Medicine and Health Sciences Commons^™

Cd40-Cd40 Ligand Interactions In Experimental Allergic Encephalomyelitis And Multiple Sclerosis., Koen Gerritse, Jon D. Laman, Randolph J. Noelle, Alejandro Aruffo

Dartmouth Scholarship

We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological disease. CD40L-positive cells were co-localized with CD40-bearing cells in active lesions (perivascular infiltrates). Most of these CD40-bearing cells proved to be of the monocytic lineage (macrophages or microglial cells), and relatively few were B cells. To functionally evaluate CD40-CD40L interactions, EAE was elicited in mice by means of proteolipid-peptide immunization. Treatment with …

Impact De L'Avance En Âge Sur Les Scénarios D'Accidents Et Les Indicateurs De Lésions Dans Le Secteur De L'Administration Municipale - Tome 1 : Rapport Et Tableaux, Esther Cloutier, Patrice Duguay

Rapports de recherche scientifique

No abstract provided.

Impact De L'Avance En Âge Sur Les Scénarios D'Accidents Et Les Indicateurs De Lésions Dans Le Secteur De L'Administration Municipale - Tome 2 : Figures, Esther Cloutier, Patrice Duguay

Rapports de recherche scientifique

No abstract provided.

Impact De L'Avance En Âge Sur Les Scénarios D'Accidents Et Les Indicateurs De Lésions Dans Le Secteur De L'Administration Provinciale - Tome 2 : Figures, Esther Cloutier, Patrice Duguay

Rapports de recherche scientifique

No abstract provided.

Impact De L'Avance En Âge Sur Les Scénarios D'Accidents Et Les Indicateurs De Lésions Dans Le Secteur De L'Administration Provinciale - Tome 1 : Rapport Et Tableaux, Esther Cloutier, Patrice Duguay

Rapports de recherche scientifique

No abstract provided.

The Extranasal Glioma - A Cause Of Neonatal Respiratory Distress, Muneer Amanullah, F Attar Z

Department of Surgery Docs

Normal brain tissue in an abnonnal configuration, occurring at a site away from the cranial cavity, is temied an Extranasal Glioma. Since its first description in 1852 by Reid², only 140 patients with this entity have been reported. Heterotopic brain tissue when present in a confined area may cause obstmction, pressure and pain. Its occurrence in the nasopharyngeal region is relatively rare and only 19 cases have been reported so far², the majority presenting with respiratory distress in the early neonatal period. The objective of this report is to create an awareness amongst the physicians of …

Biochemical And Mutational Analysis Of The Histidine Residues Of Staphylococcal Enterotoxin A., M Hoffman, M Tremaine, J Mansfield, M Betley

Manuscripts, Articles, Book Chapters and Other Papers

The goal of this study was to examine the role of histidine residues in the biological activities of staphylococcal enterotoxin A (SEA). Carboxymethylated SEA was unable to stimulate murine T-cell proliferation but was resistant to monkey stomach lavage fluid degradation, suggesting that native conformation was intact. Site-directed mutagenesis of the histidine residues of SEA was subsequently performed. SEA-H44A (SEA with histidine 44 replaced with alanine), SEA-H44D, SEA-H50A, SEA-H50D, SEA-H114A, SEA-H114D, SEA-H187A, and SEA-H187D retained superantigen and emetic activities, whereas SEA-H225A and SEA-H225D were defective in the ability to stimulate T-cell proliferation. These mutants were unable to compete with SEA for …

Antisense Oligodeoxynucleotide Inhibition Of A Swelling-Activated Cation Channel In Osteoblast-Like Osteosarcoma Cells., Randall L. Duncan, Neil Kizer, Elizabeth L. Barry, Peter P A Friedman, Keith A. Hruska

Dartmouth Scholarship

By patch-clamp analysis, we have shown that chronic, intermittent mechanical strain (CMS) increases the activity of stretch-activated cation channels of osteoblast-like UMR-106.01 cells. CMS also produces a swelling-activated whole-cell conductance (Gm) regulated by varying strain levels. We questioned whether the swelling-activated conductance was produced by stretch-activated cation channel activity. We have identified a gene involved in the increase in conductance by using antisense oligodeoxynucleotides (ODN) derived from the alpha 1-subunit genes of calcium channels found in UMR-106.01 cells (alpha1S, alpha1C, and alpha1D). We demonstrate that alpha 1C antisense ODNs abolish the increase in Gm in response to hypotonic swelling following …

Jefferson Alumni Bulletin – Volume Xlv, Number 2, March 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 2, March 1996 A Conversation with the Alumni Chairman of Family Medicine, Page 4 Stanton N. Smullens ’61: Jefferson Leader, Page 14 Hospital Separates from University as Step in Forming the Jefferson Health System, Page 15 Gene That Helps Cause Gliomas is Identified, Page 16 Altered FHIT Gene is Found in Several Types of Common Cancers, Page 17 Vaccine Treats Rheumatoid Arthritis, Page 18 Blood Test Can Measure Obesity Hormone, Page 19 Gene Therapy for HIV-Infected Patients Will Begin Here, Page 21 Spitzer Authors Neonatology Text, Page 23 Gallo Discovers HIV-Suppresor Factors, page …

Coated-Products With Potent Anti-Hiv And Antimicrobial Properties, George Digenis, Alexander G. Digenis

Pharmaceutical Sciences Faculty Patents

A composition which has potent anti-HIV activity. The composition is a high energy coprecipitate of nonoxynol-9 oligomers, polyvinyl-pyrrolidone (PVP) and iodine or PVP-I and shows a pronounced synergistic, anti-HIV effect between the compounds of the composition. The invention also includes paper and plastic products coated with the composition of the invention.

Farm Worker Killed When Caught In Power Take-Off (Pto), Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 32-year-old male was killed when he was caught in a rotating power take-off (PTO) shaft. He had been involved in farming for many years and often helped his friends who owned a dairy farm. The farm worker was helping one of the owners of the farm load corn from the silage wagon into the feeding trough. Both the farm worker and the owner were experienced in operating the equipment on the farm and had worked together on this type of task before. However, the owner had always operated the equipment controls. The PTO connecting the tractor to the silage …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the winter, 1996 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's Notes - Tamara Lee
• ALHeLA executive committee minutes
• MASA manual update
• Quarterly meeting dates
• Committee reports
• CME meeting
• Alabama library association - mobile
• MLA book panel
• SOCHAP-L is born!
• Alabama library association annual meeting
• Internet of Note
• MASA workshop
• Consumer health corner
• Buuter fly to GHSLA '96

When Are Research Findings Ready For Use?, Judith A. Floyd

Nursing Faculty Research Publications

No abstract provided.

Weighing Evidence In Sexual Abuse Evaluations: An Introduction To Bayes's Theorem, James Wood

Selected Works Temporary Series

This article introduces readers to Bayes' theorem, a simple mathematical formula that can illuminate general issues and assist evaluators in the field of child sexual abuse. The theorem is applied to a case study of sexual abuse allegations that arose during a custody dispute.

Weighing Evidence In Sexual Abuse Evaluations: An Introduction To Bayes's Theorem, James Wood

Departmental Papers (Psych)

This article introduces readers to Bayes' theorem, a simple mathematical formula that can illuminate general issues and assist evaluators in the field of child sexual abuse. The theorem is applied to a case study of sexual abuse allegations that arose during a custody dispute.

Distinct Cis-Acting Elements Mediate Clock, Light, And Developmental Regulation Of The Neurospora Crassa Eas (Ccg-2) Gene., Deborah Bell-Pedersen, Jay C. Dunlap, Jennifer J. Loros

Dartmouth Scholarship

The Neurospora crassa eas (ccg-2) gene, which encodes a fungal hydrophobin, is transcriptionally regulated by the circadian clock. In addition, eas (ccg-2) is positively regulated by light and transcripts accumulate during asexual development. To sort out the basis of this complex regulation, deletion analyses of the eas (ccg-2) promoter were carried out to localize the cis-acting elements mediating clock, light, and developmental control. The primary sequence determinants of a positive activating clock element (ACE) were found to reside in a 45-bp region, just upstream from the TATA box. Using a novel unregulated promoter/reporter system developed for this study, we show …

Gtpase-Deficient G Alpha 16 And G Alpha Q Induce Pc12 Cell Differentiation And Persistent Activation Of Cjun Nh2-Terminal Kinases., Lynn E. Heasley, Brooke Storey, Gary R. Fanger, Laura Butterfield, J Zamarripa, D Blumberg, R A. Maue

Dartmouth Scholarship

Persistent stimulation of specific protein kinase pathways has been proposed as a key feature of receptor tyrosine kinases and intracellular oncoproteins that signal neuronal differentiation of rat pheochromocytoma (PC12) cells. Among the protein serine/threonine kinases identified to date, the p42/44 mitogen-activated protein (MAP) kinases have been highlighted for their potential role in signalling PC12 cell differentiation. We report here that retrovirus-mediated expression of GTPase-deficient, constitutively active forms of the heterotrimeric Gq family members, G alpha qQ209L and G alpha 16Q212L, in PC12 cells induces neuronal differentiation as indicated by neurite outgrowth and the increased expression of voltage-dependent sodium channels. Differentiation …

Étude D'Un Moyen De Prévention D'Une Maladie Professionnelle (Le Poumon Du Fermier) : Ensemencement De Bactéries Dans Le Fourrage, Caroline Duchaine, Anne Mériaux, Gaétane Racine-Bédard, Évelyne Israël-Assayag, Gilles Brochu, Marc C. Lavoie, Yvon Cormier

Rapports de recherche scientifique

No abstract provided.

Évaluation Et Étude Du Comportement Dynamique D'Un Système De Suspension Torsio-Élastique Pour Véhicules Tout Terrain, Paul-Émile Boileau, Subhash Rakheja

Rapports de recherche scientifique

No abstract provided.

Symposium On Nursing Centers: Past, Present And Future, Marilyn Frenn

College of Nursing Faculty Research and Publications

No abstract provided.

2,4-Disulfonyl Phenyl Butyl Nitrone, Its Salt And Their Use As Pharmaceuticals Free Radical Traps, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss.

Ms211: News Clips, Armin Weinberg

Works on Radiation Effects: 1990-2020

A collection of news clips I used to track what might be relevant to our work in Kazakhstan. Of note is a story about Newmont Corp's interest in developing gold resources in the region. They eventually were contacted and help support several public health education initiatives in the Semey region. See more at Armin Weinberg, PhD Papers and its finding aid.

Mss 004 Margaret A. Newman, Phd Collection Finding Aid, Jennifer Langford Ca, Mlis

Margaret A. Newman Documents and Publications

No abstract provided.

On The Order Of The Real: Nietzsche And Lacan, Babette Babich

Articles and Chapters in Academic Book Collections

No abstract provided.

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Fall, 1996 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's Notes - Tammy Lee
• Alabama Health Libraries Association Annual Business Meeting
• Committee reports
• Free MEDLINE Access on the Internet
• Letter from Atha Louise Henley
• Letter from George Marangoly
• AMA Partners-in-Health network

Adverse Cerebral Outcomes After Coronary Bypass Surgery, Gary W. Roach , M.D., Marc Kanchuger , M.D., Christina Mora Mangano , M.D., Mark Newman , M.D., Nancy Nussmeier , M.D., Richard Wolman , M.D., Anil Aggarwal , M.D., Katherine Marschall , M.D., Steven H. Graham , M.D., Ph.D., Catherine Ley , Ph.D., Gerard Ozanne , M.D., Dennis T. Mangano , Ph.D., M.D., Ahvie Herskowitz , M.D., Vera Katseva , Ph.D, Rita Sears , R.N., M.S.

Anesthesiology Publications

ABSTRACT

Background Acute changes in cerebral function after elective coronary bypass surgery are a difficult clinical problem. We carried out a multicenter study to determine the incidence and predictors of — and the use of resources associated with — perioperative adverse neurologic events, including cerebral injury.

Methods In a prospective study, we evaluated 2108 patients from 24 U.S. institutions for two general categories of neurologic outcome: type I (focal injury, or stupor or coma at discharge) and type II (deterioration in intellectual function, memory deficit, or seizures).

Results Adverse cerebral outcomes occurred in 129 patients (6.1 percent). A total of …

Social Support Mechanisms Among Athletes With Disabilities, Jeffrey J. Martin, Carol Adams Mushett

Kinesiology, Health and Sport Studies

The purpose of this investigation was to describe social support mechanisms of swimmers with disabilities and examine relationships among social support, self-efficacy, and athletic satisfaction. Results indicated that athletes felt satisfied with the social support they received. Mothers and friends provided primary support in a variety of areas requiring non-sport-related knowledge. Additionally, there were important secondary sources of support in areas requiring sport-specific knowledge. Coaches were primary sources of support in areas that required sport expertise. Fathers were also important sources of secondary support in areas that required both sport expertise and nonsport expertise. Correlational results suggested that athletes who …

Mid-Atlantic Ethics Committee Newsletter, Winter 1996

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Pharmacokinetics Of Vancomycin In Critically Ill Infants Undergoing Extracorporeal Membrane Oxygenation, R. Davis Maker, Joseph T. Dipiro, Jatinder Bhatia

Publications from the Office of the Dean

Extracorporeal membrane oxygenation (ECMO) is a widely used therapy for neonates with respiratory failure. Because of sepsis, many of these infants require antibiotics like vancomycin during ECMO treatment. ECMO transiently alters renal function and increases the circulating blood volume by 75%. Initial vancomycin pharmacokinetics were determined in 12 infants undergoing ECMO to determine an adequate drug administration regimen. Vancomycin dosage was based on current recommendations for weight and gestational age. Pharmacokinetic parameters were determined by fitting the data to a two compartment model. This study yielded a mean steady-state volume of distribution of 1.1 +/- 0.5 (range, 0.6 to 2.1) …

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the January, 1996 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• USA researchers probe unique organism
• Students receive early clinical training
• Second annual national primary care day
• Congratulations...
• Student awards
• 21st Annual meeting of the national sickle cell disease program
• Graduate research forum / visitation day
• USA awarded grant to extend access to health information network
• New cardiac care unit at USA medical center
• New faculty members
• Clinical investigation services: changing with changing needs