Medicine and Health Sciences Commons^™

A Polymorphism Of A Platelet Glycoprotein Receptor As An Inherited Risk Factor For Coronary Thrombosis., Ethan J. Weiss, Paul F. Bray, Matthew Tayback, Steven P. Schulman, Thomas S. Kickler, Lewis C. Becker, James L. Weiss, Gary Gerstenblith, Pascal J. Goldschmidt-Clermont

Cardeza Foundation for Hematologic Research

BACKGROUND: Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in the pathogenesis of acute coronary syndromes. Previously, we found a high frequency of a particular polymorphism, PlA2, of the gene encoding glycoprotein IIIa in kindreds with a high prevalence of premature myocardial infarction.

METHODS: To investigate the relation between the PlA2 polymorphism and acute coronary syndromes, we conducted a case-control study of 71 case patients with myocardial infarction or unstable angina and 68 inpatient controls without known heart disease. The …

Worker Killed In Fall From Oil Tank, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

A 50-year-old male was killed when he fell from the top of a 12-foot high oil tank. The victim was an oil gauger for a company that transports crude oil. His job was to obtain samples of the oil to check its quality. On the day of the incident he was to check the oil at a site located about 100 miles from his office. He was an experienced gauger and had been to this site many times before. This company owned four cylinder-shaped oil tanks. Three of the tanks were 15 feet high and one was 12 feet high …

Ua12/2/1 College Heights Herald, Vol. 71, No. 55, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

Regular features include:

• Just a Second
• Campus Line
• For the Record / Crime Reports
• People Poll
• Sports
• Diversions
• Movie Reviews
• Classifieds

Articles in this issue:

• Goetz, Kristina. Minimum Wage Increase on Horizon
• Stamper, John. Fair Makes Health Fun for Students
• Hall, Jason. Board of Regents to Vote on $5 Fee Hike
• Hall, Jason. Fund Provides $100,000 in Technology Grants
• Western Letting Students Pick Up Tab
• Beach, Bennie. A Hill of Trash
• Banister, Scott. Love It or Leave It – Mahmoud Abdul-Rauf
• Simmons, Darryn. Dead Week Much Better than Hell …

Phenylbutyl Nitrone Compositions And Methods For Prevention Of Gastric Ulceration, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compounds(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It is believed …

2,4-Disulfonyl Phenyl Butyl Nitrone, Its Salt And Their Use As Pharmaceuticals, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the April, 1996 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• Recognizing, intervening and preventing birth defects
• USA doctors hospital to be renamed USA children's and women's hospital
• Welcome visiting professor in the basic medical sciences
• USA transplantation center approved
• Graduate students outlooks
• Announcements...
• Cytometry Core acquires a Microphysiometer
• "Match day" results
• Expansion of new neonatal unit
• Department highlights: Emergency medicine

Communications Connection - Vol.3, No. 5 - Spring 1996, Nova Southeastern University

Communications Connection

No abstract provided.

Basics Of Research (Part 6): Quantitative Data Analysis, Cheryl Thompson, Robert Schwartz, Eric Davis, Edward A. Panacek

Journal Articles: College of Nursing

No abstract provided.

The Use Of Respite In Crisis Emergency Services: A Two Year Analysis, Anne D. Kuppinger, Mary E. Evans, Roger A. Boothroyd, Marleen Radigan

Mental Health Law & Policy Faculty Publications

Respite care is widely believed to be an important service for families raising a child with a disability. All caregivers need a break from time to time, and the need may be even greater when the caregiver is coping with the additional stress associated with a child's disability. A number of studies have demonstrated that respite care can improve family functioning (Cohen, 1982), reduce stress (Rimmerman, 1989; Wickler & Hanusa, 1990; Appoloni & Triest, 1983), and delay out-of-home placement (Cohen, 1982; Upshur, 1982) for families with a child who has a disability.

Endobronchial Tuberculosis--Manifesting By Coughing Up Of Bronchial Cartilage, A M. Memon, A Shafi, H Thawerani

Section of Pulmonary & Critical Care

No abstract provided.

Spring 1996, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Spring 1996

Toxoplasma Gondii-Induced Immune Suppression By Human Peripheral Blood Monocytes: Role Of Gamma Interferon., Jacqueline Y. Channon, Lloyd H. Kasper

Dartmouth Scholarship

The ability of Toxoplasma gondii to evade the host immune response during primary infection in humans is poorly understood. In murine toxoplasmosis, infected spleen macrophages release soluble factors that mediate a transient immunosuppression, which may allow the parasite to become established. When an enriched population of human monocytes from seronegative individuals was incubated with toxoplasmas in vitro, soluble factors that mediated market suppression of mitogen-induced lymphocyte DNA synthesis were released. Irradiated tachyzoites that do not undergo replication were sufficient stimuli for near-maximal soluble factor release. Up to 50% of the soluble factor-mediated suppression is attributable to a gamma interferon (IFN-gamma)-dependent …

"The Profession Of Dentistry:" The University Of Kentucky's Curriculum In Professional Ethics, David A. Nash

Oral Health Science Faculty Publications

Among the most important learning that occurs in our nation's colleges of dentistry is learning to be a professional. While knowledge, perceptual-motor skills, and problem-solving abilities are basic to becoming a dentist, helping aspiring colleagues to apply their newly developing skills with integrity must be a fundamental concern. Increasingly, we are realizing that the quality of health care depends as significantly on the character of the health professional as it does on the individual's knowledge and skills. Concern for character, virtue, and integrity is the domain of ethics. This paper advances a justification for including a curriculum in professional ethics …

A Tandem Duplication Within The Fibrillin 1 Gene Is Associated With The Mouse Tight Skin Mutation., Linda D. Siracusa, Rodney Mcgrath, Qing Ma, John J. Moskow, Jayanthi Manne, Paul J. Christner, Arthur M. Buchberg, Sergio A. Jimenez

Department of Medicine Faculty Papers

Mice carrying the Tight skin (Tsk) mutation have thickened skin and visceral fibrosis resulting from an accumulation of extracellular matrix molecules. These and other connective tissue abnormalities have made Tskl + mice models for scleroderma, hereditary emphysema, and myocardial hypertrophy. Previously we localized Tsk to mouse chromosome 2 in a region syntenic with human chromosome 15. The microfibrillar glycoprotein gene, fibrillin 1 (FBN1), on human chromosome 15q, provided a candidate for the Tsk mutation. We now demonstrate that the Tsk chromosome harbors a 30- to 40-kb genomic duplication within the Fbn1 gene that results in a larger than normal in-frame …

Comments On The Distribution Of Botrychium Lunarioides (Ophioglossaceae) In Texas, W. C. Holmes, T. L. Morgan, Jeffrey R. Stevens, R. D. Gooch, J. R. Singhurst

Department of Psychology: Faculty Publications

Botrychium lunarioides (Michx.) Sw. (Ophioglossaceae) is now known to be widespread and abundant throughout the eastern portion of Texas. In 1996, Do, et al. reported ten additional county records in the central portion of the Post Oak Savannah of Texas, thereby extending the known distribution of the species up to 273 km to the west. Additional field studies during 1996 have yielded nineteen new county records for the species in Texas. These new reports are primarily from the Post Oak Savannah, Pineywoods, and Blackland Prairies of northeast Texas and from the southern portion of the Post Oak Savannah. The most …

Impact De L'Avance En Âge Sur Les Scénarios D'Accidents Et Les Indicateurs De Lésions Dans Les Secteurs De La Santé Et Des Services Sociaux, De L'Administration Provinciale Et De L'Administration Municipale, Esther Cloutier, Patrice Duguay

Rapports de recherche scientifique

No abstract provided.

Distribution Des Résultats D'Analyses Environnementales Réalisées En Laboratoire : Portrait De La Situation Sur Cinq Années (1989-1993) Et Impact Des Nouvelles Normes, Claude Ostiguy, François Hébert, Pierre Larivière, Guylaine Beauchamp, Alain Lajoie, Thierry Petitjean-Roget

Rapports de recherche scientifique

No abstract provided.

Validation D'Une Démarche D'Ergonomie Participative Dans Deux Industries Du Secteur Électrique, Marie St-Vincent, Denise Chicoine, Sylvie Beaugrand

Rapports de recherche scientifique

No abstract provided.

Mise Au Point D'Une Méthode D'Échantillonnage Des Microorganismes Sur Filtre De Polycarbonate, Geneviève Marchand

Rapports de recherche scientifique

No abstract provided.

Antibody To The Ligand For Cd40 (Gp39) Inhibits Murine Aids-Associated Splenomegaly, Hypergammaglobulinemia, And Immunodeficiency In Disease-Susceptible C57bl/6 Mice., Kathy A. Green, Karen M. Crassi, Jon D. Laman, Arjan Schoneveld, Rendall R. Strawbridge, Teresa M. Foy, Randolph J. Noelle, William R. Green

Dartmouth Scholarship

Infection of genetically susceptible C57BL/6 mice with the LP-BM5 isolate of murine retroviruses cause profound splenomegaly, hypergammaglobulinemia, lymphadenopathy, and an immunodeficiency syndrome which includes the development of terminal B-cell lymphomas. Because many of these and the other manifestations of LP-BM5 virus-induced disease are similar to those seen in AIDS, this syndrome has been named murine AIDS, or MAIDS. Previous reports have shown that the onset of MAIDS depends on the presence of both CD41 T cells and B cells and have suggested that CD41 T-cell-B-cell interactions are important to disease pathogenesis. Here, we assessed the possibility that interactions between CD40 …

Disruption Of The Cbfa2 Gene Causes Necrosis And Hemorrhaging In The Central Nervous System And Blocks Definitive Hematopoiesis., Qing Wang, Terryl Stacy, Michael M Binder, Miguel Marin-Padilla, Arlene H. Sharpe, Nancy A. Speck

Dartmouth Scholarship

The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF alpha 2 protein capable of binding DNA die between embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in somitic/intersomitic regions along the presumptive spinal cord. Hemorrhaging is preceded by symmetric, bilateral necrosis in these regions. Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption …

Conditioned Stimulus Determinants Of Conditioned Response Form In Pavlovian Fear Conditioning, Stephen D. Kim, Steven Rivers, Rick A. Bevins, John J. B. Ayres

Department of Psychology: Faculty Publications

Four experiments using barpress conditioned suppression in rats found that tone evoked more freezing (immobility) than did light. Still, tone and light appeared to have similar conditioned value as assessed by suppression in Experiments 1, 2, and 3, and by blocking, second-order conditioning, and over-conditioning assays in Experiments 1, 2, and 3, respectively. Experiment 4 arranged for tone to evoke less suppression than light but more freezing. Results suggest that in fear conditioning, the nature of the conditioned stimulus affects the form of conditioned responding (strong vs. weak freezing). This conclusion extends one drawn by P. C. Holland (1977) on …

Farmer Dies In Cornpicker, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On 22 November 1995, a 52-year-old farmer died when he was caught in the corn picker he was operating. He was a full-time farmer and had been involved in the family farming business all of his life. On the day of the incident, the victim and his 20-year-old son had been working in the field together operating the corn picker. After obtaining a full load, the son transported the load back for storage while the farmer stayed in the field to finish a small section of corn. When he did not return home at the expected time, his wife and …

Identification Of A Brazil-Nut Allergen In Transgenic Soybeans, Julie A. Nordlee, Steve L. Taylor, Jeffrey A. Townsend, Laurie A. Thomas, Robert K. Bush

Department of Food Science and Technology: Faculty Publications

Background: The nutritional quality of soybeans (Glycine max) is compromised by a relative deficiency of methionine in the protein fraction of the seeds. To improve the nutritional quality, methionine-rich 2S albumin from the Brazil nut (Bertholletia excelsa) has been introduced into transgenic soybeans. Since the Brazil nut is a known allergenic food, we assessed the allergenicity of the 2S albumin.

Methods: The ability of proteins in transgenic and nontransgenic soybeans, Brazil nuts, and purified 2S albumin to bind to IgE in serum from subjects allergic to Brazil nuts was determined by radioallergosorbent tests (four …

Envy And Jealousy As Discrete Emotions: A Taxometric Analysis, Nick Haslam, Brian H. Bornstein

Department of Psychology: Faculty Publications

Envy and jealousy may differ in kind or only by degree. In a study of emotion episodes recalled by 291 subjects, two forms of taxometric analysis were used to test between categorical and dimensional models of the two emotions. The two emotions yielded strong convergent evidence of discreteness, and commonly co-occurred. However, although subjects rated their episode to contain similar levels of “envy” and “jealousy,” both terms were equally correlated with the presence of envy features and neither term was correlated substantially with the presence of jealousy features. Implications are drawn for the study of categorical distinctions between emotions, and …

Postpartum Safety And Satisfaction Following Early Discharge, Dawn M. Guthrie, J. Ivan Williams, Ellen Hodnett, Janet Rush

Kinesiology and Physical Education Faculty Publications

Two Ontario sites were involved in the evaluation of an obstetrical discharge program. Before program implementation a group of eligible women were enrolled as the preprogram control group (n = 542). During the program, eligible women who agreed to early discharge (ED) became the ED group (n = 319), and those opting not to go home early but consenting to participate in the evaluation became the concurrent group (n = 456). All groups were mailed a self-administered postpartum questionnaire. On demographic characteristics, safety and satisfaction, the ED group was comparable to the concurrent group. Hospital readmission rates did not differ …

Information Interface - Volume 21, Issue 2 - March/April 1996, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Mediating Bioethical Disputes, Diane E. Hoffmann, Naomi Karp

Faculty Scholarship

No abstract provided.

Integrating Indian Health Programs Into Medicaid Managed Care Systems, Part 2, Sara J. Rosenbaum, Ann Zuvekas

Center for Health Policy Research

The Indian Health Service (IHS), recognizing that state Medicaid programs are rapidly purchasing managed care plans for their beneficiaries and that managed care enrollment has significant implications for both Indians and Indian health facilities, convened this Roundtable to discuss options for participation in such care. The purpose of this roundtable was to identify options to increase Medicaid managed care participation by Indian health programs. These include programs operated directly by IHS, programs operated by tribes under the Indian Self-Determination Act, and urban Indian programs under Title V of the Indian Health Care Improvement Act.By design, Roundtable participants were a group …

Integrating Indian Health Programs Into Medicaid Managed Care Systems, Part 1, Sara J. Rosenbaum, Ann Zuvekas

Center for Health Policy Research

The Indian Health Service (IHS), recognizing that state Medicaid programs are rapidly purchasing managed care plans for their beneficiaries and that managed care enrollment has significant implications for both Indians and Indian health facilities, convened this Roundtable to discuss options for participation in such care. The purpose of this roundtable was to identify options to increase Medicaid managed care participation by Indian health programs. These include programs operated directly by IHS, programs operated by tribes under the Indian Self-Determination Act, and urban Indian programs under Title V of the Indian Health Care Improvement Act.By design, Roundtable participants were a group …