Medicine and Health Sciences Commons^™

The Effects Of Suxamethonium And Pancuronium On The Haemodynamic Response To Endotracheal Intubation, F A. Khan, R S. Kamal

Department of Anaesthesia

The pharmacological effects of suxamethonium and pancuronium on the cardiovascular system may vary and therefore alter the haemodynamic response to intubation. The arterial blood pressure, the heart rate and the rate pressure product were measured as parameters of haemodynamic change in forty adult ASA. I and II patients undergoing laryngoscopy and endotracheal intubation in a randomised controlled study. The patients were induced with either thiopentone/suxamethonium (Group A) or thiopentone/pancuronium (Group B). There was no significant difference between the groups on comparison of systolic and diastolic blood pressure changes. Pancuronium, however, caused a significantly higher rise in the heart rate after …

Clinical Features And Management Of Malignant Ascites, I Malik, S Abubakar, I Rizwana, F Alam, J Rizvi, A Khan

Section of Cardiology

Retrospective analysis of 45 patients (33 females, 12 males) with cytologically-proven malignant ascites is presented. Abdominal pain was the most frequent symptom (69%). Fiftythree percent cases had low serum albumin. Ascitic fluid was haemorrhagic or serosanguinous in 48% cases, in the rest it was clear or straw-coloured. Peritoneal effusion was exudative in 84% cases. Mean glucose content of ascitic fluid was 95 mg/dl and the mean white cell count of 919 cells/cmm. Vast majority (82%) of the cases had metastatic adenocarcinomas. Primary malignancy was mostly ovarian (47%) followed by non-Hodgkin's lymphoma (11%) and gall bladder carcinoma (9%). Primary site could …

Gestational Diabetes In A Developing Country, Experience Of Screening At The Aga Khan University Medical Centre, Karachi, Khalid S. Khan, Javaid H. Rizvi, Rahat Qureshi, Rauf Mazhar

Department of Obstetrics & Gynaecology

In order to determine the prevalence of glucose intolerance in pregnancy, 1267 consecutive women attending the antenatal clinic of the Aga khan University Medical Centre were subjected to a 75g glucose challenge followed 2hr later by plasma glucose determination irrespective of gestation on the first antenatal visit. The test was repeated at 28-32 weeks of gestation if the patients had an abnormal initial screen at < 28 weeks gestation and a normal glucose tolerance test on diagnostic follow-up and for those who had a risk factor for gestational diabetes and a normal initial screen at < 28 weeks gestation. The glucose challenge test was abnormal (2hr plasma glucose> 1 40mg%) in 8.6% of the screened population. Follow-up oral glucose tolerance test on these patients revealed a prevalence of 3.2% of gestationat diabetes and 1.9% of impaired glucose tolerance test based on the modified …

Chloramphenicol Therapy Of Typhoid Fever, Z A. Bhutta, S H. Naqvi, S Durrani, A Suria

Department of Paediatrics and Child Health

In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 versus 15.4 +/- 6.1 mcg/ml) chloramphenicol concentrations were comparable in both groups, a significantly wider range was found in the group receiving 100 mg/kg/day. Potentially toxic levels (greater than 30 mcg/ml) developed in two patients with liver dysfunction. …

Gestational Diabetes In A Developing Country, Experience Of Screening At The Aga Khan University Medical Centre, Karachi, Khalid S. Khan, Javaid H. Rizvi, Rahat N. Qureshi, Rauf Mazhar

Department of Obstetrics & Gynaecology

In order to determine the prevalence of glucose intolerance in pregnancy, 1267 consecutive women attending the antenatal clinic of the Aga Khan University Medical Centre were subjected to a 75 g glucose challenge followed 2 hr later by plasma glucose determination irrespective of gestation on the first antenatal visit. The test was repeated at 28-32 weeks of gestation if the patients had an abnormal initial screen at less than 28 weeks gestation and a normal glucose tolerance test on diagnostic follow-up and for those who had a risk factor for gestational diabetes and a normal initial screen at less than …

Bacterial Isolates In Neutropenic Febrile Patients, M Karim, W Khan, B Farooqi, I Malik

Section of Internal Medicine

One hundred consecutive patients with documented bacteremia and neutrophil count of 0.5 x 10(9)/L or below were retrospectively studied to determine the pattern of infection at the Aga Khan University Hospital in Karachi. These included patients with primary haematologic malignancies presenting with low counts, and those patients with cancer who developed neutropenia as a result of chemotherapy. The gram negative organism pseudomonas aeruginosa was the most common bacterial organism isolated constituting 31% of all positive blood cultures. Gram positive organisms were frequently isolated comprising 24% of all isolates of which 15% were Staph.aureus. Staph. epidermidis was not isolated in this …

Disparity Between Reimbursement-Driven Practice And Humanistic Values Of Occupational Therapy., Janice P. Burke, Joanne C. Cassidy

Department of Occupational Therapy Faculty Papers

In January 1990, clinicians, educators, and researchers met at the Directions for the Future Symposium in San Diego to delineate, discuss, and debate a wide range of economic, political, and social issues that are influencing the evolution of occupational therapy practice and education. By examining these factors in an open and thorough way, therapists believe they will be able to develop proactive positions that will ensure the continued well-being of the field. In this paper, we will consider two distinctly opposing forces that dramatically affect and present considerable obstacles to occupational therapists. On the one hand, occupational therapists are taught …

Cells That Express All Five Proteins Of Vesicular Stomatitis Virus From Cloned Cdnas Support Replication, Assembly, And Budding Of Defective Interfering Particles, Asit K. Pattnaik, Gail W. Wertz

School of Veterinary and Biomedical Sciences: Faculty Publications

An alternative approach to structurefunction analysis of vesicular stomatitis virus (VSV) gene products and their interactions with one another during each phase of the viral life cycle is described. We showed previously by using the vaccinia viruslT7 RNA polymerase expression system that when cells expressing the nucleocapsid protein (N), the phosphoprotein (NS), and the large polymerase protein (L) of VSV were superinfected with defective interfering (DI) particles, rapid and efflicient replication and amplification of DI particle RNA occurred. Here, we demonstrate that all five VSV proteins can be expressed simultaneously when cells are cotransfected with plasmids containing the matrix protein …

Interview With Walter Francis Becket, 1898-1991 (Fa 114), Manuscripts & Folklife Archives

Folklife Archives Oral Histories

Transcription of interview with Walter Francis Becket conducted by John E. Long on 28 January 1991. From folk studies student project concerning Becket's education, early practice as a physician, and his employment at the Bowling Green/Warren County [Kentucky] Hospital.

Interleukin-1 Or Phorbol Induction Of The Stromelysin Promoter Requires An Element That Cooperates With Ap-1., Karen Sirum-Connolly, Constance E. Brinckerhoff

Dartmouth Scholarship

Interieukin-1, a mediator of inflammation, or tumor promoting phorbol esters induce transcription of stromelysin, a metalloproteinase that degrades extracellular matrix molecules and that is overexpressed in diseases such as rheumatoid arthritis. Sequences required for induction of transcription of the human stromelysin promoter are contained on a 46 base pair fragment. This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1. Maximal induction requires functional …

Using Joint Fact-Finding To Resolve Disputes Over Cleanup Of Hazardous Waste Sites, R. Steven Konkel

Environmental Health Science Faculty and Staff Research

This research demonstrates how and why joint fact-finding works to break impasses in negotiations and overcome obstacles to the cleanup of hazardous waste sites. Superfund cleanup negotiations often involve multiple-party, multi-issue disputes. Disputes often arise over identification of the responsible parties, allocation of cost and liability, definition and interpretation of cleanup standards, and development of a viable settlement structure. In 1988, Marks and Susskind identified disagreements over the accuracy and validity of data as critical barriers to cleanup of Superfund and other hazardous waste sites. Disputes over data have led to delays, costly supplemental studies, and site fragmentation into multiple …

Efficacy And Cost-Effectiveness Of Adjuvant Chemotherapy In Women With Node-Negative Breast-Cancer - A Decision-Analysis Model, Bruce E. Hillner , M.D., Thimas J. Smith M. D.

Internal Medicine Publications

BACKGROUND.

In 1988 the National Cancer Institute issued a Clinical Alert that has been widely interpreted as recommending that all women with node-negative breast cancer receive adjuvant chemotherapy. Acceptance of this recommendation is controversial, since many women who would not have a recurrence would be treated.

METHODS.

Using a decision-analysis model, we studied the cost effectiveness of chemotherapy in cohorts of 45-year-old and 60-year-old women with node-negative breast cancer by calculating life expectancy as adjusted for quality of life. The analysis evaluated different scenarios of the benefit of therapy: improved disease-free survival for five years, with a lesser effect on …

Information Interface - Volume 15, Issue 1 - January/February 1991, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Southeastern University Of The Health Sciences Catalog 1991-1993, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Pharmacokinetics Of Ceftibuten-Cis And Its Trans Metabolite In Healthy Volunteers And In Patients With Chronic Renal Insufficiency, Judy Shepard Kelloway, Walid M. Awni, Chin C. Lin, Josephine Lim, Melton B. Affrime, William F. Keane, Gary R. Matzke, Charles E. Halstenson

Pharmacotherapy and Outcomes Science Publications

The impact of renal insufficiency on the dispositions of 300 mg of orally administered ceftibuten-cis, a new broad-spectrum oral cephalosporin, and its primary metabolite ceftibuten-trans was characterized in 30 adult subjects. Subjects were divided into five groups of six subjects each on the basis of their 24-h ambulatory creatinine clearances (CL_CR). The apparent total body clearance (CL_P/F; where F is absolute bioavailability) and renal clearance of ceftibuten-cis were significantly lower in subjects with end-stage renal disease (on maintenance hemodialysis; group V) and in those with severe (CL_CR, 5 …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Fall, 1991 edition of the ALHeLa newsletter - Synapse.

Contents include:

• ALHeLA holds annual meeting
• Lucretia McClure delivers keynote address
• President's column by Barbara Doughty
• Minutes- September 27, 1991
• Library Updates
• Union list update
• ALICAT expands to include serials
• DIALOG searching tutorial available
• MLA CE awards available
• Association & Membership news
• Alabama union list of serials periodicals reporting form.

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Summer, 1991 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's column - 1991 ALHeLA meeting scheduled for September
• COME ONE, COME ALL!! - CE program to be held at the 1991 annual meeting on September 26
• Silent Auction
• Report on the 1990 annual meeting of the Alabama Health Libraries Association, INC.
• NLM, RML AND Association News
• News from ALHeLA members

Ada Constitution & Bylaws (1991), American Dental Association

Constitution & Bylaws

The ADA Commons Constitution & Bylaws archival collection comprises printed issues of the American Dental Association's Constitution and Bylaws. The collection also includes the ADA Charter and the ADA Code of Ethics issued 1924-1946.

Samuel D. Gross, M.D., A Bibliography (1834-1887)

Samuel D. Gross, M.D. A Bibliography (1834-1887)

Table of Contents:

Works by Dr. Gross

Case Reports and Periodical Articles page 1

Books and Monographs page 44

Biographies and Obituaries page 47

Works about Dr. Gross

Reviews of Books and Monographs page 49

Biographical Sketches and Obituaries page 50

Police Evidence And Court Outcomes For Drunk Driving Cases, Dale E. Berger

CGU Faculty Publications and Research

From police arrest records and case narratives, we collected information on the evidence reported from each of four phases of a drunk-driving arrest.

Interaction Between Tetraethylammonium And Amino Acid Residues In The Pore Of Cloned Voltage-Dependent Potassium Channels, Michael Kavanaugh, Michael D. Varnum, Peregrine B. Osborne, Macdonald J. Christie, Andreas E. Busch, John P. Adelman, R. Alan North

Biomedical and Pharmaceutical Sciences Faculty Publications

Extracellular tetraethylammonium (TEA) inhibits currents in Xenopus oocytes that have been injected with mRNAs encoding voltage-dependent potassium channels. Concentration-response curves were used to measure the affinity of TEA; this differed up to 700-fold among channels RBK1 (KD 0.3 mM), RGK5 (KD 11 mM), and RBK2 (KD greater than 200 mM). Studies in which chimeric channels were expressed localized TEA binding to the putative extracellular loop between trans-membrane domains S5 and S6. Site-directed mutagenesis of residues in this region identified the residue Tyr379 of RBK1 as a crucial determinant of TEA sensitivity; substitution of Tyr in the equivalent positions of RBK2 …

Audiologic Services: A Parent's View, Amy Popp

Independent Studies and Capstones

This paper discusses a study to determine desirable characteristics of audiologists who provide services to a pediatric population.

Perceptual Validation Of An Acoustic Metric For Measuring Vowel Production By Deaf Children, Regina M. Gilbert

Independent Studies and Capstones

This paper discusses a study to validate the metric developed in the Geers and Moog Cochlear Implant Study at CID to measure the speech production of hearing impaired children.

Word Level Speech Perception Under Four Levels Of Simulated Profound Hearing Loss, Trisha Ruddick

Independent Studies and Capstones

This paper discusses a study to determine average performance on word discrimination tests using the CID Early Speech Perception Test (ESP).

Parental Observations Of Children's Responses To Three Sensory Aids: Cochlear Implant, Tactile Aid, Hearing Aid, Nilam Patel

Independent Studies and Capstones

This study discusses a project undertaken to determine the benefits of sensory aids for hearing impaired children based on parental observations over a twelve month period.

High Frequency Audiometry: Sound Suite Versus Hospital Room, Lisa Gullegde Potts

Independent Studies and Capstones

This paper discusses a study to assess and compare frequency audiometric thresholds obtained under two listening environments--a sound suite and a typical hospital room.

Communication Between Caregivers And Deaf Patients During Hospitalization, Jenny Castles

Independent Studies and Capstones

This paper discusses a study to identify major problems in communication during hospitalization perceived by deaf patients and by nurses.

Evaluaton Of A Genetic Marker Within The Organ Of Corti Of Transgenic Mice, Julie A. Decker

Independent Studies and Capstones

This paper reviews a study to evaluate a genetic marker within the organ of Corti in transgenic mice for potential use in cell lineage studies.

Occupational Hearing Conservation In A Rural Woodworking Company, Tammy Dunn

Independent Studies and Capstones

This paper discusses a study to evaluate noise exposure and hearing thresholds of workers in a small woodworking company in a rural area.

Performance Of Postlinguistically Deaf Cochlear Implant Patients On The Connected Speech Test (Version 3), Ramona P. Sarkis

Independent Studies and Capstones

This paper discusses a study on postlingual cochlear implantees and the effectiveness of the CST in evaluating enhancement of speech recognition abilities.