominating Committee
• Executive Committee by Pat Hall (Secretary / Treasure)
• Proposed Amendments
• Plan to Attend by Maureen Battistella (Annual Program Chair)
• Workshop by Maureen Battistella
• SE/A RMLS by Jane A. Lambremont
• MLA certification exam scheduled
• Editor's corner

John Paul Scott Oral History, John Paul Scott

Oral History Collection

Susan Mehrtens' Note:

Dr. J.P. Scott was the head of animal behavioral research at Hamilton Station. He carne to our meeting with a thoughtful outline, and spoke to it for most of our interview. His tape, as a result, is mostly a monologue. This tape is extremely valuable because Jax threw away all the records of Hamilton Station, so only the accounts of Scott, Fuller and Fox (in this project) can provide a record of this aspect of the Lab's past. Scott indicates how pervasive was the network in which his work was conducted, and how many noteworthy figures or …

Interview With Princess O'Flynn Bareis Regarding Her Life (Fa 154), Manuscripts & Folklife Archives

Folklife Archives Oral Histories

Transcription of an interview with Princess O'Flynn Bareis conducted by Cathy Behan for an oral history project titled "A Generation Remembers, 1900-1949." Bareis discusses her life and times, including information about growing up in Utica, Daviess County, Kentucky, education, religion, the general store her grandfather owned, African Americans, and her experience with mental illness and spouse abuse.

Alternatives Sought To Save Lab Animals, Jim Detjen

Popular Press Items

No abstract provided.

Dale Foley Oral History, Dale Foley

Oral History Collection

Susan Mehrtens' Note:

Dale Foley was the administrative "right arm" of both Little and Green, and, as such, was in a position to comment on the Lab's financial and administrative activities from the perspective of a key participant. As we began, he brought out several pages of notes, which formed the basis of the monologue that followed. To my surprise, his tape consists almost totally of accounts of the acquisition of property and building of the major Jax buildings. Aside from references to several valued Jax volunteers--several of them wealthy Trustees--Foley stuck to the physical plant in his interview. Intuitively, …